scholarly journals Effect of Entecavir Combined with Adefovir Dipivoxil on Clinical Efficacy and TNF-α and IL-6 Levels in Patients with Hepatitis B Cirrhosis

2021 ◽  
Vol 2021 ◽  
pp. 1-5
Author(s):  
Yonghuan Yu ◽  
Xinfeng Cui ◽  
Jingjing Zhao ◽  
Ting Jia ◽  
Baofeng Ren ◽  
...  
Keyword(s):  
Liver Fibrosis ◽  
Hepatitis B ◽  
Liver Function ◽  
Adefovir Dipivoxil ◽  
Adverse Reactions ◽  
Statistical Significance ◽  
Effective Rate ◽  
Control Group ◽  
Tnf Α ◽  
Experimental Group

Objective. The purpose of the study was to investigate the effect of entecavir combined with adefovir dipivoxil on clinical efficacy and TNF-α and IL-6 levels in patients with hepatitis B cirrhosis. Methods. A total of 100 patients with hepatitis B cirrhosis admitted to our hospital between January 2018 and June 2019 were randomly selected and divided into the control group (n = 50) and experimental group (n = 50) according to the order of admission. Among them, the control group patients were treated with entecavir, while the patients in the experimental group received entecavir combined with adefovir dipivoxil. After that, the effective rate of treatment, the incidence of adverse reactions, liver function indexes, liver fibrosis condition, and TNF-α and IL-6 expression levels were all compared between the two groups. Results. The effective rate of treatment in the experimental group was significantly higher than that in the control group, with statistical significance ( p < 0.001 ); the incidence of adverse reactions of the patients in the experimental group was significantly lower than that in the control group, with statistical significance ( p < 0.001 ); the liver function indexes in the experimental group were significantly better than those in the control group, with statistical significance ( p < 0.001 ); the number of patients with liver fibrosis in the experimental group was significantly less than that in the control group, with statistical significance ( p < 0.001 ); the TNF-α and IL-6 expression levels in the experimental group were significantly lower than those in the control group, with statistical significance ( p < 0.001 ). Conclusion. Entecavir combined with adefovir dipivoxil in the treatment of hepatitis B cirrhosis can effectively improve the therapeutic effect and reduce the serum inflammatory factor levels, with high safety, which is worthy of application and popularization.

scholarly journals Clinical Observation on the Effect of Chinese Medicine Five-Color Therapy on the Treatment of Children with Chronic Urticaria

2020 ◽  
Vol 4 (3) ◽  
Author(s):  
Yu Zhu ◽  
Lu Shi
Keyword(s):  
Chinese Medicine ◽  
Traditional Chinese Medicine ◽  
Chronic Urticaria ◽  
Statistical Significance ◽  
Effective Rate ◽  
Control Group ◽  
Color Treatment ◽  
Income Data ◽  
Grouping Method ◽  
Experimental Group

Objective: To analyze the clinical treatment effect of traditional Chinese medicine five-color therapy on chronic urticaria in children. Methods: The income data target of this article is 80 children with chronic urticaria. The grouping method is a randomized method with 40 children in each group. The experimental group was treated with five-color treatment of traditional Chinese medicine, and the control group was treated with western medicine. The incidence, treatment and recurrence of adverse reactions in children with chronic urticaria were compared between the two groups. Results: Showed total effective rate of children with chronic urticaria in the experimental group was compared with the control group, P<0.05, the data showed statistical significance. Conclusion: Stated use of TCM five-color therapy in the treatment of children with chronic urticaria can significantly improve safety.

scholarly journals Therapeutic effect of nifedipine combined with enalapril on elderly patients with coronary heart disease complicated with hypertension

2018 ◽  
Vol 2 (6) ◽  
Author(s):  
Xiaoye Wang
Keyword(s):  
Blood Pressure ◽  
Coronary Heart Disease ◽  
Heart Disease ◽  
Elderly Patients ◽  
Adverse Reactions ◽  
Effective Rate ◽  
Control Group ◽  
Significant Difference ◽  
Pre Treatment ◽  
Experimental Group

【Abstract】Objective: Toanalyze the efficacy of combined drug therapy for elderly patients with coronary heart disease and hypertension.METHODS:Sixty-six elderly patients with coronary heart disease and hypertension were enrolled from December 2017 to November 2018. They were randomly divided into two groups, 33 patients in each group. Patients in the experimental group received nifedipine. In combination with enalapril, patients enrolled in the control group received nifedipine monotherapy.RESULTS:Compared with the control group, the total effective rate, Serum Nitric Oxide (Serum NO) after treatment, CRP after treatment, HCY after treatment, and blood pressure after treatment were significantly improved (P<0.05). Serum NO and treatment before treatment in the 2 groups. There was no significant difference in pre-CRP, pre-treatment HCY, pre-treatment blood pressure, and adverse reactions during treatment (P>0.05).Conclusion: Theelderly patients with coronary heart disease and hypertension are treated with nifedipine and enalapril.

scholarly journals Therapeutic Effect of Oral Administration and External Therapy of Traditional Chinese Medicine on Cervical Tuberculous

2019 ◽  
Vol 3 (3) ◽  
Author(s):  
Guoqiang Yang ◽  
Jin Zhang
Keyword(s):  
Statistical Analysis ◽  
Chinese Medicine ◽  
Traditional Chinese Medicine ◽  
Oral Administration ◽  
Total Effective Rate ◽  
Statistical Significance ◽  
Effective Rate ◽  
Control Group ◽  
Treatment Data ◽  
Experimental Group

Objective: To analyze the clinical effect and value of oral administration and external therapy of traditional Chinese medicine for treatment of cervical tuberculous lymphadenopathy. Methods: A total of 56 patients with cervical tuberculous lymphadenopathy admitted to our hospital from January 1 to January 2018 were recruited. By using double-blind method, the patients were divided into control group (n=28) and experimental group (n=28). Control group comprised of patients with conventional anti-tuberculosis treatment, while the experimental group comprised of patients treated with oral administration and external therapy of traditional Chinese medicine. Total effective rate, incidence of complication and level of T lymphocyte subsets were compared between the two groups of cervical tuberculous lymphadenopathy patients. Results: Post-treatment data of total effective rate, complication rate, CD3+, CD4+, CD8+, CD4+/CD8+ of the experimental group were compared with the control group. P<0.05; statistical analysis showed statistical significance. Post-treatment data of CD3+, CD4+, CD8+, CD4+/CD8+ of both control and experimental groups were compared with pre-treatment data. P<0.05; statistical analysis showed statistical significance. Conclusion: Oral administration and external therapy of traditional Chinese medicine possesses significant effect in treatment of cervical tuberculous lymphadenopathy.

scholarly journals Clinical Evaluation of Pinggan Yiqi Yangshen Recipe Combined with Labetalol Hydrochloride and Magnesium Sulfate in the Treatment of PIH

2021 ◽  
Vol 2021 ◽  
pp. 1-7
Author(s):  
Ping Li ◽  
Jie Zhao ◽  
Peipei Gao ◽  
Hongcui Qu
Keyword(s):  
Blood Pressure ◽  
Renal Function ◽  
Magnesium Sulfate ◽  
Pregnancy Outcomes ◽  
Adverse Reactions ◽  
Fetal Distress ◽  
Effective Rate ◽  
Control Group ◽  
Labetalol Hydrochloride ◽  
Experimental Group

Background. To observe the clinical effect of Pinggan Yiqi Yangshen recipe combined with labetalol hydrochloride and magnesium sulfate in the treatment of pregnancy-induced hypertension (PIH). Methods. A total of 126 patients with PIH diagnosed in our hospital from January 2016 to May 2018 were randomly divided into the control group and the experimental group, with 63 cases in each group. The control group was treated with labetalol combined with magnesium sulfate. On the basis of the control group, the experimental group was treated with Pinggan Yiqi Yangshen recipe. Clinical efficacy, blood pressure, renal function, and biochemical indexes were compared between the two groups. Moreover, pregnancy outcomes and adverse reactions were compared between the two groups. Results. After treatment, the total effective rate in the experimental group was higher than in the control group. Blood pressure and mean arterial pressure in the experimental group were more significantly downregulated than the control group. Renal function indexes and biochemical indexes in the experimental group were more significant than those in the control group. The incidence of cesarean section, preterm birth, and abnormal fetal heart rate in the experimental group was significantly lower than that in the control group. There was no difference in the incidence of fetal distress, postpartum hemorrhage, neonatal asphyxia, and adverse reactions between the two groups. Conclusion. Pinggan Yiqi Yangshen recipe combined with labetalol hydrochloride and magnesium sulfate can effectively reduce the blood pressure of patients with PIH, help patients to return to normal levels of biochemical indexes and renal function indexes, and improve pregnancy outcomes with high safety, which is worthy of further promotion and application in clinical practice.

scholarly journals Efficacy and Safety of Omeprazole and Amoxicillin in the Treatment of Gastric Ulcer

2021 ◽  
Vol 5 (3) ◽  
Author(s):  
Jie Liu ◽  
Minghui Xiao ◽  
Jianping Hui
Keyword(s):  
Gastric Ulcer ◽  
Recurrence Rate ◽  
Breath Test ◽  
Adverse Reactions ◽  
Effective Rate ◽  
Control Group ◽  
Research Subjects ◽  
Before And After ◽  
Positive Rate ◽  
Experimental Group

Objective: To study the effect of omeprazole and amoxicillin in the treatment of patients with gastric ulcer. Methods: 88 patients with gastric ulcer in our hospital from March 2018 to March 2020 were selected as research subjects and divided into experimental group (44 cases were treated with omeprazole + amoxicillin) and control group (44 cases were treated with omeprazole). The therapeutic effect, positive rate of breath test before and after treatment, recurrence rate within half a year and adverse reactions were compared between the two groups. Results: The total effective rate of the experimental group (97.73%, 43 / 44) was higher than that of the control group (84.09%, 37 / 44), P < 0.05; After treatment, the positive rate of breath test in the experimental group (22.73%, 10 / 44) was lower than that in the control group (47.73%, 21 / 44), P < 0.05; The recurrence rate in the experimental group was 4.55% (2 / 44), which was significantly higher than that in the control group (20.45%, 9 / 44), P < 0.05; The incidence of adverse reactions in the experimental group (9.09%, 4 / 44) was significantly lower than that in the control group (15.91%, 7 / 44), P < 0.05. Conclusion: In the process of clinical treatment of gastric ulcer, omeprazole combined with amoxicillin has significant effect, not only the recurrence rate is low, but also the incidence of adverse events should be less, and the treatment is safer. 

scholarly journals Short Term Efficacy of Entecavir in the Treatment of Decompensated Chronic Hepatitis B Cirrhosis

2020 ◽  
Vol 4 (6) ◽  
Author(s):  
Weiwei Fu
Keyword(s):  
Chronic Hepatitis ◽  
Hepatitis B ◽  
Liver Function ◽  
Chronic Hepatitis B ◽  
Adverse Reactions ◽  
Hbv Dna ◽  
Control Group ◽  
Observation Group ◽  
Short Term ◽  
Short Term Treatment

Objective: To explore the effect of entecavir on patients with decompensated chronic hepatitis B cirrhosis. Methods: From October 2007 to December 2019, 100 patients with decompensated chronic hepatitis B cirrhosis who were treated in our hospital were selected to carry out this study. The clinical data of the patients were analyzed. According to whether entecavir treatment was carried out, 100 patients were divided into two groups, 50 cases in the control group and 50 cases in the observation group. The control group was treated with conventional drugs, and the observation group was treated with entecavir. Liver function indexes, liver fibrosis indexes, HBV-DNA negative conversion rate and incidence of adverse reactions were compared between the two groups. Results: Compared with the control group, the liver function indexes of the observation group were lower, P < 0.05; Compared with the control group, the observation group was better, P < 0.05; The negative rate of HBV-DNA in the observation group was lower than that in the control group (P < 0.05); There was no difference in the incidence of adverse reactions between the two groups, P > 0.05. Conclusion: Entecavir can not only improve the liver function, but also enhance the short-term treatment effect, without increasing adverse reactions, and has high safety, which is worthy of recommendation.

scholarly journals Clinical effect of Hongteng decoction combined with levofloxacin in the treatment of chronic pelvic inflammatory disease and its effect on inflammatory factors

2019 ◽  
Vol 3 (1) ◽  
Author(s):  
Yanting Wei ◽  
Hongning Su ◽  
Dandan Geng ◽  
Weimin Huo ◽  
Miao Zhou Zhou ◽  
...  
Keyword(s):  
Pelvic Inflammatory Disease ◽  
Inflammatory Disease ◽  
Adverse Reactions ◽  
Statistical Significance ◽  
Inflammatory Factors ◽  
Control Group ◽  
Observation Group ◽  
Physical Pain ◽  
Tnf Α ◽  
Life Function

Objective: To explore the clinical therapeutic effect of Hongteng decoction combined with levofloxacin on chronic pelvic inflammatory disease (CPID) patients and its effect on the expression of inflammatory factors. Methods: 72 patients with CPID who were diagnosed and treated in * * hospital from January 2020 to December 2020 were selected and randomly divided into observation group (n = 36) and control group (n = 36). The control group was treated with levofloxacin and the observation group was treated with Hongteng decoction retention enema on the basis of the control group. Both groups were treated continuously for 2 courses. The clinical therapeutic effects of the two groups were compared, and the changes of related inflammatory indexes such as interleukin-2 (IL-2), interleukin-10 (IL-10), C-reactive protein (CRP) and tumor necrosis factor-α (TNF-α) were compared between the two groups before and after treatment. The score of quality of life and the occurrence of adverse reactions before treatment were compared. Results: The total effective rate of the observation group was significantly higher than that of the control group, and the difference was statistically significant (P<0.05). The inflammatory indexes of IL-2, IL-10, CRP and TNF-α in 2 groups before treatment were compared, and there was no statistical significance (P>0.05). After treatment, the expression of IL-2 and IL-10 in the observation group was higher than that in the control group, and the expression of CRP and TNF-α was lower than that in the control group, with statistical significance (P<0.05). There were no significant differences in physical pain, life function, social function and mental health scores between the two groups before treatment (P>0.05). After treatment, scores of physical pain, life function, social function and mental health in the observation group were higher than those in the control group, and the differences were statistically significant (P<0.05). After treatment, there was no significant difference in the incidence of adverse reactions between the observation group and the control group (P>0.05). Conclusion: Hongteng decoction combined with levofloxacin has definite efficacy in the treatment of CPID, which can effectively improve the clinical symptoms of patients and inhibit inflammatory response, and is worthy of clinical promotion. Key words: Hongteng decoction; Levofloxacin; Pelvic inflammatory disease; Clinical effect; Inflammatory cytokines.

scholarly journals Analysis of the Effect of Pantoprazole and Omeprazole on Pain Relief in Patients with Gastric Ulcer

2021 ◽  
Vol 5 (3) ◽  
Author(s):  
Minghui Xiao ◽  
Jie Liu ◽  
Jianping Hui
Keyword(s):  
Helicobacter Pylori ◽  
Gastric Ulcer ◽  
Pain Relief ◽  
Recurrence Rate ◽  
Conversion Rate ◽  
Adverse Reactions ◽  
Effective Rate ◽  
Control Group ◽  
Experimental Group ◽  
Negative Conversion

Objective: To analyze the effect of pantoprazole and omeprazole in the treatment of patients with gastric ulcer. Methods: The treatment effect, recurrence rate, helicobacter pylori negative conversion rate, adverse reaction status and pain relief time of the two groups were compared. Results: The total effective rate of the experimental group (97.78%, 44 / 45) was higher than that of the control group (84.44%, 38 / 45), P < 0.05;The recurrence rate (4.44%, 2 / 45) and Helicobacter pylori negative conversion rate (95.56%, 43 / 45) of the experimental group were significantly higher than those of the control group (P < 0.05); The incidence of adverse reactions in the experimental group (11.11%, 5 / 45) was lower than that in the control group (15.56%, 7 / 45) (P > 0.05);The pain relief time of the experimental group was (2.24 ± 1.16) d, which was shorter than that of the control group (P < 0.05). Conclusion: In the process of clinical treatment of gastric ulcer, pantoprazole has significant curative effect and low recurrence rate, which can eradicate Helicobacter pylori as soon as possible, shorten the pain time and make the treatment safer.

scholarly journals Clinical Effect of Radiotherapy Combined with Capecitabine after Neoadjuvant Therapy for Rectal Cancer

2021 ◽  
Vol 2021 ◽  
pp. 1-6
Author(s):  
Qibo Zhang ◽  
Haibin Teng
Keyword(s):  
Rectal Cancer ◽  
Neoadjuvant Therapy ◽  
Cancer Patients ◽  
Adverse Reactions ◽  
Clinical Effect ◽  
Statistical Significance ◽  
Progression Free Survival ◽  
Control Group ◽  
Free Survival ◽  
Experimental Group

Objective. The purpose of the study was to investigate the clinical effect of radiotherapy combined with capecitabine in rectal cancer patients after neoadjuvant therapy. Methods. 80 rectal cancer patients who underwent neoadjuvant therapy in our hospital from February 2016 to February 2018 were selected as the study subjects and divided into the control group (n = 40) and experimental group (n = 40) according to the order of admission. Among them, the control group was treated with radiotherapy, while the experimental group was treated with radiotherapy combined with capecitabine. The therapeutic efficacy, CEA levels, the incidence and recurrence rate of adverse reactions, as well as the progression-free survival and survival rate after 2-year treatment were analyzed in the two groups. Results. The effective rate of treatment in the experimental group of 87.5% (35/40) was significantly higher than 50% (20/40) in the control group, with statistical significance (X2 = 13.09, P < 0.001 ). After treatment, the CEA levels in the two groups both decreased significantly, and the CEA level in the experimental group of 3.75 ± 1.76 ng/ml was significantly lower than 7.35 ± 2.11 ng/ml in the control group, with statistical significance (T = 8.29, P < 0.001 ). The incidence and the recurrence rate of adverse reactions of 5% (2/40) and 10% (4/40), respectively, in the experimental group were significantly lower than those of 40% (16/40) and 30% (12/40) in the control group, with statistical significance (X2 = 14.05, 5.00, P < 0.001 , 0.05). After the 2-year follow-up, it was found that the progression-free survival of 21.53 ± 6.23 months in the experimental group was significantly longer than that of 18.18 ± 5.41 months in the control group, with statistical significance (T = 2.57, P < 0.05 ), and the 2-year survival rate of 97.5% (39/40) in the experimental group was significantly higher than 80% (32/40) in the control group, with statistical significance (T = 6.13, P < 0.05 ). Conclusion. Radiotherapy combined with capecitabine in rectal cancer patients after neoadjuvant therapy can improve the therapeutic efficacy with fewer adverse reactions and longer patients’ survival, which is worthy of popularization and application after neoadjuvant therapy for rectal cancer.

scholarly journals AMELIORATIVE EFFECT OF HESPERIDIN ON CARBON TETRACHLORIDE INDUCED LIVER FIBROSIS IN RATS

2017 ◽  
Vol 9 (7) ◽  
pp. 45 ◽  
Author(s):  
Asmaa Ramadan Abdel-sttar ◽  
Marwa Mahmoud Khalaf ◽  
Amira M. Aboyoussef ◽  
Ali Ahmed Abosaif
Keyword(s):  
Carbon Tetrachloride ◽  
Liver Fibrosis ◽  
Liver Function ◽  
Lipid Profile ◽  
Transforming Growth Factor ◽  
Density Lipoprotein ◽  
Liver Weight ◽  
Transforming Growth Factor Β1 ◽  
Control Group ◽  
Tnf Α

Objective: Exposure to carbon tetrachloride leads to serious liver injury and fibrosis. This study was aimed to evaluate the hepatoprotective effects of hesperidin against carbon tetrachloride (CCl4)-induced liver fibrosis in rats compared with the reference drug silymarin. Methods: Wistar albino rats were divided into five groups, each of eight rats. Animals were allocated into a control group, corn oil group and fibrosis control group. The remaining two groups received in addition to CCl4, silymarin (100 mg/kg/d) as a reference treatment and hesperidin (200 mg/kg/d). At the end of experimental period, the biomarkers of specific fibrosis [hepatic transforming growth factor β1 (TGF-β1) and hydroxyproline (HYP)], liver function [serum alanine transaminase (ALT), aspartate transaminase (AST), albumin and total bilirubin], oxidative stress [hepatic malondialdehyde (MDA), glutathione (GSH) and catalase (CAT)], inflammatory [hepatic myeloperoxidase (MPO), serum tumor necrosis factor alpha (TNF-α)], relative liver weight, lipid profile [total cholesterol, serum triglycerides, high-density lipoprotein cholesterol (HDL-Ch) and low density lipoprotein cholesterol (LDL-Ch)] were evaluated, supported by liver histopathological study and immunohistochemistry of alpha-smooth muscle actin (α-SMA) in liver sections.Results: Hesperidin significantly decreased hepatic transforming growth factor β1, hydroxyproline, the serum liver function markers of ALT, AST and total bilirubin, the hepatic content of MDA and MPO activity, the serum pro-inflammatory cytokine TNF-α, relative liver weight, and the serum lipid profile markers cholesterol, triglycerides and LDL. On the other hand, Hesperidin significantly increased albumin, the hepatic content of GSH and CAT, and serum lipid profile of LDL. In addition, liver sections obtained from these groups showed marked histopathological and immunohistochemistry of α-SMA improvement.Conclusion: Hesperidin may be promising protective agent against liver fibrosis through improvement of liver function, modulation of the fibrous scar formation, anti-inflammatory and antioxidant potentials.

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