scholarly journals A Possible Relationship between Peri-Implantitis, Titanium Hypersensitivity, and External Tooth Resorption: Metal-Free Alternative to Titanium Implants

2021 ◽  
Vol 2021 ◽  
pp. 1-8
Author(s):  
Andrea Enrico Borgonovo ◽  
Rachele Censi ◽  
Virna Vavassori ◽  
Mauro Savio ◽  
Dino Re
Keyword(s):  
Bone Loss ◽  
Titanium Implant ◽  
Titanium Implants ◽  
Implant Surface ◽  
Tooth Resorption ◽  
Dental Implant Surface ◽  
Titanium Dental Implant ◽  
Nonsurgical Therapy ◽  
Zirconia Implants

Titanium dental implant surface does not remain unaltered but may corrode and release ions or particles which trigger soft and hard tissue damage. Titanium may induce clinically relevant hypersensitivity in patients chronically exposed. A 56-year-old female patient presented peri-implantitis around a single titanium implant positioned three years earlier. Despite nonsurgical therapy, a rapid bone loss associated with pain and swelling occurred, and adjacent teeth presented external resorption. Compromised teeth were removed, and three titanium implants were inserted. Six months later, the patient complained about high mucosa sensitivity and implant exposure. At clinical and radiographic examinations, tissue inflammation and vertical bone loss involved the new implants and the process of external resorption affected the teeth. The blood test confirmed titanium hypersensitivity. Titanium implants were removed, and 5 zirconia implants were placed. No sign of bone loss or tooth resorption was recorded at clinical and radiographic control during 18 months of follow-up.

scholarly journals Cigarette Smoke and E-Cigarette Vapor Dysregulate Osteoblast Interaction With Titanium Dental Implant Surface

2019 ◽  
Vol 45 (1) ◽  
pp. 2-11 ◽  
Author(s):  
Mahmoud Rouabhia ◽  
Humidah Alanazi ◽  
Hyun Jin Park ◽  
Reginaldo Bruno Gonçalves
Keyword(s):  
Adverse Effects ◽  
Cigarette Smoke ◽  
Dental Implant ◽  
Caspase 3 ◽  
Titanium Implant ◽  
Implant Surface ◽  
Implant Material ◽  
Dental Implant Surface ◽  
Titanium Dental Implant ◽  
Osteoblast Attachment

The purpose of this study was to determine the possible deleterious effects of e-cigarette vapor on osteoblast interaction with dental implant material. Osteoblasts were cultured onto Ti6Al4V titanium implant disks and were then exposed or not to whole cigarette smoke (CS), as well as to nicotine-rich (NR) or nicotine-free (NF) e-vapor for 15 or 30 minutes once a day for 1, 2, or 3 days, after which time various analyses were performed. Osteoblast growth on the titanium implant disks was found to be significantly (P < .001) reduced following exposure to CS and to the NR and NF e-vapors. Osteoblast attachment to the dental implant material was also dysregulated by CS and the NR and NF e-vapors through a decreased production of adhesion proteins such as F-actin. The effects of CS and e-cigarette vapor on osteoblast growth and attachment were confirmed by reduced alkaline phosphatase (ALP) activity and tissue mineralization. The adverse effects of CS and the NR and NF e-vapors on osteoblast interaction with dental implant material also involved the caspase-3 pathway, as the caspase-3 protein level increased following exposure of the osteoblasts to CS or e-vapor. It should be noted that the adverse effects of CS on osteoblast growth, attachment, ALP, and mineralized degradation were greater than those of the NR and NF e-vapors, although the latter did downregulate osteoblast interaction with the dental implant material. Overall results suggest the need to consider e-cigarettes as a possible contributor to dental implant failure and/or complications.

scholarly journals Single tooth restoration in the maxillary esthetic zone using a one-piece ceramic implant with 1 year of follow-up: case series

2021 ◽  
Vol 7 (1) ◽  
Author(s):  
Miren Vilor-Fernández ◽  
Ana-María García-De-La-Fuente ◽  
Xabier Marichalar-Mendia ◽  
Ruth Estefanía-Fresco ◽  
Luis-Antonio Aguirre-Zorzano
Keyword(s):  
Case Series ◽  
Biological Properties ◽  
Titanium Implants ◽  
Plaque Index ◽  
Marginal Bone Loss ◽  
Bleeding On Probing ◽  
Probing Depth ◽  
Zirconia Implants ◽  
Ceramic Implant

Abstract Background Oral implants have helped clinicians to improve the quality of life for many patients. The material of choice for dental implants currently remains titanium type IV, whose mechanical and biological properties have been proven throughout the history of implantology. Yet, this material is not exempt from complications. For these reasons, ceramic alternatives to titanium have emerged. Thus, the purpose of this study is to evaluate peri-implant hard and soft tissue stability with the use of a one-piece ceramic implant (Straumann® PURE Ceramic Implant) during 1 year of follow-up. Study design One-piece all-ceramic zirconia (ZrO2) implants were placed to replace single missing teeth in the esthetic zone. Six to 8 weeks after the procedure, the definitive prosthesis was fabricated. At the time of prosthesis, placement (T0) photographs and periapical radiographs were taken, and the following clinical parameters were recorded: probing depth (PD), plaque index (PI), bleeding on probing (BOP), suppuration on probing (SOP), distance from gingival margin to incisal edge (GM-IE), and Jemt papilla index (JPI). Follow-up appointments were scheduled at 4 (T4), 8 (T8), and 12 (T12) months, when the same parameters were recorded. In addition, plaque control was reinforced and prophylaxis was carried out. In this last appointment, a final periapical radiograph was taken to assess marginal bone loss. Results A total of 32 zirconia implants were placed in 28 patients (16 women and 12 men, aged between 34 and 67 years). The survival and success rate were 96.9%. The increase in probing depth from baseline to 12 months was 0.78 mm. Assessments of plaque index and bleeding on probing showed a slight increase throughout the study. Conclusions The results obtained with the Straumann® PURE Ceramic implants show them to exhibit very good clinical behavior. The survival rate of the implants of our pilot study was 96.9%. For these reasons, we can say that zirconia implants could be an alternative to titanium implants in the esthetic zone.

scholarly journals Marginal Bone Loss and Aesthetics Around Zirconia and Titanium Dental Implants-A Metanalysis

2020 ◽  
Author(s):  
Pulijala Sathwika ◽  
Rampalli Viswa Chandra
Keyword(s):  
Bone Loss ◽  
Randomized Controlled Trials ◽  
Meta Analysis ◽  
Titanium Implants ◽  
Controlled Trials ◽  
Marginal Bone Loss ◽  
Randomized Controlled ◽  
Cie Lab ◽  
Titanium Dental Implants ◽  
Zirconia Implants

AIM: To evaluate and compare the marginal bone loss and aesthetic outcomes of zirconia implants with titanium implants in randomized controlled trials (RCTs). MATERIAL AND METHODS: Electronic [PubMed] and hand searches were performed to identify randomized controlled trials that were published between January 2008 to April 2020 which investigated and compared various outcomes between zirconia and titanium dental implants. Outcomes included assessment of marginal bone loss and aesthetics using spectrophotometric measurements. Meta-analysis was performed to estimate the above parameters among various studies. RESULTS: A total of 58 articles were screened for titles and abstracts. Subsequently 8 articles were selected for data extraction and evaluation. Zirconia implants were investigated and compared to titanium implants for marginal bone loss [MBL]. Customized zirconia and titanium abutments seated over implants were analyzed for aesthetic outcomes using spectrophotometric method using CIE-Lab measurements. Meta-analysis estimated that zirconia implants exhibited marginal bone loss reduction of 0.179mm (95% CI, 0.02 to 0.33) and -0.242mm (95% CI, -4.026 to 3.542) in aesthetic measurements than titanium implants. CONCLUSIONS: No heterogeneity was observed among studies analyzed for marginal bone loss and significant differences were noticed between two groups. Noticeable heterogeneity was observed among studies assessing aesthetics using spectrophotometry and CIE-Lab measurements and results revealed no many significant differences between the two groups.

scholarly journals Bioactive Coating on Titanium Dental Implants for Improved Anticorrosion Protection: A Combined Experimental and Theoretical Study

Coatings ◽  
2019 ◽  
Vol 9 (10) ◽  
pp. 612 ◽  
Author(s):  
Jozefina Katić ◽  
Ankica Šarić ◽  
Ines Despotović ◽  
Nives Matijaković ◽  
Marin Petković ◽  
...  
Keyword(s):  
Dental Implant ◽  
Density Functional ◽  
Surface Characterization ◽  
Electrochemical Impedance ◽  
Artificial Saliva ◽  
Titanium Implant ◽  
Attenuated Total Reflection ◽  
Implant Surface ◽  
Bioactive Coating ◽  
Dental Implant Surface

In recent years, extensive studies have been continuously undertaken on the design of bioactive and biomimetic dental implant surfaces due to the need for improvement of the implant–bone interface properties. In this paper, the titanium dental implant surface was modified by bioactive vitamin D3 molecules by a self-assembly process in order to form an improved anticorrosion coating. Surface characterization of the modified implant was performed by field emission scanning electron microscopy (FE-SEM), attenuated total reflection Fourier transform infrared spectroscopy (ATR-FTIR), and contact angle measurements (CA). The implant’s electrochemical stability during exposure to an artificial saliva solution was monitored in situ by electrochemical impedance spectroscopy (EIS). The experimental results obtained were corroborated by means of quantum chemical calculations at the density functional theory level (DFT). The formation mechanism of the coating onto the titanium implant surface was proposed. During a prolonged immersion period, the bioactive coating effectively prevented a corrosive attack on the underlying titanium (polarization resistance in order of 107 Ω cm2) with ~95% protection effectiveness.

Natural Nacre Coatings on Titanium Implant Grown by Fresh Water Bivalve Shell

2006 ◽  
Vol 309-311 ◽  
pp. 743-746 ◽  
Author(s):  
Xiao Xiang Wang ◽  
Lei Xie ◽  
Cheng Luo ◽  
Ri Zhi Wang
Keyword(s):  
Fresh Water ◽  
Dental Implant ◽  
Titanium Surface ◽  
Close Contact ◽  
Titanium Implant ◽  
Biologically Active ◽  
Nacreous Layer ◽  
Transitional Layer ◽  
Implant Surface ◽  
Titanium Dental Implant

Titanium dental implant screws were implanted into the pearl sacs of a fresh water bivalve (hyriopsis cumingii Lea) by replacing the pearls. After 45 days of cultivation, the implant surfaces were deposited with a nacre coating with iridescent luster. The coating was about 200-600 µm in thickness and composed of a laminated nacreous layer and a transitional non-laminated layer that consisted mainly of vaterite and calcite polymorphs of calcium carbonate. The transitional layer was around 2-10 µm thick in the convex and flat region of the implant surface and could form close contact with titanium surface; while the transitional layer was much thicker in the steep concave regions and could not form close contact with the titanium surface. The improvement to the design of the dental implant with respect to this coating method was suggested in the paper. The results suggest that it is possible to fabricate a biologically active and degradable, and mechanically tough and strong nacre coating on titanium dental implant by this novel coating technology.

scholarly journals Impact of High-Altitude Hypoxia on Early Osseointegration With Bioactive Titanium

2021 ◽  
Vol 12 ◽  
Author(s):  
Yarong Wang ◽  
Zekun Gan ◽  
Haibin Lu ◽  
Ziyi Liu ◽  
Peng Shang ◽  
...  
Keyword(s):  
Bone Formation ◽  
High Altitude ◽  
Bone Repair ◽  
Titanium Implant ◽  
Titanium Implants ◽  
Implant Surface ◽  
Altitude Hypoxia ◽  
Oral Implants ◽  
Hypoxic Environment

Nowadays, the bone osseointegration in different environments is comparable, but the mechanism is unclear. This study aimed to investigate the osseointegration of different bioactive titanium surfaces under normoxic or high-altitude hypoxic environments. Titanium implants were subjected to one of two surface treatments: (1) sanding, blasting, and acid etching to obtain a rough surface, or (2) extensive polishing to obtain a smooth surface. Changes in the morphology, proliferation, and protein expression of osteoblasts on the rough and smooth surfaces were examined, and bone formation was studied through western blotting and animal-based experiments. Our findings found that a hypoxic environment and rough titanium implant surface promoted the osteogenic differentiation of osteoblasts and activated the JAK1/STAT1/HIF-1α pathway in vitro. The animal study revealed that following implant insertion in tibia of rabbit, bone repair at high altitudes was slower than that at low altitudes (i.e., in plains) after 2weeks; however, bone formation did not differ significantly after 4weeks. The results of our study showed that: (1) The altitude hypoxia environment would affect the early osseointegration of titanium implants while titanium implants with rough surfaces can mitigate the effects of this hypoxic environment on osseointegration, (2) the mechanism may be related to the activation of JAK1/STAT1/HIF-1α pathway, and (3) our results suggest the osteogenesis of titanium implants, such as oral implants, is closely related to the oxygen environment. Clinical doctors, especially dentists, should pay attention to the influence of hypoxia on early osseointegration in patients with high altitude. For example, it is better to choose an implant system with rough implant surface in the oral cavity of patients with tooth loss at high altitude.

scholarly journals Peri-Implant Tissue Behaviour Next to Different Titanium Surfaces: 16-Year Post-Trial Follow-Up

2021 ◽  
Vol 11 (20) ◽  
pp. 9625
Author(s):  
Francesca Delucchi ◽  
Enrico Pozzetti ◽  
Francesco Bagnasco ◽  
Paolo Pesce ◽  
Domenico Baldi ◽  
...  
Keyword(s):  
Bone Loss ◽  
Titanium Implants ◽  
First Year ◽  
Bone Maintenance ◽  
Probing Depth ◽  
Bone Level ◽  
Titanium Surfaces ◽  
Post Trial ◽  
And Control

The present post-trial follow-up investigated the influence of titanium implants with different surface treatments on clinical behavior of soft and hard peri-implant tissues. Each of the 18 included patients received at least two adjacent implants: one control implant with a dual acid-etched (DAE) surface in their apical portion and a machined coronal part, and one test implant with a DAE surface up to its coronal portion. Peri-implant bone level change (BLC), probing depth (PD), bleeding on probing (BOP) and plaque index (PI) were recorded. A total of 42 implants was inserted. The mean follow-up period was 9.3 years (range: 5–16 years) and there were six dropouts. No implant failed. Moderate crestal bone remodeling occurred during the first year after implant insertion, with lower bone loss next to test implants compared to control ones (0.80 vs. 1.39 mm; p = 0.002). This difference was also detected at the 5- (p = 0.011), 6- (p = 0.008) and 7-year follow-up appointment (p = 0.027). No statistically significant differences were found in bone resorption between implants rehabilitated with ceramic vs. composite resin veneering material. No statistically significant differences were detected between test and control implants for BOP, PI, and PD at any time point. The results of the present study suggest that DAE surfaces reduce peri-implant bone loss in the initial phase of healing compared to machined surfaces, while they do not significantly affect soft peri-implant tissue and bone maintenance in the long-term. In conclusion, the minimally rough surfaces favour peri-implant bone maintenance and their effect is greater in the first year post implant insertion.

scholarly journals Molecular-Level Understanding of the Influence of Ions and Water on HMGB1 Adsorption Induced by Surface Hydroxylation of Titanium Implants

2021 ◽  
Author(s):  
Dineli Ranathunga ◽  
Alexandra Arteaga ◽  
Claudia C. Biguetti ◽  
Danieli C. Rodrigues ◽  
Steven O. Nielsen
Keyword(s):  
Biological Activity ◽  
Structural Changes ◽  
High Mobility ◽  
Titanium Implant ◽  
Water Layer ◽  
Titanium Implants ◽  
Surgical Trauma ◽  
Hmgb1 Protein ◽  
Implant Surface ◽  
Surface Hydroxylation

<div><div><div><p>Due to its excellent chemical and mechanical properties, titanium has become the material of choice for orthopedic and dental implants to promote rehabilitation via bone anchorage and osseointegration. Titanium osseointegration is partially related to its capability to form a TiO<sub>2</sub> surface layer and its ability to interact with key endogenous proteins immediately upon implantation, establishing the first bone-biomaterial interface. Surgical trauma caused by implantation results in the release of High Mobility Group Box 1 (HMGB1) protein, which is a prototypic DAMP (Damage Associated Molecular Pattern) with multiple roles in inflammation and tissue healing. To develop different surface strategies that improve the clinical outcome of titanium-based implants by controlling their biological activity, a molecular-scale understanding of HMGB1-surface interactions is desired. Here, we use molecular dynamics (MD) computer simulations to provide direct insight into the HMGB1 interactions and the possible molecular arrangements of HMGB1 on fully hydroxylated and non-hydroxylated rutile (110) TiO<sub>2</sub> surfaces. The results establish that HMGB1 is most likely to be adsorbed directly onto the surface regardless of surface hydroxylation, which is undesirable because it could affect its biological activity by causing structural changes to the protein. The hydroxylated TiO<sub>2</sub> surface shows a greater affinity for HMGB1 than the non-hydroxylated surface. The water layer on the non-hydroxylated TiO<sub>2</sub> surface prevents ions and the protein from directly contacting the surface. However, it was observed that if the ionic strength increases, the total number of ions adsorbed on the two surfaces increases, and the protein’s direct adsorption ability decreases. These findings will help to understand the HMGB1-TiO<sub>2</sub> interactions upon implantation, as well as the development of different surface strategies by introducing ions or ionic materials to the titanium implant surface to modulate its interactions with HMGB1 to preserve biological function.</p></div></div></div>

scholarly journals Peri-Implant Bone Loss and Peri-Implantitis: A Report of Three Cases and Review of the Literature

2016 ◽  
Vol 2016 ◽  
pp. 1-8 ◽  
Author(s):  
Vanchit John ◽  
Daniel Shin ◽  
Allison Marlow ◽  
Yusuke Hamada
Keyword(s):  
Soft Tissue ◽  
Bone Loss ◽  
Dental Implant ◽  
Patient Selection ◽  
Treatment Options ◽  
Prevalence Rates ◽  
Review Of The Literature ◽  
Follow Up Care ◽  
Nonsurgical Therapy

Dental implant supported restorations have been added substantially to the clinical treatment options presented to patients. However, complications with these treatment options also arise due to improper patient selection and inadequate treatment planning combined with poor follow-up care. The complications related to the presence of inflammation include perimucositis, peri-implant bone loss, and peri-implantitis. Prevalence rates of these complications have been reported to be as high as 56%. Treatment options that have been reported include nonsurgical therapy, the use of locally delivered and systemically delivered antibiotics, and surgical protocols aimed at regenerating the lost bone and soft tissue around the implants. The aim of this article is to report on three cases and review some of the treatment options used in their management.

Does surface anodisation of titanium implants change osseointegration and make their extraction from bone any easier?

2008 ◽  
Vol 21 (03) ◽  
pp. 202-210 ◽  
Author(s):  
J. Langhoff ◽  
J. Mayer ◽  
L. Faber ◽  
S. Kaestner ◽  
G. Guibert ◽  
...  
Keyword(s):  
Stainless Steel ◽  
Titanium Implant ◽  
Titanium Implants ◽  
Implant Surface ◽  
Bone Implant ◽  
High Bone ◽  
Titanium Surfaces ◽  
Anodized Titanium ◽  
Titanium Implant Surface

Summary Objectives: Titanium implants have a tendency for high bone-implant bonding, and, in comparison to stainless steel implants are more difficult to remove. The current study was carried out to evaluate, i) the release strength of three selected anodized titanium surfaces with increased nanohardness and low roughness, and ii) bone-implant bonding in vivo. These modified surfaces were intended to give improved anchorage while facilitating easier removal of temporary implants. Material and methods: The new surfaces were referenced to a stainless steel implant and a standard titanium implant surface (TiMAX™). In a sheep limb model, healing period was 3 months. Bone-implant bonding was evaluated either biomechanically or histologically. Results: The new surface anodized screws demonstrated similar or slightly higher bone-implantcontact (BIC) and torque release forces than the titanium reference. The BIC of the stainless steel implants was significant lower than two of the anodized surfaces (p=0.04), but differences between stainless steel and all titanium implants in torque release forces were not significant (p=0.06). Conclusion: The new anodized titanium surfaces showed good bone-implant bonding despite a smooth surface and increased nanohardness. However, they failed to facilitate implant removal at 3 months.

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