scholarly journals The Treatment of Cholecystitis and Cholelithiasis by Tibetan Medicine

2021 ◽  
Vol 2021 ◽  
pp. 1-21
Author(s):  
Lin Pan ◽  
Jie Gao ◽  
Yunfeng Han ◽  
Yi Shi ◽  
Xi Tang ◽  
...  
Keyword(s):  
Chemical Constituents ◽  
Tibetan Medicine ◽  
Potential Drug ◽  
Potential Mechanism ◽  
Health It ◽  
Medical Systems ◽  
Pharmacological Activities ◽  
Drug Candidates ◽  
Medicinal Value ◽  
The World

Cholecystitis and cholelithiasis is one of the factors threatening human health. It is very important to find drugs for the treatment of cholecystitis and cholelithiasis. Tibetan medicine is one of the traditional medical systems in China. It has rich experience in treating various diseases. This paper summarizes the treatment of cholecystitis and cholelithiasis through literature review of Tibetan medicine monographs, drug standards, Tibetan medicine, and prescriptions. In the Tibetan medicine system, 170 kinds of Tibetan medicine and 38 kinds of Tibetan prescriptions were found to treat cholecystitis and cholelithiasis. Among them, there are 35 modern researches related to the treatment of cholecystitis and cholelithiasis. Their names, families, medicinal parts, chemical constituents, and pharmacological activities are introduced in detail. These Tibetan medicines and prescriptions may be a precious gift of ancient Tibetan medicine to the world, and may also become potential drug candidates for the treatment of cholecystitis and cholelithiasis. Modern phytochemistry, pharmacology, metabonomics, and/or clinical trials can be used to confirm its medicinal value in the treatment of cholecystitis and cholelithiasis, identify active compounds, clarify its potential mechanism of action, and clarify its toxicity and side effects. This article provides a new idea and source for the treatment of cholecystitis and cholelithiasis.

scholarly journals Analgesic and Antiinflammatory Activity of Genus Aconitum: A Phytochemical and Ethnopharmacological Review

2016 ◽  
Vol 02 ◽  
pp. 94
Author(s):  
Muhammad Shahzad Aslam ◽  
Muhammad Syarhabil Ahmad ◽  
◽  
Keyword(s):  
Traditional Medicine ◽  
Antiinflammatory Activity ◽  
Chemical Constituents ◽  
Common Species ◽  
Pharmacological Activities ◽  
Traditional Use ◽  
Antiinflammatory Agents ◽  
Comprehensive Knowledge ◽  
The World ◽  
China And Japan

The genusAconitumhas been reviewed for distribution in the world, traditional use, isolated chemical constituents, and pharmacological activities of some common species.Aconitumspecies are traditionally used throughout Asia, particularly in China and Japan, as an analgesic and antiinflammatory medicine. Lappaconitine and Yunaconitine are common chemical constituents that may justify the use of these species as analgesic and antiinflammatory agents in Asian traditional medicine. The aim of the present paper is to further review the comprehensive knowledge of the plants of this genus including the traditional uses, chemical constituents, and pharmacology.

scholarly journals Phytochemical, Therapeutic, and Ethnopharmacological Overview for a Traditionally Important Herb:Boerhavia diffusaLinn.

2014 ◽  
Vol 2014 ◽  
pp. 1-19 ◽  
Author(s):  
Shikha Mishra ◽  
Vidhu Aeri ◽  
Praveen Kumar Gaur ◽  
Sanjay M. Jachak
Keyword(s):  
Chemical Analysis ◽  
Disease Burden ◽  
Therapeutic Potential ◽  
Chemical Constituents ◽  
Urinary System ◽  
Pharmacological Activities ◽  
The World ◽  
Therapeutic Properties ◽  
Therapeutic Activities ◽  
Boerhavia Diffusa

Boerhavia diffusa(BD) is a plant ofrasayanacategory as per ayurvedic claims. It is reported to possess antiaging, disease prevention, and life strengthening activities which hold enormous influence in disease burden and affordability/availability of healthcare in the world.Objective.This paper has been compiled to comment on the studies reported for BD to highlight its chemical and therapeutic potential along with its ethnopharmacological considerations.Methods.In the present paper, a detailed account of chemical constituents and pharmacological activities has been presented. All the findings were correlated with modern pharmacological activities to appraise the value of BD.Results.Chemical analysis of BD gives a wide variety of chemical constituents, namely, rotenoids, flavonoids, xanthones, purine nucleoside, lignans, and steroids. Various ethnopharmacological reports emphasize its role in disorders of reproductive system, gastrointestinal system, respiratory system, urinary system, hepatic system/jaundice, cardiovascular system, and cancer.Conclusions.The studies on the therapeutic activities of BD range from studies on crude extracts to isolated compounds; however some of the studies require sophistication and validated results. BD is a plant of enormous importance in the purview of its chemical and therapeutic properties.

scholarly journals Solidago virgaurea L.: A Review of Its Ethnomedicinal Uses, Phytochemistry, and Pharmacological Activities

2020 ◽  
Author(s):  
Cornelia Fursenco ◽  
Tatiana Calalb ◽  
Livia Uncu ◽  
Mihaela Dinu ◽  
Robert Ancuceanu
Keyword(s):  
Chemical Constituents ◽  
Pharmacological Activities ◽  
Inflammatory Agent ◽  
Aerial Parts ◽  
The World ◽  
Solidago Virgaurea ◽  
Clinical Models ◽  
Potential Benefits ◽  
Ethnomedicinal Uses ◽  
Published Research

Solidago virgaurea L. (European goldenrod, Woundwort), Asteraceae, is a familiar medicinal plant in Europe and other parts of the world, widely used and among the most researched species from its genus. The aerial parts of European goldenrod have long been used for urinary tract conditions and as an anti-inflammatory agent in the traditional medicine of different peoples. Its main chemical constituents are flavonoids (mainly derived from quercetin and kaempferol), C6-C1 and C6-C3 compounds, terpenes (mostly from the essential oil), and a large number of saponin molecules (mainly virgaureasaponins and solidagosaponins). Published research on its potential activities is critically reviewed here: antioxidant, antiinflammatory, analgesic, spasmolitic, antihypertensive, diuretic, antibacterial, antifungal, antiparasite, cytotoxic and antitumor, antimutagenic, antiadipogenic, antidiabetic, cardioprotective, and antisenescence. The evidence concerning its potential benefits is mainly derived from non-clinical studies, some effects are rather modest, whereas others are more promising, but need more confirmation in both non-clinical models and clinical trials.

scholarly journals A comprehensive review on the pharmacological properties of Diplazium esculentum, an edible fern

2020 ◽  
Vol 3 (1) ◽  
pp. 01-09
Author(s):  
Tapas Chaudhuri
Keyword(s):  
Chemical Constituents ◽  
Folk Medicine ◽  
Pharmacological Activities ◽  
Comprehensive Review ◽  
Wide Range ◽  
Structural Formulas ◽  
The World ◽  
Ethnomedicinal Plant ◽  
Young Leaves ◽  
Ethnomedicinal Uses

Diplazium esculentum (Family: Athyriaceae), one of the most popular wild edible fern, is considered as a pharmacologically diverse ethnomedicinal plant. The coiled fronds and young leaves of this plant have a wide range ethnomedicinal uses in folk medicine around the world directed for a number of ailments. The present article is the first comprehensive review on the pharmacological activities of this particular edible fern. The structural formulas of all the chemical constituents identified and isolated so far from D. esculentum are also provided in the present review. The most thoroughly studied pharmacological activities viz., antioxidant, antimicrobial, immunomodulatory, neuromodulatory, anti-fertility, cytotoxic, etc.) of the D. esculentum extracts have been discussed. This comprehensive review will be of help for the future researchers investigating for more potent compounds and their pharmacological activities.

Chemical Constituents and Bioactivities of Gorgonian Corals

2020 ◽  
Vol 24 (12) ◽  
pp. 1315-1330
Author(s):  
Hui Lei ◽  
Peng Jiang ◽  
Dan Zhang
Keyword(s):  
Biological Activities ◽  
Chemical Constituents ◽  
Structural Features ◽  
Mechanisms Of Action ◽  
Pharmacological Properties ◽  
Pharmacological Activities ◽  
Lead Compounds ◽  
Medicinal Value ◽  
Gorgonian Corals ◽  
New Compounds

Gorgonian corals are considered as a rich source of secondary metabolites with unique structural features and biological activities. A large number of novel metabolites with potent pharmacological properties have been isolated from gorgonian corals. Some of these compounds have exhibited to possess new mechanisms of action, which hold great promises as potential lead compounds in future marine drug development. This review aims to provide an overview of chemical constituents and biological activities of gorgonian corals from 2015 to December, 2019. Some 145 metabolites, including 16 sesquiterpenoids, 62 diterpenoids, 62 steroids and 5 alkaloids were reported during this period and their pharmacological activities were investigated. Moreover, the peculiar structure and potential medicinal value of these new compounds are discussed in this review.

In-vivo evaluation of lipid lowering ability of Chloris paraguaiensis extracts

2020 ◽  
Vol 7 (2) ◽  
pp. 21-24
Author(s):  
Pavani C H
Keyword(s):  
Medicinal Plants ◽  
Chemical Constituents ◽  
The Body ◽  
Lipid Lowering ◽  
Medical Systems ◽  
In Vivo Evaluation ◽  
Standard Drug ◽  
Anti Oxidant ◽  
And Control

Hyperlipidemia is the immediate results of the excessive fat intake in food. This results in the elevated levels of cholesterol and triglycerides in the blood. This leads to heart conditions like CAD, hypertension, congestive heart failure as risk factors which can be lethal. There are many drugs to treat and control the lipids levels in the body. These drugs are either designed to prevent LDL accumulation and VLDL synthesis. Some drugs also lower the elevated levels of saturated lipids in the body. But many drugs are known to cause side effects and adverse effects; therefore, alternatives to the drugs are the subjects for current investigations. Herbs and medicinal plants are used as treatment sources for many years. They have been used in the Indian medical systems like Ayurveda, Siddha etc. As the application of herbs in the treatment is growing, there is an urgent need for the establishment of Pharmacological reasoning and standardization of the activity of the medicinal plants. Chloris paraguaiensis Steud. is Poyaceae member that is called locally as Uppugaddi. Traditionally it is used to treat Rheumatism, Diabetes, fever and diarrhoea. The chemical constituents are known to have anti-oxidant properties and most of the anti-oxidants have anti-hyperlipidemic activity too. Since the plant has abundant flavonoid and phenol content, the current research focusses on the investigation of the anti-hyperlipidemic activity of the plant Chloris extracts. Extracts of Chloris at 200mg/kg showed a comparably similar anti hyperlipidemia activity to that of the standard drug. The extracts showed a dose based increase in the activity at 100 and 200mg/kg body weight.

Pharmacognostical and pharmacological activity of Justicia gendarussa burm.f.: a comprehensive review

2020 ◽  
Vol 11 (3) ◽  
pp. 3384-3390
Author(s):  
Ashish ◽  
Anjali ◽  
Dixit Praveen K ◽  
Nagarajan K ◽  
Sahoo Jagannath
Keyword(s):  
Pharmacological Activity ◽  
Chemical Constituents ◽  
Biological Action ◽  
Andaman Islands ◽  
Comprehensive Review ◽  
Medicinal Value ◽  
Anti Oxidant ◽  
Phytochemical Constituents ◽  
Pharmacologically Active ◽  
Different Parts

Justicia gendarussa Burm .f. (family Acanthaceae) which is also known as willow-leaves and commonly known as Nili-Nirgundi, it is very commonly found nearby to China and its availability is very common in larger parts of India and Andaman islands. Traditionally it is used to treat various sorts of disorders such as wound healing, anti-inflammatory, anti-oxidant, antiproliferative, anti-arthritic etc. Justicia gendarussa is one of the crucial herbs which has been used in the Ayurveda. Majorly leaves parts of the plant shows the pharmacological activity but the root of the plant Justicia gendarussa is also have the important medicinal values. A large variety of pharmacologically active constituents i.e., alkaloids, flavonoids, saponin, carbohydrates, steroids, triterpenoids, carotenoids, aminoacids, tannins, phenolics, coumarines and anthaquinones are also present in this plant and they makes the plant pharmacologically important. The activity of the plant is also dependent on the solvent which is used for the extraction the various vital chemical constituents. The different- different parts of the plants having the different medicinal values also differ in the chemical values. This review is not only focused on the essential phytochemical constituents which is available in the plant but it also explains their necessary medicinal value to shows the essential biological action and phytopharmacological actions of various parts of the plant.

Recent Advances in the Development of Antimicrobial Peptides (AMPs): Attempts for Sustainable Medicine?

2018 ◽  
Vol 25 (21) ◽  
pp. 2503-2519 ◽  
Author(s):  
Anne Kokel ◽  
Marianna Torok
Keyword(s):  
Side Effects ◽  
Antimicrobial Peptides ◽  
Potential Drug ◽  
Green Technologies ◽  
Specific Antibodies ◽  
Structural Modifications ◽  
Drug Candidates ◽  
Induce Resistance ◽  
Conventional Antibiotics

Background: Since the first isolation of antimicrobial peptides (AMPs) they have attracted extensive interest in medicinal chemistry. However, only a few AMP-based drugs are currently available on the market. Despite their effectiveness, biodegradability, and versatile mode of action that is less likely to induce resistance compared to conventional antibiotics, AMPs suffer from major issues that need to be addressed to broaden their use. Notably, AMPs can lack selectivity leading to side effects and cytotoxicity, and also exhibit in vivo instability. Several strategies are being actively considered to overcome the limitations that restrain the success of AMPs. Methods: In the current work, recent strategies reported for improving AMPs in the context of drug design and delivery were surveyed, and also their possible impact on patients and the environment was assessed. Results: As a major advantage AMPs possess an easily tunable skeleton offering opportunities to improve their properties. Strategic structural modifications and the beneficial properties of cyclic or branched AMPs in term of stability have been reported. The conjugation of AMPs with nanoparticles has also been explored to increase their in vivo stability. Other techniques such as the coupling of AMPs with specific antibodies aim to increase the selectivity of the potential drug towards the target. These strategies were evaluated for their effect on the environment highlighting green technologies. Conclusion: Although further research is needed taking into account both environmental and human health consequences of novel AMPs, several of these compounds are promising drug candidates for use in sustainable medicine.

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