scholarly journals Positive Association between Triglyceride-Rich Lipoprotein Cholesterol and Diabetes Mellitus in Hypertensive Patients

2021 ◽  
Vol 2021 ◽  
pp. 1-8
Author(s):  
Wei Zhou ◽  
Yu Yu ◽  
Lingjuan Zhu ◽  
Wangsheng Fang ◽  
Yu Tao ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Healthy Lifestyle ◽  
Positive Association ◽  
Hdl Cholesterol ◽  
Study Data ◽  
Lipoprotein Cholesterol ◽  
Lipid Lowering ◽  
Hypertensive Patients ◽  
Triglyceride Rich Lipoprotein ◽  
New Strategy

Background. The association between triglyceride-rich lipoprotein cholesterol (TRL-C) and diabetes mellitus (DM) remains unclear because of limited research and data. The aim of this study was to explore the independent association between TRL-C and DM in hypertensive patients and to examine whether a healthy lifestyle would have an impact on this relationship. Methods. In this study, data from 13,721 hypertensive patients who were not treated with lipid-lowering drugs were analyzed. TRL-C was calculated from total cholesterol (TC) minus [LDL cholesterol + HDL cholesterol]. DM was defined as fasting plasma glucose of ≥7.0 mmol/L and/or self-reported history of hypoglycemic drug use. Results. After adjusting for potential confounding factors, the TRL-C was significantly positively associated with elevated DM (odds ratio (OR): 1.73 and 95% confidence interval (CI): 1.54–1.94). In subgroup analysis, a healthy lifestyle (HL) failed to modify the positive association between TRL-C and DM (HL: OR 1.93, 95%CI 1.58–2.36; non-HL: OR 1.72, 95%CI 1.50–1.98; P for interaction = 0.38). Conclusion. The results showed a positive association between TRL-C and DM in hypertensive patients. A healthy lifestyle failed to diminish the relationship between TRL-C and DM. The novel findings indicate that TRL-C might be a reliable marker of DM and may provide a new strategy for the prevention and treatment of DM.

scholarly journals A U-Shaped Association between LDL-C/HDL-C Ratio and all-Cause Mortality in Elderly Hypertensive Patients: A Prospective Cohort Study

2020 ◽  
Author(s):  
Yu Yu ◽  
Minghui Li ◽  
Xiao Huang ◽  
Wei Zhou ◽  
Tao Wang ◽  
...  
Keyword(s):  
Reference Group ◽  
Survival Curve ◽  
Density Lipoprotein ◽  
Lipoprotein Cholesterol ◽  
Lipid Lowering ◽  
Hypertensive Patients ◽  
All Cause Mortality ◽  
Elderly Hypertensive ◽  
Elderly Hypertensive Patients

Abstract Background: Low-density lipoprotein cholesterol/high-density lipoprotein- cholesterol (LDL-C/HDL-C) ratio is an excellent predictor of cardiovascular disease (CVD). However, previous studies linking LDL-C/HDL-C ratio to mortality have been inconsistent and limited by short follow-up. Therefore, the aim of the present study was to determine whether LDL-C/HDL-C ratio could be an effective predictor of all-cause mortality in elderly hypertensive patients.Methods: We selected 6,941 hypertensive patients aged 65 years or older and untreated with lipid-lowering drugs from the Chinese Hypertension Registry for analysis. The endpoint of the study was all-cause mortality. The relationship between LDL-C/HDL-C ratio and all-cause mortality by using multivariate cox proportional hazards regression, smoothing curve fitting (penalized spline method), subgroup analysis and Kaplan–Meier survival curve to address.Results: During a median follow-up of 1.72 years, 157 all-cause deaths occurred. A U-shaped association was found between LDL-C/HDL-C ratio and all-cause mortality. The LDL-C/HDL-C ratio was divided into five groups according to quintiles. Compared to the reference group (Q3: 1.67-2.10), both lower (Q1 and Q2) and higher (Q4 and Q5) LDL-C/HDL-C ratios were associated with higher all-cause mortality (<1.67: HR 1.81, 95% CI: 1.08-3.03; ≥2.10: HR 2.00, 95% CI: 1.18-3.39). Compare with lower and higher LDL-C/HDL-C ratio groups, patients with LDL-C/HDL-C ratio of 1.67-2.10 had a significant higher survival probability (log-rank P = 0.038).Conclusion: Our results suggested that there was a U-shaped association between LDL-C/HDL-C ratio and all-cause mortality. Both lower and higher LDL-C/HDL-C ratios were associated with increased all-cause mortality in elderly hypertensive patients.

scholarly journals Increase in Pulse Pressure Relates to Diabetes Mellitus and Low HDL Cholesterol, but Not to Hyperlipidemia in Hypertensive Patients Aged 50 Years or Older.

2002 ◽  
Vol 25 (3) ◽  
pp. 335-341 ◽  
Author(s):  
Takako MIYAGI ◽  
Hiromi MURATANI ◽  
Yorio KIMURA ◽  
Koshiro FUKIYAMA ◽  
Yuhei KAWANO ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Pulse Pressure ◽  
Hdl Cholesterol ◽  
Hypertensive Patients ◽  
Low Hdl

scholarly journals Evaluation of Serum HDL and LDL levels in Type II Diabetes Mellitus

2013 ◽  
Vol 1 (1) ◽  
pp. 21 ◽  
Author(s):  
K R Joshi ◽  
K K Hiremath ◽  
S P Gupta
Keyword(s):  
Diabetes Mellitus ◽  
Type Ii Diabetes ◽  
Ldl Cholesterol ◽  
Low Density Lipoprotein ◽  
Density Lipoprotein ◽  
Hdl Cholesterol ◽  
Type Ii Diabetes Mellitus ◽  
Lipoprotein Cholesterol ◽  
Control Group ◽  
Type Ii

  Introduction: Diabetes mellitus is a type of metabolic disorder characterized by hyperglycemia resulting from defect in insulin secretion, insulin action or both. This study intended to compare High Density Lipoprotein Cholesterol (HDL) and Low Density Lipoprotein Cholesterol (LDL) profile between type II diabetic and non-diabetic subjects and also find the correlation between HDL and LDL cholesterol in type II diabetic.   Methods: The study was conducted on 100 total subjects out of which experimental group with 50 subjects of known Type II Diabetes mellitus and control group with 50 subjects.   Results: The result of the present study suggests that fasting blood sugar and LDL cholesterol levels were increased but HDL cholesterol level was reduced in type II diabetic subjects when compared to controls.   Conclusion: The estimation of HDL cholesterol and LDL cholesterol in type II diabetes mellitus is very useful as it may serve as a useful parameter to monitor the prognosis of the patient.

scholarly journals Usage of plasmapheresis in combined therapy of diabetics

1994 ◽  
Vol 40 (5) ◽  
pp. 13-16
Author(s):  
Ye. I. Sokolov ◽  
S. V. Podachina ◽  
V. I. Zabotnov ◽  
Ye. B. Zanina
Keyword(s):  
Diabetes Mellitus ◽  
Blood Plasma ◽  
Density Lipoprotein ◽  
Lipoprotein Cholesterol ◽  
Lipid Lowering ◽  
Erythrocyte Membranes ◽  
Side Reactions ◽  
Type I ◽  
Patients With Diabetes ◽  
Insulin Dependent

Clinical observations have repeatedly proved that myocardial infarction in patients with diabetes mellitus (DM) is much more difficult, gives greater mortality, its complications such as acute heart failure, arrhythmia, and relapses are more often observed. The basis of the atherosclerotic process both in diabetes and without it, the main place is given to hyperlipoproteinemia (hypercholesterolemia, hypertriglyceridemia and hypoalpha-cholesterolemia). Most patients with severe type I diabetes mellitus (insulin-dependent, IDDM) and type II diabetes mellitus (non-insulin-dependent, NIDDM) showed an increase in plasma levels of low and very low density lipoprotein cholesterol (cholesterol-LDL and cholesterol-VLDL, respectively) and a decrease high density lipoprotein cholesterol (HDL-C; anti-atherogenic factor). The use of lipid-lowering drugs for the correction of hyperlipoproteinemia in patients with diabetes is often ineffective or the effect obtained is short-term in nature, side reactions often develop. In recent years, in order to reduce the level of lipids in blood plasma (coronary heart disease, familial hypercholesterolemia, etc.), extracorporeal methods aimed at massive removal of the plasma lipid pool have begun to be used. According to the authors, the rapid and massive removal of atherogenic lipid fractions from plasma contributes to the release of the steroid from the tissue pool. In the pathogenesis of the development of vascular complications in patients with IDDM and NIDDM, a significant place is given to dysfunction of erythrocyte membranes. Functional disorders are directly dependent on violations of the structure of membrane lipids. Changes in the structure of the lipid bilayer of the erythrocyte membrane in patients with diabetes contribute to increased microviscosity of membranes, reduced deformability, and hinder their passage through the microcirculation system, which can be the cause of tissue hypoxia and one of the links in the pathogenesis of angiopathy in patients with diabetes. The aim of this work was to study the possible correction of the lipid spectrum of blood plasma and erythrocyte membranes in patients with diabetes when the plasmapheresis method is included in the complex therapy.

scholarly journals A U-shaped association between the LDL-cholesterol to HDL-cholesterol ratio and all-cause mortality in elderly hypertensive patients: a prospective cohort study

2020 ◽  
Vol 19 (1) ◽  
Author(s):  
Yu Yu ◽  
Minghui Li ◽  
Xiao Huang ◽  
Wei Zhou ◽  
Tao Wang ◽  
...  
Keyword(s):  
Reference Group ◽  
Survival Curve ◽  
Density Lipoprotein ◽  
Lipoprotein Cholesterol ◽  
Lipid Lowering ◽  
Hypertensive Patients ◽  
All Cause Mortality ◽  
Elderly Hypertensive ◽  
Elderly Hypertensive Patients

Abstract Background The low-density lipoprotein cholesterol/high-density lipoprotein- cholesterol (LDL-C/HDL-C) ratio is an excellent predictor of cardiovascular disease (CVD). However, previous studies linking the LDL-C/HDL-C ratio to mortality have yielded inconsistent results and been limited by short follow-up periods. Therefore, the aim of the present study was to determine whether the LDL-C/HDL-C ratio could be an effective predictor of all-cause mortality in elderly hypertensive patients. Methods A total of 6941 hypertensive patients aged 65 years or older who were not treated with lipid-lowering drugs were selected from the Chinese Hypertension Registry for analysis. The endpoint of the study was all-cause mortality. The relationship between the LDL-C/HDL-C ratio and all-cause mortality was determined using multivariate Cox proportional hazards regression, smoothing curve fitting (penalized spline method), subgroup analysis and Kaplan–Meier survival curve analysis. Results During a median follow-up of 1.72 years, 157 all-cause deaths occurred. A U-shaped association was found between the LDL-C/HDL-C ratio and all-cause mortality. Patients were divided according to the quintiles of the LDL-C/HDL-C ratio. Compared to the reference group (Q3: 1.67–2.10), patients with both lower (Q1 and Q2) and higher (Q4 and Q5) LDL-C/HDL-C ratios had higher all-cause mortality (< 1.67: HR 1.81, 95% CI: 1.08–3.03; ≥2.10: HR 2.00, 95% CI: 1.18–3.39). Compared with the lower and higher LDL-C/HDL-C ratio groups, patients with LDL-C/HDL-C ratios of 1.67–2.10 had a significantly higher survival probability (log-rank P = 0.038). Conclusions The results suggest that there is a U-shaped association between the LDL-C/HDL-C ratio and all-cause mortality. Both lower and higher LDL-C/HDL-C ratios were associated with increased all-cause mortality in elderly hypertensive patients.

Abstract P197: The Relationship Between Thyroid-Stimulating Hormone Levels and Lipoprotein Subfractions in the Brazilian Longitudinal Study of Adult Health (ELSA-Brasil)

Circulation ◽  
2018 ◽  
Vol 137 (suppl_1) ◽  
Author(s):  
Erique J Peixoto-Miranda ◽  
Alessandra C Goulart ◽  
Marcio S Bittencourt ◽  
Michael Blaha ◽  
Steven Jones ◽  
...  
Keyword(s):  
Longitudinal Study ◽  
Multinomial Logistic Regression ◽  
Thyroid Stimulating Hormone ◽  
Lipoprotein Cholesterol ◽  
Lipid Lowering ◽  
Adult Health ◽  
Middle Aged ◽  
Lipoprotein Subfractions ◽  
Triglyceride Rich Lipoprotein ◽  
Stimulating Hormone

Background and purpose: Although the relation between thyroid disorders and heart diseases had been described since decades ago, the association of thyroid-stimulating hormone (TSH) and lipoproteins is not very well elucidated. Hypothesis: to verify if there are associations with TSH levels, lipid and lipoprotein subfractions in the Brazilian Longitudinal Study of Adult Health (ELSA-Brasil). Methods: We evaluated at the ELSA-Brasil baseline (2008-2010) 3,742 middle-aged participants (1,960 women and 1,782 women) without previous cardiovascular disease and people who were taking neither drugs that can interfere with thyroid function nor lipid-lowering agents. All of them had their levels of total-cholesterol and its sub-fractions (LDL, VLDL and HDL subclasses); triglycerides and triglyceride-rich lipoprotein cholesterol [TRL-C (VLDL1+2-C VLDL3-C + IDL-C)] determined by ultracentrifugation (Vertical Auto Profile, Atherotech). We also calculated T-Chol/HDL-C and triglycerides/HDL-C ratios. The application multinomial logistic regression model obtained odds ratios (OR) with its respective 95% confidence interval (95% CI). They are presented as adjusted for age, sex, educational level, hypertension, diabetes, and smoking. Lipids tertiles were evaluated as dependent variables, the quintiles of TSH were considered as an independent variable, using first quintiles of TSH as the reference. Results: The main associations obtained were between the highest levels of TSH (5th quintile) with the highest levels (3rd tertiles) of VLDL-C, OR=1.55 (95%CI, 1.18-2.04); triglycerides, OR=1.71 (95%CI, 1.30-2.24); VLDL-3-C, OR=1.48 (95%CI, 1.13-1.94); TC/HDL-C ratio, OR=1.37 (95%CI; 1.04-1.81) and TG/HDL-C ratio, OR=1.71 (95%CI; 1.29-2.26). A positive association between the lowest levels of HDL3-C (1st tertile) and the highest of TSH was also verified with OR= 1.43 (95%CI, 1.10-1.87). In women, we found positive associations with the 5th TSH quintiles and the 3rd tertiles of VLDL-C, OR 1.68;(95%CI 1.18-2.41); non-HDL-C, OR,1.50; (95%CI,1.04-2.16); Triglyceride-rich Lipoprotein Cholesterol,OR 1.42 (95%CI 1.00-2.02); VLDL3-C (OR,1.68;95%CI 1.16-2.45), TC/HDL-C ratio (OR 1.86;95% CI 1.29-2.69) and TG/HDL-C-ratio (OR 1.62;95%CI 1.12-2.35). In men, we found associations between the 5th quintile of TSH and the 3rd tertiles of TG (OR 1.59; 95%CI 1.07-2.36) and TG/HDL-C-ratio (OR 1.71; 95%CI 1.15-2.55). Conclusions: In this sample of middle-aged participants from ELSA-Brasil, an unfavorable lipid profile, which included triglyceride-rich lipoproteins and their remnants were mostly associated with high levels of TSH. In the other hand, we observed a risky association between the lowest levels of HDL3-C and the highest levels of TSH. The majority of our findings were mainly reproduced among women.

scholarly journals Apolipoprotein B, Triglyceride-Rich Lipoproteins, and Risk of Cardiovascular Events in Persons with CKD

2019 ◽  
Vol 15 (1) ◽  
pp. 47-60 ◽  
Author(s):  
Julio Alejandro Lamprea-Montealegre ◽  
Natalie Staplin ◽  
William G. Herrington ◽  
Richard Haynes ◽  
Jonathan Emberson ◽  
...  
Keyword(s):  
Cardiovascular Events ◽  
Ldl Cholesterol ◽  
Hdl Cholesterol ◽  
Lipoprotein Cholesterol ◽  
Atherosclerotic Cardiovascular Disease ◽  
Vascular Events ◽  
Apo B ◽  
Increased Risk ◽  
Triglyceride Rich Lipoprotein ◽  
Log Ratio

Background and objectivesTriglyceride-rich lipoproteins may contribute to the high cardiovascular risk of patients with CKD. This study evaluated associations of apo-B and markers of triglyceride-rich lipoproteins with cardiovascular events in people with CKD.Design, setting, participants, & measurementsAnalyses were conducted in 9270 participants with CKD in the Study of Heart and Renal Protection (SHARP): 6245 not on dialysis (mean eGFR 26.5 ml/min per 1.73 m2), and 3025 on dialysis when recruited. Cox regression methods were used to evaluate associations of lipids with incident atherosclerotic and nonatherosclerotic vascular events, adjusting for demographics and clinical characteristics. Hazard ratios (HRs) were calculated per 1 SD higher level for apo-B, HDL cholesterol, LDL cholesterol, triglyceride-rich lipoprotein cholesterol (i.e., total cholesterol minus LDL cholesterol minus HDL cholesterol), non-HDL cholesterol, log triglyceride, and log ratio of triglyceride to HDL cholesterol.ResultsDuring a median follow-up of 4.9 years (interquartile range, 4.0–5.5 years), 1406 participants experienced at least one atherosclerotic vascular event. In multivariable adjusted models, positive associations with atherosclerotic vascular events were observed for apo-B (HR per 1 SD, 1.19; 95% confidence interval, 1.12 to 1.27), triglycerides (1.06; 1.00 to 1.13), the ratio of triglyceride to HDL cholesterol (1.10; 1.03 to 1.18), and triglyceride-rich lipoprotein cholesterol (1.14; 1.05 to 1.25). By contrast, inverse associations with nonatherosclerotic vascular events were observed for each of these lipid markers: apo-B (HR per 1 SD, 0.92; 0.85 to 0.98), triglycerides (0.86; 0.81 to 0.92), the ratio of triglyceride to HDL cholesterol (0.88; 0.82 to 0.94), and triglyceride-rich lipoprotein cholesterol (0.85; 0.77 to 0.94).ConclusionsHigher apo-B, triglycerides, ratio of triglyceride to HDL cholesterol, and triglyceride-rich lipoprotein cholesterol concentrations were associated with increased risk of atherosclerotic vascular events in CKD. Reducing triglyceride-rich lipoproteins using novel therapeutic agents could potentially lower the risk of atherosclerotic cardiovascular disease risk in the CKD population.

scholarly journals Control of Risk Factors for Cardiovascular Disease Among Adults with Previously Diagnosed Type 2 Diabetes Mellitus: A Descriptive Study from a Middle Eastern Arab Population

2012 ◽  
Vol 6 (1) ◽  
pp. 133-140 ◽  
Author(s):  
Jawad A Al-Lawati ◽  
Mohammed N. Barakat ◽  
Ibrahim Al-Zakwani ◽  
Medhat K. Elsayed ◽  
Masoud Al-Maskari ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Risk Factors ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Risk Factor ◽  
Density Lipoprotein ◽  
Lipoprotein Cholesterol ◽  
Lipid Lowering ◽  
Cvd Risk

Background: Despite the high burden of type 2 diabetes mellitus (T2DM) in Oman, there are scarce data from a nationally representative sample on the level of glycaemia and other cardiovascular (CVD) risk factor control. Objective: To estimate the proportion of patients with T2DM at goal for glycaemia and CVD risk factors using the National Diabetes Guidelines (NDG) and the American Diabetes Association (ADA) clinical care guidelines; and to assess the quality of selected services provided to patients with T2DM. Methods: A sample of 2,551 patients (47% men) aged ≥20 years with T2DM treated at primary health care centers was selected. Patient characteristics, medical history and treatment were collected from case notes, Diabetes Registers and computer frameworks including the use of the last 3 laboratory investigations results and blood pressure (BP) readings recorded in 2007. Results: The overall mean age of the cohort was 54±13 years with an average median duration of diabetes of 4 (range 2 to 6) years. Over 80% of patients were overweight or obese (body mass index (BMI) of ≥25 Kg/m2). Sixty-nine percent were on oral anti-diabetic medication, 52% on anti-hypertensives and 40% on lipid lowering drugs. Thirty percent of patients were at goal for glycosylated haemoglobin level (<7%), 26% for BP (systolic/diastolic <130/80 mmHg), 55% for total cholesterol (<5.2 mmol/l), 4.5% for low-density lipoprotein cholesterol (<1.8 mmol/l), 52% for high-density lipoprotein cholesterol (>1 mmol/l for men, >1.3 mmol/l for women), and 61% for triglycerides (<1.7 mmol/l). Over 37% had micro-albuminuria and 5% had diabetic nephropathy. Conclusion: Control of hyperglycaemia and other CVD risk factor appears to be suboptimal in Omani patients with T2DM and need to be addressed in the triad of patient, physician and health system.

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