scholarly journals Pain Changes Induced by Acupuncture in Single Body Areas in Fibromyalgia Syndrome: Results from an Open-Label Pragmatic Study

2021 ◽  
Vol 2021 ◽  
pp. 1-8
Author(s):  
Marco Di Carlo ◽  
Giacomo Beci ◽  
Fausto Salaffi
Keyword(s):  
Disease Severity ◽  
Fibromyalgia Syndrome ◽  
Pain Scale ◽  
The Self ◽  
Manual Acupuncture ◽  
Open Label ◽  
Single Body ◽  
Left Buttock ◽  
High Disease Severity ◽  
Pragmatic Study

To date, there is considerable evidence of the effectiveness of acupuncture in fibromyalgia syndrome (FM). However, it is not known in which body areas acupuncture is more effective. The objective of this study was to assess the improvements of pain induced by acupuncture in single body areas in patients with FM. In this open-label pragmatic study, FM patients in a state of high disease severity were consecutively enrolled and treated with a course of 8 weekly sessions of manual acupuncture. Patients were assessed with the Self-Administered Pain Scale (SAPS) of the Fibromyalgia Assessment Status at baseline and at the end of eight acupuncture sessions. Acupuncture sessions were all conducted with the same acupuncture formula (LV3, SP6, ST36, LI4, CV6, CV12, Ex-HN-3, and GV20) in each session and in each patient. Ninety-six FM patients completed the course of treatment. All the 16 body areas assessed by SAPS showed improvement in pain. A statistically significant improvement was achieved in 12 of the 16 body areas investigated, with the best results in abdomen and forearms ( p = 0.001 ), while the worst results were registered for neck ( p = 0.058 ), chest ( p = 0.059 ), left buttock ( p = 0.065 ), and right thigh ( p = 0.052 ). The treatment has also shown significant effectiveness in improving fatigue and sleep quality ( p < 0.0001 ). Acupuncture has a beneficial effect on pain in all body areas in FM patients with high disease severity, with the greatest effects in the abdominal region and in the forearms, allowing a personalization of the treatment.

scholarly journals Identification of non-ribosomal peptide synthetase in Ganoderma boninense Pat. that was expressed during the interaction with oil palm

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Neda Shokrollahi ◽  
Chai-Ling Ho ◽  
Nur Ain Izzati Mohd Zainudin ◽  
Mohd As’wad Bin Abul Wahab ◽  
Mui-Yun Wong
Keyword(s):  
Disease Severity ◽  
Oil Palm ◽  
Peptide Sequence ◽  
White Rot ◽  
White Rot Fungus ◽  
Ganoderma Boninense ◽  
Nrps Gene ◽  
Peptide Synthetases ◽  
Peptide Synthetase ◽  
High Disease Severity

AbstractBasal stem rot (BSR) of oil palm is a disastrous disease caused by a white-rot fungus Ganoderma boninense Pat. Non-ribosomal peptides (NRPs) synthesized by non-ribosomal peptide synthetases (NRPSs) are a group of secondary metabolites that act as fungal virulent factors during pathogenesis in the host. In this study, we aimed to isolate NRPS gene of G. boninense strain UPMGB001 and investigate the role of this gene during G. boninense-oil palm interaction. The isolated NRPS DNA fragment of 8322 bp was used to predict the putative peptide sequence of different domains and showed similarity with G. sinense (85%) at conserved motifs of three main NRPS domains. Phylogenetic analysis of NRPS peptide sequences demonstrated that NRPS of G. boninense belongs to the type VI siderophore family. The roots of 6-month-old oil palm seedlings were artificially inoculated for studying NRPS gene expression and disease severity in the greenhouse. The correlation between high disease severity (50%) and high expression (67-fold) of G. boninense NRPS gene at 4 months after inoculation and above indicated that this gene played a significant role in the advancement of BSR disease. Overall, these findings increase our knowledge on the gene structure of NRPS in G. boninense and its involvement in BSR pathogenesis as an effector gene.

Faces scales in paediatric pain assessment

2018 ◽  
Author(s):  
Alison Bliss
Keyword(s):  
Pain Intensity ◽  
Rating Scale ◽  
Critical Evaluation ◽  
Pain Scale ◽  
The Self ◽  
Self Report ◽  
Future Research ◽  
Clinical Settings ◽  
Pain Scales ◽  
Pain Rating Scale

The landmark paper discussed in this chapter is a systematic review assessing the commonly used faces pain scales employed to aid children in the self-report of their pain intensity. The review provides a critical evaluation of the Faces Pain Scale, the Faces Pain Scale-Revised (FPS-R), the Oucher pain scale, and the Wong–Baker Faces Pain Rating Scale (WBFPRS). The reviewers found that the psychometric properties of the FPS-R supported its superiority for use in research. Although they found that children, and many staff, expressed a preference for the WBFPRS, the reviewers had major concerns about this scale confounding pain intensity with affect. They also noted the paucity of research in younger children, and concluded that future research should not focus on developing more pain scales for paediatric use but on examining the appropriate application of existing scales in a wider range of clinical settings.

scholarly journals Severity of powdery mildew on winter barley in the Czech Republic in 1976–2005

2008 ◽  
Vol 43 (No. 3) ◽  
pp. 77-85 ◽  
Author(s):  
A. Dreiseitl
Keyword(s):  
Czech Republic ◽  
Powdery Mildew ◽  
Disease Severity ◽  
Field Trials ◽  
Winter Barley ◽  
Sources Of Resistance ◽  
The Czech Republic ◽  
High Infection ◽  
High Disease Severity ◽  
Important Disease

Results of scoring the reaction to powdery mildew of 240 winter barley varieties that were gradually included in 392 Czech Official Trials conducted at 21 locations were analysed. The reaction of the varieties was determined on the basis of the level of infection by the disease. Therefore, the data can also be used to assess the disease severity in years and at locations. Several characteristics indicative of disease severity were considered, including the disease severity coefficient (= average infection of susceptible varieties in trials with a high disease severity/the proportion of such trials). The value of the coefficient is inversely proportional to disease severity. The highest powdery mildew severity was found in 1976, and the years 1988, 1990 and 2003 were characterised by high infection of the examined varieties. In contrast, the disease was practically absent in 1979 and 1982, and its severity was also low in 1978, 1981, 1985, 1991 and 1998. Very low disease severity was found for the period 1977–1982 when insufficient disease severity was found on average in 78% of the trials and high disease severity in only 6% of the trials. The highest disease severity was found at locations Trutnov, Horažďovice and Chrastava. The analysis of data from a large number of field trials conducted at various locations for a period of 30 years confirmed that powdery mildew is an important disease of winter barley in the Czech Republic. Known genetic sources of resistance and current methods, such as marker assisted selection, enable breeders to solve this problem.

scholarly journals Assessing the Adequacy of the Simulation Model LATEBLIGHT Under Nicaraguan Conditions

Plant Disease ◽  
2011 ◽  
Vol 95 (7) ◽  
pp. 839-846 ◽  
Author(s):  
Jorge Ulises Blandón-Díaz ◽  
Gregory A. Forbes ◽  
Jorge L. Andrade-Piedra ◽  
Jonathan E. Yuen
Keyword(s):  
Late Blight ◽  
Simulation Model ◽  
Disease Severity ◽  
Field Experiments ◽  
Durable Resistance ◽  
Potato Production ◽  
Potato Cultivars ◽  
Disease Progress ◽  
High Disease Severity ◽  
Fungicide Control

In this study, the adequacy of the late blight simulation model LATEBLIGHT (version LB2004) was evaluated under Nicaraguan conditions. During 2007 to 2008, five field experiments were conducted in three potato-production regions in northern Nicaragua. Two susceptible (‘Cal White’ and ‘Granola’) and one resistant (‘Jacqueline Lee’) potato cultivars were evaluated without use of fungicides and with three application intervals (4, 7, and 14 days) of the fungicide chlorothalonil. The simulation model was considered adequate because it accurately predicted high disease severity in susceptible cultivars without fungicide protection, and demonstrated a decrease in the disease progress curves with additional fungicide applications, similar to that observed in the plots. The model also generally predicted inadequate fungicide control, even with a 4-day spray interval, which also occurred in the field. Lack of adequate fungicide protection would indicate the need for cultivars with higher levels of durable resistance, and that farmers should consider more effective fungicides applications (higher dosages or different chemistries) if susceptible cultivars are used.

scholarly journals Suppression of Sclerotinia Stem Rot of Soybean by Lactofen Herbicide Treatment

1999 ◽  
Vol 89 (7) ◽  
pp. 598-602 ◽  
Author(s):  
E. K. Dann ◽  
B. W. Diers ◽  
R. Hammerschmidt
Keyword(s):  
Disease Severity ◽  
Field Experiments ◽  
Lesion Size ◽  
Stem Rot ◽  
Growth Stages ◽  
Sclerotinia Stem Rot ◽  
High Disease Severity ◽  
Disease Pressure ◽  
Seed Yields ◽  
Field Plots

Severity of Sclerotinia stem rot of soybean after treatment with lactofen (Cobra) and other herbicides was assessed in field experiments conducted in Michigan from 1995 to 1997. At sites where disease pressure was high, disease severity was reduced 40 to 60% compared with controls when lactofen was applied at the V3 (1995 and 1996) or R1 (1997) growth stages. Corresponding seed yields were unchanged or up to 20% greater when lactofen was applied at the R1 stage in 1997. Disease severity was not reduced by lactofen treatments in years and at sites where disease pressure was low to medium, and corresponding yields often were reduced by ≈10%. High levels of glyceollin accumulated in lactofen-injured leaves collected from field plots in 1996 and 1997. High glyceollin content in lactofen-treated leaves was associated with significant reductions in lesion size when leaves were challenge-inoculated with Sclerotinia sclerotiorum.

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