scholarly journals Corrigendum to “Inhibitory Effect of Paquinimod on a Murine Model of Neutrophilic Asthma Induced by Ovalbumin with Complete Freund’s Adjuvant”

2021 ◽  
Vol 2021 ◽  
pp. 1-1
Author(s):  
Jong-Uk Lee ◽  
Jong Sook Park ◽  
Ji Ae Jun ◽  
Min Kyung Kim ◽  
Hun Soo Chang ◽  
...  
Keyword(s):  
Murine Model ◽  
Inhibitory Effect ◽  
Complete Freund’S Adjuvant ◽  
Freund’S Adjuvant ◽  
Complete Freund's Adjuvant ◽  
Freund's Adjuvant

scholarly journals Inhibitory Effect of Paquinimod on a Murine Model of Neutrophilic Asthma Induced by Ovalbumin with Complete Freund’s Adjuvant

2021 ◽  
Vol 2021 ◽  
pp. 1-9
Author(s):  
Jong-Uk Lee ◽  
Jong Sook Park ◽  
Ji Ae Jun ◽  
Min Kyung Kim ◽  
Hun Soo Chang ◽  
...  
Keyword(s):  
Murine Model ◽  
Complete Freund’S Adjuvant ◽  
Dependent Manner ◽  
Neutrophilic Inflammation ◽  
Caspase 1 ◽  
Tnf Α ◽  
Ifn Γ ◽  
Freund’S Adjuvant ◽  
Complete Freund's Adjuvant ◽  
Freund's Adjuvant

Background. Quinoline-3-carboxamides have been used to treat autoimmune/inflammatory diseases in humans because they inhibit the functions of S100 calcium-binding protein A9 (S100A9), which participates in the development of neutrophilic inflammation in asthmatics and in an animal model of neutrophilic asthma. However, the therapeutic effects of these chemicals have not been evaluated in asthma. The purpose of this study was to evaluate the effect of paquinimod, one of the quinoline-3-carboxamides, on a murine model of neutrophilic asthma. Methods. Paquinimod was orally administered to 6-week-old C57BL/6 mice sensitized and challenged with ovalbumin (OVA)/complete Freund’s adjuvant (CFA) and OVA. Lung inflammation and remodeling were evaluated using bronchoalveolar lavage (BAL) and histologic findings including goblet cell count. S100A9, caspase-1, IL-1β, MPO, IL-17, IFN-γ, and TNF-α were measured in lung lysates using western blotting. Results. Paquinimod restored the enhancement of airway resistance and the increases in numbers of neutrophils and macrophages of BAL fluids and those of goblet cells in OVA/CFA mice toward the levels of sham-treated mice in a dose-dependent manner (0.1, 1, 10, and 25 mg/kg/day, p.o.). Concomitantly, p20 activated caspase-1, IL-1β, IL-17, TNF-α, and IFN-γ levels were markedly attenuated. Conclusion. These data indicate that paquinimod effectively inhibits neutrophilic inflammation and remodeling in the murine model of neutrophilic asthma, possibly via downregulation of IL-17, IFN-γ, and IL-1β.

scholarly journals Sulforaphane Modulates Joint Inflammation in a Murine Model of Complete Freund’s Adjuvant-Induced Mono-Arthritis

Molecules ◽  
2018 ◽  
Vol 23 (5) ◽  
pp. 988 ◽  
Author(s):  
João Silva Rodrigues ◽  
Cristiane Silva e Silva ◽  
Thayanne França Muniz ◽  
Alana de Aquino ◽  
Larissa Neuza da Silva Nina ◽  
...  
Keyword(s):  
Murine Model ◽  
Joint Inflammation ◽  
Complete Freund’S Adjuvant ◽  
Freund’S Adjuvant ◽  
Complete Freund's Adjuvant ◽  
Freund's Adjuvant
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