scholarly journals Comparisons of Vitreal Angiogenic, Inflammatory, Profibrotic Cytokines, and Chemokines Profile between Patients with Epiretinal Membrane and Macular Hole

2021 ◽  
Vol 2021 ◽  
pp. 1-8
Author(s):  
Lu Chen ◽  
Weiwei Zhang ◽  
Ping Xie ◽  
Jiangdong Ji ◽  
Huiming Qian ◽  
...  
Keyword(s):  
Macular Hole ◽  
Epiretinal Membrane ◽  
Enzyme Linked Immunosorbent Assay ◽  
Bonferroni Correction ◽  
Cytokines And Chemokines ◽  
Luminex Technology ◽  
Vitreous Sample ◽  
Healthy Control ◽  
Pars Plana ◽  
Vitreoretinal Diseases

Objectives. Idiopathic epiretinal membrane (iERM) or idiopathic macular hole (iMH) is frequently used as a “healthy” control in comparison of vitreous cytokines with other vitreoretinal diseases. This study aimed to investigate if there is a difference in vitreal cytokines expression between patients with iERM and iMH. Methods. In this prospective study, all subjects received standard pars plana vitrectomy surgery, and 0.5 ml of native vitreous sample was extracted during the vitrectomy. Luminex technology and enzyme-linked immunosorbent assay were used to profile the concentration of 52 classic angiogenic, inflammatory, and profibrotic cytokines and chemokines. Statistical analyses were performed by the Mann–Whitney U test, followed by multiple comparisons by the Bonferroni correction. Results. Vitreal samples from 13 iERM and 24 iMH were studied. Of the 52 tested cytokines, 41 were similar in expression, and 5 were under the detection limit, while 6 cytokines (MMP-8, Eotaxin, MIP-1a, RANTES, TGF-β2, and IL-4) were differently expressed between two groups ( p < 0.05 ). Nevertheless, these significances disappeared after the adjustment of Bonferroni correction. Conclusion. The tested cytokines showed similar expression between iERM and iMH patients. This indicates that eyes with iERM or iMH can be together served as “healthy” controls.

scholarly journals Direct cost of pars plana vitrectomy for the treatment of macular hole, epiretinal membrane and vitreomacular traction: a bottom-up approach

2015 ◽  
Vol 17 (8) ◽  
pp. 991-999 ◽  
Author(s):  
Elena Nicod ◽  
Timothy L. Jackson ◽  
Federico Grimaccia ◽  
Aris Angelis ◽  
Marc Costen ◽  
...  
Keyword(s):  
Macular Hole ◽  
Direct Cost ◽  
Epiretinal Membrane ◽  
Pars Plana Vitrectomy ◽  
Vitreomacular Traction ◽  
Bottom Up ◽  
Pars Plana

scholarly journals Prophylactic Circumferential Laser Retinopexy in Macular Hole and Epiretinal Membrane Surgeries

2020 ◽  
Vol 14 (1) ◽  
pp. 9-14
Author(s):  
Oded Ohana ◽  
Ran Rutenberg ◽  
Elad Moisseiev ◽  
Zvi Davidovich ◽  
Anat Lowenstein ◽  
...  
Keyword(s):  
Macular Hole ◽  
Epiretinal Membrane ◽  
Control Group ◽  
Complication Rates ◽  
Kaplan Meier ◽  
Retinal Breaks ◽  
Macular Diseases ◽  
Retinal Tears ◽  
Small Gauge ◽  
Pars Plana

Background: The role of PCLR in vitrectomy surgeries for macular diseases is controversial. Several studies report a reduction in post-operative RD rates, while other studies do not show such reduction. reducing complications stemming from intra- and post- operative retinal tears, especially at sclerotomy sites, are suggested as reasons for PCLR use. Objective: To investigate the effect of PCLR on the rate of post-operative RD in patients undergoing pars plana vitrectomy for either Macular Hole (MH) or epiretinal membrane (ERM). Methods: This retrospective study included 179 eyes of 170 patients who underwent vitrectomy for either MH or ERM between 2006-2012. Recorded parameters included demographic information, diagnosis, lens status, use and type of tamponade, whether PCLR was performed, follow-up period, the occurrence of RD, the cause and time of RD. Outcome and complication rates were compared between patients who received PCLR (PCLR group) and those who did not (Control group). Results: The study included 179 eyes of 170 patients. 126 eyes had PCLR while 53 eyes did not. Pre-operative demographics data, best-corrected visual acuity, lens status and indication for macular surgery were similar between the two groups. Post-operative RD was diagnosed in one eye (1.8%) in the control group and 5 eyes (3.9%) in the PCLR group (Kaplan-Meier survival analysis, log-rank p = 0.28). Conclusion: PCLR was not correlated with a decrease in RD in MH and ERM surgeries in our cohort. Intra-operative and post-operative examination for small retinal breaks is essential in all surgeries. PCLR might be unnecessary in small gauge vitrectomies.

scholarly journals Eccentric Macular Hole after Pars Plana Vitrectomy for Epiretinal Membrane Without Internal Limiting Membrane Peeling: A Case Report

2017 ◽  
Vol 6 (2) ◽  
pp. 391-395
Author(s):  
Christina Garnavou-Xirou ◽  
Tina Xirou ◽  
Stamatina Kabanarou ◽  
Ilias Gkizis ◽  
Stavros Velissaris ◽  
...  
Keyword(s):  
Case Report ◽  
Macular Hole ◽  
Epiretinal Membrane ◽  
Pars Plana Vitrectomy ◽  
Internal Limiting Membrane ◽  
Internal Limiting Membrane Peeling ◽  
Membrane Peeling ◽  
Pars Plana

Combining cataract surgery with 25-gauge high-speed pars plana vitrectomy: A prospective study

2020 ◽  
pp. 112067212090203
Author(s):  
Alfonso Savastano ◽  
Chiara Lenzetti ◽  
Lucia Finocchio ◽  
Daniela Bacherini ◽  
Fabrizio Giansanti ◽  
...  
Keyword(s):  
Visual Acuity ◽  
Postoperative Complications ◽  
Prospective Study ◽  
Macular Hole ◽  
Epiretinal Membrane ◽  
Pars Plana Vitrectomy ◽  
Visual Outcome ◽  
Group A ◽  
Pars Plana ◽  
Group B

Purpose: To compare visual outcome and postoperative complications of combined 25-gauge pars plana vitrectomy and phacoemulsification with vitrectomy alone surgery in patients with epiretinal membrane and macular hole. Methods: A total of 110 eyes (73 eyes with epiretinal membrane and 37 eyes with macular hole) were enrolled in this prospective study. The eyes were divided into two groups: Group A included 55 eyes which underwent phacovitrectomy at the same time and Group B included 55 eyes which underwent vitrectomy alone. Follow-up visits were at 1, 3, and 6 months. Results: The best-corrected visual acuity correlation by analysis of variance measurement showed statistically non-significant differences between the two groups ( p = 0.32). The post hoc analysis from baseline, 1°, 2°, and 3° follow-ups was not statistically significant ( p > 0.05). The most common postoperative complication was cystoid macular edema that has been detected in 11 patients (10%) (seven eyes in Group A and four eyes in Group B): 2 patients (1.8%) developed a chronic macular edema. Intraocular hypertension occurred in five eyes (4.5%) (three in Group A and two in Group B). Four eyes (3.6%) underwent another surgical procedure for a persistent macular hole (two in Group A and two in Group B). The intraocular lens repositioning was performed one day after surgery in three eyes (2.7%) (Group A). The mean preoperative visual acuity was not different between the two groups ( p = 0.80). Conclusion: No significative differences between combined surgery and vitrectomy alone have been detected, in terms of postoperative complications and visual outcome.

scholarly journals Complement Anaphylatoxins and Inflammatory Cytokines as Prognostic Markers for COVID-19 Severity and In-Hospital Mortality

2021 ◽  
Vol 12 ◽  
Author(s):  
Bandar Alosaimi ◽  
Ayman Mubarak ◽  
Maaweya E. Hamed ◽  
Abdullah Z. Almutairi ◽  
Ahmed A. Alrashed ◽  
...  
Keyword(s):  
Inflammatory Cytokines ◽  
Group Analysis ◽  
Treatment Strategies ◽  
Enzyme Linked Immunosorbent Assay ◽  
Survival Group ◽  
Cytokines And Chemokines ◽  
Pathway Activation ◽  
Prognostic Utility ◽  
Healthy Control ◽  
Critical Patients

COVID-19 severity due to innate immunity dysregulation accounts for prolonged hospitalization, critical complications, and mortality. Severe SARS-CoV-2 infections involve the complement pathway activation for cytokine storm development. Nevertheless, the role of complement in COVID-19 immunopathology, complement‐modulating treatment strategies against COVID-19, and the complement and SARS‐CoV‐2 interaction with clinical disease outcomes remain elusive. This study investigated the potential changes in complement signaling, and the associated inflammatory mediators, in mild-to-critical COVID-19 patients and their clinical outcomes. A total of 53 patients infected with SARS-CoV-2 were enrolled in the study (26 critical and 27 mild cases), and additional 18 healthy control patients were also included. Complement proteins and inflammatory cytokines and chemokines were measured in the sera of patients with COVID-19 as well as healthy controls by specific enzyme-linked immunosorbent assay. C3a, C5a, and factor P (properdin), as well as interleukin (IL)-1β, IL-6, IL-8, tumor necrosis factor (TNF)-α, and IgM antibody levels, were higher in critical COVID-19 patients compared to mild COVID-19 patients. Additionally, compared to the mild COVID-19 patients, factor I and C4-BP levels were significantly decreased in the critical COVID-19 patients. Meanwhile, RANTES levels were significantly higher in the mild patients compared to critical patients. Furthermore, the critical COVID-19 intra-group analysis showed significantly higher C5a, C3a, and factor P levels in the critical COVID-19 non-survival group than in the survival group. Additionally, IL-1β, IL-6, and IL-8 were significantly upregulated in the critical COVID-19 non-survival group compared to the survival group. Finally, C5a, C3a, factor P, and serum IL-1β, IL-6, and IL-8 levels positively correlated with critical COVID-19 in-hospital deaths. These findings highlight the potential prognostic utility of the complement system for predicting COVID-19 severity and mortality while suggesting that complement anaphylatoxins and inflammatory cytokines are potential treatment targets against COVID-19.

Peripheral levels of superoxide dismutase and glutathione peroxidase in youths in ultra-high risk for psychosis: a pilot study

CNS Spectrums ◽  
2017 ◽  
Vol 24 (03) ◽  
pp. 333-337 ◽  
Author(s):  
Maiara Zeni-Graiff ◽  
Adiel C. Rios ◽  
Pawan K. Maurya ◽  
Lucas B. Rizzo ◽  
Sumit Sethi ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
At Risk ◽  
Superoxide Dismutase ◽  
High Risk ◽  
Glutathione Peroxidase ◽  
Healthy Control Group ◽  
Enzyme Linked Immunosorbent Assay ◽  
Control Group ◽  
Ultra High Risk ◽  
Healthy Control

IntroductionOxidative stress has been documented in chronic schizophrenia and in the first episode of psychosis, but there are very little data on oxidative stress prior to the disease onset.ObjectiveThis work aimed to compare serum levels of superoxide dismutase (SOD) and glutathione peroxidase (GPx) in young individuals at ultra-high risk (UHR) of developing psychosis with a comparison healthy control group (HC).MethodsThirteen UHR subjects and 29 age- and sex-matched healthy controls (HC) were enrolled in this study. Clinical assessment included the Comprehensive Assessment of At-Risk Mental States (CAARMS), the Semi-Structured Clinical Interview for DSM-IV Axis-I (SCID-I) or the Kiddie-SADS-Present and Lifetime Version (K-SADS-PL), and the Global Assessment of Functioning (GAF) scale. Activities of SOD and GPx were measured in serum by the spectrophotometric method using enzyme-linked immunosorbent assay kits.ResultsAfter adjusting for age and years of education, there was a significant lower activity of SOD and lower GPX activity in the UHR group compared to the healthy control group (rate ratio [RR]=0.330, 95% CI 0.187; 0.584, p&lt;0.001 and RR=0.509, 95% CI 0.323; 0.803, p=0.004, respectively). There were also positive correlations between GAF functioning scores and GPx and SOD activities.ConclusionOur results suggest that oxidative imbalances could be present prior to the onset of full-blown psychosis, including in at-risk stages. Future studies should replicate and expand these results.

Prevalence and risk factors of ellipsoid zone damage after pars plana vitrectomy for idiopathic epiretinal membrane

Retina ◽  
2021 ◽  
Vol Publish Ahead of Print ◽  
Author(s):  
Michał Post ◽  
Maria Vittoria Cicinelli ◽  
Emma Clara Zanzottera ◽  
Alessandro Marchese ◽  
Francesco Bandello ◽  
...  
Keyword(s):  
Risk Factors ◽  
Epiretinal Membrane ◽  
Pars Plana Vitrectomy ◽  
Ellipsoid Zone ◽  
Idiopathic Epiretinal Membrane ◽  
Pars Plana
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