scholarly journals Plasma Lipids and Lipoproteins in Sickle Cell Disease Patients in the Northern West Bank, Palestine

2021 ◽  
Vol 2021 ◽  
pp. 1-8
Author(s):  
Fekri Samarah ◽  
Mahmoud A. Srour ◽  
Kamal Dumaidi
Keyword(s):  
Lipid Profile ◽  
Total Cholesterol ◽  
Sickle Cell ◽  
Plasma Lipids ◽  
Sickle Cell Trait ◽  
Plasma Cholesterol ◽  
Control Group ◽  
Significant Difference ◽  
Males And Females ◽  
Altered Lipid

Background. Lipid metabolism may be altered in red cell genetic disorders. The erythrocyte and plasma lipids are defected which may increase the risk of cardiovascular disease. In the present study, we hypothesized a possible link between severity of anemia and altered lipid profile in SCD. Methods. A total of 151 SCD patients, including 62 patients with sickle cell anemia (SS), 54 patients with sickle β-thalassemia (ST), and 35 individuals with sickle cell trait (AS), were studied. The control group consisted of 160 healthy individuals. Total cholesterol (TC), triglyceride (TG), and high-density lipoprotein cholesterol (HDL-C) were enzymatically measured. Results. Total cholesterol and LDL-C were significantly lower ( P value < 0.001) in SS and ST patients compared to AS individuals and AA controls. However, LDL-C was significantly lower in AS individuals (both males and female) compared to AA controls ( P value < 0.001). The HDL-C in SS and ST patients (both males and females) was significantly lower than that in AS individuals ( P value < 0.001). In addition, the HDL-C was significantly higher in SS and ST males and AS (males and females) compared to AA controls ( P value < 0.001). The HDL-C was also significantly higher in SS males ( P value < 0.001) and females ( P value < 0.05) compared to ST patients. The HDL-C was significantly higher in AS individuals ( P value < 0.001) compared to AA controls. The triglycerides in SS males was significantly lower than that in ST patients ( P value < 0.001), but there was no significant difference when compared to AS individuals and AA controls. In contrast, triglycerides in SS females were significantly lower than those in ST ( P value < 0.05), AS ( P value < 0.001), and AA controls ( P value < 0.001). In males of ST patients, triglycerides were significantly higher than those observed in AS males and AA males ( P value < 0.001). In contrast, females of ST patients have a significantly lower triglycerides compared to AS and AA females ( P value < 0.001). Conclusions. In SCD, the plasma is affected in some way, especially the plasma cholesterol that was investigated in this study. Further prospective studies should examine the contribution of an altered lipid profile to the severity and clinical complications in SCD patients.

scholarly journals Pregnancy Outcomes in Women with Sickle Cell Trait

Blood ◽  
2021 ◽  
Vol 138 (Supplement 1) ◽  
pp. 4176-4176
Author(s):  
Sarah S Sewaralthahab ◽  
Jiling Chou ◽  
Stephen Fernandez ◽  
Nawar Shara ◽  
Hedy Smith
Keyword(s):  
Sickle Cell ◽  
Subgroup Analysis ◽  
Sickle Cell Trait ◽  
Private Insurance ◽  
Adverse Outcomes ◽  
Control Group ◽  
P Value ◽  
Benign Condition ◽  
Significant Difference ◽  
Fetal Complications

Abstract Introduction Sickle cell trait (SCT) is a heterozygous condition in which individuals inherit one copy of the hemoglobin S allele (Hb S) which harbors a point mutation in codon 6 of the beta globin gene and one copy of the hemoglobin A allele (Hb A). SCT is a highly prevalent state affecting 300 million people worldwide with 5.5 million births annually. Individuals with SCT are generally asymptomatic with a normal life expectancy unlike their counterparts with sickle cell disease (Hb SS). Historically, they had been considered to have a benign condition with no adverse outcomes on quality or length of life. More recently extensive literature has been published regarding the potential morbidity associated with SCT, especially under extremes of stress or high oxygen demand states. There is a paucity of high-quality data addressing the implications of SCT on pregnancy but pregnant women with SCT appear to have an increased risk of maternal and fetal complications. We looked at the association between SCT and maternal and fetal complications via retrospective analysis. Methods We extracted data from the electronic medical records at our tertiary medical center on all deliveries that occurred between January 2015 and December 2020. A total of 21,198 deliveries occurred in this time frame. One hundred and sixty-two women with sickle cell trait (7.6%) were identified and matched in a 2:1 fashion to women without SCT controlling for age, gravidity, and race. Subgroup analysis by age, hemoglobin (Hb), body mass index (BMI), history of hypertension, and type-2 diabetes were carried out however subgroup analyses by a history of deep vein thrombosis or pulmonary embolism (DVT/PE) and chronic kidney disease (CKD) were not conducted due to the small frequencies in the "Yes" groups. Results The median age was 27.5 years and 92.5% were African American. Of the cohort, 31.7% carried private insurance, 65.4% carried federal insurance (Medicaid) and 2.9% were self-pay (defined as other). Despite the lack of statistical significance between the two cohorts, some variables were noted to have numerically noticeable differences. Vaso-occlusive crisis (VOC) was seen in 1.9% of the SCT group (n=3) and in none of the control group and pyelonephritis/UTI was seen in 11.7% of the SCT group vs 7.1% in the control group (p-value 0.123) [Table 1]. On subgroup analysis by age (≤ 35 years vs &gt;35 years) a statistically significant difference was seen in pregnancy-related hypertensive disorders (PRHD which includes gestational hypertension, preeclampsia, eclampsia, and HELLP syndrome) (60% of women with SCT vs 30% in women without SCT, p-value 0.05). VOC was only noted in women with SCT ≤ 35 years [Table 2]. When the cohorts were analyzed by Hb value ( ≤ 10 g/dL vs &gt;10 g/dL), a statistically significant difference in PRHD was noted in women with Hb &lt;10 g/dL (61% of in women with SCT vs 38.4% in women without SCT, p-value 0.033) [Table 3]. No differences were noted in subgroup analysis by essential hypertension, BMI, or type-2 diabetes. Discussion Despite the relatively small cohort, it is evident that SCT is not a benign condition in pregnancy. The racial and socioeconomic disparities are evident by the higher percentage of African Americans (92.5%) and women lacking private insurance coverage (68.3% of the cohort were covered by Medicaid or uninsured) who suffered adverse outcomes. VOC was noted exclusively in women with SCT (0.6% of the entire cohort) consistent with the notion that stress and/or hypoxia induce sickling. The interesting findings in this cohort were related to PRHD which occurred more frequently in women with SCT older than 35 years and in women with SCT and a Hb ≤10 g/dL. Although advanced maternal age and severe anemia are known risk factors for preeclampsia, the higher incidence of PRHD in women with SCT and advanced age (&gt;35 years) or anemia (Hb ≤10 g/dL) warrants specific examination in future studies. Additionally, studies are needed to interrogate the pathophysiology of the hypertensive disease that occurs in SCT pregnancies. One limitation of the current retrospective study is that we were unable to define the precise subtype of the PRHD. In future studies, we would specifically examine the incidence of pre-eclampsia causing PRHD in individuals with SCT. Figure 1 Figure 1. Disclosures No relevant conflicts of interest to declare.

scholarly journals Estimation of Serum Lipid Profile and Its Correlation with Alveolar Bone Height in Chronic Periodontitis

2019 ◽  
pp. 1-6
Author(s):  
Avadhut Kamble ◽  
Mukta Motwani ◽  
Naman Shah
Keyword(s):  
Lipid Profile ◽  
Total Cholesterol ◽  
Chronic Periodontitis ◽  
Serum Lipid ◽  
Fasting Blood Glucose ◽  
Screening Method ◽  
Serum Lipid Profile ◽  
Control Group ◽  
Group I ◽  
Significant Difference

Aim: Numerous studies have been previously carried out to find out any correlation between lipid profile and periodontitis but existence of an association does not establish whether periodontitis causes an elevation in serum lipid level or elevation in serum lipid profile predispose to periodontitis. The aim of the present study was to find any significant correlation between HDL, LDL, VLDL and cholesterol with periodontitis. Material and Methods: 100 patients with chronic periodontitis (group I) and 50 healthy patients (group II) were selected. The levels of serum lipid, including HDL, LDL, VLDL, and TOTAL CHOLESTEROL along with fasting blood glucose were assessed. The relationship between severity of periodontitis based on clinical and radiographic finding with serum lipid correlated. Results: There was no significant difference found between mean values of total cholesterol, LDL and VLDL among study and control group. Only HDL showed a highly significant difference (p< 0.00) between healthy and patient with chronic periodontitis. Conclusion: Estimation of serum lipid profile, especially HDL levels in subjects with periodontitis can be considered as a screening method for early diagnosis of atherosclerosis to avoid further progression of cardiovascular changes in early age of the life.

scholarly journals Vitamin D level, lipid profile, and vitamin D receptor and transporter gene variants in sickle cell disease patients from Kurdistan of Iraq

2021 ◽  
Author(s):  
Abdalla Hussein Hama ◽  
Ebrahim Shakiba ◽  
Zohreh Rahimi ◽  
Mehran Karimi ◽  
Hadi Mozafari ◽  
...  
Keyword(s):  
Vitamin D ◽  
Sickle Cell Disease ◽  
Lipid Profile ◽  
Total Cholesterol ◽  
Vitamin D Deficiency ◽  
Sickle Cell ◽  
Healthy Individuals ◽  
Cell Disease ◽  
Mineral Density ◽  
Significant Difference

Abstract Background. Sickle cell disease patients are susceptible to the development of vitamin D deficiency. Vitamin D through binding to vitamin receptor (VDR) exerts its function and affects gene transcription in target tissues. Also, VDR variants could affect bone mineral density. Methods. In a case-control study 101 sickle cell disease patients including 61 SS, 39 S/β-thalassemia, and 1 SD along with 110 healthy individuals from Kurdistan of Iraq were studied. The lipid profile, vitamin D level, FokI, and TaqI variants of VDR and group-specific component (GC) were detected using the standard enzymatic method, the immunodiagnostic systems limited EIA kit and PCR-RFLP methods, respectively. Results. Around 93 and 82% SS and S/β thalassemia patients, respectively had vitamin D deficiency compared to 83% healthy individuals. Severe vitamin D deficiency (<10 ng/ml) was detected in 78.7% of SS patients. Plasma levels of total cholesterol, HDL-C, and LDL-C in SCD patients were significantly lower compared to controls. Vitamin D levels were negatively correlated to TG and positively correlated to total cholesterol and HDL-C. The frequencies of the C allele of FokI were 81.7 (p=0.003), 80.2 (p=0.034), and 84.6% (p=0.011) in all SCD, SS, and SS/βthal patients, respectively compared to 69.1% in controls. However, no significant difference was detected by comparing the frequencies of VDR TaqI and GC polymorphisms between SCD patients and controls.Conclusion. In the present study we found hypocholesterolemia, high prevalence of VDR FokI C allele, and low vitamin D level among children and adults with SCD patients from Kurdistan of Iraq.

scholarly journals Lipid profile and its relevance in carcinoma breast

2017 ◽  
Vol 4 (7) ◽  
pp. 2227
Author(s):  
Hrituraj Rohariya ◽  
Pankaj Gharde ◽  
Pramita Muntode Gharde
Keyword(s):  
Breast Cancer ◽  
Lipid Profile ◽  
Total Cholesterol ◽  
Control Group ◽  
P Value ◽  
Study Group ◽  
Carcinoma Breast ◽  
Cholesterol Levels ◽  
Significant Difference ◽  
Post Menopausal

Background: Breast cancer has emerged as a rapidly growing cancer in India and has already replaced cervical cancer. According to global cancer statistics for the year 2008, breast cancer resulted in 46 million deaths. In Asia, incidence rate of breast cancer is lower but is drastically rising. Nevertheless, while dyslipidemia [high LDL-C (low density Lipo-protein-cholesterol) and low HDL-C (high density lipo-protein-cholesterol) levels] has controversial role in this disease; the specific influence of dyslipidemia in breast cancer initiation and progression is not completely understood. So, we undertook this study.Methods: The study was conducted in the department of general surgery, at Medical College and allied Hospital, in Central rural India between year 2012 and 2014. It was a case control study with a sample size of 50 female participants attending the surgery in patient department, fitting in the inclusion criteria as cases and 50 matching controls. The Data was entered in master chart was statistically analyzed by using SYSTAT version 11 and tests were applied accordingly.Results: Age is a crucial factor in malignancy, most of the studies show malignancy presents more in elder population when compared to young ones. In most patients were between 31-50 years. The youngest patient was of 36 years and the oldest was 78 years. The mean age of the patients affected was 48.54 years which is close to the values in other studies. This study also demonstrated significantly high (p value<0.01) serum TC (total cholesterol) levels of post-menopausal study group (32%, more) as compared to post-menopausal control group. The increase in Serum TC levels was more in post-menopausal study group as compared with pre-menopausal study group. Present study had not shown a significant difference (p value >0.05) between serum levels of HDL-C levels in pre-and post-menopausal control group and study group, though post-menopausal cases had slightly lower values of HDL-C when compared with pre-menopausal controls.Conclusions: We conclude from this study that there is a definite positive correlation between carcinoma breast and fasting lipid profile. The pre-and post-menopausal cases showed significant correlation as far as Total Cholesterol and LDL. Whereas there was no significant correlation between HDL, VLDL and TG (triglycerides). Body mass index has no relation with carcinoma breast.

scholarly journals Vascular endothelial dysfunction in sickle cell disease by brachial artery flow mediated dilatation

2014 ◽  
Vol 5 (3) ◽  
pp. 105-107 ◽  
Author(s):  
Pranav Kumar Raghuwanshi ◽  
Somnath Singh Raghuvanshi
Keyword(s):  
Endothelial Dysfunction ◽  
Sickle Cell Disease ◽  
Sickle Cell ◽  
Sickle Cell Trait ◽  
Control Group ◽  
Cell Disease ◽  
Significant Difference ◽  
Flow Mediated Dilatation ◽  
Artery Flow ◽  
And Control

Objective: The present study was conducted aiming to assess endothelial function in sickle cell disease (SS), sickle cell trait(SA) and compare to endothelial dysfunction between sickle cell anemia (SS), sickle cell trait (SA) cases and control (AA) patients to evaluate correlation of endothelial dysfunction. Methods: The study population comprised of, total 25 cases having sickle cell disease and sickle cell trait and 25 age and sex matched normal control. Endothelial dysfunction as assessed by brachial artery flow mediated dilatation by colour Doppler (non-invasive method)by using Siemens Sonoline 500. Statistical analysis was performed using Software Statistical Package for Social Sciences (SPSS) version 20, and P value of less than 0.05 was considered as statistically significant at 95% confidence intervals. Results: Significant difference were observed in FMD (flow mediated vasodilatation) in case and control group (p<0.05), also significant difference was demonstrated between AS and SS group. Conclusion: The percentage of flow mediated dilatation of vessel is a marker of endothelial function was significantly lower in cases as compared to controls and was also lower in AS & SS when compared to control group & significantly lower in SS group than AS group. Asian Journal of Medical Science, Volume-5(3) 2014: 105-107 http://dx.doi.org/10.3126/ajms.v5i3.9445

scholarly journals The Correlation of Use of Depo Medroxy Progesterone Acetate (DMPA) In-jections with Lipid Profile Levels in Rats

2021 ◽  
Vol 4 (1) ◽  
pp. 27-31
Author(s):  
Suratiah Suratiah ◽  
Dewa Ayu Surinati ◽  
I Dewa Gede Putu Putra Yasa
Keyword(s):  
Lipid Profile ◽  
Total Cholesterol ◽  
Low Density Lipoprotein ◽  
Density Lipoprotein ◽  
Control Group ◽  
Control Group Design ◽  
Cholesterol Levels ◽  
Significant Difference ◽  
Before And After ◽  
Long Time

Introduction: Family Planning is a national strategy of Indonesia government to manage the population growth. Depo Medroxyprogesterone Acetate (DMPA) is one of injectable contraceptives most widely used because it is simple and easy to obtain. However, it has various side effects causing imbalance of hormone estrogen, in turns to result in a decrease in HDL (High Density Lipoprotein) and an increase in LDL (Low Density Lipoprotein) which will result in an increase in total cholesterol. It will also affect changes in fat metabolism in human body due to hormonal influences. This results in dyslipidemia and atherosclerosis. Method: The method in this study is an experimental study with a pretest-posttest control group design. Results: The purpose of this study was to determine the relationship between duration of use of DMPA injections with lipid profile levels in mice. The data were analyzed by using the Paired t-test parametric test to compare between treatment groups. This study found that there were significant differences in HDL levels and total cholesterol levels between before and after administration of DMPA injections on the 14th and 35th days. There is a significant relationship between the duration of administration of DMPA injections with HDL levels and total cholesterol levels in mice. However, there was no difference in LDL levels and triglyceride levels between before and after administration of DMPA injection on day of 14 and day of 35, while, there was a significant difference between before and after the 35th day. There is no relationship between duration of administration of DMPA injections with LDL levels, while there is a relationship among mice triglycerides. Conclusions: Administration of DMPA injections for a long time lowers HDL.

Evaluation of the Relationship between Vitamin D Deficiency and Atherogenic Factors in Diabetic Patients with Metabolic Syndrome

2021 ◽  
Author(s):  
Leila Akbarbaglu ◽  
Elham Nozari Mirarkolaei ◽  
Massoumeh Hotelchi ◽  
Abbas Khonakdar-Tarsi ◽  
Mahboobeh Ghanbari ◽  
...  
Keyword(s):  
Metabolic Syndrome ◽  
Vitamin D ◽  
Serum Level ◽  
Total Cholesterol ◽  
Vitamin D3 ◽  
Atherogenic Index ◽  
Control Group ◽  
Diabetic Patients ◽  
Significant Difference ◽  
25 Oh Vitamin D

Introduction: Metabolic syndrome includes a range of disorders that increase the risk of cardiovascular disease and diabetes mellitus. In this study, we examined the serum level of vitamin D3 in diabetic individuals with metabolic syndrome compared with non-diabetic individuals without metabolic syndrome and the association of serum vitamin D3 levels with metabolic syndrome and atherogenic factor (LDL/HDL). Material and Methods: In a case-control study, we included 110 women with metabolic syndrome according to ATP III criteria and 127 healthy women as a control group. Serum concentration of total cholesterol, LDL-C, FBS, HDL-C and serum triglyceride determined by enzymatic method and colorimetric and, serum level 25-(OH) vitamin D determined by ELISA. Results: It was found that the two healthy and metabolic groups were significantly different in terms of total cholesterol levels, LDL and triglyceride levels, HDL, VLDL, FBS, atherogenic index (LDL/HDL) and vitamin D levels (p<0.05). All participants in the control group and the patient and the whole study population were divided into two categories of insufficient and sufficient based on their measured serum concentrations of 25-(OH) vitamin D. There was a significant difference between the group with insufficient levels of vitamin D in comparison with the group with sufficient levels of vitamin D in terms of total cholesterol, LDL and triglyceride levels, HDL, VLDL, FBS and atherogenic index (LDL/HDL) (p=0.000). Conclusion: The present results showed that there is a significant relationship between level 25-(OH) D and atherogenic index (LDL/HDL) and the incidence of metabolic syndrome.

scholarly journals Coenzyme q10 is potentially usedto improve lipid profile in diabetic hypercholesterolemia-induced periodontitis in the coastal area

2018 ◽  
Vol 47 ◽  
pp. 07006
Author(s):  
Saryono Saryono ◽  
Hesti Devinta ◽  
Abdul Haris Budi Widodo ◽  
Arif Imam Hidayat
Keyword(s):  
Lipid Profile ◽  
Coenzyme Q10 ◽  
Coastal Area ◽  
Positive Control ◽  
Atherogenic Index ◽  
Control Group ◽  
Treatment Groups ◽  
Significant Difference ◽  
Pap Method ◽  
Post Hoc

Contaminated water often affects the occurrence of periodontitis in the coastal area. The diabetic hypercholesterolemia-induced periodontitis in Indonesia is very high. The use of coenzyme Q10 to treat this disease has never been investigated yet. Therefore, this study aimedto analyze the effect of coenzyme Q10 on the lipid profile of diabetic hypercholesterolemia-induced periodontitis.Twenty four rats were randomized into 6 groups (G1-G6). The groups (G1-G3) are healthy, negative and positive control group respectively. The treatment groups (G4-G6) are diabetic hypercholesterolemia-induced rats given coenzyme q10 dose of 13,5; 27 and 54 mg/kg respectively. Rats were induced by periodontitis, hypercholesterolemia and diabetes mellitus. Coenzyme Q10 was administered orally using 2 mL gastric tube once a day for 14 days. Lipid profile including triglycerides, HDL, and atherogenic index (IA) was measured enzymatically by the CHOD-PAP method. Data were analyzed by one-way ANOVA test and followed by the Least Significant Difference (LSD) post hoc test.Coenzyme Q10 with a dose of 54 mg/kgis effective in lowering triglyceride, and atherogenic index and increasing HDL level in diabetic hyperlipidemia-induced periodontitis rats model. This research supports the potential effects of coenzyme Q10 supplementation to improve lipid profile in diabetic hypercholesterolemia-induced periodontitis in the coastal area.

scholarly journals The Effect of Smoking on the Lipid Profile of Inhabitant Smokers of Hasilpur, District Bahawalpur, Pakistan

2020 ◽  
Vol 10 (2) ◽  
pp. 82-86
Author(s):  
Mushtaq Hussain Lashari ◽  
Sumbel Sumera ◽  
Umer Farooq ◽  
Zia Ur Rehman ◽  
Nuzhat Sial ◽  
...  
Keyword(s):  
Lipid Profile ◽  
Serum Triglyceride ◽  
Mean Value ◽  
Heavy Smoker ◽  
Control Group ◽  
Mean Values ◽  
Significant Difference ◽  
The Mean ◽  
Control Light ◽  
Heavy Smokers

Background: Health problem are culturally associated with smoking in developing countries. Many hazardous chemicals are taken up by direct or passive smoking causing lipid peroxidation resulting in oxidative stress. Objectives: To estimate the occurrence of smoking and its effects on the lipid profile in populations of Hasilpur, Pakistan. Methodology: The current study was conducted from April - August 2014. Out of 247 apparently healthy subjects of both genders (male=220; female=27), 134 were smokers and 113 were non-smokers. In order to analyze lipid profile, blood samples were collected in early morning hours from the selected members who were asked to fast all night. By using Chem-100 chemistry analyzer, cholesterol, triglyceride, HDL, LDL and VLDL were analyzed. Results: The overall prevalence of smokers was 54.25%. The results showed 60.9% prevalence in males and 0% in females. The mean value of serum triglyceride in control, light smokers and heavy smokers was 147.4±11.7mg/dl, 190.8±41.4 and 205.3±29.7mg/dl, respectively. The results of cholesterol in control, light smokers and heavy smokers were 147.38±7.99mg/dl, 136.8 ±12. 8mg/dl and 173.44±8.63mg/dl, respectively. There was a considerable distinction in the mean level of serum triglyceride and cholesterol between the control group, light smokers and heavy smoker groups (P<00.5). The mean value of HDL of control, light smokers and heavy smokers was 30.93±1.30mg/dl, 31.10±2.45 and 34.58±1.55mg/dl, respectively. The mean values of LDL and VLDL of control, light smokers and heavy smokers were 110.46±3.63mg/dl, 106.00±4.52mg/dl, 117.19±3.48mg/dl and 33.54±3.11mg/dl, 49±9.02mg/dl, 41.06±5.34mg/dl, respectively. There was significant difference in the mean level of HDL, LDL and VLDL between the control group, light smokers and heavy smoker groups (P<0.05). Conclusion: This study concluded that smoking is the reasons of variation in the lipid profile. Elevated period of smoking and the number of smoked cigarettes/day reason the alteration in serum lipid levels and is probably related with increased danger for coronary artery disease.

scholarly journals A Comparative Study of Lipid Profile in Obese and Nonobese Men attending Master Health Checkup

2017 ◽  
Vol 21 (2) ◽  
pp. 73-75
Author(s):  
S Vinod Babu ◽  
Anusha R Jagadeesan ◽  
Jothimalar Ramalingam
Keyword(s):  
Comparative Study ◽  
Lipid Profile ◽  
Total Cholesterol ◽  
Ldl Cholesterol ◽  
Density Lipoprotein ◽  
Hdl Cholesterol ◽  
P Value ◽  
Health Checkup ◽  
Group I ◽  
Significant Difference

ABSTRACT Introduction Obesity is emerging as an epidemic worldwide. Obesity is associated with a number of comorbid conditions, such as diabetes mellitus, hypertension, cancer, dyslipidemia, cardiovascular abnormalities, anemia, obstructive sleep apnea, and psychosocial abnormalities. Aim This study aims at comparing the lipid profile levels of obese and nonobese men. Materials and methods This was a case—control study conducted at a tertiary care center. Totally, 80 men in the age group of 20 to 47 years attending the master health checkup were included in the study, out of which 40 men with normal body mass index (BMI) of 18 to 25 belonged to group I and 40 men with increased BMI of 30 and above belonged to group II. Lipid profile parameters, such as triglycerides (TGLs), total cholesterol, high-density lipoprotein (HDL) cholesterol, and low-density lipoprotein (LDL) cholesterol were estimated in them. The data were statistically analyzed using Statistical Package for the Social Sciences (SPSS) software version 15.0. Results Statistically significant difference was found in the total cholesterol levels with a p-value of 0.040 while the difference in LDL cholesterol was statistically highly significant with a p-value of 0.040. Conclusion Among lipid profile parameters, only total cholesterol and LDL cholesterol showed significant difference between the obese and nonobese individuals. However, the other parameters like HDL cholesterol and TGLs did not show any significant difference. How to cite this article Babu SV, Jagadeesan AR, Ramalingam J. A Comparative Study of Lipid Profile in Obese and Nonobese Men attending Master Health Checkup. Indian J Med Biochem 2017;21(2):73-75.

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