scholarly journals Antidiabetic Activity of Widely Used Medicinal Plants in the Sri Lankan Traditional Healthcare System: New Insight to Medicinal Flora in Sri Lanka

2021 ◽  
Vol 2021 ◽  
pp. 1-12
Author(s):  
Keddagoda Gamage Piyumi Wasana ◽  
Anoja Priyadarshani Attanayake ◽  
Kamani Ayoma Perera Wijewardana Jayatilaka ◽  
Thilak Priyantha Weerarathna
Keyword(s):  
Diabetes Mellitus ◽  
Sri Lanka ◽  
Medicinal Plants ◽  
Healthcare System ◽  
Bioactive Compounds ◽  
Antidiabetic Activity ◽  
Depth Information ◽  
Sri Lankan ◽  
New Drug ◽  
Medicinal Flora

The use of medicinal plant extracts and their isolated bioactive compounds for the management of diabetes mellitus has been tremendously increased in recent decades. The present study aimed at providing in-depth information on medicinal flora that has been widely used in the Sri Lankan traditional healthcare system for the management of diabetes mellitus. The data of this review article were obtained from published articles from January 2000 to September 2020 in scientific databases of PubMed, Web of Science, and Google Scholar. In this review, a total number of 18 medicinal plants with the antidiabetic activity were expressed, and their isolated antidiabetic active compounds were highlighted as new drug leads. Results of the reported studies revealed that medicinal plants exert a potent antidiabetic activity via both in vitro and in vivo study settings. However, bioactive compounds and antidiabetic mechanism (s) of action of many of the reported medicinal plants have not been isolated/elucidated the structure in detail, to date. Reported antidiabetic medicinal plants with other properties such as antioxidant and antihyperlipidemic activities deliver new entities for the development of antidiabetic agents with multiple therapeutic targets. This is a comprehensive review on potential antidiabetic activities of the Sri Lankan medicinal plants that have been widely used in the traditional healthcare system. The information presented here would fill the gap between the use of them by traditional healers in the traditional medicine healthcare system in Sri Lanka and their potency for development of new drug entities in future.

scholarly journals Medicinal Plants and Its Pharmacological Values

2021 ◽  
Author(s):  
Smita G. Bhat
Keyword(s):  
Medicinal Plants ◽  
Natural Resources ◽  
Bioactive Compounds ◽  
Biological Diversity ◽  
Biological Activities ◽  
Chemical Compounds ◽  
Natural Sources ◽  
Plant Parts ◽  
New Drug ◽  
Important Chemical

Plants have been used as a source of medicine for the treatment of different diseases from thousands of years ago. There is numerous evidences are available for use of plants as a medicine in the treatment of diseases in Indian, Egyptian, Chinese, Greek and Roman system of medicine. Pharmacognosy is the study of medicines derived from natural sources, mainly from plants which may further lead to development of new drug. The exploration, extraction and screening of biological diversity such as herbs, spices, microbes and other natural resources is the worldwide activity in recent years. Phytochemicals are the naturally available bioactive compounds which are derived from different plant parts and are primarily responsible for biological activities. The most important chemical compounds which are present in the plants are alkaloids, phenols, saponins, carbohydrates, terpenoids, steroids, flavonoids and tannins etc.

scholarly journals Evaluation of Antidiabetic Activity of Gymnema sylvestre and Andrographis paniculata in Streptozotocin Induced Diabetic Rats

2017 ◽  
Vol 9 (1) ◽  
Author(s):  
Prem Kumar ◽  
Sudha Rani ◽  
B Arunjyothi ◽  
P. Chakrapani ◽  
A Rojarani
Keyword(s):  
Diabetes Mellitus ◽  
Medicinal Plants ◽  
Low Cost ◽  
Diabetic Rats ◽  
Andrographis Paniculata ◽  
Antidiabetic Activity ◽  
Gymnema Sylvestre ◽  
Streptozotocin Induced Diabetes ◽  
Oxidative Effect

Diabetes mellitus is a difficult metabolic disorder that has seriously impact the human health and quality of life. Medicinal plants are being used to control diabetes However, they are not entirely effective and no one has ever been reported to have fully recovered from diabetes. Many plants have been used for the management of diabetes mellitus in various traditional systems of medicine worldwide as they are a great source of biological constituents and many of them are known to be effective against diabetes. Medicinal plants with antihyperglycemic activities are being more desired, owing to lesser sideeffects and low cost. Streptozotocin was induced to all groups of rats at dosage of 35 -55mg/kg except for the normal. Streptozotocin induced diabetes in sprague dawly rats were used to study antidiabetic activity of methonolic extract of two medicinal plants Gymnema sylvestre,Andrographis paniculata methanolic leaf extract was administered orally in graded doses of 30 mg/kg,50mg /kg sprague dawly rats Gymnema sylvestre at a dose of 30mg/kg and Andrographis paniculata at a dose of 50mg/kg showed significant anti-hyperglycemic and anti-oxidative effect which was evident from the 1st week of treatment.

scholarly journals PHARMACOLOGICAL EVALUATION OF FICUS RELIGIOSA FOR THEIR INVITRO HYPOGLYCEMIC ACTIVITY

2020 ◽  
pp. 1-2
Author(s):  
Poonam Pandey
Keyword(s):  
Diabetes Mellitus ◽  
Medicinal Plants ◽  
Metabolic Disorder ◽  
Antidiabetic Activity ◽  
Important Criterion ◽  
Ficus Religiosa ◽  
In Vitro Techniques ◽  
Pharmacological Evaluation ◽  
Disease Present

Diabetes mellitus is a metabolic disorder and its management is an important criterion for pharmacotherapy. The medicinal plants play very important role in preventing the progress of the disease. Present study deals with screening of polyherbal extracts using in-vitro techniques for its antidiabetic activity. The plants used in the present study are Ficus religiosa which use traditionally for the treatment of various ailments. In the present study different part of F. religiosa bark showed highest antioxidant and highest antidiabetic activity. This study indicates the curative beneƒOts of F. religiosa in traditional medicinal system.

Antidiabetic Activity (Anti-Hyperglycemic Activity, Anti-Hyperlipidemic Activity)/Agents From Medicinal Plants

2020 ◽  
pp. 25-48
Author(s):  
Manish Singh Sansi ◽  
Daraksha Iram ◽  
Kapil Singh Narayan ◽  
Sandeep Kumar ◽  
Om Prakash ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Insulin Secretion ◽  
Medicinal Plants ◽  
Insulin Receptor ◽  
Antidiabetic Activity ◽  
Insulin Deficiency ◽  
Receptor Function ◽  
Synthetic Drugs ◽  
Treatment Of Diabetes ◽  
Insulin Receptor Kinase

Diabetes mellitus (DM) is a chronic disease caused by inherited or acquired deficiency in insulin secretion and by decreased insulin secretion by the organ. Insulin deficiency causes the DM. Synthetic drugs are widely used in the treatment of diabetes, but they have some side effects. The antihyperglycemic and antihyperlipedemic effects of the plants are related to their ability to maintain pancreatic function. Medicinal plants constituents such as glycosides, alkaloids, terpenoids, and flavonoids mitigate DM. B. ciliata inhibits the α-glucosidase and α-amylase. Cinnamon extracts improve insulin receptor function by activating insulin receptor kinase and inhibiting insulin receptor phosphatase, which lead to an increase in insulin sensitivity. Morinda lucida also had the highest antioxidant activity, and it also inhibited the α-glucosidase. Many plants have also been shown to antihyperlipedemic effects. Finally, it can be concluded that medicinal plants have that ability to treat or prevent DM.

scholarly journals Mechanisms of Action of Flavonoids in the Management of Diabetes mellitus

2021 ◽  
Vol 11 (5-S) ◽  
pp. 194-202
Author(s):  
S Chandra Mohan ◽  
Namrata Jain ◽  
S. Sumathi
Keyword(s):  
Diabetes Mellitus ◽  
Medicinal Plants ◽  
Mechanisms Of Action ◽  
The Body ◽  
Antidiabetic Activity ◽  
Cost Of Treatment ◽  
Keywords Diabetes ◽  
Microvascular And Macrovascular Complications ◽  
Chronic Use

Management of diabetes mellitus is a challenge for clinicians. Uncontrolled hyperglycemia increases the risk of microvascular and macrovascular complications, damaging the body systems.  Although a number of antidiabetic drugs are available for therapeutic intervention, toxicity, loss of efficacy in chronic use and high cost of treatment have necessitated the search for new molecules to manage diabetes. Safety and cost are the main prerequisite for the new antidiabetic molecules. Medicinal plants and their purified phytochemicals have shown promising antidiabetic potential in the past few years. The flavonoids can be widely classified into different categories like anthocyanins, catechins, flavanols, flavones, flavanones etc. Some flavonoids have hypoglycemic properties. They may improve al-tered glucose and oxidative metabolisms of diabetic states. The hypoglycemic effect of some herbal extracts has been confirmed in human and animal models of type 2 diabetes mellitus (T2DM). Some of the important phytoconstituents from the classes of flavonoid have been discussed here. The current review summarizes the  antidiabetic activity of flavonoids, the mechanism-based action of flavonoids that target the various metabolic pathways in humans. Keywords: Diabetes mellitus, Flavonoids, Medicinal plants, mechanisms of action, T2DM

scholarly journals Investigations on anti-diabetic medicinal plants used by Sugali tribal inhabitants of Yerramalais of Kurnool district, Andhra Pradesh, India

2012 ◽  
Vol 4 (2) ◽  
pp. 19-24 ◽  
Author(s):  
S Khaleel Basha ◽  
G Sudarsanam ◽  
M Silar Mohammad ◽  
Niaz Parveen
Keyword(s):  
Diabetes Mellitus ◽  
Medicinal Plants ◽  
Rural Areas ◽  
Andhra Pradesh ◽  
Herbal Remedies ◽  
Eastern Ghats ◽  
Hypoglycemic Agents ◽  
Antidiabetic Activity ◽  
Oral Hypoglycemic Agents ◽  
Plant Materials

An Ethno-botanical survey was carried out among the Sugali tribes in Yerramalais of Eastern Ghats, Kurnool District, Andhra Pradesh for the exploration of antidiabetic herbal remedies. Diabetes mellitus is one of the common metabolic disorders with micro-and macrovascular complications that results in significant morbidity and mortality. It is considered as one of the five leading causes of death in the world. In Allopathy medicine no satisfactory effective therapy is still available to cure diabetes mellitus. There is increasing demand by patients to use natural products with antidiabetic activity due to side effects associated with the use of insulin and oral hypoglycemic agents. The art of herbal treatment has very deep roots in Indian culture. Even today in most of the rural areas people are depending on herbal drug systems for primary health care. The indigenous knowledge of local traditional healers and native plants used for the treatment of diabetics related health disorders were collected through questionnaire and personal interviews. A total of 10 informants with in the age group of 50 to 68 were interviewed, among them two were tribal practitioners. A total of 21 genera and 18 families were identified which are being used for the treatment of diabetes. Results depict that fresh plant materials were invariably preferred for the treatment of long term complications associated with diabetics. Anti-diabetic medicinal plants used by Sugalis have been listed along with plant parts used. The collected information's are arranged in the alphabetic order of the plant botanical name, family with the local (or) common name, and mode of use is listed. DOI: http://dx.doi.org/10.3329/sjps.v4i2.10435 S. J. Pharm. Sci. 4(2) 2011: 19-24

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