scholarly journals Hypopyon after Primary Cryopreserved Amniotic Membrane Transplantation for Sterile Corneal Ulceration: A Case Report and Review of the Literature

2021 ◽  
Vol 2021 ◽  
pp. 1-5
Author(s):  
Kostas G. Boboridis ◽  
Dimitrios G. Mikropoulos ◽  
Nick S. Georgiadis
Keyword(s):  
Case Report ◽  
Amniotic Membrane ◽  
Topical Treatment ◽  
Rare Complication ◽  
Amniotic Membrane Transplantation ◽  
Ocular Infection ◽  
Eye Drops ◽  
Corneal Surface ◽  
Corneal Epithelial ◽  
Corneal Epithelial Defect

Purpose. To report the acute development of hypopyon after primary cryopreserved amniotic membrane transplantation (AMT) for persistent corneal epithelial defect and sterile ulceration. Case Presentation. A selected case report of a 71-year-old male who underwent primary cryopreserved AMT for the management of long-standing corneal epithelial defects and stroma thinning. The patient developed 2 mm sterile hypopyon within 48 hours after AMT for corneal surface reconstruction. He responded well to the intensified routine postoperative topical treatment of steroid and antibiotic eye drops with the hypopyon resolving completely one week later. Five weeks after surgery, the corneal surface was smooth and epithelialized with no anterior chamber reaction or recurrence of hypopyon. Discussion. Hypopyon may develop as a rare complication of primary cryopreserved AMT for sterile corneal defects. It may be attributed to immunologic or hypersensitivity reaction and should be differentiated from active ocular infection as it resolves spontaneously with the routine postoperative topical treatment of steroid and antibiotic drops.

scholarly journals A Case of Neurotrophic Keratopathy Associated with Nasopharyngeal Carcinoma

2018 ◽  
Vol 9 (1) ◽  
pp. 114-118 ◽  
Author(s):  
Tomoko Sato ◽  
Koji Sugioka ◽  
Aya Kodama-Takahashi ◽  
Masahiko Fukuda ◽  
Hiroshi Mishima ◽  
...  
Keyword(s):  
Nasopharyngeal Carcinoma ◽  
Cavernous Sinus ◽  
Visual Disturbance ◽  
Amniotic Membrane Transplantation ◽  
Eye Drops ◽  
Epithelial Defect ◽  
Corneal Epithelial ◽  
Corneal Epithelial Defect ◽  
Defect Area ◽  
Neurotrophic Keratopathy

Purpose: To report a case of neurotrophic keratopathy associated with nasopharyngeal carcinoma. Case Report: A 59-year-old man who had been diagnosed with a nasopharyngeal carcinoma was referred to the authors because of visual disturbance and pain in his right eye. Slit-lamp examination revealed a corneal epithelial defect and corneal stromal edema surrounding the epithelial defect area in his right eye. Magnetic resonance imaging showed a mass in his cavernous sinus, which was identified as nasopharyngeal carcinoma (NPC). We diagnosed neurotrophic keratopathy associated with NPC and initiated treatment with preservative-free artificial tears, antibiotic eye drops, fibronectin, a therapeutic contact lens, and amniotic membrane transplantation. However, the persistent corneal epithelial defect was unresponsive to these treatments. Conclusion: Neurotrophic keratopathy secondary to NPC is thought to be rare. We presented a case of neurotrophic keratopathy associated with cavernous sinus metastasis of an NPC. The development of new and more effective treatments for this refractory disease is anticipated.

scholarly journals Congenital Unilateral Corneal Anaesthesia with Microphthalmos: A Case Report

2012 ◽  
Vol 2012 ◽  
pp. 1-2
Author(s):  
George Voyatzis ◽  
Achyut Mukherjee ◽  
Madhavan S. Rajan ◽  
Louise E. Allen
Keyword(s):  
Case Report ◽  
Early Diagnosis ◽  
Topical Treatment ◽  
Congenital Abnormalities ◽  
Neurological Diseases ◽  
Local Treatment ◽  
Epithelial Defect ◽  
Corneal Epithelial ◽  
Corneal Epithelial Defect ◽  
Uncommon Condition

Congenital corneal anaesthesia (CCA) is an uncommon condition difficult to diagnose. We report the case of a 20-month-old boy who presented with unilateral congenital corneal anaesthesia. The child was referred with a persistent corneal epithelial defect, unresponsive to symptomatic local treatment for over 10 months. Intensive topical treatment and strict corneal protection led to quick corneal healing. Congenital corneal anaesthesia occurs either alone or in association with neurological diseases or systemic congenital abnormalities. It is important to search for corneal anaesthesia in children with chronic ulcerations of the cornea and self-inflicted injuries. Early diagnosis and treatment are important due to the risk of poor visual prognosis. Management of CCA should aim for the prevention of epithelial defects and is a life-long process.

scholarly journals Amnwiotic Membrane Transplantation as a Treatment for Sterile Infiltration and Corneal Melting after Corneal Crosslinking for Keratoconus

2018 ◽  
Vol 9 (1) ◽  
pp. 185-189 ◽  
Author(s):  
Takanori Sasaki ◽  
Takeshi Ide ◽  
Ikuko Toda ◽  
Naoko Kato
Keyword(s):  
Visual Acuity ◽  
Diclofenac Sodium ◽  
Corneal Stroma ◽  
Amniotic Membrane Transplantation ◽  
Eye Drops ◽  
Epithelial Defect ◽  
Persistent Epithelial Defect ◽  
Corneal Crosslinking ◽  
Corneal Epithelial Defect ◽  
Corneal Melting

We report a case of corneal melting through sterile infiltration presumably due to excessive use of nonsteroidal anti-inflammatory eye drops after corneal crosslinking (CXL). It was treated using steroids combined with amniotic membrane transplantation (AMT). A 33-year-old man with progressing keratoconus underwent left eye CXL. We prescribed betamethasone and levofloxacin eye drops 5 times daily and diclofenac sodium eye drops 3 times daily for 3 days. Three days after CXL, there was a persistent epithelial defect and the left corneal stroma was clouded. His visual acuity remained unchanged. We prescribed betamethasone hourly and 20 mg prednisolone daily. At 1 week after CXL, the corneal epithelial defect and infiltration were unchanged. He had not stopped using diclofenac at the prescribed time. On day 17, we performed AMT and his cornea and visual acuity improved. AMT may be effective against persistent epithelial defects and corneal melting after CXL.

scholarly journals Stabilization of Bilateral Progressive Rheumatoid Corneal Melt with Infliximab

2012 ◽  
Vol 2012 ◽  
pp. 1-3 ◽  
Author(s):  
Sheelah F. Antao ◽  
Tariq Ayoub ◽  
Hasan Tahir ◽  
Dipak N. Parmar
Keyword(s):  
Rheumatoid Arthritis ◽  
Case Report ◽  
Amniotic Membrane ◽  
Conventional Treatment ◽  
Penetrating Keratoplasty ◽  
Amniotic Membrane Transplantation ◽  
Cyanoacrylate Glue ◽  
Ocular Discomfort ◽  
History Of ◽  
Ulcerative Keratitis

Purpose. To report the use of infliximab in the rapid stabilization of a case of progressive, bilateral rheumatoid peripheral ulcerative keratitis (PUK) that failed to respond to conventional immunosuppressive therapy.Methods. A single interventional case report.Results. A patient with rheumatoid arthritis presented with bilateral PUK following a 2-month history of ocular discomfort and redness. His systemic prednisolone (PDN) and methotrexate (MTX) were increased and, despite an initial favorable response, bilateral recurrent corneal perforations ensued. Both eyes underwent cyanoacrylate glue repair, amniotic membrane transplantation (AMT), and penetrating keratoplasty (PKP). Recurrence of the disease and bilateral perforations of the second PKP in both eyes prompted administration of intravenous infliximab immediately after the fourth PKP. The disease activity rapidly settled in both eyes, and at eighteen-month followup, after 12 infliximab infusions, the PUK remains quiescent with no further graft thinning or perforation.Conclusion. Infliximab can be used to arrest the progression of severe bilateral rheumatoid PUK in cases that are refractory to conventional treatment.

scholarly journals Outcome of Amniotic Membrane Transplant in Persistent Corneal Epithelial Defects

2021 ◽  
Vol 38 (1) ◽  
Author(s):  
Tiabbah Saleem ◽  
Syeda Ayesha Bokhari
Keyword(s):  
Amniotic Membrane ◽  
Case Series ◽  
Bullous Keratopathy ◽  
Epithelial Defect ◽  
Corneal Epithelial ◽  
Corneal Epithelial Defect ◽  
Case Series Study ◽  
Chemical Injuries ◽  
Standard Medical Treatment ◽  
Disease Study

Purpose:  To determine the outcome of amniotic membrane transplant in patients with ocular surface disease. Study Design: Interventional Case series study Place and Duration of Study:  Layton Rahmatullah Benevolent Trust Eye Hospital, Korangi 2½, Karachi, from January, 2019 to July 2019. Methods:  Patients with an age range of 20–45 years, either gender and who had persistent corneal epithelial defects as a consequence of keratitis, chemical injuries, bullous keratopathy and Mooren’s ulcers were included. Informed consent was obtained. Preserved amniotic membrane was used in all patients and they were followed at 1 week, 1, 3 and finally at 6 months and results were evaluated in terms of stable, healed and pain-free cornea. Results:  Mean age of the patients was 37.94 ± 6.78 years. Majority of the patients (60.0%) were less than 40 years of age. Out of 58 patients, 45 (77.6%) were males and 13 (22.4%) were females. Mean duration of injury was 7.67 ± 2.28 weeks with majority of patients i.e. 62% were with less than 8 weeks of duration. Most common cause of persistent corneal epithelial defect was bacterial keratitis (17.2%) followed by vegetative trauma (13.8%). Successful surgical outcome as healed cornea was observed in 53 (91.4%) patients. Conclusion:  Amniotic membrane transplant is an effective treatment for persistent corneal epithelial defects unresponsive to standard medical treatment. This surgical technique is effective in terms of healing and resolving the inflammation and preserving the useful vision. Key Words:  Persistant corneal epithelial defect, Amniotic Membrane, Bullous keratopathy.

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