scholarly journals Incidence and Factors Associated with Postoperative Delayed Hyponatremia after Transsphenoidal Pituitary Surgery: A Meta-Analysis and Systematic Review

2021 ◽  
Vol 2021 ◽  
pp. 1-13
Author(s):  
Cheng-Chi Lee ◽  
Yu-Chi Wang ◽  
Yu-Tse Liu ◽  
Yin-Cheng Huang ◽  
Peng-Wei Hsu ◽  
...  
Keyword(s):  
Systematic Review ◽  
Associated Factors ◽  
Wide Spectrum ◽  
Meta Analysis ◽  
Hospital Readmissions ◽  
Pituitary Surgery ◽  
Factors Associated ◽  
Transsphenoidal Pituitary Surgery ◽  
Factor Evaluation ◽  
Retrospective Nature

Introduction. Postoperative delayed hyponatremia is a complication associated with transsphenoidal pituitary surgery. Due to a wide spectrum of symptoms, the reported incidence and predictors of postoperative delayed hyponatremia vary among studies, and this deserves to be reviewed systematically. Methods. PubMed, EMBASE, and CENTRAL databases were searched until September 1, 2020. Studies were included when (1) the event number of delayed hyponatremia after transsphenoidal pituitary surgery was reported, or (2) the associated factors of such complication were evaluated. Results. A total of 27 studies were included for meta-analysis. The pooled incidence of overall and symptomatic delayed hyponatremia was 10.5% (95% confidence interval (CI) = 7.4–14.7%) and 5.0% (95% CI = 3.6–6.9%), respectively. No overt variations of the pooled estimates were observed upon subgroups stratified by endoscopic and microscopic procedure, publication year, and patients’ age. In addition, 44.3% (95% CI = 29.6–60.2%) of unplanned hospital readmissions within 30 days were caused by delayed hyponatremia. Among the predictors evaluated, older age was the only significant factor associated with increased delayed hyponatremia (odds ratio = 1.16, 95% CI = 1.04–1.29, P  = 0.006). Conclusion. This meta-analysis and systematic review evaluated the incidence of postoperative delayed hyponatremia and found it as a major cause of unplanned readmissions after transsphenoidal pituitary surgery. Older patients are more prone to such complications and should be carefully followed. The retrospective nature and heterogeneity among the included studies and the small number of studies used for risk factor evaluation might weaken the corresponding results. Future prospective clinical studies are required to compensate for these limitations.

scholarly journals Prevalence of potential drug- drug interactions and associated factors among outpatients and inpatients in Ethiopian Hospitals: a systematic review and Meta-analysis of observational studies

2020 ◽  
Author(s):  
Wondim Ayenew ◽  
Getahun Asmamaw ◽  
Arebu Issa
Keyword(s):  
Systematic Review ◽  
Drug Interactions ◽  
Hospital Stay ◽  
Associated Factors ◽  
Meta Analysis ◽  
Random Effect ◽  
Random Effect Model ◽  
Potential Drug ◽  
Comorbid Disease ◽  
Factors Associated

Abstract Background: Drug-drug interaction is an emerging threat to the public health. In Ethiopia, there is high possibility of occurrence of drug-drug interactions in the hospitals. This is because of increased comorbid disease, increased polypharmacy, and increased hospitalization. Therefore, this study aims to summarize the prevalence of potential drug-drug interactions and associated factors in Ethiopian hospitals. Methods: Literature search was performed through accessing legitimate databases in PubMed/MEDLINE, Google Scholar and Research Gate for English-language publications. Advanced search strategies were applied in Science Direct and HINARI to identify any additional papers and published reviews and to retrieve relevant findings closely related to prevalence of potential drug- drug interactions and associated factors with it. The search was conducted from August 3-25, 2019 and all published articles available online until the day of data collection were considered. The pooled estimate of the outcome measure were analyzed by Open Meta Analyst advanced software. By considering clinical heterogeneity among original studies, Der Simonian and Laird’s random effect model were used. I2 statistics were used to assess heterogeneity among each studies. The publication bias was assessed by CMA version-3 software and presented with funnel plot of standard error and precision with Logit event rate. Results: A total of 14 studies were included for systematic review and meta-analysis. From 14 studies, 5761 patients were included and a total of 8717 potential drug- drug interactions were found in 3259 of patients. The prevalence patients with potential drug- drug interactions in Ethiopian Hospitals were found to be 72.2% (95% confidence interval: 59.1%, 85.3%). Based on severity, the prevalence of potential drug- drug interactions were 25.1%, 52.8%, 16.9% and 1.27% for major, moderate, minor potential drug- drug interactions and contraindications respectively. The factors associated with potential drug- drug interactions were related to patient characteristics such as polypharmacy, age, comorbid disease and hospital stay. Conclusions: There is a high prevalence of potential drug- drug interactions in Ethiopian Hospitals. Polypharmacy, age, comorbid disease and hospital stay were the risk factors associated with potential drug- drug interactions.

scholarly journals The magnitude of adherence to option B plus program and associated factors among women in eastern African countries: a systematic review and meta-analysis

2020 ◽  
Vol 20 (1) ◽  
Author(s):  
Reta Tsegaye ◽  
Werku Etafa ◽  
Bizuneh Wakuma ◽  
Getu Mosisa ◽  
Diriba Mulisa ◽  
...  
Keyword(s):  
Systematic Review ◽  
Early Treatment ◽  
Odds Ratio ◽  
Associated Factors ◽  
Treatment Initiation ◽  
Meta Analysis ◽  
Cochrane Library ◽  
Counseling Services ◽  
African Countries ◽  
Factors Associated

Abstract Background Despite coverage and benefits associated with the prevention of mothers to child transmission (PMTCT) services, mothers’ adherence to option B plus is still a challenge. Though few primary studies are available on the magnitude of adherence to option B plus and factors associated in Eastern African countries, they do not provide strong evidence in helping policymakers to address suboptimal adherence to option B plus. Therefore, this systematic review and meta-analysis was intended to estimate the pooled magnitude of adherence to option B plus program and associated factors among women in Eastern African countries. Methods PubMed, Medline, HINARI, Cochrane library, the Web of Science, and Google Scholar were searched for studies reported on the magnitude of adherence to option B plus among women in Eastern African countries. The search terms used were “option B plus”, “magnitude”, “prevalence”, “PMTCT”, “ART adherence”, “associated factors”, “all lists of Eastern African countries” and their combination by Boolean operators. The effect sizes of the meta-analysis were the magnitude of adherence to option B plus and the odds ratio of the associated factors. STATA/SE V14 was used for statistical analysis, and publication bias was assessed using funnel plots and Egger’s test. Results Fourteen studies having total participants of 4883 were included in the systematic review and meta-analysis. Using the random effect model, the pooled prevalence of adherence to option B plus was 71.88% (95% CI: 58.54–85.23%). The factors associated with good adherence to option B plus PMTCT program were partner support (Adjusted odds ratio (AOR) = 4.13; 95% CI: 2.78–6.15), received counseling services (AOR = 4.12, 95% CI: 2.81–6.02), disclosure of HIV status to partner (AOR = 4.38; 95% CI: 1.79–10.70), and clinical stage of HIV/AIDS I/II (AOR = 2.62; 95% CI: 1.53–4.46). Conclusion The level of adherence to option B plus program in Eastern African countries was generally sub-optimal. Thus, a coordinated effort is needed to raise the number of mothers to be tested, and early treatment initiation for HIV positive mothers before the disease advances. Furthermore, counseling services for couples on the importance of early treatment initiation and adherence to medications must be given due attention.

scholarly journals Prevalence of potential drug- drug interactions and associated factors among outpatients and inpatients in Ethiopian Hospitals: a systematic review and Meta-analysis of observational studies

2020 ◽  
Author(s):  
Wondim Ayenew ◽  
Getahun Asmamaw ◽  
Arebu Issa
Keyword(s):  
Systematic Review ◽  
Drug Interaction ◽  
Drug Interactions ◽  
Associated Factors ◽  
Meta Analysis ◽  
Random Effect Model ◽  
Potential Drug ◽  
Comorbid Disease ◽  
Factors Associated ◽  
Drug Drug Interaction

Abstract Background: Drug-drug interaction is an emerging threat to public health. Currently, there is an increase in comorbid disease, polypharmacy, and hospitalization in Ethiopia. Thus, the possibility of drug-drug interaction occurrence is high in hospitals. This study aims to summarize the prevalence of potential drug-drug interactions and associated factors in Ethiopian hospitals.Methods: A literature search was performed by accessing legitimate databases in PubMed/MEDLINE, Google Scholar, and Research Gate for English-language publications. To fetch further related topics advanced search was also applied in Science Direct and HINARI databases. The search was conducted on August 3 to 25, 2019. All published articles available online until the day of data collection were considered. Outcome measures were analyzed with Open Meta Analyst and CMA version statistical software. Der Simonian and Laird’s random effect model, I2 statistics, and Logit event rate were also performed.Results: A total of 14 studies remained eligible for inclusion in systematic review and meta-analysis. From the included studies, around 8,717 potential drug-drug interactions were found in 3,259 peoples out of 5,761 patients. The prevalence of patients with potential drug-drug interactions in Ethiopian hospitals was found to be 72.2% (95% confidence interval: 59.1%, 85.3%). Based on severity, the prevalence of major, moderate, and minor potential drug-drug interaction was 25.1%, 52.8%, 16.9%, respectively, also 1.27% for contraindications. The factors associated with potential drug-drug interactions were related to patient characteristics such as polypharmacy, age, comorbid disease, and hospital stay.Conclusions: There is a high prevalence of potential drug-drug interactions in Ethiopian hospitals. Polypharmacy, age, comorbid disease, and hospital stay were the risk factors associated with potential drug-drug interactions.

scholarly journals Prevalence of potential drug- drug interactions and associated factors among outpatients and inpatients in Ethiopian Hospitals: a systematic review and Meta-analysis of observational studies

2020 ◽  
Author(s):  
Wondim Ayenew ◽  
Getahun Asmamaw ◽  
Arebu Issa
Keyword(s):  
Systematic Review ◽  
Health Care ◽  
Drug Interactions ◽  
Health Care System ◽  
Associated Factors ◽  
Meta Analysis ◽  
Potential Drug ◽  
Comorbid Disease ◽  
Factors Associated ◽  
Care System

Abstract Background A very few number of studies are available regarding the evaluation of potential drug- drug interactions in Sub-Saharan Africa. This is also a problem in Ethiopian health care system. Now a days, in Ethiopia polypharmacy is increased due to comorbid conditions in the hospital health care system, a large number of patients are treated in the outpatient setting and also hospitalized and there is a high possibility for drug- drug interactions. Therefore, this study aims to summarize the prevalence of potential drug- drug interactions and associated factors in hospitals, both among hospitalized patients and outpatients in Ethiopia.Method Literature search was performed through accessing legitimate databases in PubMed/MEDLINE, Google Scholar and Research Gate for English-language publications. Advanced search strategies were applied in Science Direct and HINARI to identify any additional papers and published reviews and to retrieve relevant findings closely related to prevalence of potential drug- drug interactions and associated factors with it. The search was conducted from August 22-25, 2019 and all published and unpublished articles available online until the day of data collection were considered.Results A total of 14 studies were included for systematic review and meta-analysis. From 14 studies, 5761 patients were included and a total of 8717 potential drug- drug interactions were found in 3259 of patients. The prevalence patients with potential drug- drug interactions in Ethiopian Hospitals were found to be 72.2% (95% confidence interval: 59.1%, 85.3%). Based on severity, the prevalence of potential drug- drug interactions were 25.1%, 52.8%, 16.9% and 1.27% for major, moderate, minor potential drug- drug interactions and contraindications respectively. The factors associated with potential drug- drug interactions were related to patient characteristics such as polypharmacy, age, comorbid disease and hospital stay.Conclusion There is a high prevalence of potential drug- drug interactions in Ethiopian Hospitals. From this the most prevalent drug- drug interactions were moderate severity, 52.8%. Polypharmacy, age, comorbid disease and hospital stay were the risk factors associated with potential drug- drug interactions.

scholarly journals Prevalence of potential drug- drug interactions and associated factors among outpatients and inpatients in Ethiopian Hospitals: a systematic review and Meta-analysis of observational studies

2020 ◽  
Author(s):  
Wondim Ayenew ◽  
Getahun Asmamaw ◽  
Arebu Issa
Keyword(s):  
Systematic Review ◽  
Drug Interactions ◽  
Hospital Stay ◽  
Associated Factors ◽  
Meta Analysis ◽  
Random Effect ◽  
Random Effect Model ◽  
Potential Drug ◽  
Comorbid Disease ◽  
Factors Associated

Abstract Background: Drug-drug interaction is an emerging threat to the public health. In Ethiopia, there is high possibility of occurrence of drug-drug interactions in the hospitals. This is because of increased comorbid disease, increased polypharmacy, and increased hospitalization. Therefore, this study aims to summarize the prevalence of potential drug-drug interactions and associated factors in Ethiopian hospitals. Methods: Literature search was performed through accessing legitimate databases in PubMed/MEDLINE, Google Scholar and Research Gate for English-language publications. Advanced search strategies were applied in Science Direct and HINARI to identify any additional papers and published reviews and to retrieve relevant findings closely related to prevalence of potential drug- drug interactions and associated factors with it. The search was conducted from August 3-25, 2019 and all published articles available online until the day of data collection were considered. The pooled estimate of the outcome measure were analyzed by Open Meta Analyst advanced software. By considering clinical heterogeneity among original studies, Der Simonian and Laird’s random effect model were used. I2 statistics were used to assess heterogeneity among each studies. The publication bias was assessed by CMA version-3 software and presented with funnel plot of standard error and precision with Logit event rate. Results: A total of 14 studies were included for systematic review and meta-analysis. From 14 studies, 5761 patients were included and a total of 8717 potential drug- drug interactions were found in 3259 of patients. The prevalence patients with potential drug- drug interactions in Ethiopian Hospitals were found to be 72.2% (95% confidence interval: 59.1%, 85.3%). Based on severity, the prevalence of potential drug- drug interactions were 25.1%, 52.8%, 16.9% and 1.27% for major, moderate, minor potential drug- drug interactions and contraindications respectively. The factors associated with potential drug- drug interactions were related to patient characteristics such as polypharmacy, age, comorbid disease and hospital stay. Conclusions: There is a high prevalence of potential drug- drug interactions in Ethiopian Hospitals. Polypharmacy, age, comorbid disease and hospital stay were the risk factors associated with potential drug- drug interactions.

scholarly journals Knowledge and utilisation of preconception care and associated factors among women in Ethiopia: systematic review and meta-analysis

2021 ◽  
Vol 18 (1) ◽  
Author(s):  
Alemu Degu Ayele ◽  
Habtamu Gebrehana Belay ◽  
Bekalu Getnet Kassa ◽  
Mulugeta Dile Worke
Keyword(s):  
Systematic Review ◽  
Antenatal Care ◽  
Associated Factors ◽  
Preconception Care ◽  
Meta Analysis ◽  
Grey Literature ◽  
Database Systems ◽  
Child Health Services ◽  
Measurement Tool ◽  
Care Services

Abstract Background Preconception care is the provision of biomedical, behavioural, and social health interventions provided to women and couples before conception. However, in Ethiopia, little is known and practised to support preconception care. Therefore, this study aimed to assess women’s knowledge and utilisation of preconception care and its associated factors in Ethiopia using systematic review and meta-analysis. Method In the current meta-analysis, variables were searched from different electronic database systems, which included PubMed, Google Scholar, EMBASE, HINAR, Scopus, Web of Sciences, and Grey literature. Data were extracted using a standardised data collection measurement tool. The data were analysed by using STATA 14 statistical software. I2 tests assessed heterogeneity between the studies. A random-effect model was used to forecast the pooled knowledge and utilisation of preconception care. Results Thirteen full-text studies were included. The pooled prevalence of knowledge and utilisation of preconception care among women in Ethiopia was 30.95% and 16.27% respectivelly. Secondary education (OR = 2.78, 95% CI,2.01–3.85), college and above (OR = 5.05, 95% CI,2.70–9.44), and antenatal care (OR = 3.89, 95% CI, 1.69–8.98) were significantly associated with knowledge level whereas; age (OR = 2.43, 95% CI, 1.30–4.53) and knowledge on preconception care (OR = 3.95, 95% CI,2.35–6.62) were positively associated with utilisation of preconception. Conclusions Women’s level of knowledge and utilisation of preconception care was significantly low. Educational status and antenatal care follow-up were factors shown to affect knowledge of preconception care. Age and having a sound knowledge of preconception care indicated a significant association towards utilisation of preconception care. Thus, integrating preconception care strategies and policies that can address all the components of preconception care services with other maternal and child health services will be essential when designing effective implementation strategies to improve preconception care uptake. Besides this, advocating for better education for women, awareness creation, and increasing antenatal care services are essential. Prospero registration: CRD42020218062

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