scholarly journals Human C-peptide Dose Dependently Prevents Early Neuropathy in the BB/Wor-rat

2001 ◽  
Vol 2 (3) ◽  
pp. 187-193 ◽  
Author(s):  
W. Zhang ◽  
M. Yorek ◽  
C. R. Pierson ◽  
Y. Murakawa ◽  
A. Breidenbach ◽  
...  
Keyword(s):  
Diabetic Neuropathy ◽  
Axonal Degeneration ◽  
Diabetic Rats ◽  
Nerve Fibers ◽  
C Peptide ◽  
Conserved Sequence ◽  
Structural Abnormalities ◽  
Onset Of Diabetes ◽  
Dose Dependent

In order to explore the neuroprotective and crossspecies activities of.C-peptide on type 1 diabetic neuropathy, spontaneously diabetic BB/W-rats were given increasing doses of human recombinant Cpeptide (hrC-peptide). Diabetic rats received 10, 100, 500, or 1000 μg of hrC-peptide/kg body weight/ day from onset of diabetes. After 2 months of hrC-peptide administration, 100 μg and greater doses completely prevented the nerve conduction defect, which was associated with a significant but incomplete prevention of neuralNa+/K+-ATPase activity in diabetic rats with 500 μg or greater C-peptide replacement. Increasing doses of hrC-peptide showed increasing prevention of early structural abnormalities such as paranodal swelling and axonal degeneration and an increasing frequency of regenerating sural nerve fibers. We conclude that hrC-peptide exerts a dose dependent protection on type 1 diabetic neuropathy in rats and that this effect is probably mediated by the partially conserved sequence of the active C-terminal pentapeptide

scholarly journals Dynamic Changes of Neuroskeletal Proteins in DRGs Underlie Impaired Axonal Maturation and Progressive Axonal Degeneration in Type 1 Diabetes

2009 ◽  
Vol 2009 ◽  
pp. 1-14 ◽  
Author(s):  
Hideki Kamiya ◽  
Weixian Zhang ◽  
Anders A. F. Sima
Keyword(s):  
Type 1 Diabetes ◽  
Sural Nerve ◽  
Axonal Degeneration ◽  
Nerve Fibers ◽  
Diabetes Duration ◽  
Dynamic Changes ◽  
C Peptide ◽  
Conduction Velocities ◽  
Axonal Dysfunction

We investigated mechanisms underlying progressive axonal dysfunction and structural deficits in type 1 BB/Wor-rats from 1 week to 10 month diabetes duration. Motor and sensory conduction velocities were decreased after 4 and 6 weeks of diabetes and declined further over the remaining 9 months. Myelinated sural nerve fibers showed progressive deficits in fiber numbers and sizes. Structural deficits in unmyelinated axonal size were evident at 2 month and deficits in number were present at 4 mo. These changes were preceded by decreased availability of insulin, C-peptide and IGF-1 and decreased expression of neurofilaments andβ-III-tubulin. Upregulation of phosphorylating stress kinases like Cdk5, p-GSK-3β, and p42/44 resulted in increased phosphorylation of neurofilaments. Increasing activity of p-GSK-3βcorrelated with increasing phosphorylation of NFH, whereas decreasing Cdk5 correlated with diminishing phosphorylation of NFM. The data suggest that impaired neurotrophic support results in sequentially impaired synthesis and postranslational modifications of neuroskeletal proteins, resulting in progressive deficits in axonal function, maturation and size.

scholarly journals NEUROPROTECTION OF ABELMOSCHUS ESCULENTUS L. AGAINST DIABETIC NEUROPATHY

2018 ◽  
Vol 11 (15) ◽  
pp. 28
Author(s):  
Lee Wei Yang ◽  
Santosh Fattepur ◽  
Kiran Chanabasappa Nilugal ◽  
Fadli Asmani ◽  
Eddy Yusuf ◽  
...  
Keyword(s):  
Body Weight ◽  
Sciatic Nerve ◽  
Diabetic Neuropathy ◽  
Performance Test ◽  
Neuroprotective Effect ◽  
Thermal Hyperalgesia ◽  
Diabetic Rats ◽  
Nerve Fibers ◽  
Abelmoschus Esculentus ◽  
Rotarod Performance

Objective: The present study was designed to determine the neuroprotective effect of Abelmoschus esculentus L. on alloxan-induced diabetic neuropathy in rats.Methods: Diabetes was induced in rats with a single intraperitoneal injection of alloxan monohydrate (130 mg/kg b.w). The ethanol extract of A. esculentus L. at a dose of 100 and 200 mg/kg of body weight was administered at single dose per day to alloxan-induced diabetic rats for 21 days. The fasting blood glucose was screened in the intermittent on day 0, day 14, and day 21. Behavioral tests such as thermal hyperalgesia test and rotarod performance test were performed to assess the thermal sensitivity and muscle grip strength. At the end of the study period, experimental animals were sacrificed and sciatic nerve tissues were obtained for histopathological investigation.Results: Animals treated with A. esculentus L. extarct at a dose of 200 mg/kg of body weight significantly reduced (p<0.05) in hyperglycemia and thermal hyperalgesia and significantly increased (p<0.05) in rotarod performance. The sciatic nerve fiber of diabetic rats receiving 200 mg/kg of body weight of A. esculentus L. extract also shows no swelling of nerve fibers, and lesser demyelination was observed.Conclusion: These findings demonstrate that A. esculentus L. exhibits significant antidiabetic and neuroprotective effect against alloxan-induced diabetic neuropathy in rats.

PROTECTIVE ROLE OF FICUS RACEMOSA IN DIABETES INDUCED NEUROPATHY: STRUCTURAL AND FUNCTIONAL EVIDENCES

INDIAN DRUGS ◽  
2017 ◽  
Vol 54 (11) ◽  
pp. 58-60
Author(s):  
N Solanki ◽  
◽  
S. K Bhavsar
Keyword(s):  
Sciatic Nerve ◽  
Diabetic Neuropathy ◽  
Ethanolic Extract ◽  
Protective Role ◽  
Diabetic Rats ◽  
Dependent Manner ◽  
Traditional System ◽  
Ficus Racemosa ◽  
Dose Dependent

Ficus racemosa is used in traditional system of medicine for various health problems and diseases, and is commonly known as Gular fig. The main objective was to study its effects against streptozotocin induced diabetic neuropathy by structural and functional marker. Investigation of diabetic neuropathy was carried out through functional and structural assessment in streptozotocin induced in diabetic rats. Diabetic rats were treated for 28 days in dose dependent manner of Ficus racemosa aqueous extract (250 mg/kg and 500 mg/kg) and ethanolic extract (200 mg/kg and 400 mg/kg). Study showed marked protection observed by Ficus racemosa in hippocampus region of brain and sciatic nerve tissues. Ficus racemosa treatment showed improvement in functional and structural markers, which strongly suggest its protective role in diabetic neuropathy.

Attenuation of Cardiac Functional and Structural Abnormalities by Hibiscus Sabdariffa Polyphenol-Rich Extract in Type-1-Induced Diabetic Rats

2018 ◽  
Vol 273 ◽  
pp. 19 ◽  
Author(s):  
Nur Liyana Mohammed Yusof ◽  
Satirah Zainalabidin ◽  
Norsyahida Mohd Fauzi ◽  
Siti Balkis Budin
Keyword(s):  
Diabetic Rats ◽  
Hibiscus Sabdariffa ◽  
Structural Abnormalities

scholarly journals C-Peptide Replacement Therapy and Sensory Nerve Function in Type 1 Diabetic Neuropathy

Diabetes Care ◽  
2006 ◽  
Vol 30 (1) ◽  
pp. 71-76 ◽  
Author(s):  
K. Ekberg ◽  
T. Brismar ◽  
B.-L. Johansson ◽  
P. Lindstrom ◽  
L. Juntti-Berggren ◽  
...  
Keyword(s):  
Diabetic Neuropathy ◽  
Replacement Therapy ◽  
Sensory Nerve ◽  
Nerve Function ◽  
C Peptide

scholarly journals Molecular Alterations Underlie Nodal and Paranodal Degeneration in Type 1 Diabetic Neuropathy and Are Prevented by C-Peptide

Diabetes ◽  
2004 ◽  
Vol 53 (6) ◽  
pp. 1556-1563 ◽  
Author(s):  
A. A.F. Sima ◽  
W. Zhang ◽  
Z.-G. Li ◽  
Y. Murakawa ◽  
C. R. Pierson
Keyword(s):  
Diabetic Neuropathy ◽  
C Peptide ◽  
Molecular Alterations

scholarly journals Fulminant Type 1 Diabetes as a Model of Nature to Explore the Role of C-Peptide

2008 ◽  
Vol 2008 ◽  
pp. 1-2
Author(s):  
Yuko Murase-Mishiba ◽  
A. Imagawa ◽  
Toshiaki Hanafusa
Keyword(s):  
Type 1 Diabetes ◽  
Physiological Role ◽  
Chronic Complications ◽  
Fulminant Type 1 Diabetes ◽  
C Peptide ◽  
Onset Of Diabetes ◽  
Fulminant Type

Patients with fulminant type 1 diabetes almost completely lack C-peptide even soon after the onset of the disease, and the deficiency continues for the rest of their life. Thus, fulminant type 1 diabetes could serve as a good model of nature to explore the physiological role of C-peptide. For example, patients with fulminant type 1 diabetes have diabetic chronic complications more frequently than those with classical autoimmune type 1 diabetes 5 years after the onset of diabetes, and the higher prevalence could be partly attributable to the complete lack of C-peptide in fulminant type 1 diabetes.

scholarly journals Reduction of Vascular Reactivity with Dantrolene in Type 1 Diabetic Rats is Dose‐dependent

2019 ◽  
Vol 33 (S1) ◽  
Author(s):  
Marie Roman ◽  
Jose Ramirez ◽  
Ricardo Torres ◽  
Victor Marrero ◽  
Laura Garcia ◽  
...  
Keyword(s):  
Vascular Reactivity ◽  
Diabetic Rats ◽  
Dose Dependent
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