scholarly journals Erratum to “Vitamin C as a Supplementary Therapy in Relieving Symptoms of the Common Cold: A Meta-Analysis of 10 Randomized Controlled Trials”

2021 ◽  
Vol 2021 ◽  
pp. 1-1
Author(s):  
Li Ran ◽  
Wenli Zhao ◽  
Hongwu Wang ◽  
Ye Zhao ◽  
Huaien Bu
Keyword(s):  
Vitamin C ◽  
Randomized Controlled Trials ◽  
Common Cold ◽  
Meta Analysis ◽  
Controlled Trials ◽  
Randomized Controlled ◽  
The Common

scholarly journals Extra Dose of Vitamin C Based on a Daily Supplementation Shortens the Common Cold: A Meta-Analysis of 9 Randomized Controlled Trials

2018 ◽  
Vol 2018 ◽  
pp. 1-12 ◽  
Author(s):  
Li Ran ◽  
Wenli Zhao ◽  
Jingxia Wang ◽  
Hongwu Wang ◽  
Ye Zhao ◽  
...  
Keyword(s):  
Vitamin C ◽  
Common Cold ◽  
Meta Analysis ◽  
Cochrane Library ◽  
Controlled Trials ◽  
China National Knowledge Infrastructure ◽  
Randomized Controlled ◽  
Knowledge Infrastructure ◽  
The Common ◽  
Therapeutic Doses

Aim. To investigate whether vitamin C is effective in the treatment of the common cold.Method. After systematically searching the National Library of Medicine (PubMed), Cochrane Library, Elsevier, China National Knowledge Infrastructure (CNKI), VIP databases, and WANFANG databases, 9 randomized placebo-controlled trials were included in our meta-analysis in RevMan 5.3 software, all of which were in English.Results. In the evaluation of vitamin C, administration of extra therapeutic doses at the onset of cold despite routine supplementation was found to help reduce its duration (mean difference (MD) = -0.56, 95% confidence interval (CI) [-1.03, -0.10], and P = 0.02), shorten the time of confinement indoors (MD = -0.41, 95% CI [-0.62, -0.19], and P = 0.0002), and relieve the symptoms associated with it, including chest pain (MD = -0.40, 95% CI [-0.77, -0.03], and P = 0.03), fever (MD = -0.45, 95% CI [-0.78, -0.11], and P = 0.009), and chills (MD = -0.36, 95% CI [-0.65, -0.07], and P = 0.01).Conclusions. Extra doses of vitamin C could benefit some patients who contract the common cold despite taking daily vitamin C supplements.

scholarly journals Vitamin C as a Supplementary Therapy in Relieving Symptoms of the Common Cold: A Meta-Analysis of 10 Randomized Controlled Trials

2020 ◽  
Vol 2020 ◽  
pp. 1-9
Author(s):  
Li Ran ◽  
Wenli Zhao ◽  
Hongwu Wang ◽  
Ye Zhao ◽  
Huaien Bu
Keyword(s):  
Vitamin C ◽  
Randomized Controlled Trials ◽  
Antiviral Therapy ◽  
Common Cold ◽  
Meta Analysis ◽  
Cochrane Library ◽  
Controlled Trials ◽  
China National Knowledge Infrastructure ◽  
Randomized Controlled ◽  
Vitamin C Supplementation

Aim. To investigate whether vitamin C performs well as a supplemental treatment for common cold. Method. After systematically searching through the National Library of Medicine (PubMed), Cochrane Library, Elsevier, China National Knowledge Infrastructure (CNKI), VIP databases, and Wanfang databases, 10 randomized controlled trials were selected for our meta-analysis with RevMan 5.3 software. Published in China, all 10 studies evaluated the effect of combined vitamin C and antiviral therapy for the treatment of common cold. Results. The total efficacy (RR=1.27, 95% CI (1.08, 1.48), P=0.003), the time for symptom amelioration (MD=−15.84, 95% CI (-17.02, -14.66), P<0.00001), and the time for healing (I, 95% CI (-14.98, -4.22), P=0.0005) were better with vitamin C supplementation than with antiviral therapy alone. Conclusions. Vitamin C could be used as a supplementary therapy along with antiviral regimens to relieve patients from the symptoms of common cold.

scholarly journals The Effect of Perioperative Vitamin C on Postoperative Analgesic Consumption: A Meta-Analysis of Randomized Controlled Trials

Nutrients ◽  
2020 ◽  
Vol 12 (10) ◽  
pp. 3109
Author(s):  
Kuo-Chuan Hung ◽  
Yao-Tsung Lin ◽  
Kee-Hsin Chen ◽  
Li-Kai Wang ◽  
Jen-Yin Chen ◽  
...  
Keyword(s):  
Postoperative Pain ◽  
Vitamin C ◽  
Randomized Controlled Trials ◽  
Pain Score ◽  
Meta Analysis ◽  
Morphine Consumption ◽  
Controlled Trials ◽  
Randomized Controlled ◽  
Lower Pain ◽  
Lower Pain Score

Because the analgesic effect of vitamin C against acute pain remains poorly addressed, this meta-analysis aimed at investigating its effectiveness against acute postoperative pain. A total of seven randomized controlled trials with placebo/normal controls were identified from PubMed, Cochrane Library, Medline, Google Scholar, and Embase databases. Pooled analysis showed a lower pain score (standardized mean difference (SMD) = −0.68, 95% CI: −1.01 to −0.36, p < 0.0001; I2 = 57%) and a lower morphine consumption (weighted mean difference (WMD) = −2.44 mg, 95% CI: −4.03 to −0.86, p = 0.003; I2 = 52%) in the vitamin group than that in the placebo group within postoperative 1–2 h. At postoperative 24 h, a lower pain score (SMD = −0.65, 95% CI: −1.11 to −0.19, p = 0.005; I2 = 81%) and lower morphine consumption (WMD = −6.74 mg, 95% CI: −9.63 to −3.84, p < 0.00001; I2 = 85%) were also noted in the vitamin group. Subgroup analyses demonstrated significant reductions in pain severity and morphine requirement immediately (1–2 h) and 24 h after surgery for patients receiving intravenous vitamin C but not in the oral subgroup. These findings showed significant reductions in pain score and opioid requirement up to postoperative 24 h, respectively, suggesting the effectiveness of perioperative vitamin C use. Further large-scale trials are warranted to elucidate its optimal intravenous dosage and effectiveness against chronic pain in the postoperative pain control setting.

scholarly journals Comparative Efficacy of Chinese Herbal Injections for Treating Pediatric Bronchopneumonia: A Bayesian Network Meta-Analysis of Randomized Controlled Trials

2020 ◽  
Vol 2020 ◽  
pp. 1-12
Author(s):  
Xiaojiao Duan ◽  
Haojia Wang ◽  
Jiarui Wu ◽  
Yubo Guo ◽  
Kaihuan Wang ◽  
...  
Keyword(s):  
Randomized Controlled Trials ◽  
Western Medicine ◽  
Respiratory Diseases ◽  
Meta Analysis ◽  
Controlled Trials ◽  
Comparative Efficacy ◽  
Randomized Controlled ◽  
Chinese Herbal ◽  
Disappearance Time ◽  
The Common

Introduction. Pediatric bronchopneumonia is one of the common respiratory diseases in pediatrics. Chinese herbal injections (CHIs) are widely used to treat pediatric bronchopneumonia. In this study, we examined the efficacy of CHIs in the treatment of pediatric bronchopneumonia using a network meta-analysis (NMA). Methods. Randomized controlled trials (RCTs) of CHIs combined western medicine (WM) versus WM were searched from electronic databases. WinBUGS 1.4.3 and Stata 13.0 were adopted to compute calculations and prepare graphs, respectively. Results. 168 RCTs with 21917 patients were included. The results revealed that Xixinnao injection (XXN) + WM had the most probability to be the best intervention in the four aspects of rate of clinical efficacy, antipyretic time, cough disappearance time, and lung shadow disappearance time. While as to lung shadow disappearance time, asthma disappearance time, and hospitalization time, Yanhuning injection (YHN) + WM could be the best intervention. The safety of CHIs needs to be further assessed. Conclusions. Based on this NMA, XXN + WM and YHN + WM were potential optimal therapies in pediatric bronchopneumonia, and their safety should be strictly monitored.

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