scholarly journals Disrupted Resting-State Functional Connectivity between the Dorsal Attention, Default Mode, and Frontoparietal Networks in Nonorganic Gastrointestinal Disorder Patients with Spleen Deficiency Syndrome

2021 ◽  
Vol 2021 ◽  
pp. 1-8
Author(s):  
Yanzhe Ning ◽  
Wenbin Jia ◽  
Dongqing Yin ◽  
Xinzi Liu ◽  
Hong Zhu ◽  
...  
Keyword(s):  
Functional Connectivity ◽  
Performance Test ◽  
Gastrointestinal Disorder ◽  
Deficiency Syndrome ◽  
Magnetic Resonance Imaging Scan ◽  
Healthy Controls ◽  
Resting State Functional Connectivity ◽  
Default Mode ◽  
Spleen Deficiency ◽  
Spleen Deficiency Syndrome

Introduction. Spleen deficiency syndrome (SDS), a common clinical syndrome of traditional Chinese medicine, is manifested with digestive symptoms and cognitive impairments. However, the cognitive neural mechanism in brain networks of SDS still remained unclear. Our aim was to investigate the changes between the default mode, dorsal attention, and frontoparietal networks in SDS. Methods. Twenty nonorganic gastrointestinal disorder (NOGD) patients with SDS and eighteen healthy controls were enrolled to attend functional magnetic resonance imaging scan and participated a continuous performance test (CPT) before scanning. Results. Compared with healthy controls, NOGD patients with SDS showed the significantly increased functional connectivity (FC) between dorsal attention network (DAN) and left frontal-parietal control network (LFPN) and significantly decreased FC between LFPN and default mode network (DMN). The functional network connectivity analysis showed positive correlation coefficients between the DAN and LFPN and DAN and DMN as well as negative correlation between LFPN and DMN in NOGD patients with SDS compared with healthy controls. Correlation analysis revealed that the increased FC between LFPN and DAN was positively correlated with 4-digitnumber reaction time mean (RTM) and 3-digitnumber RTM. Conclusion. Our study may provide novel insights into the relationship among the DMN, DAN, and FPN in NOGD patients with SDS to deepen our understanding of the neuropsychological mechanisms of SDS.

scholarly journals Enhanced functional connectivity of the default mode network (DMN) in patients with spleen deficiency syndrome

Medicine ◽  
2019 ◽  
Vol 98 (5) ◽  
pp. e14372 ◽  
Author(s):  
Yan-zhe Ning ◽  
Feng-zhi Wu ◽  
Song Xue ◽  
Dong-qing Yin ◽  
Hong Zhu ◽  
...  
Keyword(s):  
Functional Connectivity ◽  
Default Mode Network ◽  
Deficiency Syndrome ◽  
Default Mode ◽  
Spleen Deficiency ◽  
Spleen Deficiency Syndrome

scholarly journals Effects of escitalopram therapy on resting-state functional connectivity of subsystems of the default mode network in unmedicated patients with major depressive disorder

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Jian Cui ◽  
Yun Wang ◽  
Rui Liu ◽  
Xiongying Chen ◽  
Zhifang Zhang ◽  
...  
Keyword(s):  
Major Depressive Disorder ◽  
Functional Connectivity ◽  
Depressive Disorder ◽  
Default Mode Network ◽  
Resting State ◽  
Fmri Data ◽  
Healthy Controls ◽  
Resting State Functional Connectivity ◽  
Major Depressive ◽  
Default Mode

AbstractAntidepressants are often the first-line medications prescribed for patients with major depressive disorder (MDD). Given the critical role of the default mode network (DMN) in the physiopathology of MDD, the current study aimed to investigate the effects of antidepressants on the resting-state functional connectivity (rsFC) within and between the DMN subsystems. We collected resting-state functional magnetic resonance imaging (rs-fMRI) data from 36 unmedicated MDD patients at baseline and after escitalopram treatment for 12 weeks. The rs-fMRI data were also collected from 61 matched healthy controls at the time point with the same interval. Then, we decomposed the DMN into three subsystems based on a template from previous studies and computed the rsFC within and between the three subsystems. Finally, repeated measures analysis of covariance was conducted to identify the main effect of group and time and their interaction effect. We found that the significantly reduced within-subsystem rsFC in the DMN core subsystem in patients with MDD at baseline was increased after escitalopram treatment and became comparable with that in the healthy controls, whereas the reduced within-subsystem rsFC persisted in the DMN dorsal medial prefrontal cortex (dMPFC) and medial temporal subsystems in patients with MDD following escitalopram treatment. In addition, the reduced between-subsystem rsFC between the core and dMPFC subsystem showed a similar trend of change after treatment in patients with MDD. Moreover, our main results were confirmed using the DMN regions from another brain atlas. In the current study, we found different effects of escitalopram on the rsFC of the DMN subsystems. These findings deepened our understanding of the neuronal basis of antidepressants’ effect on brain function in patients with MDD. The trial name: appropriate technology study of MDD diagnosis and treatment based on objective indicators and measurement. URL: http://www.chictr.org.cn/showproj.aspx?proj=21377. Registration number: ChiCTR-OOC-17012566.

scholarly journals Altered Resting-State Functional Connectivity in the Default Mode Network in Male Juvenile Violent Offenders

2021 ◽  
Author(s):  
Qiaoling Sun ◽  
Yingdong Zhang ◽  
Jiansong Zhou ◽  
Xiaoping Wang
Keyword(s):  
Functional Connectivity ◽  
Default Mode Network ◽  
Resting State ◽  
Violent Offenders ◽  
Magnetic Resonance Imaging Scan ◽  
Negative Consequences ◽  
Resting State Functional Connectivity ◽  
Default Mode ◽  
Juvenile Violence ◽  
Normal Controls

AbstractYoung males are often associated with more violence, leading to some serious negative consequences. However, the physiology and the neuroimaging patterns underlying juvenile violence remain unclear. Of the limited knowledge on juvenile violence, the default mode network has been known to be associated with its pathophysiology. This study aimed to investigate functional connectivity alterations of the default mode network in male juvenile violent offenders. 31 juvenile violent offenders in a high-security facility, who were convicted of aggressive behaviors by court, and 28 normal controls from a middle school were recruited as participants. They underwent a resting-state functional magnetic resonance imaging scan. And independent component analysis approaches were used to analyze their data. Compared to the normal controls, the juvenile violent offenders showed a different default mode network pattern, with the functional connectivity increased in the posterior cingulate, and decreased in the right middle temporal, left angular, right precuneus and right middle frontal cortex. Our findings revealed that the male juvenile violent offenders were associated with abnormal default mode network functional connectivity, which might be a neuroimaging basis for their tendency to violence.

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