scholarly journals DNA Interactions with Ruthenium(II) Polypyridine Complexes Containing Asymmetric Ligands

2005 ◽  
Vol 3 (1-2) ◽  
pp. 15-28 ◽  
Author(s):  
Hui Chao ◽  
Liang-Nian Ji
Keyword(s):  
Nucleic Acid ◽  
Dna Binding ◽  
Binding Modes ◽  
Dna Interactions ◽  
Binding Properties ◽  
The Past ◽  
Polypyridine Complexes ◽  
Nucleic Acid Structures ◽  
Dna Binding Properties ◽  
Shape And Size

In an attempt to probe nucleic acid structures, numerous Ru(II) complexes with different ligands have been synthesized and investigated. In this contribution we focus on the DNA-binding properties of ruthenium(II) complexes containing asymmetric ligands that have attracted little attention in the past decades. The influences of the shape and size of the ligand on the binding modes, affinity, enantioselectivities and photocleavage of the complexes to DNA are described.

scholarly journals Antibacterial Activity and DNA Binding Properties of Bivalent Metal Complexes of Cuminaldehyde Acetoylhydrazone

2021 ◽  
Vol 37 (5) ◽  
pp. 1125-1131
Author(s):  
Y.B. Nagamani ◽  
K. Hussain Reddy ◽  
K. Srinivasulu ◽  
D. Dhanalakshmi ◽  
K. Anuja
Keyword(s):  
Antibacterial Activity ◽  
Dna Binding ◽  
Binding Constants ◽  
Dna Interactions ◽  
Bivalent Metal ◽  
Binding Properties ◽  
Hydrazone Ligand ◽  
Metal Compounds ◽  
Physico Chemical ◽  
Dna Binding Properties

Metallo-hydrazones having the formula [M(IBAH)2] (where, M = Ni(II), Cu(II) and Zn(II); IBAH = p-Isopropylbenzaldehyde acetoylhydrazone) are prepared and confirmed on the basis of physico-chemical and spectral analyses. Conductivity data revealed that the complexes are non-electrolytes. Metal-DNA interactions are investigated using absorption spectrophotometry. Binding constant (Kb) data revealed that the copper complex interact DNA more strongly than other complexes. Antibacterial activity studies indicated higher activity for complexes than the metal free hydrazone ligand. The copper compound displays higher activity. DNA binding constants are correlated with the activity of metal compounds in this article.

scholarly journals Reversible photoswitching of the DNA-binding properties of styrylquinolizinium derivatives through photochromic [2 + 2] cycloaddition and cycloreversion

2020 ◽  
Vol 16 ◽  
pp. 111-124 ◽  
Author(s):  
Sarah Kölsch ◽  
Heiko Ihmels ◽  
Jochen Mattay ◽  
Norbert Sewald ◽  
Brian O Patrick
Keyword(s):  
Dna Binding ◽  
Diffraction Analysis ◽  
Binding Constants ◽  
Binding Modes ◽  
Reaction Products ◽  
X Ray Diffraction ◽  
Binding Properties ◽  
X Ray ◽  
Spectroscopic Analyses ◽  
Dna Binding Properties

It was demonstrated that styrylquinolizinium derivatives may be applied as photoswitchable DNA ligands. At lower ligand:DNA ratios (≤1.5), these compounds bind to duplex DNA by intercalation, with binding constants ranging from K b = 4.1 × 104 M to 2.6 × 105 M (four examples), as shown by photometric and fluorimetric titrations as well as by CD and LD spectroscopic analyses. Upon irradiation at 450 nm, the methoxy-substituted styrylquinolizinium derivatives form the corresponding syn head-to-tail cyclobutanes in a selective [2 + 2] photocycloaddition, as revealed by X-ray diffraction analysis of the reaction products. These photodimers bind to DNA only weakly by outside-edge association, but they release the intercalating monomers upon irradiation at 315 nm in the presence of DNA. As a result, it is possible to switch between these two ligands and likewise between two different binding modes by irradiation with different excitation wavelengths.

scholarly journals Purification, subunit structure, and DNA binding properties of the mouse oxysterol receptor

1989 ◽  
Vol 264 (31) ◽  
pp. 18433-18439 ◽  
Author(s):  
F R Taylor ◽  
E P Shown ◽  
E B Thompson ◽  
A A Kandutsch
Keyword(s):  
Dna Binding ◽  
Subunit Structure ◽  
Binding Properties ◽  
Dna Binding Properties
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