scholarly journals Challenges in Patients with Trisomy 21: A Review of Current Knowledge and Recommendations

2021 ◽  
Vol 2021 ◽  
pp. 1-7
Author(s):  
Jennifer Robinson ◽  
Manca Tekavčič Pompe ◽  
Christina Gerth-Kahlert
Keyword(s):  
Literature Review ◽  
Trisomy 21 ◽  
Chart Review ◽  
Current Knowledge ◽  
University Hospital ◽  
Ophthalmological Examination ◽  
International Survey ◽  
Ocular Abnormalities ◽  
Common Diagnosis ◽  
Department Of Ophthalmology

Purpose. To summarize and review the common ophthalmic anomalies in children with trisomy 21 (Down syndrome) in order to propose an update to current clinical recommendations. Methods. A retrospective chart review, systemic literature review, and international survey of the frequency of ocular abnormalities, screening schedules, and challenging aspects examining children with trisomy 21. The chart review included patients treated at the Department of Ophthalmology at the University Hospital of Zurich over a two-year period. The international survey was submitted to the members of the Swiss Society of Ophthalmology, Slovenian Ophthalmological Society, and European Pediatric Ophthalmology Society. Results. Analysis of 52 patient records during the study period revealed refractive errors (astigmatism: 54% of patients, hyperopia: 26%, and myopia: 15%) as the most common diagnosis, whereas childhood cataract was reported in 5%. This is in concordance with the extended literature review of 249 publications, although congenital cataracts were reported to be higher than at our institution. The survey participants reported great challenges in taking care of these patients, despite their long professional experience (73% with over 10 years of experience). Conclusion. Care and treatment of children with trisomy 21 continues to be demanding for paediatric ophthalmologists. We recommend the following examination schedule for these patients: first, ophthalmological examination at 6–12 months of age, then once in 3–6 months for children under 2 years of age, once in 6 months for children 2–5 years of age, annually for children 5–10 years of age, and thereafter, to be decided on an individual basis depending on the presenting ocular abnormalities of the patient.

scholarly journals From Supply Chain 4.0 to Supply Chain 5.0: Findings from a Systematic Literature Review and Research Directions

Logistics ◽  
2021 ◽  
Vol 5 (3) ◽  
pp. 49
Author(s):  
Guilherme F. Frederico
Keyword(s):  
Supply Chain ◽  
Literature Review ◽  
Systematic Literature Review ◽  
Research Agenda ◽  
Industry 4.0 ◽  
Current Knowledge ◽  
Research Directions ◽  
The Subject ◽  
Strategy Innovation ◽  
Transition Issues

The main purpose of this paper is to present what the Industry 5.0 phenomenon means in the supply chain context. A systematic literature review method was used to get evidence from the current knowledge linked to this theme. The results have evidenced a strong gap related to Industry 5.0 approaches for the supply chain field. Forty-one (41) publications, including conference and journal papers, have been found in the literature. Nineteen (19) words, which were grouped in four (4) clusters, have been identified in the data analysis. This was the basis to form the four (4) constructs of Industry 5.0: Industry Strategy, Innovation and Technologies, Society and Sustainability, and Transition Issues. Then, an alignment with the supply chain context was proposed, being the basis for the incipient Supply Chain 5.0 framework and its research agenda. Industry 5.0 is still in an embryonic and ideal stage. The literature is scarce and many other concepts and discoveries are going to emerge. Although this literature review is based on few available sources, it provides insightful and novel concepts related to Industry 5.0 in the supply chain context. Moreover, it presents a clear set of constructs and a structured research agenda to encourage researchers in deploying further conceptual and empirical works linked to the subject herein explored. Organizations’ leadership, policymakers, and other practitioners involved in supply chains, and mainly those currently working with Industry 4.0 initiatives, can benefit from this research by having clear guidance regarding the dimensions needed to structurally design and implement an Industry 5.0 strategy. This article adds valuable insights to researchers and practitioners, by approaching the newest and revolutionary concept of the Industry 5.0 phenomenon in the supply chain context, which is still an unexplored theme.

Overview of information retrieval in a hospital-based health technology assessment center in a Swedish region

2021 ◽  
Vol 37 (1) ◽  
Author(s):  
Ida Stadig ◽  
Therese Svanberg
Keyword(s):  
Information Retrieval ◽  
Literature Review ◽  
Health Technology Assessment ◽  
Technology Assessment ◽  
Full Text ◽  
Health Technology ◽  
University Hospital ◽  
Literature Searching ◽  
Medical Library ◽  
Full Text Screening

Abstract Objectives This article aims to provide a brief review of information retrieval and hospital-based health technology assessment (HB-HTA) and describe library experiences and working methods at a regional HB-HTA center from the center's inception to the present day. Methods For this brief literature review, searches in PubMed and LISTA were conducted to identify studies reporting on HB-HTA and information retrieval. The description of the library's involvement in the HTA center and its working methods is based on the authors’ experience and internal and/or unpublished documents. Results Region Västra Götaland is the second largest healthcare region in Sweden and has had a regional HB-HTA center since 2007 (HTA-centrum). Assessments are performed by clinicians supported by HTA methodologists. The medical library at Sahlgrenska University Hospital works closely with HTA-centrum, with one HTA librarian responsible for coordinating the work. Conclusion In the literature on HB-HTA, we found limited descriptions of the role librarians and information specialists play in different units. The librarians at HTA-centrum play an important role, not only in literature searching but also in abstract and full-text screening.

scholarly journals The Clinical Spectrum of Primary Cutaneous CD4+ Small/Medium-Sized Pleomorphic T-Cell Lymphoproliferative Disorder: An Updated Systematic Literature Review and Case Series

Dermatology ◽  
2020 ◽  
Vol 237 (4) ◽  
pp. 618-628
Author(s):  
Philip Surmanowicz ◽  
Sean Doherty ◽  
Arunima Sivanand ◽  
Nikoo Parvinnejad ◽  
Jean Deschenes ◽  
...  
Keyword(s):  
T Cell ◽  
Literature Review ◽  
Systematic Literature Review ◽  
Lymphoproliferative Disorder ◽  
Chart Review ◽  
Retrospective Chart Review ◽  
Cutaneous Lymphoma ◽  
World Health ◽  
Treatment Modalities ◽  
Systemic Treatments

<b><i>Background:</i></b> Primary cutaneous CD4+ small/medium pleomorphic T-cell lymphoproliferative disorder (SMPLPD) is a provisional entity within the 2016 World Health Organization classification of primary cutaneous lymphomas. The condition is currently classified as a lymphoproliferative disorder to emphasize its benign course and discourage aggressive, systemic treatment modalities. <b><i>Objective:</i></b> To provide a relevant synthesis for the dermatological practitioner on the prevalence, presentation, and treatment of SMPLPD. <b><i>Methods:</i></b> We conducted an updated systematic literature review and a retrospective chart review of diagnosed cases of SMPLPD from 2 Canadian academic cutaneous lymphoma centers. <b><i>Results:</i></b> A total of 23 studies with 136 cases were extracted from the systematic review and 24 patients from our retrospective chart review. SMPLPD proved relatively common accounting for 12.5% of all cutaneous T-cell lymphomas encountered in our cutaneous lymphoma clinics, second in frequency only to mycosis fungoides. The typical clinical presentation was that of an older individual (median age 59 years) with an asymptomatic solitary lesion on their upper extremity. The most common clinical differentials were cutaneous lymphoid hyperplasia, basal cell carcinoma, and lymphoma unspecified. T follicular helper markers were reliably detected. The main treatment modalities were surgical excision, local radiation therapy, and topical or intralesional steroids. Cure was achieved in the vast majority of cases. <b><i>Conclusions:</i></b> SMPLPD is an underdiagnosed T-cell lymphoma with an overtly benign clinical course. The condition has an excellent prognosis and responds well to skin-directed therapies. Practitioners should be aware of this condition to avoid aggressive systemic treatments.

scholarly journals Visual performance and ocular abnormalities in deaf children and young adults: a literature review

2013 ◽  
Vol 92 (4) ◽  
pp. 305-310 ◽  
Author(s):  
Richard Hollingsworth ◽  
Amanda K. Ludlow ◽  
Arnold Wilkins ◽  
Richard Calver ◽  
Peter M. Allen
Keyword(s):  
Young Adults ◽  
Literature Review ◽  
Visual Performance ◽  
Deaf Children ◽  
Ocular Abnormalities ◽  
Children And Young Adults

Never Trust, Always Verify: A Multivocal Literature Review on Current Knowledge and Research Gaps of Zero-trust

2021 ◽  
pp. 102436
Author(s):  
Christoph Buck ◽  
Christian Olenberger ◽  
André Schweizer ◽  
Fabiane Völter ◽  
Torsten Eymann
Keyword(s):  
Literature Review ◽  
Current Knowledge ◽  
Research Gaps

scholarly journals Comparison of isoflurane and propofol sedation in critically ill COVID-19 patients—a retrospective chart review

2021 ◽  
Author(s):  
Azzeddine Kermad ◽  
Jacques Speltz ◽  
Guy Danziger ◽  
Thilo Mertke ◽  
Robert Bals ◽  
...  
Keyword(s):  
Acute Respiratory Distress Syndrome ◽  
Retrospective Study ◽  
Linear Regression ◽  
Chart Review ◽  
Distress Syndrome ◽  
Minute Ventilation ◽  
Retrospective Chart Review ◽  
University Hospital ◽  
High Doses ◽  
End Tidal

Abstract Purpose In this retrospective study, we compared inhaled sedation with isoflurane to intravenous propofol in invasively ventilated COVID-19 patients with ARDS (Acute Respiratory Distress Syndrome). Methods Charts of all 20 patients with COVID-19 ARDS admitted to the ICU of a German University Hospital during the first wave of the pandemic between 22/03/2020 and 21/04/2020 were reviewed. Among screened 333 days, isoflurane was used in 97 days, while in 187 days, propofol was used for 12 h or more. The effect and dose of these two sedatives were compared. Mixed sedation days were excluded. Results Patients’ age (median [interquartile range]) was 64 (60–68) years. They were invasively ventilated for 36 [21–50] days. End-tidal isoflurane concentrations were high (0.96 ± 0.41 Vol %); multiple linear regression yielded the ratio (isoflurane infusion rate)/(minute ventilation) as the single best predictor. Infusion rates were decreased under ECMO (3.5 ± 1.4 versus 7.1 ± 3.2 ml∙h−1; p < 0.001). In five patients, the maximum recommended dose of propofol of 4 mg∙hour−1∙kg−1ABW was exceeded on several days. On isoflurane compared to propofol days, neuro-muscular blocking agents (NMBAs) were used less frequently (11% versus 21%; p < 0.05), as were co-sedatives (7% versus 31%, p < 0.001); daily opioid doses were lower (720 [720–960] versus 1080 [720–1620] mg morphine equivalents, p < 0.001); and RASS scores indicated deeper levels of sedation (− 4.0 [− 4.0 to − 3.0] versus − 3.0 [− 3.6 to − 2.5]; p < 0.01). Conclusion Isoflurane provided sufficient sedation with less NMBAs, less polypharmacy and lower opioid doses compared to propofol. High doses of both drugs were needed in severely ill COVID-19 patients.

Using Formative Research to Inform a BCC Strategy to Increase Food Security and Dietary Diversity in Low-Income Rural Communities

2021 ◽  
Vol 6 (3) ◽  
Author(s):  
Turk T ◽  
◽  
Safdar NF ◽  
Hashmi S ◽  
Shah N ◽  
...  
Keyword(s):  
Literature Review ◽  
Nutrition Education ◽  
Low Income ◽  
Rural Areas ◽  
Dietary Diversity ◽  
Current Knowledge ◽  
Formative Research ◽  
Lessons Learned ◽  
Attitudes And Practices ◽  
Kitchen Gardens

Background: Adequate nutrition is a public health priority, particularly in low-income rural areas where there is a high prevalence of malnutrition and stunting. Baluchistan is an arid desert and mountainous province with the worst health indicators in Pakistan. The objective of this research study was to identify current knowledge, attitudes and practices of vulnerable women with young children residing in remote areas of Baluchistan and assess their information needs to guide the development of a BCC nutrition strategy materials and activities. Methods: This study design incorporated formative research via eight focus group discussions with demand and supply-side program beneficiaries (n=124) to assess current nutrition knowledge, attitudes and beliefs toward kitchen gardens and proposed nutrition resources. Semi-structured interviews (n=16) were also conducted to provide program intelligence from key informants. A literature review supported the development of discussion agenda based on predominant behavioral theories. Data analysis was conducted with in vivo qualitative software coupled with grounded theory with qualitative findings triangulated. Results: The study identified important factors for the development of BCC resources and activities. Opportunities included effective nutrition education, improved income and livelihoods from kitchen gardens, women’s empowerment and gender equality. Challenges included traditional cultural practices, entrenched food preparation behaviour, environmental and infrastructural constraints. Conclusions: Lessons learned highlight the benefits of integrating formative research methods with a comprehensive literature review and behavioural theories for the development of BCC resources for nutrition programs in insecure and resource-constrained settings.

Trust and Relationship Development Among Users in Dark Web Child Sexual Exploitation and Abuse Networks: A Literature Review From a Psychological and Criminological Perspective

2021 ◽  
pp. 152483802110572
Author(s):  
Juliane A. Kloess ◽  
Madeleine van der Bruggen
Keyword(s):  
Literature Review ◽  
Current Knowledge ◽  
Research Question ◽  
Sexual Exploitation ◽  
Relationship Development ◽  
Expert Advice ◽  
Future Research ◽  
Child Sexual Exploitation ◽  
Criminological Perspective ◽  
Dark Web

The increased potential and speed of the Internet has changed the nature of sexual crimes against children. It enables individuals with a sexual interest in children to meet, interact, and engage in illegal activities. The literature review presented here aims to provide an overview of the current knowledge and understanding of trust and relationship development among users of online networks that are dedicated to the sexual exploitation and abuse of children. A systematic search using six databases was conducted to identify relevant literature from a psychological and a criminological perspective. Twenty-one studies met the inclusion criteria that centered around the key aspects of the literature review’s research question, namely, (i) child sexual exploitation and abuse, (ii) Dark Web platforms, (iii) online forums and networks, and (iv) trust and relationship development. Our findings reveal that the engagement in interpersonal communication and interactions with like-minded others serves various functions, including validation, normalization, and support, as well as access to expert advice, information, and material. Dark Web networks are high-stake and risky environments, where users have to manage a continuous flow of threats, with information about others and their trustworthiness being limited. The establishment and maintenance of trust is of social and technical relevance, and users have to navigate a number of demands and commitments. Findings are discussed in relation to theoretical and practical implications, as well as directions for future research.

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