scholarly journals TCF7L1 Genetic Variants Are Associated with the Susceptibility to Cervical Cancer in a Chinese Population

2021 ◽  
Vol 2021 ◽  
pp. 1-8
Author(s):  
Jingjing Chen ◽  
Yuanfang Xu ◽  
Hongyuan Hu ◽  
Tianbo Jin
Keyword(s):  
Cervical Cancer ◽  
Genetic Variants ◽  
Multifactor Dimensionality Reduction ◽  
Lower Risk ◽  
Healthy Subjects ◽  
Prognostic Markers ◽  
Multifactor Dimensionality Reduction Analysis ◽  
Cervical Cancer Risk ◽  
Stratified Analysis ◽  
The Impact

Background. Cervical cancer (CC) is the second most common tumor in women worldwide. Studies have been accepted that genetic variations play an important role in the development of CC. The aim of this study was to evaluate the impact of TCF7L1 variants on CC risk. Methods. 508 patients of cervical cancer and 497 healthy subjects were recruited to determine the impact of TCF7L1 polymorphisms on CC susceptibility. The associations were investigated by computing odds ratios (ORs) and 95% confidence intervals. The effect of SNP-SNP interactions on CC risk was explored by multifactor dimensionality reduction analysis. Results. Our study showed that rs11904127 (OR 0.79, p = 0.010 ) and rs62162674 (OR 0.82, p = 0.044 ) of TCF7L1 significantly decreased cervical cancer risk. Stratified analysis indicated that rs11904127 and rs62162674 present decreased susceptibility to CC in age > 51 years (OR 0.74, p = 0.019 ; OR 0.72, p = 0.014 , respectively). Haplotype analyses revealed that Grs2366264Trs11689667Crs62162674 has a lower risk to cervical cancer ( OR = 0.43 , p = 0.018 ). Besides, there is strong interaction of rs11904127 and rs2366264. Conclusion. Rs11904127 and rs62162674 in TCF7L1 are related to cervical cancer. We suggest that these variants can be used as prognostic markers for judging the susceptibility to cervical cancer.

scholarly journals The impact of genetic variants inIL1R2on cervical cancer risk among Uygur females from China: A case-control study

2018 ◽  
Vol 7 (1) ◽  
pp. e00516 ◽  
Author(s):  
Fanglin Niu ◽  
Tianchang Wang ◽  
Jing Li ◽  
Mengdan Yan ◽  
Dianzhen Li ◽  
...  
Keyword(s):  
Cervical Cancer ◽  
Cancer Risk ◽  
Genetic Variants ◽  
Case Control Study ◽  
Case Control ◽  
Cervical Cancer Risk ◽  
The Impact ◽  
Control Study

Genetic variants in microRNAs are associated with cervical cancer risk

Mutagenesis ◽  
2019 ◽  
Vol 34 (2) ◽  
pp. 127-133 ◽  
Author(s):  
Shizhi Wang ◽  
Haixia Zhu ◽  
Bo Ding ◽  
Xinrui Feng ◽  
Wenxuan Zhao ◽  
...  
Keyword(s):  
Cervical Cancer ◽  
Cancer Risk ◽  
Genetic Variants ◽  
Cervical Cancer Risk

scholarly journals RIPK1 Polymorphisms Alter the Susceptibility to Cervical Cancer among the Uyghur population in China

2020 ◽  
Author(s):  
Lili Han ◽  
Sulaiya Husaiyin ◽  
Chunhua Ma ◽  
Mayinuer Niyazi
Keyword(s):  
Cervical Cancer ◽  
Cancer Risk ◽  
Cancer Susceptibility ◽  
Clinical Stage ◽  
Binary Logistic Regression ◽  
Interacting Protein ◽  
Logistic Regression Models ◽  
Cervical Cancer Risk ◽  
Uyghur Population ◽  
Stratified Analysis

Abstract Background: RIPK1 (receptor-interacting protein kinase-1) plays a role in cancer development, whereas no clear studies focused on the cervical cancer. The objective of this study was to evaluate the relationship between RIPK1 polymorphisms and cervical cancer risk among the Uyghur population. Methods: We performed a case-control study including 342 cervical cancer patients and 498 age-matched healthy controls. Four RIPK1 genetic variants (rs6907943, rs2077681, rs9503400 and rs17548629) were genotyped with Agena MassARRAY platform. The associations between RIPK1 polymorphisms and cervical cancer risk were assessed under Binary logistic regression models. False discovery rate (FDR) was used to improve the results reliability. Results: The results showed rs2077681 was significantly associated with cervical cancer risk under various genetic models (codominant: OR = 3.14, 95% CI = 1.40-7.07, p = 0.006, FDR- p = 0.018; recessive: OR = 3.20, 95% CI = 1.43-7.16, p = 0.005, FDR-0.018). The stratified analysis indicated that the relationships of rs6907946, rs9503400 and rs17548629 with cervical cancer risk were statistically significant in the subgroup of clinical stage ( p < 0.05). Conclusion: Our findings demonstrated that RIPK1 polymorphisms were associated with cervical cancer susceptibility among the Uyghur population in China, and RIPK1 polymorphisms might be involved in the development of cervical cancer.

Association between six genetic variants of IL-17A and IL-17F and cervical cancer risk: a case–control study

Tumor Biology ◽  
2015 ◽  
Vol 36 (5) ◽  
pp. 3979-3984 ◽  
Author(s):  
Qiongying Lv ◽  
Dingjun Zhu ◽  
Juan Zhang ◽  
Yuexiong Yi ◽  
Shujuan Yang ◽  
...  
Keyword(s):  
Cervical Cancer ◽  
Cancer Risk ◽  
Genetic Variants ◽  
Case Control Study ◽  
Case Control ◽  
Cervical Cancer Risk ◽  
Control Study

scholarly journals Regular Low-Dose Oral Metronidazole Is Associated With Fewer Vesicovaginal and Rectovaginal Fistulae in Recurrent Cervical Cancer: Results From a 10-Year Retrospective Cohort

2019 ◽  
pp. 1-10
Author(s):  
Reena George ◽  
Thotampuri Shanthi Prasoona ◽  
Ramu Kandasamy ◽  
Thenmozhi Mani ◽  
Shakila Murali ◽  
...  
Keyword(s):  
Cervical Cancer ◽  
Lower Risk ◽  
Retrospective Cohort ◽  
Group Performance ◽  
Performance Status ◽  
Eastern Cooperative Oncology Group ◽  
Inverse Association ◽  
Recurrent Cervical Cancer ◽  
Risk Of Death ◽  
The Impact

PURPOSE Anaerobic necrosis in cervical cancer can lead to malodor, fistulae, and treatment abandonment. In this retrospective cohort study, we examined the association between maintenance metronidazole and the incidence of malignant fistulae in recurrent cervical cancer. METHODS We screened all cervical cancer records registered between 2007 and 2016 in the local palliative care database at Christian Medical College, Vellore, India. There were 208 eligible patients with post-treatment residual/recurrent pelvic disease. Among them, 76 had received oral maintenance metronidazole 200 mg once per day for 2 to 86 weeks (interquartile range, 4-16 weeks). RESULTS Seventy-two patients developed at least one fistula. Forty-nine had vesicovaginal fistulae, 10 had rectovaginal fistuale, and 13 developed both types of fistulae. Patients on maintenance metronidazole had fewer fistulae (22.4% v 41.7%; P = .005), a longer median fistula-free survival (42.9 months v 14.1 months; P < .001), and a postrecurrence survival of 11.5 months versus 8.7 months ( P = .112). We performed Cox multivariable proportional hazards regression analysis on the data from the subset of 146 patients observed until death. Bladder/rectal infiltration had a higher risk of fistula (HR, 5.24; P = .011), whereas distant metastases (HR, 2.46; P = .012) and Eastern Cooperative Oncology Group performance status greater than 1 (HR, 1.64; P = .008) were associated with a higher risk of death. Maintenance metronidazole was associated with a lower risk of fistula (hazard ratio [HR], 0.33; 95% CI, 0.16 to 0.67; P = .002) and a lower risk of death (HR, 0.56; 95% CI, 0.39 to 0.81; P = .002). CONCLUSION Our data indicate that there is a significant inverse association between oral maintenance metronidazole and malignant fistulae in locally recurrent cervical cancer. The impact of this simple intervention on pelvic symptoms, fistulae, and survival should be evaluated in prospective studies.

scholarly journals TNFAIP8L1 and FLT1 polymorphisms alter the susceptibility to cervical cancer amongst uyghur females in China

2019 ◽  
Vol 39 (7) ◽  
Author(s):  
Lili Han ◽  
Sulaiya Husaiyin ◽  
Chunhua Ma ◽  
Lin Wang ◽  
Mayinuer Niyazi
Keyword(s):  
Cervical Cancer ◽  
Logistic Regression ◽  
Regression Analysis ◽  
Odds Ratio ◽  
Linkage Disequilibrium Block ◽  
Nucleotide Polymorphisms ◽  
Single Nucleotide ◽  
Cervical Cancer Risk ◽  
Increased Risk ◽  
Stratified Analysis

Abstract TNFAIP8L1 and FLT1 play critical roles in the occurrence and development of tumors, but no in-depth studies have been carried out in cervical cancer. The present study aims to research the correlation between polymorphisms of these two genes and the risk of cervical cancer in the Uygur women. The study involved 342 cervical cancer patients and 498 healthy women. Five single nucleotide polymorphisms (SNPs) from the TNFAIP8L1 gene and the FLT1 gene were selected and genotyped. Odds ratio and 95% CIs were calculated by logistic regression analysis to evaluate the correlation between SNPs and cervical cancer risk. The alleles rs9917028-A (P=0.032), rs10426502-A (P=0.007), and rs1060555-G (P=0.026) of TNFAIP8L1 were associated with a decreased risk of cervical cancer. In the multiple genetic models, these three SNPs were also associated with the risk of cervical cancer. The stratified analysis showed that TNFAIP8L1-rs10426502, -rs1060555, and FLT1-rs9513111 were associated with a decreased risk of cervical cancer amongst people older than 43 years. Moreover, the haplotypes AG (P=0.007) and GC (P=0.026) of linkage disequilibrium block rs10426502|rs1060555 in TNFAIP8L1 were significantly associated with an increased risk of cervical cancer. Our results suggested that the relationships between TNFAIP8L1 and FLT1 polymorphisms and the risk of cervical cancer amongst Uyghur females.

scholarly journals Polymorphisms in endoplasmic reticulum aminopeptidase genes are associated with cervical cancer risk in a Chinese Han population

2020 ◽  
Author(s):  
Chuanyin Li ◽  
Yaheng Li ◽  
Zhiling Yan ◽  
Shuying Dai ◽  
Shuyuan Liu ◽  
...  
Keyword(s):  
Cervical Cancer ◽  
Endoplasmic Reticulum ◽  
Lower Risk ◽  
Antigen Processing ◽  
Intraepithelial Neoplasia ◽  
Candidate Snps ◽  
Nucleotide Polymorphisms ◽  
Chinese Han ◽  
Cervical Cancer Risk ◽  
Healthy Control

Abstract Background: antigen-processing machinery molecules play crucial roles in infectious diseases and cancers. Studies have shown that variants in endoplasmic reticulum aminopeptidase (ERAP) genes can influence the enzymatic activity of ERAP proteins and are associated with the risk of cancers. In the current study, we evaluated the influence of ERAP gene (ERAP1 and ERAP2) variants on susceptibility to cervical intraepithelial neoplasia (CIN) and cervical cancer.Methods: Six single nucleotide polymorphisms (SNPs) in ERAP1 and 5 SNPs in ERAP2 were selected and genotyped in 556 CIN patients, 1072 cervical cancer patients, and 1262 healthy control individuals. Candidate SNPs were genotyped using SNaPshot assay. And the association of these SNPs with CIN and cervical cancer was analysed.Results: the results showed that allelic and genotypic frequencies of rs26653 in ERAP1 were significantly different between cervical cancer and control groups (P=0.001 and 0.004). The allelic frequencies of rs27044 in ERAP1 and rs2287988 in ERAP2 were also significantly different between control and cervical cancer groups (P=0.003 and 0.004). Inheritance model analysis showed that genotypes at rs26618, rs26653, rs27044, and rs2287988 SNPs may be associated with the risk of cervical cancer (P=0.004, 0.001, 0.003, and 0.002). Additionally, haplotype analysis results showed that the ERAP1 haplotype, rs26618T-rs26653G-rs27044C-rs30187T-rs3734016C, was associated with a lower risk of cervical cancer (P=0.001; OR=0.804, 95%CI:0.711-0.910). The ERAP2 haplotypes rs2248374A-rs2549782G-rs2287988G-rs2548538A-rs1056893T might be the risk factor of cervical cancer (P=0.009; OR=1.592, 95%CI:1.122-2.258). Haplotype rs2248374G-rs2549782T-rs2287988A-rs2548538T-rs1056893T of ERAP2 might be associated with lower risk of cervical cancer (P=0.003; OR=0.835,95%CI:0.740-0.942). Conclusion: Our results indicated that rs26653 and rs27044 in ERAP1 and rs2287988 in ERAP2 influenced susceptibility to cervical cancer.

scholarly journals RIPK1 Polymorphisms Alter the Susceptibility to Cervical Cancer among the Uyghur population in China

2019 ◽  
Author(s):  
Lili Han ◽  
Sulaiya Husaiyin ◽  
Chunhua Ma ◽  
Mayinuer Niyazi
Keyword(s):  
Cervical Cancer ◽  
Cancer Risk ◽  
Cancer Susceptibility ◽  
Interacting Protein ◽  
Logistic Regression Models ◽  
Cervical Cancer Risk ◽  
Codominant Model ◽  
Uyghur Population ◽  
Stratified Analysis ◽  
The Relationship

Abstract Background: RIPK1 (receptor-interacting protein kinase-1) plays a role in cancer development, whereas no clear studies focused on the cervical cancer. The objective of this study was to evaluate the relationship between RIPK1 polymorphisms and cervical cancer risk among the Uyghur population. Methods: We performed a case-control study including 342 cervical cancer patients and 498 age-matched healthy controls. Five RIPK1 genetic variants (rs6907943, rs3736724, rs2077681, rs9503400 and rs17548629) were genotyped with Agena MassARRAY platform. The associations between RIPK1 polymorphisms and cervical cancer risk were assessed under multivariate logistic regression models. Results: The results showed rs3736724 and rs2077681 were significantly associated with cervical cancer risk under various genetic models ( p < 0.05). The stratified analysis indicated that the relationships of rs2077681 and rs17548629 with cervical cancer risk were statistically significant in the subgroups of elderly individuals (age > 43 years) and stage. Additional, rs3736724 decreased the cervical cancer risk among the subjects aged ≤ 43 years in codominant model ( p = 0.043). Rs6907943 and rs9503400 could influence the susceptibility of cervical cancer for the patients with different stage ( p < 0.05). Conclusion: Our findings demonstrated that RIPK1 polymorphisms are associated with cervical cancer susceptibility among the Uyghur population in China, and may be involved in the development of cervical cancer.

Human papillomavirus (HPV) 18 genetic variants and cervical cancer risk in Taizhou area, China

Gene ◽  
2018 ◽  
Vol 647 ◽  
pp. 192-197 ◽  
Author(s):  
Hui-Hui Xu ◽  
Ling-Zhi Zheng ◽  
Ai-Fen Lin ◽  
Shan-Shan Dong ◽  
Ze-Ying Chai ◽  
...  
Keyword(s):  
Cervical Cancer ◽  
Human Papillomavirus ◽  
Cancer Risk ◽  
Genetic Variants ◽  
Cervical Cancer Risk ◽  
Hpv 18
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