scholarly journals Evaluation of Sex Hormone Levels in Patients with Pemphigus Vulgaris in Comparison to the Healthy Population

2021 ◽  
Vol 2021 ◽  
pp. 1-6
Author(s):  
Fatemeh Lavaee ◽  
Fahimeh Rezazadeh ◽  
Nasrin Saki ◽  
Zahra Tavazo ◽  
Saman Baghaei
Keyword(s):  
Sex Hormones ◽  
Pemphigus Vulgaris ◽  
Serum Levels ◽  
Cross Sectional Study ◽  
Control Group ◽  
Case Group ◽  
Healthy Population ◽  
Healthy Controls ◽  
Cross Sectional ◽  
The Mean

Background and Aim. The onset of autoimmune diseases is associated with the levels of sex hormones. Pemphigus vulgaris is an autoimmune disease with a higher prevalence in postmenopausal women. The present study is aimed at evaluating the sex hormones’ levels in patients with pemphigus vulgaris in comparison to healthy controls. Materials and Methods. This cross-sectional study was performed on patients with pemphigus vulgaris referred to Faghihi Hospital and Shiraz Dental Faculty in 2017-2018. The participants included 26 women with histopathologically confirmed pemphigus vulgaris and 26 healthy age-matched controls. The serum levels of luteinizing hormone (LH), follicle-stimulating hormone (FSH), estrogen, progesterone, testosterone, prolactin, dehydroepiandrosterone (DHEA), and dihydrotestosterone (DHT) were evaluated in both groups. Independent t -test and two-way ANOVA were used for data analysis. Results. The mean age of the patients was 49.88 ± 10.46 years and that of the control group was 49.92 ± 11.30 years. Unlike the case group, the DHEA serum level was significantly higher among nonmenopausal participants in the control group. Moreover, the levels of testosterone and DHEA were significantly lower in the case group in comparison to the control group ( p = 0.015 and p = 0.026 , respectively). Conclusion. Considering the effects of age and menopause, the serum levels of testosterone and DHEA were significantly lower in the patients with pemphigus vulgaris than in the healthy controls. Hence, these hormones might have a role in the pathogenesis of pemphigus vulgaris.

scholarly journals Comparison of the sex hormones’ serum level in women with recurrent aphthous stomatitis and healthy population: a cross-sectional study

2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Fatemeh Lavaee ◽  
Zahra Ranjbar ◽  
Mina Jalalian ◽  
Mohammad Amin Amiri
Keyword(s):  
Serum Level ◽  
Sex Hormones ◽  
Cross Sectional Study ◽  
Recurrent Aphthous Stomatitis ◽  
Aphthous Stomatitis ◽  
Control Group ◽  
Healthy Population ◽  
Sectional Study ◽  
Cross Sectional ◽  
The Mean

Abstract Background In this study, we aimed to evaluate the sex hormonal serum level in patients with recurrent aphthous stomatitis and compare them with healthy participants. Methods This cross-sectional study was done on patients with recurrent aphthous stomatitis who had referred to Shiraz Dental Faculty, Oral and Maxillofacial Medicine Department during 2018–2019. The non -menopause women with recurrence of at least 3 lesions per year were enrolled in this study. The mean serum level of FSH, LH, PRL (prolactin), testosterone, DHT (Dihydrotestosterone), DHEA-S (Dehydroepiandrosterone sulfate), estradiol and progesterone of 30 participants in each group of case and control were measured and compared. The data were analyzed by SPSS version 18 and independent T-test, Mann–Whitney U test, Spearman’s correlation coefficient test, Chi-square test and Fisher’s test. Results The mean serum level of DHEA-S in patients with recurrent aphthous stomatitis (RAS) was significantly lower than the control group (p value = 0.02). In addition to DHEA-S, the mean serum level of testosterone was lower in the evaluation group although this difference was not significant (p value = 0.057). Considering the effect of age on the mean serum level of sex hormones, our results revealed that only DHEA-S mean serum level was decreased by increasing the age of participants in patients with RAS (p value = 0.018). The number of participants with abnormal range of testosterone (p value < 0.0001) and progesterone (p value = 0.037) serum level was significantly more in patients with RAS. The frequency of RAS in a year did not show a significant relationship with the serum level of the evaluated hormones. Conclusion The patients with RAS had a lower serum level of DHEA-S. The mean serum level of testosterone and progesterone was significantly abnormal in RAS patients.

scholarly journals The effect of gamma radiation on plasma levels of zinc and selenium in nuclear medicine staff

2018 ◽  
Vol 21 (1) ◽  
pp. 51-56
Author(s):  
Mahdiyeh Mirnam Niha ◽  
Mehdi Salehi Barough
Keyword(s):  
Nuclear Medicine ◽  
Gamma Radiation ◽  
Graphite Furnace ◽  
Serum Zinc ◽  
Serum Levels ◽  
Cross Sectional Study ◽  
Control Group ◽  
Cross Sectional ◽  
Significant Difference ◽  
The Mean

Background and aims: Gamma radiation is widely being used in medical-imaging centers. The aim of this study was to measure possible alterations in serum zinc and selenium levels among nuclear medicine staff. Methods: This cross-sectional study was carried out on 30 nuclear medicine staff as well as on 10 individuals as the control group. Blood samples (20 mL) were obtained from the participants and the serum specimens were isolated by centrifugation at 4000 rpm for 7 minutes. The samples were then used for measurement of zinc and selenium levels. Zinc and selenium levels were measured using atomic absorption spectroscopy (AAS) with a graphite furnace. The mean serum levels of zinc and selenium were compared using SPSS. Results: The mean level of zinc in the radiated group (70.91±14.46 μmol/L) was significantly lower than that in the control group (89.75±17.35 μmol/L) (P=0.002). A negative significant correlation was found between the duration of exposure to radiation and zinc levels (P=0.005). Furthermore, a negative significant relationship was observed between the mean radiation dose after 5 years and zinc concentration (P=0.019). Non-significant difference was found in the mean level of selenium between control (1.71±0.35 μmol/L) and radiation (2.13±1.12 μmol/L) groups. Furthermore, no significant correlation was found between selenium level and exposure time. Conclusion: Based on the results, declined level of zinc can be considered as one of the possible mechanisms caused by gamma radiation on cells which may be associated with oxidative damage. Therefore, zinc therapy can be helpful for those who work at medical radiation centers; however, it merits further studies.

scholarly journals Comparison of the Sex Hormones’ Serum Level in Women With Recurrent Aphthous Stomatitis and Healthy Population: A Cross-Sectional Study

2021 ◽  
Author(s):  
Fatemeh Lavaee ◽  
Zahra Ranjbar ◽  
Mina Jalalian ◽  
Mohammad Amin Amiri
Keyword(s):  
Serum Level ◽  
Sex Hormones ◽  
Cross Sectional Study ◽  
Recurrent Aphthous Stomatitis ◽  
Aphthous Stomatitis ◽  
Control Group ◽  
P Value ◽  
Sectional Study ◽  
Cross Sectional ◽  
The Mean

Abstract Background:In this study, we aimed to evaluate the sex hormonal serum level in patients with recurrent aphthous stomatitis and compare them with healthy participants.Methods:This cross-sectional study was done on patients with recurrent aphthous stomatitis who had referred to Shiraz Dental Faculty, Oral and Maxillofacial Medicine Department during 2018-2019. The non -menopause women with recurrence of at least 3 lesions per year were enrolled in this study.The mean serum level of FSH, LH, PRL (prolactin), testosterone, DHT (Dihydrotestosterone), DHEA-S (Dehydroepiandrosterone sulfate), estradiol and progesterone of 30 participants in each group of case and control were measured and compared. The data were analyzed by SPSS version 18 and independent T-test, Mann-Whitney U test, Spearman’s correlation coefficient test, Chi-square test and Fisher’s test.Results: The mean serum level of DHEA-S in patients with recurrent aphthous stomatitis (RAS) was significantly lower than the control group (p value=0.002). In addition to DHEA-S, the mean serum level of testosterone was lower in the evaluation group although this difference was not significant (p value=0.057).Considering the effect of age on the mean serum level of sex hormones, our results revealed that only DHEA-S mean serum level was decreased by increasing the age of participants in patients with RAS (p value=0.018).The number of participants with abnormal range of testosterone (p value<0.0001) and progesterone (p value=0.037) serum level was significantly more in patients with RAS. The frequency of RAS in a year did not show a significant relationship with the serum level of the evaluated hormones.Conclusion: The patients with RAS had a lower serum level of DHEA-S. The mean serum level of testosterone and progesterone was significantly abnormal in RAS patients.

scholarly journals Level of Serum Electrolytes in Chronic Alcoholic Patients

2015 ◽  
Vol 1 (2) ◽  
pp. 31-34
Author(s):  
Mithileshwer Raut ◽  
Sangita Ghimire ◽  
Prashant Regmi ◽  
Sanjay Kumar Raut ◽  
Bharat Jha
Keyword(s):  
Serum Levels ◽  
Cross Sectional Study ◽  
University Teaching ◽  
Healthy Controls ◽  
Chronic Alcoholic ◽  
Cross Sectional ◽  
Sodium Potassium ◽  
Mean Values ◽  
Calcium Phosphorus ◽  
The Mean

BACKGROUND: The aim of this study is to establish serum levels of sodium, potassium, magnesium, calcium and phosphorus in chronic alcoholic patients.METHODS: This cross-sectional study was conducted in Tribhuvan University Teaching Hospital (TUTH).  A total of 90 chronic alcoholic patients visiting to psychiatry department of TUTH were included in the study. Age of patients ranges from 20-50 years. Study also included 90 non-alcoholic healthy controls that were age matched.RESULTS: Among the 90 chronic alcoholic patients and 90 normal healthy controls, majority of patients (95.5%) and controls (82%) were male, only few patients were female (4.5%). The mean age of the cases and controls were 35.42 ± 5.6 years, 34.53 ± 3.5 years respectively. In this study, the mean values of Serum Sodium and Potassium were lower in cases (133.58 ± 7.8, sodium and 3.64 ± 0.65, potassium) as compared to controls ( 139.43 ± 3.85, sodium and 4.15 ± 0.43, potassium) with the significant correlation in both groups (p<0.001). Calcium, phosphorus and magnesium level was depleted in cases compared to control groups.CONCLUSIONS: Hyponatremia and hypokalemia are the most common electrolyte abnormalities observed in chronic alcoholic patients.

scholarly journals Effect of Juvenile Idiopathic Arthritis on the Temporomandibular Joint and Occlusion in Children and Young Adolescents: A Descriptive Cross-sectional Study

2020 ◽  
Author(s):  
Sajja Rishitha ◽  
J Sharada Reddy ◽  
K Suhasini ◽  
I Hemachandrika ◽  
P Tarasingh ◽  
...  
Keyword(s):  
Cross Sectional Study ◽  
Control Group ◽  
Class Ii Malocclusion ◽  
Healthy Controls ◽  
Age Group ◽  
Sectional Study ◽  
Cross Sectional ◽  
The Mean ◽  
Children And Young Adolescents ◽  
And Control

Introduction: Juvenile Idiopathic Arthritis (JIA) is a chronic rheumatic disease, with a prevalence of 1 in 1000 children under the age of 16 years. The clinical symptoms include inflammation of joints, swelling of synovial membrane resulting in growth disturbances and loss of bone density. Aim: To assess the effect of JIA on the development of Temporomandibular Joint (TMJ) and occlusion in children and young adolescents in the age group of 8-16 years and to evaluate the effect of TMJ arthritis on the growth of maxilla and mandible. Materials and Methods: This is a descriptive cross-sectional study with a study and control group. A total of 44 children with JIA attending the Department of Rheumatology, Nizam Institute of Medical Sciences (NIMS), within the age group of 8-16 years were screened and enrolled in study from May-July 2014. A gender and sex-matched healthy control group were enrolled from Paediatric Dentistry outpatient specialty. For the measurement and comparison of arch perimeters of mandible and maxilla, the JIA and control group were divided into sub-groups 1 (8-10 y), 2 (11-13 y), and 3 (14-16 y). All the parameters were recorded and subjected to statistical analysis. An Independent sample t-test was used to find a significant difference for maxillary and mandibular arch perimeters among both the groups. Chi-square test was used to know the difference for TMJ parameters, occlusion and occlusal abnormalities. The level of significance was set at p<0.05 for all tests. Results: Children in the JIA group had reported TMJ pain on movement (40.9%), clicking sounds (36.4%), and dislocation (22.7%). Angle’s class II malocclusion was seen in 36.4% compared to the control group (4.5%). The mean arch perimeter of the mandible was significantly less among JIA children in subgroups 2 (73.00±3.03 mm), and 3 (71.77±6.27 mm) when compared to healthy controls. Other occlusal abnormalities such as increased overjet (34.1%), decreased overbite (31.8%), and crowding (54.5%) were reported in significant percentages compared to healthy controls. Conclusion: The mean arch perimeter of the mandible in the JIA group is less when compared to children of the same age in the control group. There is increased predilection of developing Angle’s class II Malocclusion in the JIA group. From a paediatric dentist perspective, it’s important to understand the overall impact of JIA on stomatognathic system, and an early intervention is recommended.

scholarly journals Changes in Serum Lipid in First Trimester of Pregnancy

2013 ◽  
Vol 25 (1) ◽  
pp. 25-27
Author(s):  
THJ Moonmoon ◽  
K Begum ◽  
M Amanullah ◽  
S Rabeya ◽  
MA Bari
Keyword(s):  
Blood Pressure ◽  
Diastolic Blood Pressure ◽  
Serum Lipid ◽  
First Trimester ◽  
Cross Sectional Study ◽  
Control Group ◽  
Case Group ◽  
Cross Sectional ◽  
First Trimester Of Pregnancy ◽  
The Mean

A cross-sectional study was conducted in the department of Obstetrics & Gynaecology, Bangabandhu Sheikh Mujib Medical University (BSMMU), Dhaka to determine the changes in serum lipid in 1st trimester of pregnancy over a period I year. A total of 91 subjects (60 women at first trimester of pregnancy assigned to case and 31 nonpregnant women with regular menstruation assigned to control) were included in the study. The mean age was significantly higher in control group than in case group (27.0± 4.3vs 24.4± 3.6 years respectively, p = 0.002). Lower socioeconomic class was predominance in case group (58.3%) and middle class (53.7%) in control group. The mean systolic and diastolic blood pressure was significantly higher in case group compared to control group. About 12% of patients had low HDL compared to 4.9% of controls (p=0.240). Raised LDL and raised triglycerides were found in 3.3% and 5% of the cases respectively while none of the control group had raised LDL and triglyceride (p = 0.350 and p = 0.25 respectively). The systolic and diastolic blood pressure was positively correlated with total cholesterol and HDL. However, LDL and triglyceride exhibit negative linear relationship in the both systolic and diastolic blood pressure. From this study, it can be concluded that pregnant mothers in their trimester had slightly altered serum lipids compared to their nonpregnant counterpart. DOI: http://dx.doi.org/10.3329/medtoday.v25i1.16065 Medicine Today 2013 Vol.25(1): 25-27

Effect of Medialization of the Trochlear Groove and Lateralization of the Tibial Tubercle on TT-TG Distance: A Cross-sectional Study of Dysplastic and Nondysplastic Knees

2021 ◽  
pp. 036354652098781
Author(s):  
Mathias Paiva ◽  
Lars Blønd ◽  
Per Hölmich ◽  
Kristoffer Weisskirchner Barfod
Keyword(s):  
Trochlear Dysplasia ◽  
Cross Sectional Study ◽  
Magnetic Resonance Images ◽  
Tibial Tubercle ◽  
Control Group ◽  
Trochlear Groove ◽  
Sectional Study ◽  
Cross Sectional ◽  
Mean Values ◽  
The Mean

Background: Tibial tubercle–trochlear groove (TT-TG) distance is often used as a measure of lateralization of the TT and is important for surgical planning. Purpose: To investigate if increased TT-TG distance measured on axial magnetic resonance images is due to lateralization of the TT or medialization of the TG. Study Design: Cross-sectional study; Level of evidence, 3. Methods: A total of 84 knees (28 normal [NK], 28 with trochlear dysplasia [TD], and 28 with patellar dislocation without TD [PD]) were examined. The medial border of the posterior cruciate ligament (PCL) was chosen as the central anatomic landmark. The distance from the TT to PCL (TT-PCL) was measured to examine the lateralization of the TT. The distance from the TG to the PCL (TG-PCL) was measured to examine the medialization of the TG. Between-group differences were investigated by use of 1-way analysis of variance. Results: The mean values for TT-TG distance were 8.7 ± 3.6 mm for NK, 12.1 ± 6.0 mm for PD, and 16.7 ± 4.3 mm in the TD group ( P < .01). The mean values for TT-PCL distance were 18.5 ± 3.6 mm for NK, 18.5 ± 4.5 mm for PD, and 21.2 ± 4.2 mm in the TD group ( P = .03). The mean values for TG-PCL distance were 9.6 ± 3.0 mm for NK, 7.1 ± 3.4 mm for PD, and 5.1 ± 3.3 mm in the dysplastic group ( P < .01). Conclusion: The present results indicate that increased TT-TG distance is due to medialization of the TG and not lateralization of the TT. Knees with TD had increased TT-TG distance compared with the knees of the control group and the knees with PD. The TT-PCL distance did not differ significantly between groups, whereas the TG-PCL distance declined with increased TT-TG.

scholarly journals Interleukin-37 as an anti-inflammatory cytokine: does its relation to disease activity suggest its potential role in rheumatoid arthritis therapy?

2021 ◽  
Vol 48 (1) ◽  
Author(s):  
Eman A. Baraka ◽  
Mona G. Balata ◽  
Shereen H. Ahmed ◽  
Afaf F. Khamis ◽  
Enas A. Elattar
Keyword(s):  
Rheumatoid Arthritis ◽  
Disease Activity ◽  
Cross Sectional Study ◽  
Healthy Controls ◽  
Tender Joint ◽  
Cross Sectional ◽  
Reactive Protein ◽  
Significant Difference ◽  
The Mean ◽  
Anti Inflammatory

Abstract Background This study aimed to measure the serum and synovial interleukin (IL)-37 levels in rheumatoid arthritis (RA) patients compared to patients with primary knee osteoarthritis (PKOA) and healthy controls and to detect its relation to RA disease activity. Results This cross-sectional study included 50 RA patients with a mean age of 40.24 ± 8.62 years, 50 patients with PKOA with a mean age of 56.69 ± 4.21, and 40 healthy controls with a mean age of 41.75 ± 7.38 years. The mean serum IL-37 level in the RA patients (382.6 ± 73.97 pg/ml) was statistically significantly (P < 0.001) the highest among the studied groups; however, it showed a non-significant difference between the PKOA patients (70.38 ± 27.49 pg/ml) and the healthy controls (69.97 ± 25.12 pg/ml) (P > 0.94). Both serum and synovial IL-37 levels were significantly positively correlated with disease activity scores (r = 0.92, P< 0.001 and r = 0.85, P < 0.001), tender joint counts (r = 0.83, P < 0.001 and r = 0.82, P < 0.001 ), swollen joint counts (r = 0.72, P < 0.001 and r = 0.60, P < 0.001), visual analog scale (r = 0.82, P < 0.001 and r = 0.82, P < 0.001), erythrocyte sedimentation rate (r = 0.75, P < 0.001 and r = 0.65, P < 0.001), and C-reactive protein (r = 0.93, P < 0.001 and r = 0.79, P < 0.001), respectively. Conclusion Serum and synovial IL-37 were significantly elevated in the RA patients, and they were closely correlated. Being less invasive, the serum IL-37 could be a marker of disease activity and could reflect the effective disease control by drugs. Having an anti-inflammatory effect could not suggest IL-37 as the key player to control inflammation alone, but its combination with other anti-proinflammatory cytokines could be investigated.

scholarly journals Is suicidal ideation associated with allergic asthma and allergic rhinitis?

2018 ◽  
Vol 44 (1) ◽  
pp. 31-35 ◽  
Author(s):  
Martín Bedolla-Barajas ◽  
Norma Angélica Pulido-Guillén ◽  
Bolívar Vivar-Aburto ◽  
Jaime Morales-Romero ◽  
José Raúl Ortiz-Peregrina ◽  
...  
Keyword(s):  
Allergic Rhinitis ◽  
Suicidal Ideation ◽  
Allergic Asthma ◽  
Allergic Diseases ◽  
Cross Sectional Study ◽  
University Hospital ◽  
Control Group ◽  
Healthy Controls ◽  
Cross Sectional ◽  
And Control

ABSTRACT Objective: To investigate whether there is an association between suicidal ideation (SI) and allergic diseases in adults. Methods: This was a comparative cross-sectional study involving individuals ranging from 20 to 50 years of age recruited from a university hospital in the city of Guadalajara, Mexico. We included patients with a confirmed diagnosis of allergic asthma, those with a confirmed diagnosis of allergic rhinitis, and healthy controls. All subjects completed the Beck Depression Inventory-II (BDI-II), which includes an item that evaluates the presence of suicidal thoughts or desires within the last two weeks, in order to identify SI. Results: The sample comprised 115 patients with allergic asthma, 111 patients with allergic rhinitis, and 96 healthy controls. The number of individuals identified with SI in the three groups were, respectively, 17 (14.8%), 13 (11.7%), and 8 (8.3%). Regarding the presence of SI, no statistically significant association was found in the allergic asthma group (OR = 1.98; 95% CI: 0.78-4.64; p = 0.154) or in the allergic rhinitis group (OR = 1.46; 95% CI: 0.58-3.68; p = 0.424) when they were compared with the control group. However, the presence of depression was associated with SI in the three groups: allergic asthma (OR = 12.36; 95% CI: 2.67-57.15; p = 0.001); allergic rhinitis (OR = 6.20; 95% CI: 1.66-23.14; p = 0.006); and control (OR = 21.0; 95% CI: 3.75-117.36; p < 0,001). Conclusions: In comparison with the control group, no association was found between SI and the groups with allergic diseases. In contrast, there was association between SI and depression in the three groups.

scholarly journals Association between endometriosis, headache, and migraine

2019 ◽  
Vol 11 (1) ◽  
pp. 19-24 ◽  
Author(s):  
Burcin Karamustafaoglu Balci ◽  
Zehra Kabakci ◽  
Damla Y Guzey ◽  
Bartu Avci ◽  
Murathan Guler ◽  
...  
Keyword(s):  
Nervous System ◽  
Autonomic Nervous System ◽  
Medical Records ◽  
Cross Sectional Study ◽  
Control Group ◽  
Cross Sectional ◽  
Autonomic Nervous ◽  
Screening Questions ◽  
The Mean ◽  
Id Migraine

Introduction: Available data suggest that there is an association between endometriosis and a group of disorders including autonomic nervous system irregularities. A deeper understanding of relationship between endometriosis and autonomic nervous system is needed as it may lead to novel discoveries on the causes or consequences of endometriosis. In this study, we analyzed the prevalence of migraine in patients with endometriosis. Methods: In this cross-sectional study, medical records of women were reviewed through January 2013 to December 2017. Women with laparoscopically proven endometriosis (n = 185) were compared with those without endometriosis (n = 168). The 3-item screening questions (ID Migraine™) test was used to screen migraine. Data were analyzed using SPSS v25 (IBM Corporation). The χ2 test was used for analyzing the nominal parameters and group comparisons. Pearson χ2 was used to study the association between endometriosis and migraine. Results: The mean age was 31.86 ± 4.49 years of the endometriosis group and 28.95 ± 5.11 years of the controls (p = 0.408). The two pre-screening questions of ID Migraine test were answered positively by 86 patients of the endometriosis group (75.4%) and by 53 patients of the control group (54.6%) (p = 0.001). Of these patients, 51 (44.7% of endometriosis group) and 26 (26.8% of control group) were diagnosed as having migraine using 3-item Migraine questionnaire (p = 0.007). Conclusion: This study showed that the prevalence of migraine was significantly higher in patients with endometriosis. Because there is a strong correlation, patients with endometriosis should be screened for headache and migraine to increase the benefits of care.

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