scholarly journals Transcranial Ultrasound Stimulation of the Anterior Cingulate Cortex Reduces Neuropathic Pain in Mice

2021 ◽  
Vol 2021 ◽  
pp. 1-14
Author(s):  
Xiangjun Feng ◽  
Lili Niu ◽  
Meng Long ◽  
Kaixuan Luo ◽  
Xiaowei Huang ◽  
...  
Keyword(s):  
Chronic Pain ◽  
Neuropathic Pain ◽  
Anterior Cingulate Cortex ◽  
Intervention Group ◽  
Cingulate Cortex ◽  
Anterior Cingulate ◽  
Control Group ◽  
Mechanical Threshold ◽  
Stimulation Of

Focused ultrasound (FUS) is a potential tool for treating chronic pain by modulating the central nervous system. Herein, we aimed to determine whether transcranial FUS stimulation of the anterior cingulate cortex (ACC) effectively improved chronic pain in the chronic compress injury mice model at different stages of neuropathic pain. The mechanical threshold of pain was recorded in the nociceptive tests. We found FUS stimulation elevated the mechanical threshold of pain in both short-term ( p < 0.01 ) and long-term ( p < 0.05 ) experiments. Furthermore, we determined protein expression differences in ACC between the control group, the intervention group, and the Sham group to analyze the underlying mechanism of FUS stimulation in improving neuropathic pain. Additionally, the results showed FUS stimulation led to alterations in differential proteins in long-term experiments, including cellular processes, cellular signaling, and information storage and processing. Our findings indicate FUS may effectively alleviate mechanical neuropathic pain via the ACC’s stimulation, especially in the chronic state.

scholarly journals Long-Term Results of Deep Brain Stimulation of the Anterior Cingulate Cortex for Neuropathic Pain

2017 ◽  
Vol 106 ◽  
pp. 625-637 ◽  
Author(s):  
Sandra G.J. Boccard ◽  
Simon J. Prangnell ◽  
Laurie Pycroft ◽  
Binith Cheeran ◽  
Liz Moir ◽  
...  
Keyword(s):  
Neuropathic Pain ◽  
Deep Brain Stimulation ◽  
Anterior Cingulate Cortex ◽  
Brain Stimulation ◽  
Cingulate Cortex ◽  
Anterior Cingulate ◽  
Long Term Results ◽  
Deep Brain ◽  
Stimulation Of

scholarly journals Musical Hallucinations in Chronic Pain: The Anterior Cingulate Cortex Regulates Internally Generated Percepts

2021 ◽  
Vol 12 ◽  
Author(s):  
Ashlyn Schmitgen ◽  
Jeremy Saal ◽  
Narayan Sankaran ◽  
Maansi Desai ◽  
Isabella Joseph ◽  
...  
Keyword(s):  
Chronic Pain ◽  
Electrical Stimulation ◽  
Anterior Cingulate Cortex ◽  
Case Series ◽  
Cingulate Cortex ◽  
Brain Network ◽  
Anterior Cingulate ◽  
Functional Brain Network ◽  
Band Activity ◽  
Stimulation Of

The anterior cingulate cortex (ACC) has been extensively implicated in the functional brain network underlying chronic pain. Electrical stimulation of the ACC has been proposed as a therapy for refractory chronic pain, although, mechanisms of therapeutic action are still unclear. As stimulation of the ACC has been reported to produce many different behavioral and perceptual responses, this region likely plays a varied role in sensory and emotional integration as well as modulating internally generated perceptual states. In this case series, we report the emergence of subjective musical hallucinations (MH) after electrical stimulation of the ACC in two patients with refractory chronic pain. In an N-of-1 analysis from one patient, we identified neural activity (local field potentials) that distinguish MH from both the non-MH condition and during a task involving music listening. Music hallucinations were associated with reduced alpha band activity and increased gamma band activity in the ACC. Listening to similar music was associated with different changes in ACC alpha and gamma power, extending prior results that internally generated perceptual phenomena are supported by circuits in the ACC. We discuss these findings in the context of phantom perceptual phenomena and posit a framework whereby chronic pain may be interpreted as a persistent internally generated percept.

scholarly journals Long-term potentiation in the anterior cingulate cortex and chronic pain

2014 ◽  
Vol 369 (1633) ◽  
pp. 20130146 ◽  
Author(s):  
Min Zhuo
Keyword(s):  
Chronic Pain ◽  
Anterior Cingulate Cortex ◽  
Dorsal Horn ◽  
Glutamate Release ◽  
Cingulate Cortex ◽  
Long Term Potentiation ◽  
Anterior Cingulate ◽  
Spinal Cord Dorsal Horn ◽  
Term Potentiation

Glutamate is the primary excitatory transmitter of sensory transmission and perception in the central nervous system. Painful or noxious stimuli from the periphery ‘teach’ humans and animals to avoid potentially dangerous objects or environments, whereas tissue injury itself causes unnecessary chronic pain that can even last for long periods of time. Conventional pain medicines often fail to control chronic pain. Recent neurobiological studies suggest that synaptic plasticity taking place in sensory pathways, from spinal dorsal horn to cortical areas, contributes to chronic pain. Injuries trigger long-term potentiation of synaptic transmission in the spinal cord dorsal horn and anterior cingulate cortex, and such persistent potentiation does not require continuous neuronal activity from the periphery. At the synaptic level, potentiation of excitatory transmission caused by injuries may be mediated by the enhancement of glutamate release from presynaptic terminals and potentiated postsynaptic responses of AMPA receptors. Preventing, ‘erasing’ or reducing such potentiation may serve as a new mechanism to inhibit chronic pain in patients in the future.

The Increased In Vivo Firing of Pyramidal Cells But not Interneurons in the Anterior Cingulate Cortex After Neuropathic Pain

2021 ◽  
Author(s):  
Da-Yu Zhu ◽  
Ting-Ting Cao ◽  
Hong-Wei Fan ◽  
Ming-Zhe Zhang ◽  
Hao-Kai Duan ◽  
...  
Keyword(s):  
Chronic Pain ◽  
Neuropathic Pain ◽  
Firing Rate ◽  
Anterior Cingulate Cortex ◽  
Pyramidal Cells ◽  
Cingulate Cortex ◽  
Anterior Cingulate ◽  
High Frequency Stimulation ◽  
Nociceptive Information

Abstract Chronic pain damages the balance between excitation and inhibition in the sensory cortex. It has been confirmed that the activity of cortical glutamatergic pyramidal cells increases after chronic pain. However, whether the activity of inhibitory interneurons synchronized changed remains obscure, especially in in vivo conditions. In the present study, we checked the firing rate of pyramidal cells and interneurons in the anterior cingulate cortex, a main cortical area for the regulation of nociceptive information in mice with spared nerve injury by using in vivo multi-channel recording system. We found that the firing rate of pyramidal cells but not interneurons increased in the ACC, which is further confirmed by the increased FOS expression in pyramidal cells but not interneurons, in mice with neuropathic pain. Selectively high frequency stimulation of the ACC nociceptive afferent fibers only potentiated the activity of pyramidal cells either. Our results thus suggest that the increased activity of pyramidal cells contributes to the damaged E/I balance in the ACC and is important for the pain hypersensitivity in mice with neuropathic pain.

Tractography Study of Deep Brain Stimulation of the Anterior Cingulate Cortex in Chronic Pain: Key to Improve the Targeting

2016 ◽  
Vol 86 ◽  
pp. 361-370.e3 ◽  
Author(s):  
Sandra G.J. Boccard ◽  
Henrique M. Fernandes ◽  
Saad Jbabdi ◽  
Tim J. Van Hartevelt ◽  
Morten L. Kringelbach ◽  
...  
Keyword(s):  
Chronic Pain ◽  
Deep Brain Stimulation ◽  
Anterior Cingulate Cortex ◽  
Brain Stimulation ◽  
Cingulate Cortex ◽  
Anterior Cingulate ◽  
Deep Brain ◽  
Stimulation Of

scholarly journals NMDA Receptor-Dependent Synaptic Depression in Potentiated Synapses of the Anterior Cingulate Cortex of adult Mice

2021 ◽  
Vol 17 ◽  
pp. 174480692110180
Author(s):  
Man Xue ◽  
Si-Bo Zhou ◽  
Ren-Hao Liu ◽  
Qi-Yu Chen ◽  
Min Zhuo ◽  
...  
Keyword(s):  
Chronic Pain ◽  
Nmda Receptor ◽  
Anterior Cingulate Cortex ◽  
Cingulate Cortex ◽  
Synaptic Depression ◽  
Anterior Cingulate ◽  
Dependent Manner ◽  
Selective Antagonist ◽  
Adult Mice

Long-term potentiation (LTP) is an important molecular mechanism for chronic pain in the anterior cingulate cortex (ACC), a key cortical region for pain perception and emotional regulation. Inhibiting ACC LTP via various manipulations or pharmacological treatments blocks chronic pain. Long-term depression (LTD) is another form of synaptic plasticity in the ACC, which is also proved to be involved in the mechanisms of chronic pain. However, less is known about the interactive relationship between LTP and LTD in the ACC. Whether the synaptic depression could be induced after synaptic LTP in the ACC is not clear. In the present study, we used multi-channel field potential recording systems to study synaptic depression after LTP in the ACC of adult mice. We found that low frequency stimulus (LFS: 1 Hz, 15 min) inhibited theta burst stimulation (TBS)-induced LTP at 30 min after the induction of LTP. However, LFS failed to induce depression at 90 min after the induction of LTP. Furthermore, NMDA receptor antagonist AP-5 blocked the induction of synaptic depression after potentiation. The GluN2B-selective antagonist Ro25-6981 also inhibited the phenomenon in the ACC, while the GluN2A-selective antagonist NVP-AAM077 and the GluN2C/D-selective antagonist PPDA and UBP145 had no any significant effect. These results suggest that synaptic LTP can be depressed by LTD in a time dependent manner, and GluN2B-containing NMDA receptors play important roles in this form of synaptic depression.

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