scholarly journals Severe Hemolysis in a COVID-19 Patient with Paroxysmal Nocturnal Hemoglobinuria

2021 ◽  
Vol 2021 ◽  
pp. 1-6
Author(s):  
Steve Biko Otieno ◽  
Alaa Altahan ◽  
Fnu Kaweeta ◽  
Saradasri Karri ◽  
Fnu Alnoor ◽  
...  
Keyword(s):  
Severe Acute Respiratory Syndrome ◽  
Respiratory Infection ◽  
Paroxysmal Nocturnal Hemoglobinuria ◽  
Laboratory Tests ◽  
Cell Damage ◽  
Complement Regulation ◽  
Upper Respiratory Infection ◽  
Facial Swelling ◽  
Upper Respiratory

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the virus that causes coronavirus disease 2019 (COVID-19), has been demonstrated to be able to activate complement, making patients with deficiency in negative complement regulation, such as paroxysmal nocturnal hemoglobinuria (PNH), particularly vulnerable to complement-mediated cell damage. We report a case of a patient who presented with fatigue, facial swelling, and upper respiratory infection (URI) symptoms and was found to have COVID-19 with laboratory tests showing severe hemolysis and pancytopenia secondary to PNH.

Do Children Who Experience Laryngospasm Have an Increased Risk of Upper Respiratory Tract Infection?

1996 ◽  
Vol 85 (3) ◽  
pp. 475-480. ◽  
Author(s):  
Mark S. Schreiner ◽  
Irene O'Hara ◽  
Dorothea A. Markakis ◽  
George D. Politis
Keyword(s):  
Confidence Interval ◽  
Respiratory Infection ◽  
Odds Ratio ◽  
Signs And Symptoms ◽  
Control Group ◽  
Upper Respiratory Tract ◽  
Upper Respiratory Infection ◽  
Airway Surgery ◽  
Increased Risk ◽  
Upper Respiratory

Background Laryngospasm is the most frequently reported respiratory complication associated with upper respiratory infection and general anesthesia in retrospective studies, but prospective studies have failed to demonstrate any increase in risk. Methods A case-control study was performed to examine whether children with laryngospasm were more likely to have an upper respiratory infection on the day of surgery. The parents of all patients (N = 15,183) who were admitted through the day surgery unit were asked if their child had an active or recent (within 2 weeks of surgery) upper respiratory infection and were questioned about specific signs and symptoms to determine if the child met Tait and Knight's definition of an upper respiratory infection. Control subjects were randomly selected from patients whose surgery had occurred within 1 day of the laryngospasm event. Results Patients who developed laryngospasm (N = 123) were 2.05 times (95% confidence interval 1.21-3.45) more likely to have an active upper respiratory infection as defined by their parents than the 492 patients in the control group (P < or = 0.01). The development of laryngospasm was not related to Tait and Knight's definition for an upper respiratory infection or to recent upper respiratory infection. Children with laryngospasm were more likely to be younger (odds ratio = 0.92, 95% confidence interval 0.87-0.99), to be scheduled for airway surgery (odds ratio = 2.08, 95% confidence interval 1.21-3.59), and to have their anesthesia supervised by a less experienced anesthesiologist (odds ratio = 1.69, 95% confidence interval 1.04-2.7) than children in the control group. Conclusion Laryngospasm was more likely to occur in children with an active upper respiratory infection, children who were younger, children who were undergoing airway surgery, and children whose anesthesia were supervised by less experienced anesthesiologists. Understanding the risk factors and the magnitude of the likely risk should help clinicians make the decision as to whether to anesthetize children with upper respiratory infection.

scholarly journals Relationship between Kleine-Levin Syndrome and Upper Respiratory Infection in Taiwan

SLEEP ◽  
2012 ◽  
Vol 35 (1) ◽  
pp. 123-129 ◽  
Author(s):  
Yu-Shu Huang ◽  
Christian Guilleminault ◽  
Kuang-Lin Lin ◽  
Fang-Ming Hwang ◽  
Feng-Yuan Liu ◽  
...  
Keyword(s):  
Respiratory Infection ◽  
Upper Respiratory Infection ◽  
Upper Respiratory
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