scholarly journals The Association of Serum IL-10 Levels with the Disease Activity in Systemic-Onset Juvenile Idiopathic Arthritis Patients

2021 ◽  
Vol 2021 ◽  
pp. 1-7
Author(s):  
Yu Peng ◽  
Xiaohui Liu ◽  
Zhao Duan ◽  
Junkai Duan ◽  
Yulan Zhou
Keyword(s):  
Juvenile Idiopathic Arthritis ◽  
Disease Activity ◽  
Sedimentation Rate ◽  
Serum Levels ◽  
Interleukin 10 ◽  
C Reactive Protein ◽  
Clinical Marker ◽  
Reactive Protein ◽  
Erythrocyte Sedimentation ◽  
Systemic Onset

Objectives. Interleukin-10 (IL-10) has been suggested as a biomarker of disease activity in patients with adult-onset Still’s disease (AOSD). In this study, we evaluated the serum IL-10 levels and investigated its clinical relevance in systemic-onset juvenile idiopathic arthritis (SoJIA). Methods. IL-10 levels were determined in 21 patients diagnosed with SoJIA and 35 patients with fever diseases which were suspected as SoJIA, and IL-10 levels were compared between SoJIA patients with regard to disease activity, disease courses, and other biomarkers. Results. Patients with SoJIA had significantly higher levels of IL-10 compared to patients with other febrile diseases. The serum levels of IL-10 were significantly higher in active SoJIA compared to inactive and positively correlated with known disease activity markers such as erythrocyte sedimentation rate (ESR), C-reactive protein level (CRP), ferritin (FER), and IL-6 levels. Moreover, the levels of IL-10 at diagnosis were significantly higher in SoJIA patients with a nonmonocyclic pattern than in patients with a monocyclic pattern. Compared to CRP, ESR, FER, and IL-6, IL-10 levels were superior in predicting monocyclic patients from nonmonocyclic patients. Conclusion. Compared to other febrile diseases, SoJIA patients have markedly higher levels of IL-10 which may assist with diagnosis. And a clear association of serum IL-10 levels with disease activity and disease courses in SoJIA was found. These results suggest that serum IL-10 might be a reliable clinical marker in SoJIA.

scholarly journals Title: Predictive value of Erythrocyte Sedimentation Rate and C-Reactive Protein in Behcet's Disease Activity and Manifestations: A Cross-Sectional Study

2021 ◽  
Author(s):  
Amirhossein Parsaei ◽  
Soroush Moradi ◽  
Maryam Masoumi ◽  
Fereydoun Davatchi ◽  
Anahita Najafi ◽  
...  
Keyword(s):  
Disease Activity ◽  
Erythrocyte Sedimentation Rate ◽  
Sedimentation Rate ◽  
Predictive Value ◽  
Behcet’S Disease ◽  
Behçet's Disease ◽  
C Reactive Protein ◽  
Behcet's Disease ◽  
Reactive Protein ◽  
Erythrocyte Sedimentation

Abstract Background: Behcet’s disease (BD) as a chronic inflammatory condition that affects the eyes, skin, central nervous system, gastrointestinal tract and vessels. According to the literature, the exact value of C-reactive protein (CRP) and erythrocyte sedimentation rate (ESR) in predicting active manifestations of BD remains controversial. In this study, we aim to assess and compare values of ESR and CRP between BD patients with active/ inactive BD and active/inactive manifestations of the disease. Moreover, we try to determine the predictive value of ESR and CRP for disease activity.Methods: Participants (n=514) were drug-naïve BD patients; Based on last two visits, ESR and CRP values, disease activity, and active manifestations were recorded. The Man-Whitney U test measured the associations, and the binomial logistic regression evaluated the predictive value of ESR and CRP for active disease and each active manifestation. The sensitivity and specificity and the area under the curve (AUC) for each model were determined using receiver operating characteristic curves (ROC). Multiple regressions were run to predict BD activity score from ESR and CRP.Result: Patients with active ocular, oral, genital, joint and dermal manifestations had higher ESR and CRP values (Mann-Whitney U test, p< 0.05 for all). Binomial logistic regressions showed that ESR had valuable predictive value for active BD (OR =1.09[1.04-1.13] , AUC = 0.79[0.74-0.83], p<0.001) and active vascular manifestations (1.03[1.01-1.05], AUC = 0.85[0.79-0.92], p<0.001). CRP had good predictive value for active vascular manifestations (OR 1.98[1.45-2.72], AUC = 0.86[0.8-0.91], p<0.001,). The optimal value of ESR ≥ 10.5 and ESR ≥ 42.5 could predict active BD and active vascular manifestations with Sensitivity,Specificity = 71%,75% and =81%, 83% respectively.Conclusions: ESR and CRP are both associated with active BD and most manifestations of the diseases. They can be used for the prediction of active BD and active vascular manifestations in BD patients. Further studies can help to confirm the findings of the current research.

Interchangeability of 28-joint disease activity scores using the erythrocyte sedimentation rate or the C-reactive protein as inflammatory marker

2014 ◽  
Vol 33 (6) ◽  
pp. 783-789 ◽  
Author(s):  
Liseth Siemons ◽  
Harald E. Vonkeman ◽  
Peter M. ten Klooster ◽  
Piet L. C. M. van Riel ◽  
Mart A. F. J. van de Laar
Keyword(s):  
Disease Activity ◽  
Erythrocyte Sedimentation Rate ◽  
Sedimentation Rate ◽  
Inflammatory Marker ◽  
Joint Disease ◽  
C Reactive Protein ◽  
Reactive Protein ◽  
Erythrocyte Sedimentation
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