scholarly journals Improved Quantitative Susceptibility Mapping under Laplace Algorithm in Diagnosis of Parkinson’s Disease

2021 ◽  
Vol 2021 ◽  
pp. 1-9
Author(s):  
Guangxi Chen ◽  
Liang Zeng ◽  
Liu Yang ◽  
Yixian Yu ◽  
Panli Sun ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Magnetic Susceptibility ◽  
Image Quality ◽  
Diagnostic Accuracy ◽  
Susceptibility Mapping ◽  
Control Group ◽  
Dice Similarity Coefficient ◽  
Quantitative Susceptibility Mapping ◽  
Experimental Group

To explore the application value of quantitative susceptibility mapping (QSM) based on Laplace algorithm in the diagnosis of Parkinson’s disease, 48 Parkinson’s disease patients admitted to our hospital were included as the research objects. They were randomly divided into control group (24 cases) and experimental group (24 cases). All patients underwent quantitative magnetic susceptibility imaging scan. In the experimental group, the improved Laplace algorithm was used for QSM diagnosis, while in the control group, conventional QSM diagnosis was used. Through calculations of precision, recall, dice similarity coefficient, intersection-over-union (IoU), and area under the curve (AUC), the quality improvement effect of the improved Laplace algorithm for QSM image was assessed. Then, the diagnostic accuracy of the algorithm was verified by comparing with the results of QSM image diagnosis in Parkinson’s patients without algorithm processing. The results showed that compared with the traditional Laplace algorithm, the improved Laplace algorithm can considerably reduce the image noise level ( P < 0.05 ). The dice, IoU, precision, and recall rate of image quality evaluation indicator were considerably improved ( P < 0.05 ), and the AUC reached 0.896. There were no significant differences in fraction anisotropy (FA) and mean diffusivity (MD) between the two groups ( P > 0.05 ) and no significant differences in magnetic susceptibility of brain nuclei between the two groups ( P > 0.05 ). However, they all showed high magnetic susceptibility in the substantia nigra region of the brain. Compared with the control group, the diagnostic accuracy of the experimental group was 97.5 ± 1.23%, which was considerably higher than that of the control group (86.5 ± 3.56%) ( P < 0.05 ). In short, the image quality of QSM based on Laplace improved algorithm was greatly improved, and the diagnostic accuracy of PD was also greatly improved, which was worthy of promotion in the field of clinical QSM imaging diagnosis of PD.

Quantitative susceptibility mapping as a biomarker for evaluating white matter alterations in Parkinson’s disease

2018 ◽  
Vol 13 (1) ◽  
pp. 220-231 ◽  
Author(s):  
Xiaojun Guan ◽  
Peiyu Huang ◽  
Qiaoling Zeng ◽  
Chunlei Liu ◽  
Hongjiang Wei ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
White Matter ◽  
Susceptibility Mapping ◽  
Quantitative Susceptibility Mapping

Effects of a core stabilization training program on balance ability in persons with Parkinson’s disease: a randomized controlled trial

2020 ◽  
Vol 34 (6) ◽  
pp. 764-772
Author(s):  
Irene Cabrera-Martos ◽  
Ana Teresa Jiménez-Martín ◽  
Laura López-López ◽  
Janet Rodríguez-Torres ◽  
Araceli Ortiz-Rubio ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Center Of Pressure ◽  
Dynamic Balance ◽  
Controlled Trial ◽  
Core Stability ◽  
Control Group ◽  
Balance Confidence ◽  
Balance Ability ◽  
Experimental Group

Objective: To explore the effects of an eight-week core stability program on balance ability in persons with Parkinson’s disease. Design: Randomized controlled trial. Setting: A local Parkinson’s association. Subjects: A total of 44 participants with a clinical diagnosis of Parkinson’s disease were randomly assigned to an experimental ( n = 22) or control group ( n = 22). Intervention: The experimental group received 24 sessions of core training, while the control group received an intervention including active joint mobilization, muscle stretching, and motor coordination exercises. Main measures: The primary outcome measure was dynamic balance evaluated using the Mini-Balance Evaluation Systems Test. Secondary outcomes included the balance confidence assessed with the Activities-specific Balance Confidence Scale and standing balance assessed by the maximal excursion of center of pressure during the Modified Clinical Test of Sensory Interaction on Balance and the Limits of Stability test. Results: After treatment, a significant between-group improvement in dynamic balance was observed in the experimental group compared to the control group (change, 2.75 ± 1.80 vs 0.38 ± 2.15, P = 0.002). The experimental group also showed a significant improvement in confidence (change, 16.48 ± 16.21 vs 3.05 ± 13.53, P = 0.047) and maximal excursion of center of pressure in forward (change, 0.86 ± 1.89 cm vs 0.17 ± 0.26 cm, P = 0.048), left (change, 0.88 ± 2.63 cm vs 0.07 ± 0.48 cm, P = 0.010), and right (change, 1.63 ± 2.82 cm vs 0.05 ± 0.17 cm, P = 0.046) directions of limits of stability compared to the control group. Conclusion: A program based on core stability in comparison with non-specific exercise benefits dynamic balance and confidence and increases center of mass excursion in patients with Parkinson’s disease.

scholarly journals Leap motion controlled video game-based therapy for upper limb rehabilitation in patients with Parkinson’s disease: a feasibility study

2019 ◽  
Vol 16 (1) ◽  
Author(s):  
Pilar Fernández-González ◽  
María Carratalá-Tejada ◽  
Esther Monge-Pereira ◽  
Susana Collado-Vázquez ◽  
Patricia Sánchez-Herrera Baeza ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Feasibility Study ◽  
Upper Limb ◽  
Serious Games ◽  
Post Treatment ◽  
Control Group ◽  
Leap Motion ◽  
Affected Side ◽  
Experimental Group

Abstract Background Non-immersive video games are currently being used as technological rehabilitation tools for individuals with Parkinson’s disease (PD). The aim of this feasibility study was to evaluate the effectiveness of the Leap Motion Controller® (LMC) system used with serious games designed for the upper limb (UL), as well as the levels of satisfaction and compliance among patients in mild-to-moderate stages of the disease. Methods A non-probabilistic sampling of non-consecutive cases was performed. 23 PD patients, in stages II-IV of the Hoehn & Yahr scale, were randomized into two groups: an experimental group (n = 12) who received treatment based on serious games designed by the research team using the LMC system for the UL, and a control group (n = 11) who received a specific intervention for the UL. Grip muscle strength, coordination, speed of movements, fine and gross UL dexterity, as well as satisfaction and compliance, were assessed in both groups pre-treatment and post-treatment. Results Within the experimental group, significant improvements were observed in all post-treatment assessments, except for Box and Blocks test for the less affected side. Clinical improvements were observed for all assessments in the control group. Statistical intergroup analysis showed significant improvements in coordination, speed of movements and fine motor dexterity scores on the more affected side of patients in the experimental group. Conclusions The LMC system and the serious games designed may be a feasible rehabilitation tool for the improvement of coordination, speed of movements and fine UL dexterity in PD patients. Further studies are needed to confirm these preliminary findings.

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