scholarly journals Value of ddPCR in the Preoperative Diagnosis of Solitary Pulmonary Nodules Based on the Observation of Virtual Reality Images of Smart Medical Treatment

2021 ◽  
Vol 2021 ◽  
pp. 1-11
Author(s):  
Xuri Mou ◽  
Guiying Sun ◽  
Yubo Shi ◽  
Liangdong Zhang ◽  
Runjie Li ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Virtual Reality ◽  
Medical Treatment ◽  
Malignant Tumors ◽  
Relevant Literature ◽  
Pulmonary Nodules ◽  
Relevant Information ◽  
Detection Methods ◽  
Noninvasive Evaluation ◽  
Solitary Pulmonary Nodules

At present, lung cancer ranks the first cause of tumor death in the world, and malignant tumors in the SPN detected by imaging account for 5–40%, most of which are peripheral lung cancer. The recovery of the solitary nodules in the lung after treatment has also been paid attention to. In order to explore the correlation of solitary pulmonary nodule (SPN) with microvessel density (MVD), vascular parameters, and vascular ratio under virtual reality images of smart medical treatment and evaluate the differentiation of SPN by ddPCR under virtual reality image observation diagnosis value, this article collects relevant information by investigating patients, investigating relevant literature, interviewing professionals, and constructing a case template, using a comprehensive quantitative and qualitative analysis method to create a damage assessment matrix. Experimental results prove that there are significant differences in the microvascular architecture within the SPN in the benign, inflammatory, and malignant groups. The correlation between ddPCR and vascular parameters (especially the ratio of luminal vessels) under the virtual reality image observation of smart medical treatment is better than other detection methods, and its accuracy is about 10% higher. Based on the observation of smart medical virtual reality images, ddPCR can be used as an index for noninvasive evaluation of tumor angiogenesis, which is helpful for the differential diagnosis of SPN.

scholarly journals SMALL NODULES LOCALIZATION ON CT IMAGES OF LUNGS

2017 ◽  
Vol XLII-2/W4 ◽  
pp. 141-144
Author(s):  
E. V. Snezhko ◽  
S. A. Kharuzhyk ◽  
A. V. Tuzikov ◽  
V. A. Kovalev
Keyword(s):  
Lung Cancer ◽  
Best Practice ◽  
Malignant Tumors ◽  
Pulmonary Nodules ◽  
World Health ◽  
Solitary Pulmonary Nodules ◽  
The World ◽  
Health Organization ◽  
Aided Diagnosis ◽  
Selection Of

According to the World Health Organization (WHO) lung cancer remains the leading cause of death of men among all malignant tumors [1, 2]. One of the reasons of such a statistics is the fact that the lung cancer is hardly diagnosed on the yearly stages when it is almost asymptomatic. The purpose of this paper is to present a Computer-Aided Diagnosis (CAD) software developed for assistance of early detection of nodules in CT lung images including solitary pulmonary nodules (SPN) as well as multiple nodules. The efficiency of nodule localization was intended to be as high as the level of the best practice. The software developed supports several functions including lungs segmentation, selection of nodule candidates and nodule candidates filtering.

scholarly journals Malignant melanoma without primary, presenting as solitary pulmonary nodule: a case report

2021 ◽  
Vol 15 (1) ◽  
Author(s):  
George Tsaknis ◽  
Muhammad Naeem ◽  
Advitya Singh ◽  
Siddharth Vijayakumar
Keyword(s):  
Lung Cancer ◽  
Malignant Melanoma ◽  
Pulmonary Nodule ◽  
Solitary Pulmonary Nodule ◽  
Past History ◽  
White Male ◽  
Pulmonary Nodules ◽  
Metastatic Malignant Melanoma ◽  
Unknown Primary ◽  
Solitary Pulmonary Nodules

Abstract Background Solitary pulmonary nodules are the most common incidental finding on chest imaging. Their management is very well defined by several guidelines, with risk calculators for lung cancer being the gold standard. Solitary intramuscular metastasis combined with a solitary pulmonary nodule from malignant melanoma without a primary site is rare. Case presentation A 57-year-old white male was referred to our lung cancer service with solitary pulmonary nodule. After positron-emission tomography, we performed an ultrasound-guided core needle biopsy of an intramuscular solitary lesion, not identified on computed tomography scan, and diagnosed metastatic malignant melanoma. The solitary pulmonary nodule was resected and also confirmed metastatic melanoma. There was no primary skin lesion. The patient received oral targeted therapy and is disease-free 5 years later. Conclusions Clinicians dealing with solitary pulmonary nodules must remain vigilant for other extrathoracic malignancies even in the absence of obvious past history. Lung metastasectomy may have a role in metastatic malignant melanoma with unknown primary.

Non-surgical management of early-stage lung cancer

2017 ◽  
Author(s):  
Jim Brown ◽  
Neal Navani
Keyword(s):  
Lung Cancer ◽  
Early Stage ◽  
Pulmonary Nodules ◽  
The Elderly ◽  
Multidisciplinary Teams ◽  
Solitary Pulmonary Nodules ◽  
Early Stage Lung Cancer ◽  
Mortality And Morbidity ◽  
Inoperable Patient ◽  
Ablative Techniques

As low-dose computed tomography screening of ‘high-risk’ smokers is occurring with increasing frequency, the incidental discovery of solitary pulmonary nodules is becoming more frequent, and lung cancer multidisciplinary teams are now often faced with balancing risk and benefit when making decisions regarding the radical treatment of patients with a clinical diagnosis of early lung cancer but borderline fitness. Surgery offers the best prospect of cure but is associated with significant mortality and morbidity; the elderly and frail experience more toxicity and a greater impact on the quality of life. This chapter reviews the criteria for assessing surgical fitness and examines the evidence for minimally invasive and ablative techniques for the treatment of early peripheral lung cancer in the medically inoperable patient.

scholarly journals Diagnosis and outcome of resected solitary pulmonary nodules after liver transplantation

2019 ◽  
Author(s):  
Mari Tone ◽  
Nobuyasu Awano ◽  
Takehiro Izumo ◽  
Hanako Yoshimura ◽  
Tatsunori Jo ◽  
...  
Keyword(s):  
Computed Tomography ◽  
Lung Cancer ◽  
Liver Transplantation ◽  
Early Stage ◽  
Lung Resection ◽  
Invasive Pulmonary Aspergillosis ◽  
Primary Lung Cancer ◽  
Pulmonary Nodules ◽  
Solitary Pulmonary Nodules ◽  
Computed Tomography Scans

Abstract Objective Solitary pulmonary nodules after liver transplantation are challenging clinical problems. Herein, we report the causes and clinical courses of resected solitary pulmonary nodules in patients who underwent liver transplantation. Methods We retrospectively obtained medical records of 68 patients who underwent liver transplantation between March 2009 and June 2016. This study mainly focused on patients with solitary pulmonary nodules observed on computed tomography scans during follow-ups that were conducted until their deaths or February 2019. Results Computed tomography scans revealed solitary pulmonary nodules in 7 of the 68 patients. Definitive diagnoses were obtained using video-assisted lung resection in all seven patients. None experienced major postoperative complications. The final pathologic diagnoses were primary lung cancer in three patients, pulmonary metastases from hepatocellular carcinoma in one patient, invasive pulmonary aspergillosis in one patient, post-transplant lymphoproliferative disorder in one patient, and hemorrhagic infarction in one patient. The three patients with lung cancer were subsequently treated with standard curative resection. Conclusions Solitary pulmonary nodules present in several serious but potentially curable diseases, such as early-stage lung cancer. Patients who present with solitary pulmonary nodules after liver transplantation should be evaluated by standard diagnostic procedures, including surgical biopsy if necessary.

scholarly journals Sputum microRNA Biomarkers for Identifying Lung Cancer in Indeterminate Solitary Pulmonary Nodules

2015 ◽  
Vol 21 (2) ◽  
pp. 484-489 ◽  
Author(s):  
Lingxiao Xing ◽  
Jian Su ◽  
Maria A. Guarnera ◽  
Howard Zhang ◽  
Ling Cai ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Pulmonary Nodules ◽  
Solitary Pulmonary Nodules

scholarly journals The combination of CTCs and CEA can help guide the management of patients with SPNs suspected of being lung cancer

2019 ◽  
Author(s):  
Jian Zheng ◽  
Xiong Ye ◽  
Yuxia Zhao ◽  
Mudan He ◽  
Hui Xiao
Keyword(s):  
Lung Cancer ◽  
Sensitivity And Specificity ◽  
Radiographic Finding ◽  
Gene Copy Number ◽  
Area Under The Curve ◽  
Pulmonary Nodules ◽  
Gene Copy ◽  
Solitary Pulmonary Nodules ◽  
Diagnostic Efficacy ◽  
Diagnostic Biomarkers

Abstract Objective: Solitary pulmonary nodules (SPNs) is a common radiographic finding and require further evaluation because of the possibility of lung cancer. This study aimed to determine the sensitivity and specificity of circulating tumour cells (CTCs) as a marker for the diagnosis of SPNs and the integration of CTCs, carcinoembryonic antigen (CEA) and imaging findings to improve the sensitivity and specificity of diagnosis in patients with SPNs suspected of being lung cancer.Method: For the serum biomarker assay, the concentration of CEA was measured by an automated electrochemiluminescence analyzer. CTCs were collected from 6 ml of blood by i-FISH method, which detects the gene copy number in eight chromosomes and the tumour-associated antigen CK18.Results: With a threshold of 6 CTC units, the method showed a sensitivity of 67.1% and a specificity of 56.5% in the diagnosis of NSCLC, especially in the upper lobe, in which the diagnostic strength was the highest (P < 0.01). CTCs, CEA and nodule type had the highest diagnostic efficacy (area under the curve, 0.827; 95% confidence interval, 0.752-0.901) in patients with SPNs being suspected lung cancer. Combining CTCs (cut-off value 12 units) with CEA (1.78 ng/ml), the method showed a sensitivity of 77.8% and a specificity of 90% in the diagnosis of NSCLC, especially in the upper lobe, sub solid nodules and nodules ≥8 mm.Conclusion: Our results demonstrated that CTCs are feasible diagnostic biomarkers in patients with SPNs, especially in the upper lobe. Furthermore, CTCs combined with CEA showed higher diagnostic efficacy in the upper lobe, sub solid nodules and nodules ≥8 mm.

The Role of FTO in Tumors and It’s Research Progress

2021 ◽  
Vol 28 ◽  
Author(s):  
Hao Wei ◽  
Zhen Li ◽  
Fang Liu ◽  
Yang Wang ◽  
Shi Ding ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Lung Cancer ◽  
Literature Search ◽  
Malignant Tumors ◽  
Reference Value ◽  
Relevant Information ◽  
Research Progress ◽  
The Relationship ◽  
Comprehensive Literature Search

Background: A malignant tumor is a disease that seriously threatens human health. At present, more and more research results show that the pathogenesis of different tumors is very complicated, and the methods of clinical treatment are also diverse. This review analyzes and summarizes the role of fat mass and obesity-associated (FTO) genes in different tumors and provides a reference value for research and drug treatment methods. Method: We conducted a comprehensive literature search using the database. According to the article's primary purpose, irrelevant articles were excluded from the research summary and included in the relevant articles. Finally, the relevant information of the article was summarized. Result: In this article, the relationship between malignant tumors and FTO is introduced by citing many documents. In addition, the inhibitors that act on FTO are listed. Conclusion: This article has shown that FTO protein is a demethylase that can regulate N6-methyladenosine (m6A) levels in mRNA and plays a crucial role in the progression and resistance of various tumors such as leukemia, breast cancer, and lung cancer.

Sign in / Sign up

Export Citation Format

Share Document