scholarly journals Corrigendum to “Chaperone-Mediated Autophagy Markers LAMP2A and HSC70 Are Independent Adverse Prognostic Markers in Primary Resected Squamous Cell Carcinomas of the Lung”

2021 ◽  
Vol 2021 ◽  
pp. 1-1
Author(s):  
Tereza Losmanová ◽  
Félice A. Janser ◽  
Magali Humbert ◽  
Igor Tokarchuk ◽  
Anna M. Schläfli ◽  
...  
Keyword(s):  
Squamous Cell ◽  
Prognostic Markers ◽  
Squamous Cell Carcinomas ◽  
Chaperone Mediated Autophagy

scholarly journals Digital scoring of EpCAM and slug expression as prognostic markers in head and neck squamous cell carcinomas

2020 ◽  
Author(s):  
Henrik Schinke ◽  
Theresa Heider ◽  
Timm Herkommer ◽  
Florian Simon ◽  
Alexandra Blancke Soares ◽  
...  
Keyword(s):  
Head And Neck ◽  
Squamous Cell ◽  
Prognostic Markers ◽  
Squamous Cell Carcinomas ◽  
Slug Expression

scholarly journals Evaluation of prognostic markers for patients with curatively resected thoracic esophageal squamous cell carcinomas

2016 ◽  
Vol 5 (6) ◽  
pp. 767-772 ◽  
Author(s):  
Masahide Ikeguchi ◽  
Yusuke Kouno ◽  
Kyoichi Kihara ◽  
Kazunori Suzuki ◽  
Kanenori Endo ◽  
...  
Keyword(s):  
Squamous Cell ◽  
Prognostic Markers ◽  
Squamous Cell Carcinomas ◽  
Esophageal Squamous Cell Carcinomas

scholarly journals The Relationship Between Human Papillomavirus Status and Other Molecular Prognostic Markers in Head and Neck Squamous Cell Carcinomas

2009 ◽  
Vol 74 (2) ◽  
pp. 553-561 ◽  
Author(s):  
Christina S. Kong ◽  
Balasubramanian Narasimhan ◽  
Hongbin Cao ◽  
Shirley Kwok ◽  
Julianna P. Erickson ◽  
...  
Keyword(s):  
Human Papillomavirus ◽  
Head And Neck ◽  
Squamous Cell ◽  
Prognostic Markers ◽  
Squamous Cell Carcinomas ◽  
The Relationship

scholarly journals Chaperone-Mediated Autophagy Markers LAMP2A and HSC70 Are Independent Adverse Prognostic Markers in Primary Resected Squamous Cell Carcinomas of the Lung

2020 ◽  
Vol 2020 ◽  
pp. 1-12
Author(s):  
Tereza Losmanová ◽  
Félice A. Janser ◽  
Magali Humbert ◽  
Igor Tokarchuk ◽  
Anna M. Schläfli ◽  
...  
Keyword(s):  
Squamous Cell ◽  
Disease Free Survival ◽  
Tissue Microarrays ◽  
Degradation Pathway ◽  
Squamous Cell Carcinomas ◽  
Prognostic Impact ◽  
Variable Expression ◽  
Dependent Protein ◽  
The Impact ◽  
Chaperone Mediated Autophagy

LAMP2A and HSC70 are crucial players in chaperone-mediated autophagy (CMA), a targeted, lysosome-dependent protein degradation pathway. Elevated LAMP2A levels, indicative of increased CMA activity, are observed in several malignancies, and CMA downregulation may be exploited therapeutically. We evaluated the impact of LAMP2A and HSC70 in pulmonary squamous cell carcinomas (pSQCC). Antibodies were validated by knockdown and overexpression experiments using three different cell lines. Expression levels in tissue were analyzed by immunohistochemistry in a cohort of 336 consecutive pSQCC using tissue microarrays. There was no significant correlation between the two markers among each other and no association with pathological parameters (TNM categories, grading). However, both high LAMP2A and HSC70 expression were associated with worse outcome, including overall survival (OS; p=0.012 and p=0.001) and disease free survival (DFS; p=0.049 and p=0.036). In multivariate analysis, both markers and a combination of them were independent adverse prognostic factors for OS (LAMP2Ahigh: HR=2.059; p<0.001; HSC70high: HR=1.987; p<0.001; LAMP2Ahigh/HSC70high: HR=1.529; p<0.001) and DFS (LAMP2Ahigh: HR=1.709; p=0.004; HSC70high: HR=1.484; p=0.027; LAMP2Ahigh/HSC70high: HR=1.342, p<0.001). The negative prognostic impact of high LAMP2A and HSC70 and their variable expression in pSQCC may justify the use of these proteins as potential biomarkers for future CMA-inhibiting therapies.

Ultrastructural features of prognostic significance in human oral cancer

1992 ◽  
Vol 50 (1) ◽  
pp. 618-619
Author(s):  
Karvita B. Ahluwalia ◽  
Nidhi Sharma
Keyword(s):  
Oral Cancer ◽  
Squamous Cell ◽  
Common Knowledge ◽  
Prognostic Significance ◽  
Growth Control ◽  
Terminal Differentiation ◽  
Squamous Cell Carcinomas ◽  
Effective Therapy ◽  
Invasive Potential ◽  
Biological Behaviour

It is common knowledge that apparently similar tumors often show different responses to therapy. This experience has generated the idea that histologically similar tumors could have biologically distinct behaviour. The development of effective therapy therefore, has the explicit challenge of understanding biological behaviour of a tumor. The question is which parameters in a tumor could relate to its biological behaviour ? It is now recognised that the development of malignancy requires an alteration in the program of terminal differentiation in addition to aberrant growth control. In this study therefore, ultrastructural markers that relate to defective terminal differentiation and possibly invasive potential of cells have been identified in human oral leukoplakias, erythroleukoplakias and squamous cell carcinomas of the tongue.

Smoking correlates with the presence of p53 mutations in squamous cell carcinomas of the head and neck (SCCHN)

1998 ◽  
Vol 23 (3) ◽  
pp. 268-269
Author(s):  
Liloglou ◽  
Scholes ◽  
Spandidos ◽  
Jones ◽  
Vaughan ◽  
...  
Keyword(s):  
Head And Neck ◽  
Squamous Cell ◽  
Squamous Cell Carcinomas ◽  
P53 Mutations
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