scholarly journals Association between Serum Testosterone Levels and Body Composition among Men 20–59 Years of Age

2021 ◽  
Vol 2021 ◽  
pp. 1-8
Author(s):  
Jiajie Ye ◽  
Xiaojun Zhai ◽  
Jinxiao Yang ◽  
Zhongxin Zhu
Keyword(s):  
Body Composition ◽  
Linear Regression ◽  
Regression Model ◽  
Testosterone Level ◽  
Linear Regression Model ◽  
Serum Testosterone ◽  
Additive Models ◽  
Serum Testosterone Level ◽  
Testosterone Levels ◽  
Multivariable Linear Regression Model

Introduction. Sex hormones play an important role in the development and maintenance of bone and muscle mass. However, studies regarding serum testosterone levels, osteoporosis, and sarcopenia in men are relatively sparse and have led to contradictory conclusions. Therefore, this study aimed to investigate the association between serum testosterone levels and body composition, including bone mineral density (BMD), appendicular lean mass index (ALMI), and appendicular fat mass index (AFMI), among men 20–59 years of age through a cross-sectional analysis of the National Health and Nutrition Examination Survey. Materials and Methods. Our analysis was based on the data for 3,875 men, 20–59 years of age. Weighted multiple regression analyses were used to estimate the independent association between serum testosterone levels and body composition. Weighted generalized additive models and smooth curve fittings were used to characterize the nonlinear associations between them. Results. The association between the serum testosterone level and lumbar BMD was positive in each multivariable linear regression model. In the model adjusted for age and race, the serum testosterone level was negatively associated with ALMI. However, in the models adjusted for body mass index, this association became positive. In addition, the association between the serum testosterone level and AFMI was negative in each multivariable linear regression model. Conclusion. Our study demonstrated a positive association of serum testosterone level with lumbar BMD and ALMI, and a negative association with AFMI, among men 20–59 years of age, suggesting that increasing testosterone levels may be beneficial to skeletal health in young and middle-aged men with low testosterone levels.

Impact of Varicocele and Varicocele Surgery on Semen Quality, Erectile Function and Serum Hormone Levels

2018 ◽  
Vol 1 (1) ◽  
pp. 129-136
Author(s):  
Badereddin Mohamad Al-Ali ◽  
Emma Persad ◽  
Andreas Lunacek ◽  
Christof Mrstik ◽  
Eugen Plas
Keyword(s):  
Testosterone Level ◽  
Erectile Function ◽  
Semen Quality ◽  
Semen Analysis ◽  
Serum Testosterone ◽  
T Test ◽  
Serum Testosterone Level ◽  
Testosterone Levels ◽  
Group 2 ◽  
Group 1

Introduction: Many studies suggest that varicoceles are associated with hypogonadism and varicocele repair can increase testosterone levels and improve erectile function.Aim: The aim of this retrospective study was to analyze the impact of varicocele and varicocele surgery on testosterone level, semen quality, and erectile function.Methods: Our study included 265 infertile males with a clinical varicocele. This group was divided into three groups: group 1 (193) patients who did not receive surgery, group 2 (72 patients) who were operated on according to the Palomo procedure and group 3 (28 patients), who acted as a control group without a varicocele. All patients completed the International Index of Erectile Function IIEF-5 (German version) and underwent semen analysis. Serum testosterone, follicle stimulating hormone (FSH), and luteinizing hormone (LH) were measured at inclusion into the study and after surgery.Main outcome measures: Changes in semen quality, erectile function, and serum hormones after surgery.Results: The IIEF-5 scores in groups 1 and 2 were 21.01 ± 2.2; and 21.74 ± 1 respectively, and the resulting t-test for equality of variance was significant (p < 0.0001). Total testosterone level in groups 1 and 2 were 3.16 ± 0.37 and 3 ± 0.01, respectively, and the resulting t-test for equality of variance was significant (p < 0.0001). The results of the semen analysis were better in group 2 (after surgery) (28.6%, p < 0.001) in comparison to group 1. Interestingly, pre-operative serum testosterone levels were lower in patients with later improvement of semen analysis (p = 0.05). Body mass index (p = 0.8), pre-operative serum FSH (p = 0.9), LH (p = 0.2), and nicotine consumption (p = 0.6) were similar in both the group that saw improvement and the group with no change in semen quality.Conclusion: Semen quality improved in 28.6% of patients after varicocele surgery. Erectile dysfunction (ED) improved after varicocele surgery. We report that lower pre-operative serum testosterone level might be a possible indicator for successful surgical outcome.

Serum testosterone level and overall survival in first-line abiraterone and enzalutamide for metastatic castration-resistant prostate cancer patients.

2020 ◽  
Vol 38 (15_suppl) ◽  
pp. e17545-e17545
Author(s):  
Maysa Tamara Silveira Vilbert ◽  
Marcelle Goldner Cesca ◽  
Natasha Carvalho Pandolfi ◽  
Vinicius Fernando Calsavara ◽  
Bruno Cezar de Mendonça Uchôa ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Overall Survival ◽  
Testosterone Level ◽  
Serum Testosterone ◽  
Serum Testosterone Level ◽  
Castration Resistant Prostate Cancer ◽  
First Line ◽  
Testosterone Levels ◽  
Castration Resistant ◽  
Low Serum

e17545 Background: Androgen receptor-targeted agents Abiraterone and Enzalutamide (Abi/Ez) prolonged overall survival in metastatic castration resistant prostate cancer (mCRPC). Patients with very-low serum testosterone levels seem to have less benefit from these therapies as well as more aggressive prostate cancer. Methods: A retrospective observational cohort study was conducted to evaluate whether a serum testosterone measured at time of start first-line therapy with Abi/Ez is related to overall survival (OS) and time-to-treatment failure (TTF) in mCRPC patients. Kaplan-Meier survival estimates and Cox-regression models were used for time-to-event analyses. The best cut-off for testosterone was defined using Log-rank statistics (Lausen and Schumacher). X² test and Mann-Whitney U-test were applied to compare categorical and continuous variables, respectively. Logistic regression was used to assess characteristics related to serum testosterone levels. Statistical significance was fixed at 0.05. Results: From May 2012 to February 2017, 100 patients were assessed. Median follow-up was 27.8 months (range 2.23 to 68.26). Pts with a high testosterone level ( > 28.2; n = 20) achieved a significantly higher OS (median 66.0 vs 31.9 mo, testosterone > 28.2 HR: 0.206, 95% CI 0.074 to 0.571, p = 0.002) and TTF (median 30.6 vs 11.8 mo, testosterone > 28.2 HR: 0.408, 95%CI 0.219 to 0.762, p = 0.005) than pts with a low serum testosterone level ( < 28.2; n = 80), regardless of receiving therapy with either Abi (n = 69) or Ez (n = 31). Pts with a higher testosterone level were younger (median 67.7 vs 73.6 years; p = 0.026), had a higher body mass index (BMI) (28.5 vs 25.9, p = 0.023) and a lower PSA at start Abi/Ez (12 vs 26, p = 0.031) than pts with lower values. Age (OR 0.93, 95%CI 0.8 to 0.9, p = 0.021), BMI (OR 1.21, 95%CI 1.1 to 1.4, p = 0.006) and baseline PSA (OR 1.2, 95%CI 1.03 to 1.4, p = 0.020) were significantly associated with testosterone > 28.2. After 4 months of Abi/Ez treatment, PSA decrease > 50% of baseline was seen more frequently in high testosterone levels group than in low testosterone levels pts (90% vs 57.5% of pts, respectively, p = 0.007). Conclusions: Pts with high levels of testosterone ( > 28.2) achieved a better OS and TTF when treated with Abi/Ez in first-line mCRPC than those with low levels. Testosterone can be considered a prognostic and predictive biomarker in this scenario, and could be used in treatment decision for this population.

scholarly journals Comparison between complication rates of laser prostatectomy electrocautery transurethral resection of the prostate: A population-based study

2014 ◽  
Vol 8 (5-6) ◽  
pp. 419 ◽  
Author(s):  
Alexandre Larouche ◽  
Andreas Becker ◽  
Jonas Schiffmann ◽  
Florian Roghmann ◽  
Giorgio Gandaglia ◽  
...  
Keyword(s):  
Linear Regression ◽  
Regression Model ◽  
Transurethral Resection ◽  
Linear Regression Model ◽  
High Volume ◽  
Patient Characteristics ◽  
Population Based ◽  
Complication Rates ◽  
Prostate Hyperplasia ◽  
Multivariable Linear Regression Model

Introduction: We compare the complication rates and length of stay (LOS) of laser transurethral resection of the prostate (L-TURP) versus electrocautery transurethral resection of the prostate (E-TURP) in a population-based cohort. L-TURP has shown enhanced intraoperative safety and equivalent efficacy relative to E-TURP in several high volume centres.Methods: Relying on the Florida Datafile as part of the Healthcare Cost and Utilization Project State Inpatient Databases (SID) between 2006 and 2008, we identified 8066 men with benign prostate hyperplasia who underwent L-TURP or E-TURP. Chi-square and Mann-Whitney tests were used to compare baseline characteristics. A multivariable linear regression model was used to analyze the effect of L-TURP versus E-TURP on complication rates and LOS.Results: Overall complication rates did not differ significantly for L-TURP compared to E-TURP in univariable (8.8 vs. 7.4%, p = 0.1) and multivariable analyses (odds ratio [OR]: 1.06, confidence interval [CI]: 0.85-1.32, p = 0.6). Individuals undergoing E-TURP were less likely to experience a LOS in excess of 1 day (46.2 vs. 59.7%, p < 0.001). A lower risk to experience a LOS in excess of 1 day was confirmed for patients undergoing L-TURP after a multivariable linear regression model (OR: 0.37, CI: 0.23-0.58, p < 0.001), but not for a LOS in excess of 2 days (OR: 0.96, CI: 0.83-1.10, p = 0.2).Conclusions: Patient characteristics and perioperative safety were similar for L-TURP and E-TURP patients. However, LOS patterns demonstrated a modest benefit for L-TURP compared to E-TURP patients.

scholarly journals Prepubertal Serum Testosterone Concentration In Vembur Rams At Different Rearing System

2017 ◽  
Vol 12 (4) ◽  
Author(s):  
R. Selvakkumar ◽  
T. Sivakumar ◽  
S. Ganesh Kumar ◽  
P. Anuradha
Keyword(s):  
Field Condition ◽  
Testosterone Level ◽  
Serum Testosterone ◽  
Serum Testosterone Level ◽  
Testosterone Concentration ◽  
Testosterone Levels ◽  
Ram Lambs ◽  
Age At Puberty

The present investigation was carried out to study the prepubertal testosterone pattern and age at puberty in Vembur rams reared under farm and farmers field condition. A total number of 8 Vembur ram lambs each from farm and farmers field were selected. The measurement of testosterone was performed by Radioimmunoassay (RIA). The serum testosterone level from 6th to 20th month of age ranged from 0.132 ± 0.04 to 3.823 ng/ml in semi intensively maintained farm males and 0.138±0.04 to 3.456±0.17 ng/ml in animals maintained at farmer’s holdings. The serum testosterone levels were crossing the concentration of 2.5 ng/ml at the age of 17 to 18th weeks and successful mounting, intromission and ejaculation were noticed after this age.

scholarly journals Multivariable Regression Equivalent Model of Interconnected Active Distribution Networks Based on Boundary Measurement

Energies ◽  
2019 ◽  
Vol 12 (12) ◽  
pp. 2339
Author(s):  
Zhang ◽  
Huang ◽  
Yang ◽  
Li
Keyword(s):  
Linear Regression ◽  
Regression Model ◽  
Linear Regression Model ◽  
Distribution Network ◽  
Distribution Networks ◽  
Equivalent Model ◽  
Boundary Node ◽  
Technical Problems ◽  
Multivariable Linear Regression Model ◽  
Multivariable Regression

With the increasing complexity of the active distribution network (ADN) due to distributed generation (DG) integration, together with the electricity market evolution, the traditional ADN is divided into multiple areas to operate independently. Due to technical problems or business privacy, the internal network regional control center cannot grasp the changes of the external regional network in time. In order to accurately reflect the distribution network operation state, a multivariable regression equivalent model is proposed in this paper. Firstly, the external network is made equivalent to a multi-port Norton model. The multivariable linear regression model is then derived based on the equivalent distribution network, and the regression model variables are constructed using boundary node information collected by the measurement equipment. Finally, the maximum likelihood estimation (MLE) is used to estimate the parameters of the multivariable linear regression model. Furthermore, case studies demonstrate the effectiveness and robustness of the proposed method, and detailed information of external ADN is unnecessary, except for the boundary node information. The proposed method can also be applied for three-phase unbalanced ADN efficiently.

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