scholarly journals Antioxidant Effect of Polygonatum sibiricum Polysaccharides in D-Galactose-Induced Heart Aging Mice

2021 ◽  
Vol 2021 ◽  
pp. 1-8
Author(s):  
Wanjun Ma ◽  
Shanshan Wei ◽  
Weijun Peng ◽  
Taoli Sun ◽  
Jianhua Huang ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Troponin T ◽  
Antioxidant Effect ◽  
Oxygen Species ◽  
Active Constituent ◽  
Pharmacological Activities ◽  
Dna Damages ◽  
Chinese Herbal ◽  
Wide Range ◽  
Cardiac Muscle Fibers

Polygonatum sibiricum polysaccharides (PSP), the extract of Polygonatum sibiricum, are demonstrated to exhibit a wide range of pharmacological activities. A recent study reported that PSP alleviated the aging of the kidney and meninges. However, the effect of PSP on heart aging remains unclear. The present study is aimed at investigating the protection of PSP on D-galactose- (D-gal-) induced heart aging. Results showed that irregularly arranged cardiac muscle fibers were observed in heart tissues of D-gal-treated mice, and the levels of cardiac troponin T (cTnT), creatine kinase (CK), p21, and p53 were increased after D-gal treatment. D-gal-induced heart aging and injury can be attenuated by oral administration of PSP. Moreover, PSP also decreased reactive oxygen species (ROS) and malondialdehyde (MDA) and increased the level of superoxide dismutase (SOD) in the hearts of D-gal-treated mice. DNA damages and lipid peroxidation induced by oxidative stress were also inhibited by PSP as indicated by reduced levels of 8-hydroxydeoxyguanosine (8-OHdG) and 4-hydroxy-2-nonenal (4-HNE). Collectively, PSP attenuated D-gal-induced heart aging via inhibiting oxidative stress, suggesting that PSP might serve as a potential effective Chinese herbal active constituent for antiaging therapy.

scholarly journals Tamoxifen and oxidative stress: an overlooked connection

2021 ◽  
Vol 12 (1) ◽  
Author(s):  
Nermin S. Ahmed ◽  
Marek Samec ◽  
Alena Liskova ◽  
Peter Kubatka ◽  
Luciano Saso
Keyword(s):  
Breast Cancer ◽  
Oxidative Stress ◽  
Gold Standard ◽  
Pharmacological Activities ◽  
Standard Drug ◽  
Menopausal Women ◽  
Wide Range ◽  
Post Menopausal ◽  
Apoptotic Effects ◽  
And Oxidative Stress

AbstractTamoxifen is the gold standard drug for the treatment of breast cancer in pre and post-menopausal women. Its journey from a failing contraceptive to a blockbuster is an example of pharmaceutical innovation challenges. Tamoxifen has a wide range of pharmacological activities; a drug that was initially thought to work via a simple Estrogen receptor (ER) mechanism was proven to mediate its activity through several non-ER mechanisms. Here in we review the previous literature describing ER and non-ER targets of tamoxifen, we highlighted the overlooked connection between tamoxifen, tamoxifen apoptotic effects and oxidative stress.

Curcuma longa extract reduces the risk of oxidative stress during intense physical exertion

2020 ◽  
pp. 43-49
Author(s):  
A. A. Khisamova ◽  
O. A. Gizinger
Keyword(s):  
Oxidative Stress ◽  
Reactive Oxygen Species ◽  
Literature Review ◽  
Curcuma Longa ◽  
Antioxidant Properties ◽  
Physical Exertion ◽  
The Body ◽  
Irreversible Processes ◽  
Oxygen Species ◽  
Wide Range

Increased physical exertion is a catalyst for oxidative stress and the production of reactive oxygen species, which entails irreversible processes in the body, leading to chronic diseases and disability. This article contains a literature review of studies that prove the effect of the antioxidant properties of Curcuma longa on cells under oxidative stress. To search for data, a wide range of literature and databases was explored: Pubmed, Google.Scholar, and Embase.

The antioxidant effect of mulberry and jamun fruit wines by ameliorating oxidative stress in streptozotocin-induced diabetic Wistar rats

2016 ◽  
Vol 7 (10) ◽  
pp. 4422-4431 ◽  
Author(s):  
Akshatha Hosahalli Srikanta ◽  
Anbarasu Kumar ◽  
Shinde Vijay Sukhdeo ◽  
Muthukumar Serva Peddha ◽  
Vijayalakshmi Govindaswamy
Keyword(s):  
Oxidative Stress ◽  
Reactive Oxygen Species ◽  
Wistar Rats ◽  
Metabolic Disorders ◽  
Reactive Oxygen ◽  
Antioxidant Effect ◽  
Oxygen Species

Polyphenols act by scavenging reactive oxygen species during oxidative stress and hence are useful in the treatment of metabolic disorders including diabetes.

scholarly journals Chemotherapy-Induced Cardiotoxicity: Overview of the Roles of Oxidative Stress

2015 ◽  
Vol 2015 ◽  
pp. 1-13 ◽  
Author(s):  
Paweorn Angsutararux ◽  
Sudjit Luanpitpong ◽  
Surapol Issaragrisil
Keyword(s):  
Oxidative Stress ◽  
Molecular Mechanisms ◽  
Chemotherapy Regimen ◽  
Model Development ◽  
Preventive Treatment ◽  
Chemotherapeutic Agents ◽  
Oxygen Species ◽  
Preventive Strategies ◽  
Wide Range ◽  
Threat To Life

Chemotherapy-induced cardiotoxicity is a serious complication that poses a serious threat to life and limits the clinical use of various chemotherapeutic agents, particularly the anthracyclines. Understanding molecular mechanisms of chemotherapy-induced cardiotoxicity is a key to effective preventive strategies and improved chemotherapy regimen. Although no reliable and effective preventive treatment has become available, numerous evidence demonstrates that chemotherapy-induced cardiotoxicity involves the generation of reactive oxygen species (ROS). This review provides an overview of the roles of oxidative stress in chemotherapy-induced cardiotoxicity using doxorubicin, which is one of the most effective chemotherapeutic agents against a wide range of cancers, as an example. Current understanding in the molecular mechanisms of ROS-mediated cardiotoxicity will be explored and discussed, with emphasis on cardiomyocyte apoptosis leading to cardiomyopathy. The review will conclude with perspectives on model development needed to facilitate further progress and understanding on chemotherapy-induced cardiotoxicity.

scholarly journals Chinese Herbal Medicines and Active Metabolites: Potential Antioxidant Treatments for Atherosclerosis

2021 ◽  
Vol 12 ◽  
Author(s):  
Luxia Song ◽  
Jie Zhang ◽  
Runmin Lai ◽  
Qiuyi Li ◽  
Jianqing Ju ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Arterial Wall ◽  
Herbal Medicines ◽  
New Drugs ◽  
Atherosclerotic Plaques ◽  
Oxygen Species ◽  
Active Metabolites ◽  
Chinese Herbal Medicines ◽  
Chinese Herbal ◽  
Complex Chronic Disease

Atherosclerosis is a complex chronic disease that occurs in the arterial wall. Oxidative stress plays a crucial role in the occurrence and progression of atherosclerotic plaques. The dominance of oxidative stress over antioxidative capacity generates excess reactive oxygen species, leading to dysfunctions of the endothelium and accelerating atherosclerotic plaque progression. Studies showed that Chinese herbal medicines and traditional Chinese medicine (TCM) might regulate oxidative stress; they have already been used to treat diseases related to atherosclerosis, including stroke and myocardial infarction. This review will summarize the mechanisms of oxidative stress in atherosclerosis and discuss studies of Chinese herbal medicines and TCM preparations treating atherosclerosis, aiming to increase understanding of TCM and stimulate research for new drugs to treat diseases associated with oxidative stress.

scholarly journals Oxidative stress and antioxidant mechanisms in human body

2019 ◽  
Vol 6 (1) ◽  
pp. 43-47
Author(s):  
Azab Elsayed Azab ◽  
 Almokhtar A Adwas ◽  
Ata Sedik Ibrahim Elsayed ◽  
Almokhtar A Adwas ◽  
 Ata Sedik Ibrahim Elsayed ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Reactive Oxygen Species ◽  
Liver Diseases ◽  
Biological Activities ◽  
Heart Diseases ◽  
Reactive Oxygen ◽  
Ischemic Heart ◽  
Oxygen Species ◽  
Ischemic Heart Diseases ◽  
Wide Range

The present review aims to high light on the oxidative stress, and prevention by internal antioxidants and external antioxidants by some natural products possessing antioxidant properties. Oxidative stress occurs when the balance between reactive oxygen species (ROS) formation and detoxification favors an increase in ROS levels, leading to disturbed cellular function. ROS causes damage to cellular macromolecules causing lipid peroxidation, nucleic acid, and protein alterations. Their formation is considered as a pathobiochemical mechanism involved in the initiation or progression phase of various diseases such as atherosclerosis, ischemic heart diseases, diabetes, and initiation of carcinogenesis or liver diseases. In order to maintain proper cell signaling, it is likely that a number of radical scavenging enzymes maintain a threshold level of ROS inside the cell. However, when the level of ROS exceeds this threshold, an increase in ROS production may lead to excessive signals to the cell, in addition to direct damage to key components in signaling pathways. ROS can also irreversibly damage essential macromolecules. Protein-bound thiol and non-protein-thiol are the major cytosolic low molecular weight sulfhydryl compound that acts as a cellular reducing and a protective reagent against numerous toxic substances including most inorganic pollutants, through the –SH group. Hence, thiol is often the first line of defense against oxidative stress. Flavonoids have been found to play important roles in the non-enzymatic protection against oxidative stress, especially in the case of cancer. Flavonoids have occurred widely in tea, fruit, red wine, vegetables, and cocoas. Flavonoids, including flavones, flavanone, flavonols, and isoflavones, are polyphenolic compounds which are widespread in foods and beverages, and possess a wide range of biological activities, of which anti-oxidation has been extensively explored. It can be concluded that oxidative stress causes irreversible damage in cellular macromolecules that leads to initiation of various diseases such as atherosclerosis, ischemic heart diseases, liver diseases, diabetes, and initiation of carcinogenesis. Antioxidants inhibit reactive oxygen species production and scavenging of free radicals. Therefore, the review recommends that high consumption of natural foods that are rich in antioxidants will provide more protection against toxic agents and related diseases.

scholarly journals Effect of an extract of Hibiscus sabdariffa L., on oxidative stress induced in Saccharomyces cerevisiae

2020 ◽  
Vol 3 (1) ◽  
pp. 41-46
Author(s):  
Franklin Pacheco Coello ◽  
Corymar Orosco-Vargas ◽  
María Peraza-Marrero ◽  
Ibis Pinto-Catari ◽  
Doralys Ramirez-Azuaje
Keyword(s):  
Oxidative Stress ◽  
Saccharomyces Cerevisiae ◽  
Antioxidant Capacity ◽  
Statistical Difference ◽  
Positive Control ◽  
Antioxidant Effect ◽  
Hibiscus Sabdariffa ◽  
Oxygen Species ◽  
Scientific World

Hibiscus sabdariffa-based infusions or drinks are characterized by their high content of bioactive compounds that provide them with an antioxidant capacity that is of great interest in the scientific world. The research consisted in evaluating the antioxidant effect of an aqueous extract of H. sabdariffa, by inducing Saccharomyces cerevisiae to an oxidative stress due to the presence of hydrogen peroxide. The Folin-Ciocalteu method was used for the determination of total phenols in the extract. To evaluate the antioxidant capacity, the extract was diluted, a concentration of 4.5 106 cells/mL of S. cerevisiae was adjusted, and then aliquots of pure and diluted extract were added. Oxidative stress inhibition was observed in each of the assays with statistical difference, relative to the positive control. These results show that H. sabdariffa has an antioxidant capacity that favors the biological activity of S. cerevisiae, contributing to the decrease of the levels of reactive oxygen species and minimizing oxidative damage.

scholarly journals EFFECT OF N-ACETYLCARNOSINE CONTAINED EYE DROP ON CATECHOLAMINE-INDUCED MORPHOFUNCTIONAL DAMAGE IN RAT RETINA

2020 ◽  
Vol 66 (4) ◽  
pp. 64-71
Author(s):  
V.V. Sanin ◽  
◽  
A.I. Yakovets ◽  
K.V. Rozova ◽  
Yu.P. Korkach ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Energy Production ◽  
Wistar Rats ◽  
Antioxidant Effect ◽  
Compensatory Mechanism ◽  
Oxygen Species ◽  
Rat Retina ◽  
Eye Tissues ◽  
Markers Of Oxidative Stress ◽  
Adrenaline Administration

The effects of N-acetylcarnosine (NAC)-contained eye drop ‘Clarastil’ on a model of adrenaline-induced high intraocular pressure (IOP) in Wistar rats were studied. The retina ultrastructure and markers of oxidative stress have been studied. NAC was found to have no significant effect on edema in the retinal ultrastructure, did not reduce endothelial thickening and histogemic barrier, and accordingly did not affect the value of IOP after prolonged adrenaline administration. However, the introduction of the eye drop prevented the swelling of the mitochondria, the formation of vacuolated crystals and probably stimulated energy production as a compensatory mechanism under conditions of hypercatecholemia. In addition, NAC significantly reduced adrenaline-induced overproduction of reactive oxygen species and lipid peroxidation products in eye tissues, indicating its antioxidant effect.

scholarly journals The Healing of Oxidative Injuries with Trehalose in UVB-Irradiated Rabbit Corneas

2019 ◽  
Vol 2019 ◽  
pp. 1-10 ◽  
Author(s):  
Cestmir Cejka ◽  
Jan Kossl ◽  
Barbora Hermankova ◽  
Vladimir Holan ◽  
Sarka Kubinova ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Corneal Epithelium ◽  
Antioxidant Properties ◽  
Antioxidant Effect ◽  
Excessive Amount ◽  
Eye Drops ◽  
Oxygen Species ◽  
Significant Suppression ◽  
Once Daily ◽  
Uvb Irradiation

Our previous research revealed that trehalose, a nonreducing disaccharide of glucose and an important stress responsive factor, proved to have anti-inflammatory, antiapoptotic, and particularly antioxidant properties in UVB-irradiated corneas. Trehalose reduced oxidative stress in corneas induced by UVB irradiation, by means of a decrease in the antioxidant/prooxidant imbalance in the corneal epithelium. In this study, we demonstrate that trehalose of 3% or 6% concentration in eye drops directly decreases oxidative stress in UVB-irradiated corneas, by removing the excessive amount of reactive oxygen species (ROS). Trehalose drops applied on corneas during UVB irradiation once daily for four days resulted in a reduction or even absence of the oxidative stress, DNA damage, and peroxynitrite formation (detected by nitrotyrosine residues), seen in buffer-treated corneas. Furthermore, trehalose treatment applied curatively after repeated irradiation for the subsequent fourteen days led to the renewal of corneal transparency and significant suppression or even absence of neovascularization. This was in contrast to buffer-treated irradiated corneas, where the intracorneal inflammation was developed and the untransparent corneas were vascularized. In conclusion, the treatment of UVB-irradiated corneas with trehalose eye drops removed the excessive amount of ROS in the corneal epithelium, leading to the suppression of oxidative stress and favorable corneal healing. The 6% trehalose showed a higher intensive antioxidant effect.

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