scholarly journals Successful Treatment of Recalcitrant Granuloma Gluteale Infantum with Topical Tacrolimus 0.03% Ointment

2021 ◽  
Vol 2021 ◽  
pp. 1-5
Author(s):  
Alexander K. C. Leung ◽  
Kin Fon Leong ◽  
Joseph M. Lam
Keyword(s):  
Contact Dermatitis ◽  
Successful Treatment ◽  
Conservative Management ◽  
Rare Complication ◽  
Skin Irritation ◽  
Calcineurin Inhibitors ◽  
Irritant Contact Dermatitis ◽  
Topical Tacrolimus ◽  
Topical Calcineurin Inhibitors

Granuloma gluteale infantum is a rare complication of irritant contact dermatitis. For the treatment of granuloma gluteale infantum, the diaper area should be kept clean and dry and the source of skin irritation should be removed or mitigated. For those infants who fail to respond to the conservative management, the use of topical calcineurin inhibitors should be considered. We report the successful treatment of a 12-month-old infant with recalcitrant granuloma gluteale infantum with the use of topical tacrolimus 0.03% ointment. To our knowledge, this is the second case reporting the use of topical calcineurin inhibitors in the treatment of recalcitrant granuloma gluteale infantum.

Efficacy of Topical Calcineurin Inhibitors in Lichen Planus

2012 ◽  
Vol 16 (4) ◽  
pp. 221-229 ◽  
Author(s):  
Michael Samycia ◽  
Andrew N. Lin
Keyword(s):  
Lichen Planus ◽  
Strong Evidence ◽  
Oral Lichen Planus ◽  
Case Reports ◽  
Calcineurin Inhibitors ◽  
Double Blind ◽  
Tacrolimus Ointment ◽  
Topical Tacrolimus ◽  
Topical Calcineurin Inhibitors ◽  
Oral Lichen

Background: Topical calcineurin inhibitors have been studied in many skin disorders, including lichen planus. Objective: To evaluate published reports of the use of topical calcineurin inhibitors in lichen planus. Methods: We searched PubMed, Ovid/Cochrane, and Embase using the keywords “tacrolimus,” “pimecrolimus,” “topical calcineurin inhibitors,” and “lichen planus.” Results: We examined 5 double-blind studies, 1 investigator-blinded study, 10 open prospective studies, 6 retrospective studies, and 28 case reports evaluating tacrolimus or pimecrolimus for oral, vulvovaginal, and cutaneous lichen planus. Conclusions: Strong evidence (double-blind and open studies) supports the use of topical tacrolimus ointment in oral lichen planus, with efficacy at least equal to topical clobetasol propionate 0.05% ointment. Treatment of oral lichen planus with topical tacrolimus ointment can result in demonstrable blood tacrolimus levels, but without clinically significant adverse events. Strong evidence (double-blind and open studies) supports the use of topical pimecrolimus 1% cream in oral lichen planus, with efficacy equal to that of topical triamcinolone acetonide 0.1% paste. For vulvovaginal lichen planus, pimecrolimus was superior to placebo in one double-blind study, and tacrolimus was effective in open studies. Only case reports support the efficacy of topical calcineurin inhibitors in cutaneous lichen planus.

scholarly journals IRRITANT CONTACT DERMATITIS ON HANDS AND DIAGNOSIS OF IT: A REVIEW

2020 ◽  
pp. 29-32
Author(s):  
ADEL MUTLAQ ALOTAIBI ◽  
FATIMAH KHALIFAH MOHAMMAD AL-SULAIMAN ◽  
MAHA BAHJAT ALMADANI
Keyword(s):  
Contact Dermatitis ◽  
Healthcare Workers ◽  
Review Process ◽  
Skin Irritation ◽  
Research Review ◽  
Healthcare Associated Infections ◽  
Irritant Contact Dermatitis ◽  
Skin Damage ◽  
Pathogen Load ◽  
Healthcare Associated

Hand hygiene (HH) is the single most important procedure that can be followed by healthcare workers (HCWs) to reduce the risk of spreading healthcare-associated infections. The irritating contact dermatitis (ICD) that occurs due to the rehashed presentation of HH products and technique is one reason often referred to for resistance. HH is the most vital method that can be followed by HCWs to reduce the possibility of spreading of infection in human being, followed by50% of HCWs. Limited researches are published related to different features of irritant contact disorders among HCWs. This study concentrates manly on the clinical application of irritant contact dermatitis on hands and its diagnosis based on an extensive research review process. It can be concluded from this review that by proper adherence and compliance to necessary HH techniques lead to skin damage and higher pathogen load. Therefore, it is important that HCWs should appreciate this concept and are given methods or tactics of expertise to avoid skin irritation and damage. Inability to provide proper policies, practices and guidelines to these workers may lead to adherence in case of an ICD appearance.

Efficacy of Topical Calcineurin Inhibitors in Psoriasis

2014 ◽  
Vol 18 (1) ◽  
pp. 8-14 ◽  
Author(s):  
Cong Wang ◽  
Andrew Lin
Keyword(s):  
Atopic Dermatitis ◽  
Open Study ◽  
English Language ◽  
Calcineurin Inhibitors ◽  
Special Role ◽  
Double Blind ◽  
Topical Tacrolimus ◽  
Topical Calcineurin Inhibitors ◽  
Cutaneous Atrophy

Background: Topical calcineurin inhibitors (tacrolimus and pimecrolimus) are indicated for the treatment of atopic dermatitis but ve also been studied in the treatment of psoriasis. Objective: To define the efficacy of topical calcineurin inhibitors in the treatment of psoriasis. Methods: We searched for English-language articles published since 1990 in PubMed, Ovid/Cochrane, and Embase using “tacrolimus,” “pimecrolimus,” or “topical calcineurin inhibitors” and “psoriasis.” Results: Nine double-blind and 13 open studies demonstrated the efficacy of topical tacrolimus in psoriasis, especially for facial, genital, and intertrigious psoriasis, and four double-blind and one open study demonstrated the efficacy of topical pimecrolimus. Conclusions: The evidence (double-blind and open studies) is strong that topical tacrolimus and, to a lesser extent, pimecrolimus have efficacy in the treatment of psoriasis. Since these agents do not cause cutaneous atrophy, they likely have a special role in facial, genital, and intertriginous psoriasis. Further studies would help define their roles in psoriasis.

Irritant contact dermatitis secondary to fiberglass: an unusual presentation

2000 ◽  
Vol 39 (5) ◽  
pp. 372-374 ◽  
Author(s):  
Joy Y. Chen ◽  
Rhea Phillips ◽  
Alan T. Lewis ◽  
Long T. Quan ◽  
Sylvia Hsu ◽  
...  
Keyword(s):  
Contact Dermatitis ◽  
Unusual Presentation ◽  
Irritant Contact Dermatitis

Vitiligo: An Updated Narrative Review

2020 ◽  
Vol 16 ◽  
Author(s):  
Alexander K. C. Leung ◽  
Joseph M. Lam ◽  
Kin Fon Leong ◽  
Kam Lun Hon
Keyword(s):  
Present Article ◽  
English Literature ◽  
Disease Onset ◽  
Clinical Manifestations ◽  
Calcineurin Inhibitors ◽  
Ultraviolet B ◽  
Lower Limbs ◽  
Treatment Modalities ◽  
Topical Corticosteroids ◽  
Topical Calcineurin Inhibitors

Background: Vitiligo is a relatively common acquired pigmentation disorder that can cause significant psychological stress and stigmatism. Objective: This article aims to familiarize physicians with the clinical manifestations, evaluation, diagnosis, and management of vitiligo. Methods: A Pubmed search was conducted in Clinical Queries using the key term "vitiligo". The search included metaanalyses, randomized controlled trials, clinical trials, observational studies, and reviews. The search was restricted to the English literature. The information retrieved from the above search was used in the compilation of the present article. The information retrieved from the above search was used in the compilation of the present article. Results: Approximately one quarter of patients with vitiligo have the onset before 10 years of age. Genetic, immunological, neurogenic and environmental factors may have a role to play in the pathogenesis. Vitiligo typically presents as acquired depigmented, well-demarcated macules/patches that appear milk- or chalk-white in color. Lesions tend to increase in number and enlarge centrifugally in size with time. Sites of predilection include the face, followed by the neck, lower limbs, trunk, and upper limbs. The clinical course is generally unpredictable. In children with fair skin, no active treatment is usually necessary other than the use of sunscreens and camouflage cosmetics. If treatment is preferred for cosmesis, topical corticosteroids, topical calcineurin inhibitors, and narrowband ultraviolet B phototherapy are the mainstays of treatment. Conclusion: The therapeutic effect of all the treatment modalities varies considerably from individual to individual. As such, treatment must be individualized. In general, the best treatment response is seen in younger patients, recent disease onset, darker skin types, and head and neck lesions. Topical corticosteroids and calcineurin inhibitors are the treatment of choice for those with localized disease. Topical calcineurin inhibitors are generally preferred for lesions on genitalia, intertriginous areas, face, and neck. Narrowband ultraviolet B phototherapy should be considered in patients who have widespread vitiligo or those with localized vitiligo associated with a significant impact on the quality of life who do not respond to treatment with topical corticosteroids and calcineurin inhibitors.

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