Studies on the Role of circRNAs in Osteoarthritis

BioMed Research International ◽

10.1155/2021/8231414 ◽

2021 ◽

Vol 2021 ◽

pp. 1-10

Author(s):

Wei Wu ◽

Jun Zou

Keyword(s):

Signaling Pathways ◽

Biological Indicator ◽

Regulatory Effect ◽

Inclusion Criteria ◽

Absorption Effect ◽

Future Studies ◽

Protein Protein Interaction ◽

Papillomavirus Infection ◽

Edge Size

Objective. Provide a reference to elucidate the mechanism of circRNAs regulating osteoarthritis (OA) and the clinical treatment. Methods. Herein, articles about circRNAs (hsa-circ) and osteoarthritis in the recent 5 years have been reviewed and the differential expression and regulatory effect of circRNAs in OA deduced. Based on these conclusions and Protein-Protein Interaction (PPI), Gene Ontology (GO), and Kyoto Encyclopedia of Genes and Genomes (KEGG) analyses of the acquired circRNAs, the potential functions and interactions of circRNAs in OA and the involved signaling pathways are discussed. Results. A total of 33 studies meeting the inclusion criteria were included in this study, and 27 circRNAs were upregulated and 8 circRNAs were downregulated in OA. A total of 31 circRNAs were finally included in the PPI, GO, and KEGG analyses. From PPI, 12 map nodes and 7 map edges were interrelated. VWF had the biggest node and edge size. From GO, VWF showed a majority of the functions. From KEGG, circRNAs are enriched in PI3K/AKT, human papillomavirus infection (HPI), and focal adhesion (FA) pathways, and VWF was involved in major pathways. Conclusion. We found that most articles about circRNAs regulating OA in the recent 5 years focused on the mechanism, especially the absorption effect of circ-miRNA as sponges in the recent 2 years, while most of the articles about their functions addressed ECM and PI3K, AKT, and mTOR signaling pathways. Future studies might focus on the functions of circRNAs, and circRNA VWF, with preferable functions, interactions, and involvement, can be used as a biological indicator to detect OA in clinical practice.

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Development and validation of a yoga module for Parkinson disease

Journal of Complementary and Integrative Medicine ◽

10.1515/jcim-2015-0112 ◽

2017 ◽

Vol 14 (3) ◽

Cited By ~ 3

Author(s):

Noopur Kakde ◽

Kashinath G. Metri ◽

Shivarama Varambally ◽

Raghuram Nagaratna ◽

H.R. Nagendra

Keyword(s):

Quality Of Life ◽

Data Analysis ◽

Parkinson Disease ◽

Content Validity ◽

Poor Quality ◽

Inclusion Criteria ◽

Future Studies ◽

Development And Validation

AbstractBackgroundParkinson’s disease (PD), a progressive neurodegenerative disease, affects motor and nonmotor functions, leading to severe debility and poor quality of life. Studies have reported the beneficial role of yoga in alleviating the symptoms of PD; however, a validated yoga module for PD is unavailable. This study developed and validated an integrated yoga module(IYM) for PD.MethodsThe IYM was prepared after a thorough review of classical yoga texts and previous findings. Twenty experienced yoga experts, who fulfilled the inclusion criteria, were selected validating the content of the IYM. A total of 28 practices were included in the IYM, and each practice was discussed and rated as (i) not essential, (ii) useful but not essential, and (iii) essential; the content validity ratio (CVR) was calculated using Lawshe’s formula.ResultsData analysis revealed that of the 28 IYM practices, 21 exhibited significant content validity (cut-off value: 0.42, as calculated by applying Lawshe’s formula for the CVR).ConclusionsThe IYM is valid for PD, with good content validity. However, future studies must determine the feasibility and efficacy of the developed module.

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Lipid Modifications in Cilia Biology

Journal of Clinical Medicine ◽

10.3390/jcm8070921 ◽

2019 ◽

Vol 8 (7) ◽

pp. 921 ◽

Cited By ~ 3

Author(s):

Kasturi Roy ◽

Ethan P. Marin

Keyword(s):

Protein Stability ◽

Signaling Pathways ◽

Protein Trafficking ◽

Specific Protein ◽

Signaling Cascades ◽

Cellular Structures ◽

Future Studies ◽

Lipid Modifications ◽

Ciliary Protein

Cilia are specialized cellular structures with distinctive roles in various signaling cascades. Ciliary proteins need to be trafficked to the cilium to function properly; however, it is not completely understood how these proteins are delivered to their final localization. In this review, we will focus on how different lipid modifications are important in ciliary protein trafficking and, consequently, regulation of signaling pathways. Lipid modifications can play a variety of roles, including tethering proteins to the membrane, aiding trafficking through facilitating interactions with transporter proteins, and regulating protein stability and abundance. Future studies focusing on the role of lipid modifications of ciliary proteins will help our understanding of how cilia maintain specific protein pools strictly connected to their functions.

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Development and validation of a Yoga module for Primary dysmenorrhoea

Journal of Ayurveda and Integrated Medical Sciences (JAIMS) ◽

10.21760/jaims.5.4.4 ◽

2020 ◽

Vol 5 (04) ◽

pp. 21-25

Author(s):

Vijaya kumar PS ◽

Manjushree N ◽

Sahana AU

Keyword(s):

Adolescent Girls ◽

Content Validity ◽

Management Tool ◽

Inclusion Criteria ◽

Future Studies ◽

Primary Dysmenorrhoea ◽

Safe Management ◽

Considerable Morbidity ◽

Development And Validation

Menstrual pain without organic pathology is considered to be primary dysmenorrhoea. Dysmenorrhoea refers to the occurrence of painful menstrual cramps of uterine origin. It is a common gynaecological condition with considerable morbidity affecting majority of the adolescent girls, yet which is under diagnosed and under treated. Yoga can be considered as a simple and safe management tool for Primary Dysmenorrhoea. Studies have reported the beneficial role of Yoga in alleviating the symptoms of Primary dysmenorrhoea; however, a validated Yoga module for Primary dysmenorrhoea is unavailable. This study developed and validated an integrated Yoga module (IYM) for Primary dysmenorrhoea. Methods: The IYM was prepared after a thorough review of classical Yoga texts and previous findings. Twenty experienced Yoga experts, who fulfilled the inclusion criteria, were selected validating the content of the IYM. A total of 38 practices were included in the IYM, and each practice was discussed and rated as (i) not essential, (ii) useful but not essential, and (iii) essential; the content validity ratio (CVR) was calculated using Lawshe’s formula. Results: Data analysis revealed that of the 38 IYM practices, 18 exhibited significant content validity (cut-off value: 0.42, as calculated by applying Lawshe’s formula for the CVR). Conclusion: The IYM is valid for Primary dysmenorrhoea, with good content validity. However, future studies must determine the feasibility and efficacy of the developed module.

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Mesophyll conductance: the leaf corridors for photosynthesis

Biochemical Society Transactions ◽

10.1042/bst20190312 ◽

2020 ◽

Vol 48 (2) ◽

pp. 429-439 ◽

Cited By ~ 3

Author(s):

Jorge Gago ◽

Danilo M. Daloso ◽

Marc Carriquí ◽

Miquel Nadal ◽

Melanie Morales ◽

...

Keyword(s):

Molecular Mechanisms ◽

Current Knowledge ◽

Main Role ◽

Mesophyll Conductance ◽

Future Studies ◽

Cell Structures ◽

Leaf Tissues ◽

Change Framework ◽

Chloroplast Stroma

Besides stomata, the photosynthetic CO2 pathway also involves the transport of CO2 from the sub-stomatal air spaces inside to the carboxylation sites in the chloroplast stroma, where Rubisco is located. This pathway is far to be a simple and direct way, formed by series of consecutive barriers that the CO2 should cross to be finally assimilated in photosynthesis, known as the mesophyll conductance (gm). Therefore, the gm reflects the pathway through different air, water and biophysical barriers within the leaf tissues and cell structures. Currently, it is known that gm can impose the same level of limitation (or even higher depending of the conditions) to photosynthesis than the wider known stomata or biochemistry. In this mini-review, we are focused on each of the gm determinants to summarize the current knowledge on the mechanisms driving gm from anatomical to metabolic and biochemical perspectives. Special attention deserve the latest studies demonstrating the importance of the molecular mechanisms driving anatomical traits as cell wall and the chloroplast surface exposed to the mesophyll airspaces (Sc/S) that significantly constrain gm. However, even considering these recent discoveries, still is poorly understood the mechanisms about signaling pathways linking the environment a/biotic stressors with gm responses. Thus, considering the main role of gm as a major driver of the CO2 availability at the carboxylation sites, future studies into these aspects will help us to understand photosynthesis responses in a global change framework.

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POPDC proteins and cardiac function

Biochemical Society Transactions ◽

10.1042/bst20190249 ◽

2019 ◽

Vol 47 (5) ◽

pp. 1393-1404 ◽

Cited By ~ 4

Author(s):

Thomas Brand

Keyword(s):

Potential Role ◽

Striated Muscle ◽

Short Review ◽

Effector Proteins ◽

Muscle Disease ◽

Disease Genes ◽

Protein Protein Interaction ◽

Interaction Partners ◽

And Function

Abstract The Popeye domain-containing gene family encodes a novel class of cAMP effector proteins in striated muscle tissue. In this short review, we first introduce the protein family and discuss their structure and function with an emphasis on their role in cyclic AMP signalling. Another focus of this review is the recently discovered role of POPDC genes as striated muscle disease genes, which have been associated with cardiac arrhythmia and muscular dystrophy. The pathological phenotypes observed in patients will be compared with phenotypes present in null and knockin mutations in zebrafish and mouse. A number of protein–protein interaction partners have been discovered and the potential role of POPDC proteins to control the subcellular localization and function of these interacting proteins will be discussed. Finally, we outline several areas, where research is urgently needed.

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Motives for Social Isolation Following a Negative Emotional Episode

Swiss Journal of Psychology ◽

10.1024/1421-0185/a000211 ◽

2018 ◽

Vol 77 (3) ◽

pp. 127-131

Author(s):

Gérald Delelis ◽

Véronique Christophe

Keyword(s):

Social Isolation ◽

Social Affiliation ◽

Semantic Categorization ◽

Future Studies ◽

Cognitive Regulation ◽

Emotional Event ◽

Regulation Strategies ◽

Emotional Events

Abstract. After experiencing an emotional event, people either seek out others’ presence (social affiliation) or avoid others’ presence (social isolation). The determinants and effects of social affiliation are now well-known, but social psychologists have not yet thoroughly studied social isolation. This study aims to ascertain which motives and corresponding regulation strategies participants report for social isolation following negative emotional events. A group of 96 participants retrieved from memory an actual negative event that led them to temporarily socially isolate themselves and freely listed up to 10 motives for social isolation. Through semantic categorization of the 423 motives reported by the participants, we found that “cognitive clarification” and “keeping one’s distance” – that is, the need for cognitive regulation and the refusal of socioaffective regulation, respectively – were the most commonly and quickly reported motives for social isolation. We discuss the findings in terms of ideas for future studies aimed at clarifying the role of social isolation in health situations.

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