scholarly journals Natural Hydroxyapatite: Green Catalyst for the Synthesis of Pyrroles, Inhibitors of Corrosion

2021 ◽  
Vol 2021 ◽  
pp. 1-11
Author(s):  
Abdelhadi Louroubi ◽  
Abdallah Nayad ◽  
Ali Hasnaoui ◽  
Rachid Idouhli ◽  
Abdessalam Abouelfida ◽  
...  
Keyword(s):  
Inhibition Efficiency ◽  
High Selectivity ◽  
Low Cost ◽  
Atom Economy ◽  
Commercial Catalyst ◽  
One Pot ◽  
Environmental Friendliness ◽  
Green Catalyst ◽  
Work Up ◽  
Natural Hydroxyapatite

Polysubstituted pyrroles have been synthesized in good yields via a four-component one-pot reaction of 1,3-dicarbonyl compounds, amines, aldehydes, and nitroalkanes using natural hydroxyapatite (HAp) as an efficient green catalyst. This strategy provides advantages such as simple experimental and work-up procedures, mild conditions, high selectivity, low cost, high atom economy, and environmental friendliness; it uses a green commercial catalyst and does not require a solvent. The electrochemical behavior of S300 steel in 1 M hydrochloric acidic was studied in the presence of these heterocyclic compounds. The results showed good inhibition efficiency for steel in acidic media.

scholarly journals Efficient and Facile One-Pot Synthesis of Novel Benzimidazoles using Rice Husk

2020 ◽  
pp. 27-32
Author(s):  
Suman Suman ◽  
Rajvir Singh ◽  
Susheel Gulati ◽  
Suprita Suprita
Keyword(s):  
Rice Husk ◽  
Room Temperature ◽  
Rice Husk Ash ◽  
Atom Economy ◽  
One Pot ◽  
Green Catalyst ◽  
Filter Pump ◽  
High Yields ◽  
Work Up ◽  
Layer Chromatography

New and facile one-pot approach for the synthesis of substituted benzimidazoles from the reaction of substituted benzaldehyde and o-phenylenediamine room temperature using Rice Husk Ash: CaCl2 (RHA:CaCl2) as a green catalyst was presented in the paper. After the completion of the reaction, the reaction mixture was poured into ice-coldwater with stirring, and the precipitated product was filtered using the filter pump. The crude product was then recrystallized from ethanol to give analytically pure samples in good to excellent yield. The purity of compounds were characterized by melting point and thin-layer chromatography. The synthesized compounds were characterized by using 1HNMR and FTIR spectral techniques.Metal-free, short reaction time, high yields, mild reaction condition, simple work-up, high atom economy, cost-effectiveness, and no need for column purification are some beauties of this methodology.

Rapid and Green One-Pot Synthesis of Novel 2-(4-Hydroxy-2-oxo-2H-chromen-3-yl)-2-(arylamino)-1H-indene-1,3(2H)-diones

2021 ◽  
Vol 18 ◽  
Author(s):  
Abolfazl Olyaei ◽  
Zahra Ghahremany ◽  
Madieh Sadeghpour
Keyword(s):  
Aromatic Amines ◽  
Low Cost ◽  
Guanidine Hydrochloride ◽  
Reaction Times ◽  
Solvent Free ◽  
One Pot ◽  
Solvent Free Conditions ◽  
The One ◽  
High Yields ◽  
Work Up

: A green and efficient protocol was developed for the one-pot three-component synthesis of novel 2-(4-hydroxy-2-oxo-2H-chromen-3-yl)-2-(arylamino)-1H-indene-1,3(2H)-dione derivatives by the reaction of 4-hydroxycoumarin, ninhydrin and aromatic amines in the presence of guanidine hydrochloride as an organocatalyst under solvent-free conditions. The present approach offers several advantages such as low cost, simple work-up, short reaction times, chromatography-free purification, high yields and greener conditions.

One Pot Synthesis of Biscoumarins and Pyranocoumarins by Coconut Juice as a Natural Catalyst

2019 ◽  
Vol 6 (1) ◽  
pp. 20-27
Author(s):  
Bipasa Halder ◽  
Himadri S. Maity ◽  
Ahindra Nag
Keyword(s):  
Aromatic Aldehydes ◽  
Environmentally Benign ◽  
One Pot ◽  
Green Catalyst ◽  
One Pot Synthesis ◽  
Volatile Organic ◽  
Electron Withdrawing Group ◽  
Work Up ◽  
Active Methylene ◽  
By Products

Background: The conception of ‘Green chemistry’ is the much inventive chemistry which is potent and more environmentally benign. It is notable that many organic reactions take place in conventional organic solvents, known as volatile organic compounds. Being concerned about the environmental impact, we report a promoting medium, coconut juice (ACC) for one-pot synthesis of biscoumarins and pyranocoumarins which is safe, harmless, green and environmentally benign. Methods and Results: Substituted biscoumarins have been achieved by the reaction of biscoumarin and substituted aromatic aldehydes in presence of ACC which acts as a green catalyst cum solvent. Each reaction showed good to excellent yield in presence of both electron donating as well as electron withdrawing group on aromatic aldehyde without formation of any by-products. Similarly, pyranocoumarins have been achieved by the reaction of biscoumarin, substituted aromatic aldehydes, active methylene nitrile in presence of ACC. All the reactions proceed smoothly and gave higher yields in case of malononitrile in comparison of ethyl-2-cyanoacetate. Conclusion: A simple, eco-friendly and novel procedure was demonstrated for the synthesis of biscoumarins and pyranocoumarins using natural feedstock coconut juice. The major importance of using ACC juice is higher yields, no work-up and no column chromatography.

Synthesis of New 5-amino-7-(aryl)-1,2,3,7-tetrahydro-8-nitroimidazo[1,2-a]pyridine- 6-carboxamide and 6-amino-2,3,4,8-tetrahydro-9-nitro-8-(aryl)-1H-pyrido[1,2- a]pyrimidine-7-carboxamide Derivatives

2018 ◽  
Vol 15 (7) ◽  
pp. 982-988 ◽  
Author(s):  
Fahimeh S. Hosseini ◽  
Mohammad Bayat
Keyword(s):  
Aromatic Aldehydes ◽  
Chromatographic Technique ◽  
Efficient Synthesis ◽  
Atom Economy ◽  
Reaction Conditions ◽  
One Pot ◽  
Synthetic Routes ◽  
High Yields ◽  
Work Up ◽  
Optimal Reaction

Aim and Objectives: Development of simple synthetic routes for widely used organic compounds from readily available reagents is one of the major tasks in organic chemistry. Therefore, new approaches for increasing the molecular diversity of simple starting materials, are needed. Herein, an efficient synthesis of imidazo[1,2-a]pyridine, pyrido[1,2-a]pyrimidine and pyrido[1,2-a][1,3]diazepine derivatives is described. Materials and Methods: A one-pot, multi-component reaction of nitro ketene aminal derived from the addition of various 1,n-diamines to 1,1-bis(methylthio)-2-nitroethene with cyanoacetamide and aromatic aldehydes is described. The reactions are completed within 2-5 h, in ethanol at reflux, in good to high yields (70-93%). The structures of products were deduced from their IR, mass, 1H NMR, and 13C NMR spectra. Results: Optimal reaction conditions for the synthesis of products were obtained, when ethanol was used as the solvent at reflux. This protocol involves Michael reaction, imine–enamine tautomerization, and cyclization sequences. Conclusion: This work represents an efficient synthesis of imidazo[1,2-a]pyridine, pyrido[1,2-a]pyrimidine and pyrido[1,2-a][1,3]diazepine derivatives via a one-pot, multi-component reaction. The advantages of this protocol are mild conditions, easy accessibility of reactants, absence of catalyst, high atom economy, simple work-up and purification process with no chromatographic technique.

One-Pot Catalytic Epoxidation Reaction of Perfluoro-2-methyl-2-pentene with Tri-n-butylamine N-Oxide or N, N-Dimethylcyclohexylamine N-Oxide

2013 ◽  
Vol 685 ◽  
pp. 357-361 ◽  
Author(s):  
Min Sha ◽  
Ren Ming Pan ◽  
Biao Jiang
Keyword(s):  
Organic Chemistry ◽  
Hydrogen Peroxide ◽  
Low Cost ◽  
Reaction Conditions ◽  
One Pot ◽  
Catalytic Epoxidation ◽  
Epoxidation Reaction ◽  
Work Up ◽  
Better Than

Perfluoro epoxy compounds are important intermediates in organic chemistry, however, the methods for preparing them are scanty. We found that in situ generated tri-n-butylamine N-oxide and N,N-Dimethylcyclohexylamine N-oxide were found to be good reagents for the epoxidation of tri-substituted Perfluoro-2-methyl-2-pentene in good to excellent yields. Catalytic epoxidation methods were developed by coupling this reaction with the N-oxidation of tertiary amine by hydrogen peroxide or MCPBA. The advantages of these methods are easy work-up, mild reaction conditions, environmentally friendly and low cost. The reaction using MCPBA as a oxidant is better than hydrogen peroxide for it is fast and high yielding.

Highly selective conversion of natural oil to alcohols or alkanes over a Pd stabilized CuZnAl catalyst under mild conditions

2019 ◽  
Vol 21 (18) ◽  
pp. 5046-5052 ◽  
Author(s):  
Ziwei Guo ◽  
Feng Zhou ◽  
Hao Wang ◽  
Xiaohao Liu ◽  
Guangyue Xu ◽  
...  
Keyword(s):  
Catalytic System ◽  
High Selectivity ◽  
Atom Economy ◽  
One Pot ◽  
Mild Conditions ◽  
Selective Conversion ◽  
Branched Alkanes ◽  
Natural Oil ◽  
Oil Components ◽  
Long Chain

A novel and green catalytic system based on a Pd stabilized CuZnAl catalyst was designed for one-pot conversion of natural oil components to the corresponding alcohols or long-chain linear and branched alkanes with high selectivity and atom economy.

Base-Mediated 1,6-Aza-Michael Addition of Heterocyclic Amines and Amides to para-Quinone Methides Leading to Meclizine-, Hydroxyzine- and Cetirizine-like Architectures

Synthesis ◽  
2019 ◽  
Vol 51 (23) ◽  
pp. 4434-4442 ◽  
Author(s):  
Deblina Roy ◽  
Gautam Panda
Keyword(s):  
Low Cost ◽  
Scale Up ◽  
Cost Effective ◽  
Heterocyclic Amines ◽  
Atom Economy ◽  
Quinone Methides ◽  
One Pot ◽  
X Ray ◽  
Wide Range ◽  
Mild Temperature

An expeditious, cost-effective synthetic methodology for a wide range of nitrogen-containing unsymmetrical trisubstituted methanes (TRSMs) is reported. The synthesis involves base-mediated 1,6-conjugate addition of heterocyclic amines and amides to substituted para-quinone methides, giving the unsymmetrical TRSMs in moderate to very good yields (up to 83%) in one pot. The low cost, mild temperature, high atom economy and yields, easy scale-up and broad substrate scope are some of the salient features of this protocol. Further, the methodology could be extended for the synthesis of meclizine-, ­hydroxyzine- and cetirizine-like molecules. The structure of one such compound, 2,6-di-tert-butyl-4-((4-chlorophenyl)(4-methylpiperazin-1-yl)methyl)phenol, was determined by single crystal X-ray analysis.

Microwave Domino Diastereoselective Synthesis of Novel Trans-4,5-Dihydro-1H-Furo[2,3-c]Pyrazoles Using Pyridinium Salts in an Aqueous Medium

2018 ◽  
Vol 42 (4) ◽  
pp. 219-223 ◽  
Author(s):  
Afshin Yazdani-Elah-Abadi ◽  
Reza Morekian ◽  
Nasim Simin ◽  
Mojtaba Lashkari
Keyword(s):  
Hydrazine Hydrate ◽  
Pyridinium Salt ◽  
Biologically Active ◽  
Domino Reaction ◽  
Diastereoselective Synthesis ◽  
Atom Economy ◽  
One Pot ◽  
Aryl Aldehyde ◽  
High Yields ◽  
Work Up

Novel fused 4,5-dihydro-1 H-furo[2,3- c]pyrazole derivatives containing both biologically active pyrazole and furan templates are synthesised by a one-pot two-step four-component domino reaction involving hydrazine hydrate, a β-keto ester, an aromatic aldehyde and a pyridinium salt catalysed by DABCO with high diastereoselectivity in H2O under microwave irradiation. To minimise the formation of byproducts, the hydrazine hydrate and ethyl acetoacetate were first irradiated until a pyrazolone was formed. Next, the aryl aldehyde, the pyridinium salt and DABCO were added and the reaction could be completed in good to excellent yields. The salient features of this eco-friendly methodology are highlighted by its short reaction time (10–12 min), high yields, high atom-economy, efficiency of producing five new bonds (2C–C, C=N, C–N and one C–O), two new rings and two stereocentres in a single operation, absence of any tedious work-up or purification and avoidance of separation of intermediates.

Ag-TiO2 Nanoparticles-Catalyzed Three-Component Synthesis of 12-Aryl-8,9,10,12-Tetrahydrobenzo[a]-Xanthen-11-Ones in Aqueous Medium

2022 ◽  
Vol 25 ◽  
Author(s):  
Mahsa Lotfi Omran ◽  
Seyed Mohammad Vahdat ◽  
Farhosh Kiani Barforosh
Keyword(s):  
Tio2 Nanoparticles ◽  
Cost Efficiency ◽  
Room Temperature ◽  
Chromatographic Method ◽  
Low Cost ◽  
Easy Access ◽  
Atom Economy ◽  
One Pot ◽  
The Difference ◽  
By Products

Background: Ag–TiO2 nanoparticles catalyzed synthesis of 12-aryl-8,9,10,12-tetrahydrobenzo[a]-xanthen-11-ones have been enhanced via a three-component one-pot reaction betweenβ–naphthol, several aldehydes and dimedone in H2O at room temperature. Xanthenes are essential intermediates in chemistry owing to their vast difference in biological activity. Methods: This process offered significant advantages containing appropriate cost efficiency, low amount of the catalyst, application of low-cost available Ag–TiO2 nanoparticles catalyst, purification of the product by non-chromatographic method, easy process, good atom economy, simple isolation and reusability of nanocatalyst. Result: Ag–TiO2 nanoparticles catalyst shows easy access to Xanthenes with appropriate yields in short reaction time and purity. This nanoparticles catalyst was recycled and recovered by easy filtration and was reused up to five times with only an unimportant loss in its catalytic efficacy. Conclusion: This method achieves to have a numerous scope relating to the difference in the aldehydes. Correspondingly, the attractive of this research was that H2O was the only by-products.

scholarly journals A Convenient One-Pot Synthesis of 1-Aryl-Substituted 4-Iodopyrazol-3-Ols via Aromatisation and Oxidative Iodination Reactions

2018 ◽  
Vol 42 (1) ◽  
pp. 24-27
Author(s):  
Jingjing Liu ◽  
Shanguang Yang ◽  
Ruimei Dong ◽  
Zhudan Jin ◽  
Mingliang Wang
Keyword(s):  
Hydrogen Peroxide ◽  
Sulfuric Acid ◽  
Sodium Iodide ◽  
Catalytic Amount ◽  
Atom Economy ◽  
One Pot ◽  
Environmental Friendliness ◽  
Short Reaction Time ◽  
One Pot Synthesis ◽  
Oxidative Iodination

A convenient and economical one-pot synthesis of a series of new 1-aryl-substituted 4-iodopyrazole-3-ols from easily available pyrazolidin-3-ones in the presence of sodium iodide, 30% solution of hydrogen peroxide and a catalytic amount of sulfuric acid in dichloromethane via aromatisation and oxidative iodination reactions are described. This protocol has the advantages of high atom economy, cost-effectiveness, short reaction time and environmental friendliness.

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