scholarly journals Corrigendum to “Health-Related Quality of Life and Sleep Quality after 12 Months of Treatment in Nonsevere Obstructive Sleep Apnea: A Randomized Clinical Trial with Continuous Positive Airway Pressure and Mandibular Advancement Splints”

2021 ◽  
Vol 2021 ◽  
pp. 1-1
Author(s):  
Lars M. Berg ◽  
Torun K. S. Ankjell ◽  
Yi-Qian Sun ◽  
Tordis A. Trovik ◽  
Oddveig G. Rikardsen ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Clinical Trial ◽  
Airway Pressure ◽  
Positive Airway Pressure ◽  
Mandibular Advancement ◽  
Health Related Quality ◽  
Obstructive Sleep ◽  
Related Quality ◽  
Health Related

scholarly journals The role of sham continuous positive airway pressure as a placebo in controlled trials: Best Apnea Interventions for Research Trial

SLEEP ◽  
2019 ◽  
Vol 42 (8) ◽  
Author(s):  
Michelle L Reid ◽  
Kevin J Gleason ◽  
Jessie P Bakker ◽  
Rui Wang ◽  
Murray A Mittleman ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Airway Pressure ◽  
Positive Airway Pressure ◽  
Controlled Trials ◽  
Health Related Quality ◽  
Life Outcomes ◽  
Related Quality ◽  
Health Related

Abstract Study Objectives The main objective of this study was to evaluate the role of sham continuous positive airway pressure (CPAP) compared to conservative medical therapy (CMT) as a control arm in the Best Apnea Interventions for Research (BestAIR) study by assessing differences in subjectively and objectively measured outcomes, adverse events, adherence, and retention rates. Methods BestAIR is a clinical trial aimed to identify important design features for future randomized controlled trials of CPAP. Participants with obstructive sleep apnea were randomized to one of four groups; two control arms (CMT, sham-CPAP) and two active CPAP arms (with and without behavioral interventions). Blood pressure and health-related quality of life outcomes were assessed at baseline, 6 and 12 months. Study outcomes, retention, and adverse event rates were compared between the two control arms. Sham-CPAP adherence and self-efficacy were also compared to active-CPAP adherence (without behavioral intervention). Results Our sample included 86 individuals in the control arms and 42 participants in the active-CPAP arm. There were no differences in longitudinal profiles in blood pressure, health-related quality of life outcomes, dropout rates, or adverse events in sham-CPAP group compared to CMT-only group (all ps > 0.05); standardized differences were generally small and with inconsistent directionality across measurements. When compared to active-CPAP, sham-CPAP was associated with 93 fewer minutes/night of usage over 12 months (p = 0.007) and lower outcome expectations (p < 0.05). Conclusion We observed no evidence of differences in objectively or subjectively measured outcomes with the use of sham-CPAP compared to CMT group. The lower adherence on sham-CPAP and poorer self-efficacy compared to active-CPAP may suggest differences in perceived benefit. Registration NCT 01261390 Best Apnea Interventions for Research (BestAIR) www.clinicaltrials.gov

scholarly journals Impact of TG4010 Vaccine on Health-Related Quality of Life in Advanced Non-Small-Cell Lung Cancer: Results of a Phase IIB Clinical Trial

PLoS ONE ◽  
2015 ◽  
Vol 10 (7) ◽  
pp. e0132568 ◽  
Author(s):  
Christine Rotonda ◽  
Amélie Anota ◽  
Mariette Mercier ◽  
Bérangère Bastien ◽  
Gisèle Lacoste ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Lung Cancer ◽  
Clinical Trial ◽  
Small Cell Lung Cancer ◽  
Small Cell ◽  
Health Related Quality ◽  
Small Cell Lung ◽  
Related Quality ◽  
Health Related
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