scholarly journals Kimura’s Disease: A Rare Cause of Unilateral Tonsillar Enlargement

2021 ◽  
Vol 2021 ◽  
pp. 1-4
Author(s):  
Prakash Khanal ◽  
Agya Shrestha
Keyword(s):  
Histopathological Examination ◽  
Cervical Lymphadenopathy ◽  
Neck Region ◽  
Rare Condition ◽  
Surgical Excision ◽  
Kimura’S Disease ◽  
Inflammatory Disorder ◽  
Serum Ige ◽  
History Of ◽  
High Index Of Suspicion

Introduction. Kimura’s disease is a rare inflammatory disorder of unknown cause, commonly seen in young Asian males. Case Report. A 61-year-old male patient presented with a history of right tonsillar mass and cervical lymphadenopathy. The patient underwent hematological investigation and imaging followed by resection of tonsillar mass. Based on histopathological and subsequent immunohistochemistry reports, the case was diagnosed as Kimura’s disease of the tonsil. Discussion. Kimura’s disease commonly presents as painless subcutaneous masses in the head and neck region or cervical lymphadenopathy. Kimura’s disease presenting as a tonsillar mass is a very rare condition. Patients usually have peripheral eosinophilia and elevated levels of serum IgE. The diagnosis is based on the clinical and histopathologic findings in a biopsy of the mass and/or lymph node along with elevated peripheral eosinophil and serum IgE level. Conclusion. The clinical presentation of Kimura’s disease is highly variable. Kimura’s disease should be considered as a differential diagnosis in patients presenting with a tonsillar mass. A high index of suspicion along with histopathological examination helps in the early diagnosis and management. Surgical excision is the treatment of choice.

Eosinophilic chronic rhinosinusitis and concurrent Kimura’s disease treated with mepolizumab

2021 ◽  
Vol 14 (1) ◽  
pp. e232627
Author(s):  
Jacqueline Ho ◽  
Sophie Walter ◽  
Richard J Harvey
Keyword(s):  
English Language ◽  
Cervical Lymphadenopathy ◽  
Upper Airway ◽  
Neck Region ◽  
Kimura’S Disease ◽  
Inflammatory Disorder ◽  
Head And Neck Region ◽  
Chronic Inflammatory Disorder ◽  
First Case ◽  
Eosinophilic Chronic Rhinosinusitis

Kimura’s disease is a rare, benign, chronic inflammatory disorder characterised by its eosinophilic infiltrate. Patients often present with one or more progressively enlarging subcutaneous lymph nodes in the head and neck region or enlarging salivary glands. We describe the case of a 26-year-old man presenting with severe peripheral eosinophilia and upper airway inflammatory symptoms, who later developed cervical lymphadenopathy and formally diagnosed with Kimura’s disease. Based on our English-language MEDLINE literature search, to our knowledge this is the first case report describing treatment of Kimura’s disease with mepolizumab.

scholarly journals Diagnostic dilemmas of head and neck tuberculosis: our experience and review of literature

2020 ◽  
Vol 6 (5) ◽  
pp. 934
Author(s):  
Pallavi Pavithran ◽  
Mahesh S. G.
Keyword(s):  
Head And Neck ◽  
Extrapulmonary Tuberculosis ◽  
Cervical Lymphadenopathy ◽  
Neck Region ◽  
Review Of Literature ◽  
Nodal Disease ◽  
Head And Neck Region ◽  
History Of ◽  
Tuberculous Otitis Media ◽  
High Index Of Suspicion

<p class="abstract"><strong>Background:</strong> The aim of the study was to highlight the varied and changing presentations of head and neck tuberculosis, discuss the difficulties in diagnosis and treatment.</p><p class="abstract"><strong>Methods:</strong> This was a 5 years retrospective analysis of patients with extrapulmonary tuberculosis (EPTB) of the head and neck region.  </p><p class="abstract"><strong>Results:</strong> 43 patients with EPTB were studied. Most had cervical lymphadenopathy (35), 9 had laryngeal, 7 tuberculous otitis media, and one patient each of PNS, oropharyngeal and retropharyngeal involvement. 8 patients had pulmonary TB, 2 had Potts spine, and 5 gave history of previous TB. FNAC was effective in nodal disease, PPD test positive in 20% and HPE was used to make the diagnosis in other types.</p><p class="abstract"><strong>Conclusions:</strong> TB is re-emerging as a significant cause of morbidity. Diagnosing EPTB requires high index of suspicion. Cervical lymphadenopathy is the commonest presentation, followed by larynx, and then ear. FNAC is a reliable and convenient way to diagnose lymphadenopathy. Hitopathological examination needed for confirmation, and for other sites. Further investigations are needed to exclude pulmonary or systemic TB. All patients should be categorised into proper category of anti-tuberculous treatment (ATT) and treated according to ATT regimen.</p>

scholarly journals A rare case of Kimura lymphadenpathy in elderly female

2020 ◽  
Vol 7 (10) ◽  
pp. 3452
Author(s):  
Vinayagam Ganesan ◽  
Venkatesh Sadayan Periyasamy ◽  
Muralidharan Kannaian
Keyword(s):  
Rare Case ◽  
Immunoglobulin E ◽  
Histopathological Examination ◽  
Renal Involvement ◽  
Cervical Lymphadenopathy ◽  
Surgical Excision ◽  
Excision Biopsy ◽  
Kimura’S Disease ◽  
Recurrence Rates ◽  
Elderly Female

Kimura's disease (KD) is a chronic inflammatory disease, a rare variety. It usually presents as non-tender subcutaneous swelling in head and neck region, predominantly in preauricular and submandibular area and is often associated with cervical lymphadenopathy, marked peripheral eosinophilia and an elevated immunoglobulin E (IgE) level. Renal involvement is the only systemic manifestation.4 Nephrotic syndrome is the most common manifestation of renal disease in KD. Diagnosis through Fine needle aspiration cytology (FNAC) is misleading and can easily be mistaken as a malignant disease. So, diagnosis is therefore only established by histopathological examination. The treatment of KD involves one of three major approaches are surgical excision, irradiation, or steroid therapy. Surgical excision is recommended as the treatment of choice but carries recurrence rates of 33-50%. In our study, we are reporting a case of elderly female who presented with left sided cervical lymphadenopathy for which excision biopsy was done and the histopathology examination shown as kimura lymphadenopathy, a rare case.

scholarly journals Kimura Disease of the Nose

2021 ◽  
Vol 6 (2) ◽  
pp. 61-64
Author(s):  
Zalilah Musa ◽  
Abdul Razak Ismail ◽  
Irfan Mohamad
Keyword(s):  
Head And Neck ◽  
Histopathological Examination ◽  
Subcutaneous Tissue ◽  
Neck Region ◽  
Surgical Excision ◽  
Unknown Etiology ◽  
Inflammatory Disorder ◽  
Kimura Disease ◽  
Nasal Bridge ◽  
Chronic Inflammatory Disorder

Introduction: Kimura disease is a rare chronic inflammatory disorder affecting the subcutaneous tissue. It is of unknown etiology mainly occurring in head and neck region. Case report: A 34-year-old Malay lady presented with a gradually enlarging, painless right nasal bridge mass for one year duration. Clinical examination revealed a firm, immobile swelling measuring 2 cm x 2 cm. Nasal endoscopy showed no extension of the mass into the right nasal cavity. Surgical excision was performed where histopathological examination reported as finding consistent with Kimura disease. Conclusion: Kimura disease is extremely a rare benign disease, which can affect the head and neck structures. Manifestation at the nasal region is an extremely rare occurrence. Histopathological examination is needed to diagnose the disease.

Oropharyngeal Kimura’s disease: a diagnostic dilemma and therapeutic challenge

2020 ◽  
Vol 13 (10) ◽  
pp. e236366
Author(s):  
Prasanna Kumar Saravanam ◽  
Aishwarya Gajendran ◽  
Nethra Dinakaran ◽  
Dhaarani Jayaraman
Keyword(s):  
Histopathological Examination ◽  
Subcutaneous Tissue ◽  
Neck Region ◽  
Treatment Modalities ◽  
Kimura’S Disease ◽  
Inflammatory Disorder ◽  
First Line ◽  
Diagnostic Dilemma ◽  
Head And Neck Region ◽  
Chronic Inflammatory Disorder

Kimura’s disease is a chronic inflammatory disorder involving subcutaneous tissue and locoregional lymph nodes of head and neck region, characterised by angiolymphoid proliferation. It is typically associated with peripheral eosinophilia, increased serum IgE and lymphadenopathy. Diagnosis is usually based on histopathological examination. Though various treatment modalities have been put forward, surgical management remains the first line of treatment, followed by systemic steroids application. This case report discusses the diagnostic dilemma and therapeutic management of a rare clinical presentation and management of oropharyngeal Kimura’s disease in a young immunocompetent woman.

Intraorbital Abscess: A Rare Cause of Orbit Compression

FACE ◽  
2021 ◽  
pp. 273250162110050
Author(s):  
Samuel Ruiz ◽  
Rizal Lim
Keyword(s):  
Pediatric Population ◽  
Rare Complication ◽  
Disease Process ◽  
Rare Condition ◽  
External Drainage ◽  
Direct Extension ◽  
Life Threatening ◽  
History Of ◽  
High Index Of Suspicion ◽  
Prompt Diagnosis

Introduction: Intraorbital abscess is a rare complication of rhinosinusitis that affects most commonly the pediatric population. It is thought to be caused by direct extension or venous spread of infections from contiguous sites and can lead to life-threatening complications, like permanent visual loss and cerebral abscesses. Objectives: Intraorbital abscess is a rare condition that requires prompt diagnosis and treatment to avoid serious complications. Our objectives are to provide an overview of this rare disease process and its management including our successful treatment experience. Case Description: We present a 2 case report of a 13-year-old pediatric male and a 66-year-old male with history of chronic sinusitis who presented with a right intraorbital abscess successfully treated with external drainage with decompression of the orbit. Conclusion: When intraorbital abscess is encountered, a high index of suspicion is needed to allow prompt and accurate diagnosis for this infrequent condition. Timely surgical drainage of the abscess is needed to prevent the development of fatal complications.

scholarly journals Rituximab Treatment in a Patient with Kimura Disease and Membranous Nephropathy: Case Report

2021 ◽  
pp. 116-123
Author(s):  
Roald Vissing-Uhre ◽  
Alastair Hansen ◽  
Susanne Frevert ◽  
Ditte Hansen
Keyword(s):  
Case Report ◽  
Membranous Nephropathy ◽  
Neck Region ◽  
Renal Diseases ◽  
Kimura’S Disease ◽  
Inflammatory Disorder ◽  
Kimura Disease ◽  
Chronic Inflammatory Disorder ◽  
Eosinophil Granulocytes ◽  
Anti Cd20

Kimura disease (KD) is a chronic, inflammatory disorder with slowly developing subcutaneous tumor-like swellings, often occurring in the head and neck region. KD is diagnosed based on histology, elevated levels of immunoglobulin type E, and increased peripheral eosinophil granulocytes. KD may coexist with glomerular renal diseases, and this case report is based on a patient with KD-associated membranous nephropathy. Patients with membranous nephropathy without KD have demonstrated responsiveness to treatment with monoclonal anti-CD20 antibodies. This case report is the first to investigate the effect of rituximab treatment in a patient with KD-associated membranous nephropathy. A 30-year-old Italian man living in Denmark was diagnosed with Kimura’s disease based on subcutaneous nodules with eosinophil angiolymphoid hyperplasia. The patient was admitted to the hospital due to nephrotic syndrome. Serology showed eosinophil granulocytosis and negative PLA2-receptor antibody. Renal biopsy showed membranous nephropathy, and the patient was treated with systemic methylprednisolone followed by cyclosporin and then cyclophosphamide with only partial remission. Ultimately, treatment with intravenous rituximab was initiated, which resulted in overall remission and no nephrotic relapses at 30 months of follow-up. Thus, intravenous rituximab effectively decreased proteinuria and prevented nephrotic relapses in a patient with treatment-refractory membranous nephropathy due to KD.

scholarly journals Intravascular Glomus Tumor of the Forearm Causing Chronic Pain and Focal Tenderness

2014 ◽  
Vol 2014 ◽  
pp. 1-4 ◽  
Author(s):  
Sang Ki Lee ◽  
Dae Geon Song ◽  
Won Sik Choy
Keyword(s):  
Chronic Pain ◽  
Glomus Tumor ◽  
Rare Condition ◽  
Surgical Excision ◽  
Vascular Tumor ◽  
Glomus Tumors ◽  
Contrast Magnetic Resonance ◽  
History Of ◽  
Subcutaneous Layer ◽  
Magnetic Resonance Imaging Mri

Introduction. A glomus tumor is a benign vascular tumor derived from glomus cells and occurs mainly in the subcutaneous layer of the subungual or digital pulp. Extradigital glomus tumors have been reported within the palm, wrist, forearm, foot, bone, stomach, colon, cervix, and mesentery. Glomus tumors can originate from the intraosseous, intramuscular, periosteal, intravascular, and intraneural layers. However, a glomus tumor originating from the intravascular layer of the forearm is a rare condition.Case Report. A 44-year-old woman had a 7-year history of chronic pain and focal tenderness of the forearm. No hypersensitivity or sensory alterations were observed. Contrast magnetic resonance imaging (MRI) showed a mass measuring 5 × 3 × 2 mm leading to a vein. Surgical excision was performed, and the tumor was completely resected. Finding of gross examination revealed a dark-red, well-defined soft tissue tumor, and histologic examination confirmed that the mass was a glomus tumor. The patient’s symptoms were completely resolved postoperatively.Conclusion. Intravascular glomus tumors rarely occur in the forearm; therefore, a thorough physical exam, comprehensive medical history, in-depth imaging, and early surgical excision upon clinical suspicion may be helpful to prevent a delayed or incorrect diagnosis.

scholarly journals Ameloblastic Fibrosarcoma of the Mandible: A Case Report and Brief Review of the Literature

2015 ◽  
Vol 2015 ◽  
pp. 1-5 ◽  
Author(s):  
Abelardo Loya-Solis ◽  
Karla Judith González-Colunga ◽  
Cynthia M. Pérez-Rodríguez ◽  
Natalie Sofía Ramírez-Ochoa ◽  
Luis Ceceñas-Falcón ◽  
...  
Keyword(s):  
Histopathological Examination ◽  
Surgical Excision ◽  
Second Molar ◽  
Odontogenic Epithelium ◽  
Left Mandible ◽  
Long Term Follow Up ◽  
History Of ◽  
Ameloblastic Fibrosarcoma ◽  
Mitotic Figures ◽  
One Year

Ameloblastic fibrosarcoma is an uncommon odontogenic tumor composed of a benign epithelial component and a malignant ectomesenchymal component most frequently seen in the third and fourth decades of life. It mainly presents as a painful maxillary or mandibular swelling. Radiographs show a radiolucent mass with ill-defined borders. Radical surgical excision and long-term follow-up are the suggested treatment. We report the case of a 22-year-old female with a 2-month history of an asymptomatic swelling in her left mandible. Examination revealed an exophytic growth measuring3×3 cm extending from the mandibular left first premolar to the second molar. The patient underwent a left hemimandibular resection. Histopathological examination revealed a biphasic tumor composed of inconspicuous islands of benign odontogenic epithelium and an abundant malignant mesenchymal component with marked cellularity, nuclear pleomorphism, hyperchromatism, and moderate mitotic figures with clear margins; one year after the surgical procedure, the patient is clinically and radiologically disease-free.

scholarly journals Kimura’s disease: a diagnostic and therapeutic enigma

2018 ◽  
Vol 6 (6) ◽  
pp. 2176
Author(s):  
Vinay Bharat ◽  
Abhishek Gupta ◽  
Rani Bansal ◽  
Priya Gupta ◽  
Mamta Gupta
Keyword(s):  
Lymph Nodes ◽  
Elevated Serum ◽  
Neck Region ◽  
Kimura’S Disease ◽  
Inflammatory Disorder ◽  
Neck Swelling ◽  
Peripheral Eosinophilia ◽  
Head And Neck Region ◽  
Chronic Inflammatory Disorder ◽  
Reactive Hyperplasia

Kimura’s disease is a rare chronic inflammatory disorder present in 2nd and 3rd decade. It has a predilection for head and neck region presenting as a slowly growing painless swelling. It is usually accompanied by peripheral eosinophilia and elevated serum IgE and hence it was initially thought to be of allergic origin. Histologically the lesions are characterized by reactive hyperplasia of lymph nodes, eosinophilic infiltration and increase in postcapillary venules. Authors have reported a male patient with a slowly growing right sided neck swelling which is recurring even after course of steroids and excision done twice at an interval of 6 months. Kimura’s disease although a benign Lymphoid disorder but the incidence of recurrence despite taking treatment is a cause of much concern for the patient.

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