scholarly journals Invasive Candidiasis Associated with Adenovirus Pneumonia

2021 ◽  
Vol 2021 ◽  
pp. 1-3
Author(s):  
Guwani Liyanage ◽  
Madhusha Gonapaladeniya ◽  
Thushari Dissanayake
Keyword(s):  
Candida Albicans ◽  
Preschool Child ◽  
Invasive Candidiasis ◽  
Candida Parapsilosis ◽  
Respiratory Infections ◽  
Severe Pneumonia ◽  
High Morbidity ◽  
Invasive Candida Infection ◽  
Adenovirus Pneumonia ◽  
Candida Infections

Invasive Candida infections in immunocompetent children lead to high morbidity and mortality despite available treatment. Candida albicans and Candida parapsilosis are the most common pathogens; however, there are newly emerging pathogenic non-albicans species. Adenovirus accounts for at least 5–10% of respiratory infections in children, and specific serotypes are associated with severe pneumonia. To the best of our knowledge, invasive Candida infection complicating adenovirus-associated pneumonia in immunocompetent children has not been reported previously. Herein, we describe a preschool child with invasive candidiasis associated with adenovirus pneumonia.

scholarly journals TUBERCULOSIS INFECTION MIGHT INCREASE THE RISK OF INVASIVE CANDIDIASIS IN AN IMMUNOCOMPETENT PATIENT

2015 ◽  
Vol 57 (3) ◽  
pp. 273-275 ◽  
Author(s):  
Xiao-Hua CHEN ◽  
Yun-Chao GAO ◽  
Yi ZHANG ◽  
Zheng-Hao TANG ◽  
Yong-Sheng YU ◽  
...  
Keyword(s):  
Candida Albicans ◽  
Invasive Candidiasis ◽  
Rare Case ◽  
Spinal Tuberculosis ◽  
Immunocompetent Patient ◽  
Antituberculous Therapy ◽  
Lower Back ◽  
Immunosuppressed Patients ◽  
History Of ◽  
Candida Infections

Deep Candida infections commonly occur in immunosuppressed patients. A rare case of a multiple deep organ infection with Candida albicans and spinal tuberculosis was reported in a healthy young man. The 19-year-old man complained of month-long fever and lower back pain. He also had a history of scalded mouth syndrome. Coinfection with Mycobacterium tuberculosis and Candida albicans was diagnosed using the culture of aspirates from different regions. Symptoms improved considerably after antifungal and antituberculous therapy. This case illustrates that infection with tuberculosis might impair the host's immune system and increase the risk of invasive candidiasis in an immunocompetent patient.

scholarly journals Whole genome and targeted-amplicon sequencing of fluconazole-susceptible and -resistant Candida parapsilosis isolates from Kuwait reveals a previously undescribed N1132D polymorphism in CDR1

2020 ◽  
Author(s):  
Mohammad Asadzadeh ◽  
Mohammed Dashti ◽  
Suhail Ahmad ◽  
Wadha Alfouzan ◽  
Abbas Alameer
Keyword(s):  
Candida Albicans ◽  
Invasive Candidiasis ◽  
Candida Parapsilosis ◽  
Amplicon Sequencing ◽  
Whole Genome

Candida parapsilosis is an opportunistic yeast pathogen causing invasive candidiasis in susceptible patients, surpassing even Candida albicans in frequency in some centers/geographical areas and also causes ∼35% of all candidemia cases in neonates (1-5).…

scholarly journals Mass Spectrometry-Based Proteomic and Immunoproteomic Analyses of the Candida albicans Hyphal Secretome Reveal Diagnostic Biomarker Candidates for Invasive Candidiasis

2021 ◽  
Vol 7 (7) ◽  
pp. 501
Author(s):  
Catarina Vaz ◽  
Aida Pitarch ◽  
Emilia Gómez-Molero ◽  
Ahinara Amador-García ◽  
Michael Weig ◽  
...  
Keyword(s):  
Candida Albicans ◽  
Invasive Candidiasis ◽  
High Morbidity ◽  
Diagnostic Biomarker ◽  
Predisposing Factor ◽  
Host Interaction ◽  
Antibody Reactivity ◽  
Extracellular Region ◽  
Wall Cell ◽  
Intracellular Compartments

Invasive candidiasis (IC) is associated with high morbidity and mortality in hospitalized patients if not diagnosed early. Long-term use of central venous catheters is a predisposing factor for IC. Hyphal forms of Candida albicans (the major etiological agent of IC) are related to invasion of host tissues. The secreted proteins of hyphae are involved in virulence, host interaction, immune response, and immune evasion. To identify IC diagnostic biomarker candidates, we characterized the C. albicans hyphal secretome by gel-free proteomic analysis, and further assessed the antibody-reactivity patterns to this subproteome in serum pools from 12 patients with non-catheter-associated IC (ncIC), 11 patients with catheter-associated IC (cIC), and 11 non-IC patients. We identified 301 secreted hyphal proteins stratified to stem from the extracellular region, cell wall, cell surface, or intracellular compartments. ncIC and cIC patients had higher antibody levels to the hyphal secretome than non-IC patients. Seven secreted hyphal proteins were identified to be immunogenic (Bgl2, Eno1, Pgk1, Glx3, Sap5, Pra1 and Tdh3). Antibody-reactivity patterns to Bgl2, Eno1, Pgk1 and Glx3 discriminated IC patients from non-IC patients, while those to Sap5, Pra1 and Tdh3 differentiated between cIC and non-IC patients. These proteins may be useful for development of future IC diagnostic tests.

scholarly journals Mass Spectrometry-based Proteomic and Immunoproteomic Analyses of the Candida albicans Hyphal Secretome Reveal Diagnostic Biomarker Candidates for Invasive Candidiasis

2021 ◽  
Author(s):  
Catarina Vaz ◽  
Aida Pitarch ◽  
Emilia Gómez-Molero ◽  
Ahinara Amador-García ◽  
Michael Weig ◽  
...  
Keyword(s):  
Candida Albicans ◽  
Invasive Candidiasis ◽  
High Morbidity ◽  
Diagnostic Biomarker ◽  
Predisposing Factor ◽  
Host Interaction ◽  
Antibody Reactivity ◽  
Extracellular Region ◽  
Wall Cell ◽  
Intracellular Compartments

Invasive candidiasis (IC) is associated with high morbidity and mortality in hospitalized patients if not diagnosed early. Long-term use of central venous catheters is a predisposing factor for IC. Hyphal forms of Candida albicans (the major etiological agent of IC) are related to invasion of host tissues. The secreted proteins of hyphae are involved in virulence, host interaction, immune response, and immune evasion. To identify IC diagnostic biomarker candidates, we characterized the C. albicans hyphal secretome by gel-free proteomic analysis, and further assessed the antibody-reactivity patterns to this subproteome in serum pools from 12 patients with non-catheter-associated IC (ncIC), 11 patients with catheter-associated IC (cIC), and 11 non-IC patients. We identified 301 secreted hyphal proteins stratified to stem from the extracellular region, cell wall, cell surface, or intracellular compartments. ncIC and cIC patients had higher antibody levels to the hyphal secretome than non-IC patients. Seven secreted hyphal proteins were identified to be immunogenic (Bgl2, Eno1, Pgk1, Glx3, Sap5, Pra1 and Tdh3). Antibody-reactivity patterns to Bgl2, Eno1, Pgk1 and Glx3 discriminated IC patients from non-IC patients, while those to Sap5, Pra1 and Tdh3 differentiated between cIC and non-IC patients. These proteins may be useful for development of future IC diagnostic tests.

CANDIDA DIAGNOSTIC PLATFORMS: ESSENTIAL IN EARLY MANAGEMENT OF CANDIDA INFECTIONS

2021 ◽  
Vol 5 (2) ◽  
pp. 59-71
Author(s):  
Yahaya Hassan ◽  
Ibrahim Aminu ◽  
Sharif Alhassan Abbdullahi
Keyword(s):  
Invasive Candidiasis ◽  
Culture Method ◽  
Clinical Decision ◽  
Diagnostic Techniques ◽  
Latex Agglutination ◽  
Diagnostic Methods ◽  
High Morbidity ◽  
Early Management ◽  
Specificity And Sensitivity ◽  
Candida Infections

Invasive candidiasis (IC) is associated with high morbidity and mortality. Candida species have significant roles in invasive candidiasis andthe emergence of clinical strains that are difficult to treat due tovirulent and resistant properties. Expansion of fungal pathogen diversity necessitates the development and adoption of new methods for prompt diagnosis and management. The review aimed to highlight the relevance of different Candida diagnostic methods for prompt management of Candida infections. The conventional gold standard diagnostic phenotypic-based (culture)method is time-consuming, associated withlow specificity and subjective interpretation.The specificity and sensitivity performances for candidaemia or deep-seated candidiasis of biochemical-based methods, including VITEK, API 20C AUX, and latex agglutination, have higher resolution than the culture. Nucleic acid-basedpolymerase chain reaction diagnostic techniques have been rapidly evolving. PCR will improve the diagnostic performance and patient outcome. The PCR technique uses different ribosomal DNA gene complexes, including D1/D2, ITS1/ITS4, or IGS1/IGS2, ashelpful markersto delineate the main pathogenic fungal species belonging to different genera. Sensitive and specific diagnostic methods for Candida speciesare significant for clinical decision and effective clinical outcome.

Enhanced IgE response to Candida albicans in postoperative invasive candidiasis

1996 ◽  
Vol 26 (4) ◽  
pp. 452-460 ◽  
Author(s):  
J. SAVOLAINEN ◽  
A. RANTALA ◽  
M. NERMES ◽  
L. LEHTONEN ◽  
M. VIANDER
Keyword(s):  
Candida Albicans ◽  
Invasive Candidiasis ◽  
Ige Response

scholarly journals The Novel Arylamidine T-2307 MaintainsIn VitroandIn VivoActivity against Echinocandin-Resistant Candida albicans

2014 ◽  
Vol 59 (2) ◽  
pp. 1341-1343 ◽  
Author(s):  
Nathan P. Wiederhold ◽  
Laura K. Najvar ◽  
Annette W. Fothergill ◽  
Rosie Bocanegra ◽  
Marcos Olivo ◽  
...  
Keyword(s):  
Body Weight ◽  
Candida Albicans ◽  
Invasive Candidiasis ◽  
Placebo Control ◽  
The Novel ◽  
Content Type ◽  
Fungal Burden ◽  
Potential Use

ABSTRACTWe evaluated thein vitroandin vivoactivities of the investigational arylamidine T-2307 against echinocandin-resistantCandida albicans. T-2307 demonstrated potentin vitroactivity, and daily subcutaneous doses between 0.75 and 6 mg/kg of body weight significantly improved survival and reduced fungal burden compared to placebo control and caspofungin (10 mg/kg/day) in mice with invasive candidiasis caused by an echinocandin-resistant strain. Thus, T-2307 may have potential use in the treatment of echinocandin-resistantC. albicansinfections.

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