scholarly journals Homogeneity Test of Many-to-One Risk Differences for Correlated Binary Data under Optimal Algorithms

Complexity ◽  
2021 ◽  
Vol 2021 ◽  
pp. 1-29
Author(s):  
Keyi Mou ◽  
Zhiming Li
Keyword(s):  
Binary Data ◽  
Estimation Error ◽  
Control Group ◽  
Homogeneity Test ◽  
Optimal Algorithms ◽  
Score Statistic ◽  
Correlated Binary Data ◽  
Treatment Groups ◽  
Multiple Treatment ◽  
Rate Score

In clinical studies, it is important to investigate the effectiveness of different therapeutic designs, especially, multiple treatment groups to one control group. The paper mainly studies homogeneity test of many-to-one risk differences from correlated binary data under optimal algorithms. Under Donner’s model, several algorithms are compared in order to obtain global and constrained MLEs in terms of accuracy and efficiency. Further, likelihood ratio, score, and Wald-type statistics are proposed to test whether many-to-one risk differences are equal based on optimal algorithms. Monte Carlo simulations show the performance of these algorithms through the total averaged estimation error, SD, MSE, and convergence rate. Score statistic is more robust and has satisfactory power. Two real examples are given to illustrate our proposed methods.

scholarly journals The Effect of Duration of Use of Depomedroxyprogesterone Acetate on the Thickness of the Vaginal Epithelium of Mice

2021 ◽  
Vol 9 (A) ◽  
pp. 73-77
Author(s):  
Nora Veri ◽  
Cut Mutiah ◽  
Dewita Dewita ◽  
Henniwati Henniwati
Keyword(s):  
Treatment Group ◽  
Social Marketing ◽  
Vaginal Epithelium ◽  
Control Group ◽  
Homogeneity Test ◽  
Average Thickness ◽  
Treatment Groups ◽  
Epithelial Thickness ◽  
Significant Difference ◽  
Levene Test

BACKGROUND: Depomedroxyprogesterone acetate (DMPA) is one of the most effective contraceptive methods currently widely used. Injectable contraceptives, including DMPA, are growing in popularity because of their ease of use, effectiveness and affordability. The use of DMPA also has advantages such as not interfering with sexual relations, does not need male participation, does not require storage space, and is easy to obtain and helps increase body weight. AIM: The aim of the study was to analyze the effect of the duration of use of DMPA on the thickness of the vaginal epithelium of mice. METHODS: The research design used in this study was true experimental with a post-test only control group design approach. This research was carried out treatment at a dose of 0.39 mg/mouse/day DMPA exposure in mice. The phenomenon observed in this study was the thickness of the vaginal epithelium of mice. This study used mice with the completely randomized design method and was carried out at the Pharmacology Laboratory and the Anatomical Pathology Laboratory, FKH Unsyiah. The collection of data technique was conducted by observation with a light microscope to calculate the average thickness of the vaginal epithelium of mice injected with DMPA in the four groups. The data analysis technique was carried out in five stages, namely, the normality test of the sample data with the Shapiro–Wilk test, the homogeneity test of variance with the Levene test, and comparing the thickness of the vaginal epithelium in each of the two treatment groups using the independent t-test. RESULTS: The finding revised that there was a significant difference in the thickness of the vaginal epithelium in the two treatment groups 10 days and 15 days of DMPA exposure which was indicated by a p = 0.003 (p < 0.05). DMPA exposure levels cause thinning of the vaginal epithelial thickness. The average thickness of vaginal epithelium exposure to DMPA for 10 days in the control group was 182536.33 ± 5773.465. In the treatment group, exposure to DMPA for 10 days, the thickness of the vaginal epithelium was 168322.33 ± 7611.300. The mean vaginal epithelial thickness in the 15-day DMPA exposure group in the control group was 177242.83 ± 9689.558. In the 15-day DMPA exposure treatment group, the thickness of the vaginal epithelium was 138674.83 ± 17176.124. CONCLUSION: The application of social marketing has not been effective in changing the smoking behavior of students in Aceh. The application of social marketing needs to be supported by internal and external Islamic Boarding Schools.

scholarly journals Artikel Pemanfaatan Lidah Mertua Sebagai Hair Tonic Untuk Perawatan Rambut Rontok

2018 ◽  
Vol 10 (2) ◽  
pp. 181
Author(s):  
Aprilia Aprilia Aprilia
Keyword(s):  
Sampling Technique ◽  
Control Group ◽  
Homogeneity Test ◽  
Control Group Design ◽  
Treatment Groups ◽  
Average Value ◽  
Normality Test ◽  
Equivalent Control ◽  
Group 2 ◽  
Experimental Group

Hair is said to fall out if it reaches 50-100 strands. This research aims to analyze the use of senseviera as hair tonic for the treatment of hair loss .This research is a quasi-experiment with the design of Non Equivalent Control Group Design. The population is women aged 19-25 years who use hijab. The sampling technique was carried out by purposive sampling technique conducted voluntarily as many as 9 people. After obtaining the data, the normality test, homogeneity test and variance analysis test (ANAVA) were first carried out and continued with the duncan test.The results of the analysis showed that there was no change in the control group (X1) with an average value of 2.33 (pretest) to 2.73 (posttest). For the experimental group 1 frequency of 2 times a day (X2) since the first treatment (pretest) can be seen changes with an average of 2.00 (pretest) to 3, 33 (posttest). Whereas in the experimental group 2 frequency 1 time 3 days (X3) also changed since and get an average of 2.00 (pretest) to 3.07 (posttest). The average calculation of the three treatment groups stated that Fcount> Ftable (5,810> 1,860), which means that there was a significant.

scholarly journals Homogeneity Test for Correlated Binary Data

PLoS ONE ◽  
2015 ◽  
Vol 10 (4) ◽  
pp. e0124337 ◽  
Author(s):  
Changxing Ma ◽  
Guogen Shan ◽  
Song Liu
Keyword(s):  
Binary Data ◽  
Homogeneity Test ◽  
Correlated Binary Data

ENGARUH MODEL PEMBELAJARAN AKTIF COURSE REVIEW HORAY TERHADAP HASIL BELAJAR BIOLOGI SISWA KELAS VIII SMP NEGERI 10 BATAM

SIMBIOSA ◽  
2014 ◽  
Vol 3 (2) ◽  
Author(s):  
Ramses Ramses ◽  
Nurhaty Purnama Sari ◽  
Harni Lainy Br.Bakkara
Keyword(s):  
Active Learning ◽  
Learning Outcomes ◽  
Learning Model ◽  
T Test ◽  
Eighth Grade ◽  
Control Group ◽  
Homogeneity Test ◽  
Control Group Design ◽  
Eighth Grade Students ◽  
Biology Learning

This study aims to know the influence of active learning model Course Review Horay to biology learning outcomes at eighth grade students of SMP Negeri 10 Batam academic year 2013/2014. This research design is  randomized experiment using posttest only control-group design. The study population is all the eighth grade students of  SMP Negeri 10 Batam with reached population consist of 7 classes. The sampling technique using a simple random sampling. Samples were selected class VIII5 as control class and VIII8 as experiment class. The instrument  that use in this research is the form of the test. Requirement have been in the form of normality and homogeneity test, which showed that normal and homogeneous data. Technique of data analysis conducted by the t test. The result analysis of data using the t test showed the tvalue 3.01 and ttable is 2.00 (tvalue > ttable). The results showed that the active learning result model Course Review Horay give effect to increase student learning outcomes from the average of the experimental class 82,57 and control class 76,04. Thus, the hypothesis put forward acceptable significance level (α = 0.05). Thus, it can be concluded that the using of active learning model Course Review Horay influential on learning outcomes of biology at eighth grade students of SMP Negeri 10 Batam. Keywords: Course Review Horay, Biology Learning Outcomes.

Changes of IL-4 and IFN-g expression in monocytes and T-helper lymphocytes while modeling of systemic juvenile idiopathic arthritis in Wistar rats

2018 ◽  
pp. 61-69
Author(s):  
В.Н. Сахаров ◽  
П.Ф. Литвицкий ◽  
Е.И. Алексеева ◽  
Н.А. Маянский ◽  
Р.Ш. Закиров
Keyword(s):  
Juvenile Idiopathic Arthritis ◽  
Peripheral Blood Mononuclear Cells ◽  
Wistar Rats ◽  
Mononuclear Cells ◽  
Systemic Juvenile Idiopathic Arthritis ◽  
Control Group ◽  
Peripheral Blood Mononuclear ◽  
Treatment Groups ◽  
Blood Mononuclear Cells ◽  
T Helpers

Цель исследования - изучение перепрограммирования мононуклеарных лейкоцитов на модели системного ювенильного идиопатического артрита (сЮИА), воспроизводимой у крыс Wistar с использованием полного адъюванта Фрейнда и липополисахарида. Методика. сЮИА воспроизведен у 6-месячных крыс-самцов Wistar. На 40-е сут. эксперимента животные были разделены на 3 группы: 1-я группа - контроль; 2-я - группа доксициклина; 3-я - группа дексаметазона. Взятие проб крови у животных проводили на нулевые, 41-е и 55-е сут. Мононуклеарные клетки периферической крови выделяли гравиметрически, после чего окрашивали их на маркеры и внутриклеточные цитокины. Дифференцировали моноциты (CD3-CD4+) и Т-хелперы (CD3+CD4+). Анализировали динамику внутриклеточной экспрессии интерлейкина IL-4 (рассматривали как маркер про-М2 фенотипа, так как в случае выделения из клетки ИЛ-4 служит стимулятором М2 поляризации макрофагов) и IFN-g (как маркер про-М1 фенотипа) по данным проточной цитофлуориметрии. Применяли непараметрический статистический тест Mann-Whitney-Wilcoxon в программе R для статистической обработки данных. Результаты и заключение. При моделировании сЮИА выявлено закономерное изменение фенотипа моноцитов. Применение же доксициклина и дексаметазона приводило к более ранней поляризации их по про-М2-пути в отношении моноцитов (на 41-е сут.) в сравнении с контролем. Про-М1 эффект (на 55-е сут., в сравнении с контролем) выявлен также в группах доксициклина и дексаметазона. У животных разных групп обнаружены характерные динамические изменения внутриклеточной экспрессии цитокинов. Важно, что различная направленность поляризации фенотипа при сЮИА и применении препаратов наблюдается не только у моноцитов, но и у Т-хелперов. The study objective was to evaluate targeted reprogramming of peripheral blood mononuclear cells in systemic juvenile idiopathic arthritis (sJIA) modeled in 6-month-old male Wistar rats by co-administration of complete Freund’s adjuvant and lipopolysaccharide. Methods. On day 40 of the experiment, rats were divided into three groups: control, doxycycline, and dexamethasone groups. Blood samples were collected on days 0, 41, and 55. Peripheral blood mononuclear cells were isolated gravimetrically and stained for markers and cytokines. Monocytes (CD3-CD4+) and T-helpers (CD3+CD4+) were differentiated as target cells. IL-4 was considered a marker for the pro-M2 phenotype since IL-4 can activate M2 macrophage polarization; IFN-g was considered a marker for the pro-M1 phenotype. Time-related changes in the intracellular expression of IL-4 and IFN-g were studied using flow cytometry. Data were analyzed using nonparametric statistical tests (Mann-Whitney-Wilcoxon) in the R environment for statistical computing. Results and conclusions. Monocytes (like macrophages) underwent reprogramming during the development of modeled sJIA disease. In monocytes of doxycycline and dexamethasone treatment groups, pro-M2 effects were observed earlier (day 41) than in the control group. Pro-M1 effects were observed in monocytes of doxycycline and dexamethasone groups on day 55, as compared with the control group. Characteristic time-related changes of intracellular cytokine expression were described for different groups. Importantly, the differently directed phenotype polarization was observed in sJIA and treatment groups for both monocytes and T-helpers.

The Using of Film Media to Analyze Intrinsic Element in Literature in High School

2019 ◽  
Vol 1 (2) ◽  
pp. 60
Author(s):  
Hendrick L ◽  
Martono Martono ◽  
Indri Astuti
Keyword(s):  
Data Analysis ◽  
Student Learning ◽  
Learning Outcomes ◽  
Literary Work ◽  
Student Learning Outcomes ◽  
T Test ◽  
Control Group ◽  
Homogeneity Test ◽  
Learning Material ◽  
Literary Works

This study examined the use of film media on Indonesian Language. The problem revealed was how is student learning outcomes, and what is the outcomes difference between learning to analyze the intrinsic elements of literary works using film media and using conventional learning approaches in class XI students of SMA N 1 Tumbang Titi. This type of research is experimental research. The design used was Post-test Only Control Group Design. Data analysis was done by normality test, homogeneity test, and t-test (Paired Simple t-Test). Data collection techniques in the form of tests. Based on the results of data analysis, it can be concluded that student learning outcomes analysis the intrinsic elements of literary works after being given conventional learning is 54.38 while student learning outcomes analyze the intrinsic elements of literary works after using film media is 71, 67. Besides, after analyzing the data statistically, the results show that there are significant differences between the learning outcomes of the material analyzing the intrinsic elements of literary work between those who use film media and conventional learning. Indonesian language learning material becomes the intrinsic elements of literature in class XI students of SMA N 1 Tumbang Titi using film media can also improve student learning outcomes and contribute to the scale of effectiveness of 32,64. Thus, learning with film media can be used by teachers in the field of learning Indonesian in analyzing intrinsic elements of literary works.Keywords: Utilization of Film Media, Intrinsic Elements of Literary Work

Mechanism Involved in Fortification by Berberine in CDDP-Induced Nephrotoxicity

2020 ◽  
Vol 13 (4) ◽  
pp. 342-352 ◽  
Author(s):  
Vipin K. Verma ◽  
Salma Malik ◽  
Ekta Mutneja ◽  
Anil K. Sahu ◽  
Kumari Rupashi ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Renal Tissue ◽  
Isoquinoline Alkaloid ◽  
Experimental Models ◽  
Beclin 1 ◽  
Control Treatment ◽  
Control Group ◽  
Treatment Groups ◽  
Single Intraperitoneal Injection ◽  
Male Wistar Rats

Background: The activation of Nrf2/HO-1 pathway has been shown to protect against cisplatin- induced nephrotoxicity by reducing oxidative stress. Berberine (Ber), an isoquinoline alkaloid, has demonstrated antioxidant, anti-inflammatory and anti-apoptotic activities in various experimental models. Aim: To check the effect of Ber on cisplatin-induced nephrotoxicity and to explore the involved mechanism. Methods: Adult male Wistar rats were divided into 6 groups: Normal, cisplatin-control, treatment groups and per se group. Normal saline and Ber (20, 40 and 80 mg/kg; p.o.) was administered to rats for 10 days. A single intraperitoneal injection of cisplatin (8 mg/kg) was injected on 7th day to induced nephrotoxicity. On 10th day, rats were sacrificed, the kidney was removed and stored for the estimation of various parameters. Results: As compared to cisplatin-control group, Ber pretreatment improved renal function system and preserved renal architecture. It also diminished oxidative stress by upregulating the expression of Nrf2/HO-1 proteins. In addition, Ber attenuated the cisplatin mediated inflammation and apoptosis. Furthermore, it also reduced the phosphorylation of p38/JNK and PARP/Beclin-1 expression in the kidney. Conclusion: Ber attenuated renal injury by activating Nrf2/HO-1 and inhibiting JNK/p38MAPKs/ PARP/Beclin-1 expression which prevented oxidative stress, inflammation, apoptosis and autophagy in renal tissue.

Efficacy of Ovsynch and Ovsynch Plus Protocol for Improvement of Fertility in Postpartum Sahiwal Cows

2019 ◽  
Vol 14 (04) ◽  
Author(s):  
J. P. Lakher ◽  
M. K. Awasthi ◽  
J. R. Khan ◽  
M. R. Poyam
Keyword(s):  
Fixed Time ◽  
Conception Rate ◽  
Control Group ◽  
Group Iii ◽  
Treatment Groups ◽  
Group I ◽  
Early Postpartum ◽  
The Status ◽  
Sahiwal Cows ◽  
And Control

The present study was conducted to investigate the efficacy of Ovsynch and Ovsynch plus protocol in postpartum (day 60) Sahiwal cows (n=18). Animals were randomly divided into three equal groups, viz., Ovsynch group Ovsynch plus group and Control group. Animals of group I (n = 6) were treated with traditional Ovsynch protocol. The animals (n = 6) of group II were treated with Ovsynch plus protocol which consisted of an initial intramuscular injection of eCG (Folligon) @ 250 IU on day 60 postpartum followed 3 days later by GPG (Ovsynch) protocol. In group-III Control, no treatment was given to animals (n = 6). Treated animals were inseminated at a fixed time between 14 and 20 hrs after second GnRH injection, irrespective of estrus detection. Blood samples were collected from each animal on days 50 and 60 postpartum to determine the status of cyclicity in animals based on serum concentrations of progesterone (P4). A third blood sample was collected on the day of prostaglandin treatment to determine the response of first GnRH injection. Four animals each were cyclic, and two were acyclic in both treatment groups. Four animals each responded to first GnRH treatment in both treatment groups. Similarly, two animals each got conceived giving conception rate of 50% (2/4) in each treatment. In the control group, one out of 6 animals got conceived yielding 16.66 % conception rate (1/6) during the study period. It may be thus concluded that Ovsynch and Ovsynch plus protocol may be used during the early postpartum period to improve the reproductive efficiency in postpartum Sahiwal cows.

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