scholarly journals Research on Integrated Learning of Industrial Clusters in Self-Created Districts

2021 ◽  
Vol 2021 ◽  
pp. 1-8
Author(s):  
Liyuan Pang ◽  
Yangmin Zhou ◽  
Yingjing Chu
Keyword(s):  
Adaptive Learning ◽  
Industrial Clusters ◽  
Support Vector ◽  
Integrated Learning ◽  
Essential Factor ◽  
Negotiation Strategy ◽  
Data Set ◽  
Multilateral Negotiation ◽  
Negotiation Model ◽  
Coordination Strategy

Under the premise of coordinated procurement bilateral and multi-issue negotiation, adaptive negotiation strategy has become an essential factor for multiagent conflict resolution. This paper studies an adaptive negotiation strategy based on selective integrated learning, which effectively improves negotiation. First, take the suppliers and purchasing companies in the cluster supply chain as the research objects and analyze the characteristics of multilateral negotiation of collaborative procurement. Secondly, the support vector machine algorithm performs adaptive learning for each evaluation data set to estimate the concession range. On this basis, remove the few submodels that perform poorly, recombine the calculation weights, and establish a multiagent clustered supply collaborative procurement negotiation model. The simulation experiment proves the feasibility of the adaptive negotiation strategy and the effectiveness of the adaptive coordination strategy based on selective ensemble learning proposed in this paper from the aspects of concession range prediction error rate, prediction accuracy rate, and negotiation utility.

scholarly journals Iterative Reweighted Noninteger Norm Regularizing SVM for Gene Expression Data Classification

2013 ◽  
Vol 2013 ◽  
pp. 1-10 ◽  
Author(s):  
Jianwei Liu ◽  
Shuang Cheng Li ◽  
Xionglin Luo
Keyword(s):  
Machine Learning ◽  
Support Vector Machine ◽  
Adaptive Learning ◽  
Predictive Accuracy ◽  
Learning Algorithm ◽  
Training Dataset ◽  
Support Vector ◽  
Data Set ◽  
Cancer Data ◽  
Public Data

Support vector machine is an effective classification and regression method that uses machine learning theory to maximize the predictive accuracy while avoiding overfitting of data.L2regularization has been commonly used. If the training dataset contains many noise variables,L1regularization SVM will provide a better performance. However, bothL1andL2are not the optimal regularization method when handing a large number of redundant values and only a small amount of data points is useful for machine learning. We have therefore proposed an adaptive learning algorithm using the iterative reweightedp-norm regularization support vector machine for 0 <p≤ 2. A simulated data set was created to evaluate the algorithm. It was shown that apvalue of 0.8 was able to produce better feature selection rate with high accuracy. Four cancer data sets from public data banks were used also for the evaluation. All four evaluations show that the new adaptive algorithm was able to achieve the optimal prediction error using apvalue less thanL1norm. Moreover, we observe that the proposedLppenalty is more robust to noise variables than theL1andL2penalties.

scholarly journals Abnormal Water Quality Monitoring Based on Visual Sensing of Three-Dimensional Motion Behavior of Fish

Symmetry ◽  
2019 ◽  
Vol 11 (9) ◽  
pp. 1179
Author(s):  
Shuhong Cheng ◽  
Kaopeng Zhao ◽  
Dianfan Zhang
Keyword(s):  
Water Quality ◽  
Three Dimensional ◽  
Water Quality Monitoring ◽  
Quality Monitoring ◽  
Support Vector ◽  
Motion Trajectory ◽  
Integrated Learning ◽  
Monitoring Method ◽  
Data Set ◽  
Extreme Gradient Boosting

In the context of the problem of water pollution, the movement characteristics and patterns of fish under normal water quality and abnormal water quality are clearly different. This paper proposes a biological water quality monitoring method combining three-dimensional motion trajectory synthesis and integrated learning. The videos of the fish movement are captured by two cameras, and the Kuhn-Munkres (KM) algorithm is used to match the target points of the fish body. The Kalman filter is used to update the current state and find the optimal tracking position as the tracking result. The Kernelized Correlation Filters (KCF) algorithm compensates the targets that are lost in the tracking process and collision or occlusion in the movement process, reducing the errors caused by illumination, occlusion and water surface fluctuation effectively. This algorithm can directly obtain the target motion trajectory, avoiding the re-extraction from the centroid point in the image sequence, which greatly improves the efficiency. In order to avoid the one-sidedness of the two-dimensional trajectory, the experiment combines the pixel coordinates of different perspectives into three-dimensional trajectory pixel coordinates, so as to provide a more authentic fish swimming trajectory. We then select a representative positive and negative sample data set; the number of data sets should have symmetry. The base classifier capable of identifying different water quality is obtained by training. Finally, support vector machine(SVM), eXtreme Gradient Boosting (XGBoost) and pointnet based classifiers are combined into strong classifiers through integrated learning. The experimental results show that the integrated learning model can reflect the water quality effectively and accurately under the three-dimensional trajectory pixel coordinates of fish, and the recognition rate of water quality is above 95%.

A Computational Method for the Identification of Endolysins and Autolysins

2020 ◽  
Vol 27 (4) ◽  
pp. 329-336 ◽  
Author(s):  
Lei Xu ◽  
Guangmin Liang ◽  
Baowen Chen ◽  
Xu Tan ◽  
Huaikun Xiang ◽  
...  
Keyword(s):  
Support Vector Machine ◽  
Cell Wall ◽  
Experimental Results ◽  
Computational Method ◽  
Lytic Enzyme ◽  
Support Vector ◽  
Lytic Enzymes ◽  
Data Set ◽  
Optimal Feature ◽  
Better Than

Background: Cell lytic enzyme is a kind of highly evolved protein, which can destroy the cell structure and kill the bacteria. Compared with antibiotics, cell lytic enzyme will not cause serious problem of drug resistance of pathogenic bacteria. Thus, the study of cell wall lytic enzymes aims at finding an efficient way for curing bacteria infectious. Compared with using antibiotics, the problem of drug resistance becomes more serious. Therefore, it is a good choice for curing bacterial infections by using cell lytic enzymes. Cell lytic enzyme includes endolysin and autolysin and the difference between them is the purpose of the break of cell wall. The identification of the type of cell lytic enzymes is meaningful for the study of cell wall enzymes. Objective: In this article, our motivation is to predict the type of cell lytic enzyme. Cell lytic enzyme is helpful for killing bacteria, so it is meaningful for study the type of cell lytic enzyme. However, it is time consuming to detect the type of cell lytic enzyme by experimental methods. Thus, an efficient computational method for the type of cell lytic enzyme prediction is proposed in our work. Method: We propose a computational method for the prediction of endolysin and autolysin. First, a data set containing 27 endolysins and 41 autolysins is built. Then the protein is represented by tripeptides composition. The features are selected with larger confidence degree. At last, the classifier is trained by the labeled vectors based on support vector machine. The learned classifier is used to predict the type of cell lytic enzyme. Results: Following the proposed method, the experimental results show that the overall accuracy can attain 97.06%, when 44 features are selected. Compared with Ding's method, our method improves the overall accuracy by nearly 4.5% ((97.06-92.9)/92.9%). The performance of our proposed method is stable, when the selected feature number is from 40 to 70. The overall accuracy of tripeptides optimal feature set is 94.12%, and the overall accuracy of Chou's amphiphilic PseAAC method is 76.2%. The experimental results also demonstrate that the overall accuracy is improved by nearly 18% when using the tripeptides optimal feature set. Conclusion: The paper proposed an efficient method for identifying endolysin and autolysin. In this paper, support vector machine is used to predict the type of cell lytic enzyme. The experimental results show that the overall accuracy of the proposed method is 94.12%, which is better than some existing methods. In conclusion, the selected 44 features can improve the overall accuracy for identification of the type of cell lytic enzyme. Support vector machine performs better than other classifiers when using the selected feature set on the benchmark data set.

In silico Prediction of Inhibitory Constant of Thrombin Inhibitors Using Machine Learning

2019 ◽  
Vol 21 (9) ◽  
pp. 662-669 ◽  
Author(s):  
Junnan Zhao ◽  
Lu Zhu ◽  
Weineng Zhou ◽  
Lingfeng Yin ◽  
Yuchen Wang ◽  
...  
Keyword(s):  
Machine Learning ◽  
Prediction Models ◽  
Regression Tree ◽  
Large Data ◽  
Thrombin Inhibitors ◽  
Coagulation Cascade ◽  
Gradient Boosting ◽  
Support Vector ◽  
Data Set ◽  
Descriptor Selection

Background: Thrombin is the central protease of the vertebrate blood coagulation cascade, which is closely related to cardiovascular diseases. The inhibitory constant Ki is the most significant property of thrombin inhibitors. Method: This study was carried out to predict Ki values of thrombin inhibitors based on a large data set by using machine learning methods. Taking advantage of finding non-intuitive regularities on high-dimensional datasets, machine learning can be used to build effective predictive models. A total of 6554 descriptors for each compound were collected and an efficient descriptor selection method was chosen to find the appropriate descriptors. Four different methods including multiple linear regression (MLR), K Nearest Neighbors (KNN), Gradient Boosting Regression Tree (GBRT) and Support Vector Machine (SVM) were implemented to build prediction models with these selected descriptors. Results: The SVM model was the best one among these methods with R2=0.84, MSE=0.55 for the training set and R2=0.83, MSE=0.56 for the test set. Several validation methods such as yrandomization test and applicability domain evaluation, were adopted to assess the robustness and generalization ability of the model. The final model shows excellent stability and predictive ability and can be employed for rapid estimation of the inhibitory constant, which is full of help for designing novel thrombin inhibitors.

Rational Design of Colchicine Derivatives as anti-HIV Agents via QSAR and Molecular Docking

2019 ◽  
Vol 15 (4) ◽  
pp. 328-340 ◽  
Author(s):  
Apilak Worachartcheewan ◽  
Napat Songtawee ◽  
Suphakit Siriwong ◽  
Supaluk Prachayasittikul ◽  
Chanin Nantasenamat ◽  
...  
Keyword(s):  
Molecular Docking ◽  
Rational Design ◽  
External Validation ◽  
Rational Drug Design ◽  
Support Vector ◽  
Data Set ◽  
Qsar Models ◽  
Anti Hiv Agents ◽  
Anti Hiv ◽  
Colchicine Derivatives

Background: Human immunodeficiency virus (HIV) is an infective agent that causes an acquired immunodeficiency syndrome (AIDS). Therefore, the rational design of inhibitors for preventing the progression of the disease is required. Objective: This study aims to construct quantitative structure-activity relationship (QSAR) models, molecular docking and newly rational design of colchicine and derivatives with anti-HIV activity. Methods: A data set of 24 colchicine and derivatives with anti-HIV activity were employed to develop the QSAR models using machine learning methods (e.g. multiple linear regression (MLR), artificial neural network (ANN) and support vector machine (SVM)), and to study a molecular docking. Results: The significant descriptors relating to the anti-HIV activity included JGI2, Mor24u, Gm and R8p+ descriptors. The predictive performance of the models gave acceptable statistical qualities as observed by correlation coefficient (Q2) and root mean square error (RMSE) of leave-one out cross-validation (LOO-CV) and external sets. Particularly, the ANN method outperformed MLR and SVM methods that displayed LOO−CV 2 Q and RMSELOO-CV of 0.7548 and 0.5735 for LOOCV set, and Ext 2 Q of 0.8553 and RMSEExt of 0.6999 for external validation. In addition, the molecular docking of virus-entry molecule (gp120 envelope glycoprotein) revealed the key interacting residues of the protein (cellular receptor, CD4) and the site-moiety preferences of colchicine derivatives as HIV entry inhibitors for binding to HIV structure. Furthermore, newly rational design of colchicine derivatives using informative QSAR and molecular docking was proposed. Conclusion: These findings serve as a guideline for the rational drug design as well as potential development of novel anti-HIV agents.

QSAR Study of PARP Inhibitors by GA-MLR, GA-SVM and GA-ANN Approaches

2020 ◽  
Vol 16 (8) ◽  
pp. 1088-1105
Author(s):  
Nafiseh Vahedi ◽  
Majid Mohammadhosseini ◽  
Mehdi Nekoei
Keyword(s):  
Present Report ◽  
Principal Component ◽  
Parp Inhibitors ◽  
Support Vector ◽  
Ann Model ◽  
Statistical Parameters ◽  
Qsar Study ◽  
Data Set ◽  
Test Set ◽  
Non Linear

Background: The poly(ADP-ribose) polymerases (PARP) is a nuclear enzyme superfamily present in eukaryotes. Methods: In the present report, some efficient linear and non-linear methods including multiple linear regression (MLR), support vector machine (SVM) and artificial neural networks (ANN) were successfully used to develop and establish quantitative structure-activity relationship (QSAR) models capable of predicting pEC50 values of tetrahydropyridopyridazinone derivatives as effective PARP inhibitors. Principal component analysis (PCA) was used to a rational division of the whole data set and selection of the training and test sets. A genetic algorithm (GA) variable selection method was employed to select the optimal subset of descriptors that have the most significant contributions to the overall inhibitory activity from the large pool of calculated descriptors. Results: The accuracy and predictability of the proposed models were further confirmed using crossvalidation, validation through an external test set and Y-randomization (chance correlations) approaches. Moreover, an exhaustive statistical comparison was performed on the outputs of the proposed models. The results revealed that non-linear modeling approaches, including SVM and ANN could provide much more prediction capabilities. Conclusion: Among the constructed models and in terms of root mean square error of predictions (RMSEP), cross-validation coefficients (Q2 LOO and Q2 LGO), as well as R2 and F-statistical value for the training set, the predictive power of the GA-SVM approach was better. However, compared with MLR and SVM, the statistical parameters for the test set were more proper using the GA-ANN model.

scholarly journals Comparison of Spectroscopic Techniques Combined with Chemometrics for Cocaine Powder Analysis

2020 ◽  
Vol 44 (8) ◽  
pp. 851-860
Author(s):  
Joy Eliaerts ◽  
Natalie Meert ◽  
Pierre Dardenne ◽  
Vincent Baeten ◽  
Juan-Antonio Fernandez Pierna ◽  
...  
Keyword(s):  
Gas Chromatography ◽  
Near Infrared ◽  
Evaluation Criteria ◽  
Classification Model ◽  
Support Vector ◽  
Spectroscopic Techniques ◽  
Data Set ◽  
Promising Tool ◽  
Powder Analysis ◽  
Mir Spectra

Abstract Spectroscopic techniques combined with chemometrics are a promising tool for analysis of seized drug powders. In this study, the performance of three spectroscopic techniques [Mid-InfraRed (MIR), Raman and Near-InfraRed (NIR)] was compared. In total, 364 seized powders were analyzed and consisted of 276 cocaine powders (with concentrations ranging from 4 to 99 w%) and 88 powders without cocaine. A classification model (using Support Vector Machines [SVM] discriminant analysis) and a quantification model (using SVM regression) were constructed with each spectral dataset in order to discriminate cocaine powders from other powders and quantify cocaine in powders classified as cocaine positive. The performances of the models were compared with gas chromatography coupled with mass spectrometry (GC–MS) and gas chromatography with flame-ionization detection (GC–FID). Different evaluation criteria were used: number of false negatives (FNs), number of false positives (FPs), accuracy, root mean square error of cross-validation (RMSECV) and determination coefficients (R2). Ten colored powders were excluded from the classification data set due to fluorescence background observed in Raman spectra. For the classification, the best accuracy (99.7%) was obtained with MIR spectra. With Raman and NIR spectra, the accuracy was 99.5% and 98.9%, respectively. For the quantification, the best results were obtained with NIR spectra. The cocaine content was determined with a RMSECV of 3.79% and a R2 of 0.97. The performance of MIR and Raman to predict cocaine concentrations was lower than NIR, with RMSECV of 6.76% and 6.79%, respectively and both with a R2 of 0.90. The three spectroscopic techniques can be applied for both classification and quantification of cocaine, but some differences in performance were detected. The best classification was obtained with MIR spectra. For quantification, however, the RMSECV of MIR and Raman was twice as high in comparison with NIR. Spectroscopic techniques combined with chemometrics can reduce the workload for confirmation analysis (e.g., chromatography based) and therefore save time and resources.

scholarly journals Approach to hand posture recognition based on hand shape features for human–robot interaction

2021 ◽  
Author(s):  
Jing Qi ◽  
Kun Xu ◽  
Xilun Ding
Keyword(s):  
Gaussian Mixture ◽  
Human Robot Interaction ◽  
Polar Coordinates ◽  
Support Vector ◽  
Hand Posture ◽  
Data Set ◽  
Hand Shape ◽  
Hand Posture Recognition ◽  
Hand Segmentation ◽  
Posture Recognition

AbstractHand segmentation is the initial step for hand posture recognition. To reduce the effect of variable illumination in hand segmentation step, a new CbCr-I component Gaussian mixture model (GMM) is proposed to detect the skin region. The hand region is selected as a region of interest from the image using the skin detection technique based on the presented CbCr-I component GMM and a new adaptive threshold. A new hand shape distribution feature described in polar coordinates is proposed to extract hand contour features to solve the false recognition problem in some shape-based methods and effectively recognize the hand posture in cases when different hand postures have the same number of outstretched fingers. A multiclass support vector machine classifier is utilized to recognize the hand posture. Experiments were carried out on our data set to verify the feasibility of the proposed method. The results showed the effectiveness of the proposed approach compared with other methods.

scholarly journals Correlation between the structure and skin permeability of compounds

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Ruolan Zeng ◽  
Jiyong Deng ◽  
Limin Dang ◽  
Xinliang Yu
Keyword(s):  
Large Data ◽  
Qsar Model ◽  
Coefficient Of Determination ◽  
Support Vector ◽  
Skin Permeability ◽  
Data Set ◽  
Test Set ◽  
Svm Algorithm ◽  
Svm Model ◽  
Toxicity Relationship

AbstractA three-descriptor quantitative structure–activity/toxicity relationship (QSAR/QSTR) model was developed for the skin permeability of a sufficiently large data set consisting of 274 compounds, by applying support vector machine (SVM) together with genetic algorithm. The optimal SVM model possesses the coefficient of determination R2 of 0.946 and root mean square (rms) error of 0.253 for the training set of 139 compounds; and a R2 of 0.872 and rms of 0.302 for the test set of 135 compounds. Compared with other models reported in the literature, our SVM model shows better statistical performance in a model that deals with more samples in the test set. Therefore, applying a SVM algorithm to develop a nonlinear QSAR model for skin permeability was achieved.

scholarly journals Classification of Prefrontal Cortex Activity Based on Functional Near-Infrared Spectroscopy Data upon Olfactory Stimulation

2021 ◽  
Vol 11 (6) ◽  
pp. 701
Author(s):  
Cheng-Hsuan Chen ◽  
Kuo-Kai Shyu ◽  
Cheng-Kai Lu ◽  
Chi-Wen Jao ◽  
Po-Lei Lee
Keyword(s):  
Prefrontal Cortex ◽  
Infrared Spectroscopy ◽  
Near Infrared Spectroscopy ◽  
Near Infrared ◽  
Kernel Functions ◽  
Olfactory Stimulation ◽  
Support Vector ◽  
Hemodynamic Response Function ◽  
Functional Near Infrared Spectroscopy ◽  
Data Set

The sense of smell is one of the most important organs in humans, and olfactory imaging can detect signals in the anterior orbital frontal lobe. This study assessed olfactory stimuli using support vector machines (SVMs) with signals from functional near-infrared spectroscopy (fNIRS) data obtained from the prefrontal cortex. These data included odor stimuli and air state, which triggered the hemodynamic response function (HRF), determined from variations in oxyhemoglobin (oxyHb) and deoxyhemoglobin (deoxyHb) levels; photoplethysmography (PPG) of two wavelengths (raw optical red and near-infrared data); and the ratios of data from two optical datasets. We adopted three SVM kernel functions (i.e., linear, quadratic, and cubic) to analyze signals and compare their performance with the HRF and PPG signals. The results revealed that oxyHb yielded the most efficient single-signal data with a quadratic kernel function, and a combination of HRF and PPG signals yielded the most efficient multi-signal data with the cubic function. Our results revealed superior SVM analysis of HRFs for classifying odor and air status using fNIRS data during olfaction in humans. Furthermore, the olfactory stimulation can be accurately classified by using quadratic and cubic kernel functions in SVM, even for an individual participant data set.

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