scholarly journals Optic Neuritis Presented as Syndrome of Inappropriate Antidiuretic Hormone Secretion in an 8 Year Old

2021 ◽  
Vol 2021 ◽  
pp. 1-4
Author(s):  
T. G. M. Prasadani ◽  
Kapila Panditha ◽  
D. Irugalbandara
Keyword(s):  
Optic Nerve ◽  
Optic Neuritis ◽  
Antidiuretic Hormone ◽  
Hormone Secretion ◽  
Initial Presentation ◽  
Water Excretion ◽  
Inappropriate Antidiuretic Hormone Secretion ◽  
Demyelinating Disorder ◽  
Patient Will ◽  
Periventricular Area

Optic neuritis is a rare demyelinating disorder, which involves the optic nerve. It can be a monophasic self-limiting illness due to postinfectious or postvaccination etiology. It can also be an initial presentation of a relapsing demyelinating disorder such as multiple sclerosis or neuromyelitis optica spectrum of disorders. It is characterized to aquaporin-4 antibody-rich areas in the brain, optic nerve, and spinal cord. The hypothalamus and periventricular area are also rich in specific antibodies and may lead to dysfunction in the hypothalamic-pituitary axis. Antidiuretic hormone (ADH) is synthesized in the hypothalamus and stored in the posterior pituitary and may secrete inappropriately due to this disturbance. This will impair water excretion from the kidney, leading to hyponatremia. When hyponatremia is significant, the patient will present with confusion, agitation, and convulsions. This case report discusses acute symptomatic hyponatremia as the initial presentation of optic neuritis due to syndrome of inappropriate ADH secretion (SIADH).

TREATMENT OF ACUTE POST-OPERATIVE INAPPROPRIATE ANTIDIURETIC HORMONE SECRETION WITH DIPHENYLHYDANTOIN

1974 ◽  
Vol 76 (3) ◽  
pp. 625-628 ◽  
Author(s):  
Alex M. Landolt
Keyword(s):  
Diabetes Insipidus ◽  
Antidiuretic Hormone ◽  
Intravenous Administration ◽  
Hormone Secretion ◽  
Urine Concentration ◽  
Water Excretion ◽  
Inappropriate Antidiuretic Hormone Secretion ◽  
Antidiuretic Hormone Secretion

ABSTRACT Post-operative inappropriate antidiuretic hormone (ADH) secretion was observed 6 times in a group of 26 patients without diabetes insipidus before surgery for craniopharyngioma. Fourteen patients with existing diabetes insipidus did not show this disturbance. Intravenous administration of diphenylhydantoin (250 mg q. 8 h) controlled the hyponatraemia during the interphase of abnormal urine concentration and established an increased transitory water excretion in an 8 year old child operated upon for craniopharyngioma.

scholarly journals Unusual paraneoplastic syndrome of inappropriate antidiuretic hormone secretion with gastric cancer

2019 ◽  
Vol 7 (8) ◽  
pp. 3192 ◽  
Author(s):  
Ananth Pai ◽  
Saniya Pervin
Keyword(s):  
Antidiuretic Hormone ◽  
Serum Sodium ◽  
Paraneoplastic Syndrome ◽  
Hormone Secretion ◽  
Upper Gastrointestinal Endoscopy ◽  
Water Excretion ◽  
Inappropriate Antidiuretic Hormone Secretion ◽  
Antidiuretic Hormone Secretion ◽  
Proliferative Growth ◽  
Loss Of Appetite

Syndrome of inappropriate antidiuretic hormone secretion (SIADH) results in impaired water excretion and consequent water intoxication and hyponatremia. In patients with cancer, SIADH is most commonly driven by ectopic ADH production, a paraneoplastic syndrome frequently seen in small cell lung cancer. A 63 year old male presented with loss of appetite, vomiting and hiccups. No abnormalities were detected on physical examination. Upper gastrointestinal endoscopy showed a proliferative growth in the stomach and histopathology report confirmed gastric adenocarcinoma. His laboratory investigations revealed low serum sodium and further work up for SIADH confirmed the diagnosis. The patient was treated with hypertonic saline and he improved symptomatically. He was subsequently treated with two cycles of capecitabine and oxaliplatin. The patient was asymptomatic and maintained a serum sodium in the range of 120 to 130 mEq/L, with a serum sodium of 127 mEq/L on follow up.

An experimental model of syndrome of inappropriate antidiuretic hormone secretion in the rat

1984 ◽  
Vol 247 (4) ◽  
pp. E540-E553 ◽  
Author(s):  
J. G. Verbalis
Keyword(s):  
Experimental Model ◽  
Antidiuretic Hormone ◽  
Arginine Vasopressin ◽  
Hormone Secretion ◽  
Extracellular Fluid ◽  
Free Water ◽  
Urinary Flow ◽  
Water Excretion ◽  
Inappropriate Antidiuretic Hormone Secretion ◽  
Antidiuretic Hormone Secretion

An experimental model of the syndrome of inappropriate antidiuretic hormone secretion (SIADH) was developed using continuous subcutaneous infusions of arginine vasopressin (AVP) or 1-desamino-8-D-arginine vasopressin (DDAVP) in conscious unrestrained rats drinking 5% dextrose solution. Retention of both ingested water and endogenously generated free water from tissue catabolism was the primary determinant of hyponatremia using either AVP or DDAVP infusions. Natriuresis occurred transiently following water expansion but only slightly further lowered plasma [Na+]. Cessation of antidiuretic infusion resulted in free water excretion with correction of plasma [Na+]. Erythrocyte cell volume was significantly increased in hyponatremic animals and intracellular [K+] and [Na+] both decreased equivalently, consistent with dilution of intracellular fluid by retained water. This model of SIADH differs significantly from those previously described, in that escape from the hydroosmotic effect of AVP and DDAVP does not occur in the absence of high urinary flow rates. The observed results using this model suggest that the retained water in SIADH primarily resides intracellularly following isotonic equilibration of extracellular fluid volume.

scholarly journals Small cell carcinoma of the cervix complicated by syndrome of inappropriate antidiuretic hormone secretion: a case report

2021 ◽  
Vol 49 (2) ◽  
pp. 030006052098565
Author(s):  
Cai-Fu Zhao ◽  
Su-Fen Zhao ◽  
Ze-Qing Du
Keyword(s):  
Cell Carcinoma ◽  
Antidiuretic Hormone ◽  
Small Cell Carcinoma ◽  
Poor Prognosis ◽  
Hormone Secretion ◽  
Clinical Manifestations ◽  
Small Cell ◽  
Laboratory Examination ◽  
Inappropriate Antidiuretic Hormone Secretion ◽  
Antidiuretic Hormone Secretion

Small cell carcinoma of the cervix is a rare malignant tumor in the clinical setting. Clinical manifestations of this tumor are mostly similar to those of normal types of cervical cancer. Small cell carcinoma of the cervix only shows symptoms of neuroendocrine tumors, such as syndrome of inappropriate antidiuretic hormone secretion (SIADH). Most of the hyponatremia caused by SIADH can be managed after removal of the cause. Hyponatremia is a predictor of poor prognosis and can be used as an indicator of partial recurrence. We report a case of small cell carcinoma of the cervix complicated by SIADH. Our patient presented with irregular vaginal bleeding after menopause. After one cycle of chemotherapy, there was trembling of the limbs, and a laboratory examination showed low Na+ and low Cl− levels. After limited water intake, intravenous hypertonic saline, and intermittent diuretic treatment, the patient’s blood Na+ levels returned to normal. After a radical operation, the above-mentioned symptoms disappeared.

scholarly journals Syringomyelia associated with inappropriate antidiuretic hormone secretion

2014 ◽  
Vol 2014 (apr11 1) ◽  
pp. bcr2013202575-bcr2013202575
Author(s):  
P. Barros Alcalde ◽  
A. Gonzalez Quintela ◽  
M. Pena Seijo ◽  
A. Pose-Reino
Keyword(s):  
Antidiuretic Hormone ◽  
Hormone Secretion ◽  
Inappropriate Antidiuretic Hormone Secretion ◽  
Antidiuretic Hormone Secretion
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