scholarly journals Disseminated Coccidioidomycosis Presenting as Septic Shock with Multiorgan Failure

2021 ◽  
Vol 2021 ◽  
pp. 1-6
Author(s):  
Olufemi Aduroja ◽  
Jerome Okudo ◽  
Angelica Padilla
Keyword(s):  
Septic Shock ◽  
Distress Syndrome ◽  
Multiorgan Failure ◽  
Severe Disease ◽  
Miliary Tuberculosis ◽  
Hiv Positive ◽  
Chest Imaging ◽  
Coccidioides Immitis ◽  
Coccidioides Posadasii ◽  
Severe Morbidity

Coccidioidomycosis is a fungal infection caused by Coccidioides immitis and Coccidioides posadasii. While infections are usually mild, severe disease occurs in immunocompromised patients. Dissemination is associated with severe morbidity and mortality. Because of the tendency of this disease to imitate many diseases, diagnosis may be difficult on presentation. We present a case of disseminated coccidioidomycosis in a patient who was initially managed as miliary tuberculosis. In endemic areas, coccidioidomycosis is one of the two top differentials for miliary micronodular distribution on chest imaging. The patient was a recently diagnosed HIV positive patient and presented to the hospital with multiorgan failure, septic shock, and acute respiratory distress syndrome. He rapidly deteriorated and died within three days of presentation at the emergency department.

scholarly journals Miliary Tuberculosis-Related Acute Respiratory Distress Syndrome Complicated with Hemophagocytic Lymphohistiocytosis Syndrome

2019 ◽  
Vol 2019 ◽  
pp. 1-4
Author(s):  
Sz-Jiun Shiu ◽  
Ting-Ting Li ◽  
Bor-Jen Lee ◽  
Pin-Kuei Fu ◽  
Chen-Yu Wang ◽  
...  
Keyword(s):  
Acute Respiratory Distress Syndrome ◽  
Respiratory Distress Syndrome ◽  
Respiratory Distress ◽  
Hemophagocytic Lymphohistiocytosis ◽  
Distress Syndrome ◽  
Case Reports ◽  
Multiorgan Failure ◽  
Miliary Tuberculosis ◽  
Bone Marrow Aspiration ◽  
Underlying Disease

Acute respiratory distress syndrome (ARDS) and hemophagocytic lymphohistiocytosis (HLH) are accompanied with poor outcome and high mortality when miliary tuberculosis is a causative pathogen for both of them. A patient complicated with ARDS and HLH is unusual in critical care, and few case reports are present in PudMed. Besides, the relationship between HLH and ARDS is still unknown and has not been reviewed in the literature. In this report, we present the case of a 74-year-old Taiwanese woman suffering from pulmonary tuberculosis and miliary tuberculosis, and she developed ARDS and HLH on the 3rd day after admission. We arranged serial laboratory examination, various serum markers, bone marrow aspiration, and bronchoscopy with alveolar lavage for survey; we prescribed empirical antibiotics and antituberculosis medication soon after alveolar lavage showing positive acid-fast stain. She was extubated on hospital day 31 and discharged on hospital day 73. In conclusion, early diagnosis and intervention for underlying disease and intensive bundle care for multiorgan failure are crucial for both ARDS and HLH.

scholarly journals Fatal Disseminated Tuberculous Peritonitis following Spontaneous Abortion: A Case Report

2014 ◽  
Vol 2014 ◽  
pp. 1-5
Author(s):  
Munire Erman Akar ◽  
Tayfun Toptas ◽  
Havva Sutcu ◽  
Haney Durmus ◽  
Murat Ozekinci ◽  
...  
Keyword(s):  
Septic Shock ◽  
Spontaneous Abortion ◽  
Rare Case ◽  
Diagnostic Laparoscopy ◽  
Distress Syndrome ◽  
Clinical Course ◽  
Multiorgan Failure ◽  
Tuberculous Peritonitis ◽  
Laboratory Findings ◽  
Antituberculous Treatment

We describe a rare case of fatal disseminated tuberculous peritonitis in a young woman with rapid progressive clinical course following spontaneous abortion of 20-week gestation. Clinical and laboratory findings were initially unremarkable. She underwent diagnostic laparoscopy which revealed numerous tiny implants on the peritoneum and viscera. Histopathology showed chronic caseating granulomas, and the tissue culture grew Mycobacterium tuberculosis. At fifth day of the antituberculous treatment multiorgan failure occurred in terms of pulmonary, hepatic, and renal insufficiency. She developed refractory metabolic acidosis with coagulopathy and pancytopenia, and she died of acute respiratory distress syndrome and septic shock on her twelfth day of hospitalization.

scholarly journals Does reactivation of cytomegalovirus contribute to severe COVID-19 disease?

2021 ◽  
Vol 18 (1) ◽  
Author(s):  
Cecilia Söderberg-Nauclér
Keyword(s):  
Septic Shock ◽  
Acute Respiratory Distress Syndrome ◽  
Mortality Rate ◽  
Respiratory Distress Syndrome ◽  
Respiratory Distress ◽  
High Mortality ◽  
Hospital Care ◽  
Distress Syndrome ◽  
Multiorgan Failure ◽  
Severe Pneumonia

AbstractThe majority of people infected with SARS-CoV-2 are asymptomatic or have mild to moderate symptoms. However, for unknown reasons, about 15 % have severe pneumonia requiring hospital care and oxygen support, and about 5 % develop acute respiratory distress syndrome, septic shock, and multiorgan failure that result in a high mortality rate. The risk of severe COVID-19 is highest among those who are over 70 years of age. Why severe COVID-19 develops in some people but not others is not understood. Could some cases involve reactivation of latent cytomegalovirus (CMV)?

scholarly journals Clinical Features And Outcomes Of Streptococcus Anginosus Group Infective Endocarditis: A Multicenter Matched Cohort Study

2021 ◽  
Author(s):  
Francesc Escrihuela-Vidal ◽  
Luis Eduardo López-Cortés ◽  
Laura Escolà-Vergé ◽  
Arístides De Alarcón González ◽  
Guillermo Cuervo ◽  
...  
Keyword(s):  
Heart Failure ◽  
Septic Shock ◽  
Severe Disease ◽  
Indications For Surgery ◽  
Matched Cohort ◽  
Limited Evidence ◽  
Native Valve ◽  
Streptococcus Anginosus ◽  
Streptococcus Gallolyticus ◽  
Viridans Group Streptococci

Abstract Background Although Streptococcus anginosus group (SAG) endocarditis is considered a severe disease associated with abscess formation and embolic events, there is limited evidence to support this assumption. Methods We performed a retrospective analysis of prospectively collected data from consecutive patients with definite SAG endocarditis in 28 centers in Spain and Italy. A comparison between cases due to SAG endocarditis and viridans group streptococci (VGS) or Streptococcus gallolyticus group (SGG) was performed in a 1:2 matched analysis. Results Of 5,336 consecutive cases of definite endocarditis, 72 (1.4%) were due to SAG and matched with 144 cases due to VGS/SGG. SAG endocarditis was community acquired in 64 (88.9%) cases and affected aortic native valve in 29 (40.3%). When comparing SAG and VGS/SGG endocarditis, no significant differences were found in septic shock (8.3% vs. 3.5%, P = 0.116); valve disorder, including perforation (22.2% vs. 18.1%, P = 0.584), pseudoaneurysm (16.7% vs. 8.3%, P = 0.108), or prosthesis dehiscence (1.4% vs. 6.3%, P = 0.170); paravalvular complications, including abscess (25% vs. 18.8%, P = 0.264) and intracardiac fistula (5.6% vs. 3.5%, P = 0.485); heart failure (34.7% vs. 38.9%, P = 0.655); and embolic events (41.7% vs. 32.6%, P = 0.248). Indications for surgery (70.8% vs. 70.8%; P =1) and mortality (13.9% vs. 16.7%; P = 0.741) were similar between groups. Conclusions SAG endocarditis is an infrequent but serious condition that presents a prognosis similar to that of VGS/SGG

677: FATAL MULTIORGAN FAILURE AND SEPTIC SHOCK DUE TO DISSEMINATED COCCIDIOIDOMYCOSIS

2018 ◽  
Vol 46 (1) ◽  
pp. 325-325
Author(s):  
Isaac McCool ◽  
John Walsh ◽  
Alexandra Perry ◽  
Ryan Maves
Keyword(s):  
Septic Shock ◽  
Multiorgan Failure

Diverse disease processes of group A Streptococcus infection including severe invasive infections among members of a family

2021 ◽  
Vol 14 (4) ◽  
pp. e241339
Author(s):  
Kaori Amari ◽  
Masaki Tago ◽  
Naoko E Katsuki ◽  
Shu-ichi Yamashita
Keyword(s):  
Septic Shock ◽  
Distress Syndrome ◽  
Clinical Course ◽  
Group A Streptococcus ◽  
Bloody Stool ◽  
Laryngeal Oedema ◽  
Invasive Infections ◽  
Group A ◽  
The Right ◽  
Close Contacts

We herein report three cases of group A Streptococcus (GAS) infection in a family. Patient 1, a 50-year-old woman, was transferred to our hospital in shock with acute respiratory distress syndrome, swelling in the right neck and erythemata on both lower extremities. She required intubation because of laryngeal oedema. At the same time, patient 2, a 48-year-old man, was admitted because of septic shock, pneumonia and a pulmonary abscess. Five days later, patient 3, a 91-year-old woman, visited our clinic with bloody stool. All three patients were cured by antibiotics, and GAS was detected by specimen cultures. During these patients’ clinical course, an 84-year-old woman was found dead at home after having been diagnosed with type A influenza. All four patients lived in the same apartment. The GAS genotypes detected in the first three patients were identical. When treating patients with GAS, appropriate management of close contacts is mandatory.

1423: THERAPEUTIC PLASMA EXCHANGE FOR THROMBOCYTOPENIA-ASSOCIATED MULTIORGAN FAILURE IN SEPTIC SHOCK

2018 ◽  
Vol 46 (1) ◽  
pp. 695-695
Author(s):  
Philip Keith ◽  
Lauren Eyadiel ◽  
Jeremy Hodges ◽  
Karen Sands ◽  
Jared Watkins
Keyword(s):  
Septic Shock ◽  
Plasma Exchange ◽  
Multiorgan Failure ◽  
Therapeutic Plasma Exchange
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