scholarly journals Lack of Association of LPA Gene Polymorphisms with Coronary Artery Disease in Pakistani Subjects

2021 ◽  
Vol 2021 ◽  
pp. 1-5
Author(s):  
Saleem Ullah Shahid ◽  
Shabana N A ◽  
Steve Humphries
Keyword(s):  
Coronary Artery Disease ◽  
Coronary Artery ◽  
Disease Burden ◽  
Risk Allele ◽  
Allelic Discrimination Assay ◽  
Allelic Discrimination ◽  
Pakistani Population ◽  
Independent Risk Factors ◽  
Artery Disease ◽  
Control Study

Coronary artery disease (CAD) is the leading cause of death worldwide. Pakistan faces a high epidemic of CAD, and the disease burden is increasing with the passage of time. Several genetic markers have been reported to be significantly associated with CAD; one of them is the lipoprotein A gene. The aim of the current investigation was to genotype the LPA gene SNPs, rs3798220 and rs10455872, in Pakistani subjects with CAD in a case control study design. The genotyping was done by TaqMan allelic discrimination assay. The results showed that the cases had significantly higher prevalence of diabetes (64.6%), hypertension (62.1%), and smoking habits (29.5%). The level of cholesterol in cases was higher than in controls ( 208.25 ± 54.11 vs. 175.34 ± 43.51 , p ≤ 0.0001 ). The LDL-C was higher in cases than in controls ( 104.62 ± 37.94 vs. 77.05 ± 21.17 , p ≤ 0.0001 ). Similarly, triglycerides were also higher in cases than in controls ( 214.51 ± 74.60 vs. 190.54 ± 70.26 , p ≤ 0.0001 ), whereas HDL-C was lower in cases than in controls ( 45.13 ± 11.63 vs. 67.9 ± 17.57 , p ≤ 0.0001 ). For rs3798220, the risk allele (C) frequency was 0.005 in cases and 0.002 in controls. For rs10455872, the risk allele (G) frequency was 0.017 in cases and 0.014 in controls. The risk allele frequencies were not significantly different between cases and controls ( p > 0.05 ). In conclusion, these two LPA SNPs do not contribute significantly to CAD progression and cannot be used as independent risk factors for CAD in Pakistani population.

scholarly journals Independent assortment of GC gene polymorphism (rs2282679) and 25-hydroxyvitamin D levels in coronary artery disease

2018 ◽  
Vol 96 (4) ◽  
pp. 345-351
Author(s):  
Nada K. Sedky ◽  
Sally I. Hassanein ◽  
Mohamed Zakaria Gad
Keyword(s):  
Coronary Artery Disease ◽  
Vitamin D ◽  
Coronary Artery ◽  
Serum Levels ◽  
Allelic Discrimination Assay ◽  
Allelic Discrimination ◽  
Public Health Burden ◽  
Significant Difference ◽  
Artery Disease ◽  
Gc Gene

Coronary artery disease (CAD) remains a major public health burden. Emerging research has suggested an association between vitamin D insufficiency and CAD. Vitamin D binding protein (VDBP) is the primary vitamin D carrier and many of its genetic polymorphisms are able to induce the expression of proteins with different affinities for the vitamin, which in turn might affect its serum levels and CAD incidence. One hundred and twelve male patients, aged between 35 and 50 years, with verified CAD and 109 age- and sex-matched controls were recruited. Genotyping was performed by the TaqMan allelic discrimination assay and plasma 25(OH)D levels were assessed by HPLC-UV. Serum parathyroid hormone (s-PTH) and VDBP levels were measured using ELISA. s-25(OH)D levels in CAD patients were significantly lower than in the controls, whereas s-PTH levels were significantly higher in the CAD patients than in the controls. There was no significant difference in the distribution of GC genotypes among both groups. s-25(OH)D showed a weak inverse correlation with s-PTH levels. Serum levels of vitamin D and PTH are highly correlated with CAD incidence. However, the s-VDBP level is associated neither with disease outcome nor with vitamin D status. The GC gene variant has no effect on 25(OH)D levels.

scholarly journals PREMATURE CORONARY ARTERY DISEASE

2015 ◽  
Vol 22 (11) ◽  
pp. 1428-1437
Author(s):  
Wafa Munir Ansari ◽  
Abdul Khaliq Naveed ◽  
Dilshad Ahmed Khan
Keyword(s):  
Coronary Artery Disease ◽  
Coronary Artery ◽  
Risk Allele ◽  
Premature Coronary Artery Disease ◽  
Gene Score ◽  
Heart Study ◽  
Risk Snps ◽  
Artery Disease ◽  
Cad Risk ◽  
Control Study

Introduction: Genetic information which is specific to an individual has thepotential to improve Coronary Artery Disease (CAD) risk prediction. 13 CAD risk SNPs wereselected by removing SNPs in loci which had not been identified in CARDIoGRAMplusC4DGWAS. Linkage disequilibrium patterns differ between ethnic groups pointing towards theneed to investigate how the gene score would perform in different populations which is stilllargely unknown. Objective of the study was to investigate whether the 13 SNP CAD risk genescore has a role in the risk prediction of Pakistani Premature Coronary Artery Disease (CAD)cases and controls and to compare the CAD risk allele frequency between Pakistanis andCaucasians (samples obtained from the Northwick Park Heart Study II). Study Design: Casecontrolstudy. Setting: Army Medical College, National University of Sciences and Technology(NUST) in collaboration with the Cardiovascular Genetics Institute, University College London,UK. Materials and Methods: Total of 650 subjects with a history of chest pain were selected bynon-probability convenience sampling. Out of these subjects with > 70% stenosis in at least 1coronary vessel on angiography were labelled as Premature coronary Artery disease (PCAD)cases (n=340). The 13 SNPs were genotyped in a Pakistani case-control study (n=340 CADcases, 310 controls) using KASPar and Taqman assays. The use of 13 SNP gene score wastested in the prospective Northwick Park Heart Study (NPHSII) of 2775 healthy UK men (284cases) and the Pakistani case-control study subjects (n=650). Results: Mean ± SD age ofCAD patients was 42.7±3.80yrs while in controls it was 39.0±7.8yrs. Complete genotypingwas obtained for 635 samples (333 cases, 302 controls). The mean 13 SNP gene score wassignificantly higher in cases compared to controls (p=0.044). Odds ratio for CAD for eachquintile of 13 SNPs gene score showed a trend for higher quintiles of gene score to haveincreased odds ratio for CAD (p-value for trend=0.01) especially after adjusting for age, sexand ethnicity. There was a significant difference in risk allele frequency between Pakistanis andCaucasians (NPHSII) for all CAD risk SNPs except rs599839 (SORT1) (p=0.08). Conclusion:A 13 SNP gene score has significant potential role at differentiating between Pakistani PCADcases and controls. Risk allele frequencies for CAD differ significantly between Pakistanis andCaucasians stressing the need to develop population specific gene score keeping in view theethnic stratification.

scholarly journals Association of smoking with coronary artery disease in Nepalese populations: a case control study

2019 ◽  
Vol 8 (5) ◽  
pp. 677-685
Author(s):  
Til Bahadur Basnet ◽  
Cheng Xu ◽  
Manthar Ali Mallah ◽  
Wiwik Indayati ◽  
Cheng Shi ◽  
...  
Keyword(s):  
Risk Factors ◽  
Coronary Artery Disease ◽  
Risk Factor ◽  
Coronary Artery ◽  
Case Control Study ◽  
Case Control ◽  
Psychosocial Risk ◽  
Psychosocial Risk Factor ◽  
Artery Disease ◽  
Control Study

Abstract There are well-known traditional risk factors for coronary artery disease (CAD). Among them, smoking is one of the most prominent and modifiable risk factors. This study aims to determine the magnitude of smoking as a risk factor for CAD in the Nepalese population. A hospital-based age- and sex-matched case–control study was carried out with a total of 612 respondents. Bivariate analysis showed that the risk of developing CAD in ex-smokers and current smokers was higher (odds ratio (OR): 1.81 (confidence interval (CI): 1.21–2.7) and OR: 5.2 (CI: 3.4–7.97)), with p-values less than 0.004 and <0.00001, respectively, compared to the risk in never smokers. From stratified socio-demographic, cardio-metabolic, behavioural and psychosocial risk factor analysis, smoking was found to be associated with CAD in almost all subgroups. In the subsequent multivariate analysis, adjustment for socio-demographic, cardio-metabolic and psychosocial risk factors showed a steady increase in risk. However, further adjustment for behavioural risk factors (alcohol use and physical activity) showed that the risk was attenuated by 59% in current smokers. After adjusting for the covariates, current smokers and ex-smokers had an increased risk of CAD (OR: 6.64, 95% CI: 3.64–12.12, p < 0.00001; OR: 1.89, 95% CI: 1.08–3.31, p < 0.012, respectively) compared with non-smokers. In conclusion, smoking was found to increase the risk of CAD in the Nepalese population.

scholarly journals Association Between the Chromosome 9p21 Locus and Angiographic Coronary Artery Disease Burden

2013 ◽  
Vol 61 (9) ◽  
pp. 957-970 ◽  
Author(s):  
Kenneth Chan ◽  
Riyaz S. Patel ◽  
Paul Newcombe ◽  
Christopher P. Nelson ◽  
Atif Qasim ◽  
...  
Keyword(s):  
Coronary Artery Disease ◽  
Coronary Artery ◽  
Disease Burden ◽  
Chromosome 9P21 ◽  
Artery Disease ◽  
9P21 Locus

Distal-Vessel FFR-CT To Evaluate Cumulative Coronary Artery Disease Burden

2021 ◽  
Vol 15 (4) ◽  
pp. S23
Author(s):  
M. Chen ◽  
S. Almeida ◽  
K. Shaikh ◽  
C. Shekar ◽  
D. Dey ◽  
...  
Keyword(s):  
Coronary Artery Disease ◽  
Coronary Artery ◽  
Disease Burden ◽  
Artery Disease ◽  
Distal Vessel

Dietary inflammatory index and odds of coronary artery disease in a case-control study from Jordan

Nutrition ◽  
2019 ◽  
Vol 63-64 ◽  
pp. 98-105 ◽  
Author(s):  
Lana M. Agraib ◽  
Mohammed Azab ◽  
Abdel-Ellah Al-Shudifat ◽  
Sabika S. Allehdan ◽  
Nitin Shivappa ◽  
...  
Keyword(s):  
Coronary Artery Disease ◽  
Coronary Artery ◽  
Case Control Study ◽  
Case Control ◽  
Dietary Inflammatory Index ◽  
Inflammatory Index ◽  
Artery Disease ◽  
Control Study
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