scholarly journals Preliminary Study on the Application of Ultrahigh Field Magnetic Resonance in Moyamoya Disease

2021 ◽  
Vol 2021 ◽  
pp. 1-9
Author(s):  
Jiabin Su ◽  
Wei Ni ◽  
Baofeng Yang ◽  
Weiping Xiao ◽  
Xinjie Gao ◽  
...  
Keyword(s):  
Magnetic Resonance ◽  
Moyamoya Disease ◽  
Contrast Imaging ◽  
Ultrahigh Field ◽  
Tof Mra ◽  
Collateral Network ◽  
Fusion Images ◽  
Magnetic Resonance Imaging Mri ◽  
Severity Of The Disease ◽  
Imaging Signs

Magnetic resonance imaging (MRI) is widely used for the evaluation of moyamoya disease (MMD). In this paper, we describe the features of time-of-flight magnetic resonance angiography (TOF-MRA) and susceptibility-weighted imaging (SWI) at 7 T in a series of MMD patients. In this prospective pilot study, 7 patients (median age: 45.6 years; range: 30-52 years) with MMD and no contraindications for MRI underwent T2-weighted, SWI, and TOF-MRA sequences using a research 7 T head-only scanner. We show that such sequences at ultrahigh field (UHF) represent new and valuable approaches to unravel and characterize MMD. While SWI reveals more remarkable imaging signs related to an improved magnitude and phase contrast imaging, the collateral network pathways in MMD could be excellently delineated using 7 T TOF-MRA. In particular, using SWI and MRA fusion images in UHF MRI helps to improve the detection of bleeding points in hemorrhagic MMD. Our findings indicate that ultrahigh field MRI is very promising to access the severity of the disease and may facilitate revascularization surgery of MMD patients.

Intralateral and Perilateral Ventricular Arteries on Original Axial Magnetic Resonance Angiography in Adult Moyamoya Disease

2021 ◽  
Vol 84 (2) ◽  
pp. 119-123
Author(s):  
Mami Ishikawa ◽  
Satoshi Terao ◽  
Hiroshi Kagami ◽  
Makoto Inaba ◽  
Heiji Naritaka
Keyword(s):  
Magnetic Resonance ◽  
Magnetic Resonance Angiography ◽  
Cerebral Infarction ◽  
Moyamoya Disease ◽  
Disease Onset ◽  
Time Of Flight ◽  
Unruptured Aneurysms ◽  
Tof Mra ◽  
Adult Moyamoya Disease

<b><i>Background:</i></b> Patients with moyamoya disease often develop cerebral infarction and hemorrhage, but the ischemic and hemorrhagic subtypes are difficult to diagnose prior to disease onset. We aimed to differentiate the ischemic and hemorrhagic subtypes of moyamoya disease by analyzing the intralateral and perilateral ventricular arteries on the original axial magnetic resonance angiography (MRA) images. <b><i>Methods:</i></b> We retrospectively analyzed the intralateral and perilateral ventricular arteries on the original axial time-of-flight (TOF)-MRA images of 18 patients with hemorrhagic moyamoya disease, 25 patients with ischemic moyamoya disease, and 22 control patients with unruptured aneurysms. <b><i>Results:</i></b> There were significantly more intralateral and perilateral ventricular arteries on the original axial MRA images in the patients with hemorrhagic moyamoya disease (6.3 ± 2.7) than in those with ischemic moyamoya disease (0.8 ± 0.9) and those with unruptured aneurysms (0.4 ± 0.8). <b><i>Conclusion:</i></b> The intralateral and perilateral ventricular arteries on the original axial TOF-MRA images might suggest the hemorrhagic type of moyamoya disease prior to onset.

scholarly journals The ivy sign

2014 ◽  
Vol 18 (1) ◽  
Author(s):  
Nasreen Mahomed ◽  
Evance Chisama ◽  
Sanjay Prabhu
Keyword(s):  
Magnetic Resonance Imaging ◽  
Magnetic Resonance ◽  
Moyamoya Disease ◽  
Signal Intensity ◽  
Perivascular Spaces ◽  
Resonance Imaging ◽  
Leptomeningeal Enhancement ◽  
Weighted Magnetic Resonance Imaging ◽  
Mri Sequences ◽  
Magnetic Resonance Imaging Mri

The ivy sign refers to diffuse bilateral leptomeningeal enhancement on post- contrastT1-weighted magnetic resonance imaging (MRI) and increased signal intensity in bilateralsubarachnoid spaces and perivascular spaces on T2-weighted fluid attenuation inversionrecovery (FLAIR) MRI sequences in patients with moyamoya disease.

Abstract WP61: A Novel Application of Four-dimensional Magnetic Resonance Angiography Using Arterial Spin Labeling for Assessment of Postoperative Cerebral Hemodynamic Changes in Moyamoya Disease

Stroke ◽  
2016 ◽  
Vol 47 (suppl_1) ◽  
Author(s):  
Haruto Uchino ◽  
Masaki Ito ◽  
Ken Kazumata ◽  
Kiyohiro Houkin
Keyword(s):  
Magnetic Resonance ◽  
Magnetic Resonance Angiography ◽  
Moyamoya Disease ◽  
Arterial Spin Labeling ◽  
Early Time ◽  
Spin Labeling ◽  
Postoperative Management ◽  
Cerebral Hemodynamics ◽  
Hemodynamic Changes ◽  
Tof Mra

Introduction: Recently, four-dimensional magnetic resonance angiography without contrast enhancement using arterial spin labeling (ASL-4D MRA) has become available to visualize the intracranial arteries. However, few reports are available about the efficacy of ASL-4D MRA in moyamoya disease (MMD). Hypothesis: We hypothesized that postoperative hemodynamic changes in MMD patients could be evaluated using ASL-4D MRA. Methods: This study included 26 hemispheres of 21 patients who underwent combined direct and indirect revascularization for MMD. ASL-4D MRA was serially performed before and after surgery. We assessed the time phases where signals of the arteries were detected on ASL-4D MRA in order to analyze perioperative changes in cerebral hemodynamics. Results: The signals of the anastomosed arteries on ASL-4D MRA were detected and disappeared at significantly earlier time phase after surgery than before. This change in acute period was moderated in chronic period after surgery. Postoperative hyperperfusion was observed in 12 of 26 hemispheres within 7 days after surgery. The signals of the arteries were detected significantly earlier in hemispheres with hyperperfusion than those without. In cases with hyperperfusion, ASL-4D MRA demonstrated high intensity of peripheral middle cerebral artery (MCA) around anastomosed region in early time phase (Figure). This “early hyperintensity of MCA” was observed in all cases with hyperperfusion and corresponded to the timing of the occurrence of hyperperfusion. Furthermore, this hyperperfusion-specific sign could not be detected by routine TOF MRA. Conclusions: Noninvasive ASL-4D MRA successfully evaluated perioperative dynamic changes of cerebral blood flow and the effect of surgical revascularization in MMD. This next generation modality could also visualize cerebral hemodynamics in cases with postoperative hyperperfusion and would be quite useful for appropriate postoperative management.

Headache as unusual presentation in moyamoya disease

2021 ◽  
Vol 11 (2) ◽  
pp. 115-118
Author(s):  
Pathik Shah ◽  
Keyword(s):  
Magnetic Resonance ◽  
Moyamoya Disease ◽  
Treatment Strategies ◽  
Rare Condition ◽  
Research Committee ◽  
Conventional Angiography ◽  
Moyamoya Angiopathy ◽  
Clinical Presentations ◽  
Magnetic Resonance Imaging Mri ◽  
Collateral Vessels

Our case highlights basics of clinical presentations, causes, risk factors, epidemiology, physiology, and pathophysiology in Moyamoya diseases, along with introduction to terminologies, prospect of evaluation and various modalities available for diagnosis. Moyamoya angiopathy is characterized by a progressive stenosis of the terminal portion of the internal carotid arteries and the development of a network of abnormal collateral vessels. This chronic cerebral angiopathy is observed in children and adults. It mainly leads to brain ischemic events in children, and to ischemic and hemorrhagic events in adults. This is a rare condition, with a marked prevalence gradient between Asian countries and Western countries. Two main nosological entities are identified. On the one hand, moyamoya disease corresponds to isolated moyamoya angiopathy, defined as being “idiopathic” according to the Guidelines of the Research Committee on the Pathology and Treatment of Spontaneous Occlusion of the Circle of Willis. This entity is probably multifactorial and polygenic in most patients. On the other hand, moyamoya syndrome is a moyamoya angiopathy associated with an underlying condition and forms a very heterogeneous group with various clinical presentations, various modes of inheritance, and a variable penetrance of the cerebrovascular phenotype. Diagnostic and evaluation techniques rely on magnetic resonance imaging (MRI), magnetic resonance angiography (MRA) conventional angiography, and cerebral hemodynamics measurements. Revascularization surgery can be indicated, with several techniques. Characteristics of genetic moyamoya syndromes are presented, with a focus on recently reported mutations in BRCC3/MTCP1 and GUCY1A3 genes. Identification of the genes involved in moyamoya disease and several monogenic moyamoya syndromes unravelled different pathways involved in the development of this angiopathy. Studying genes and pathways involved in monogenic moyamoya syndromes may help to give insights into pathophysiological models and discover potential candidates for medical treatment strategies.

Magnetic Resonance Imaging (MRI) and Digital Subtraction Angiography Investigation of Childhood Moyamoya Disease

2017 ◽  
Vol 32 (13) ◽  
pp. 1027-1034 ◽  
Author(s):  
Peiji Song ◽  
Jing Qin ◽  
Han Lun ◽  
Penggang Qiao ◽  
Anming Xie ◽  
...  
Keyword(s):  
Magnetic Resonance Imaging ◽  
Magnetic Resonance ◽  
Digital Subtraction Angiography ◽  
Moyamoya Disease ◽  
Pediatric Population ◽  
Cerebral Arteries ◽  
Digital Subtraction ◽  
Resonance Imaging ◽  
Magnetic Resonance Imaging Mri ◽  
Angiographic Examination

Because digital subtraction angiography (DSA) is not an ideal angiographic examination for moyamoya disease in the pediatric population, magnetic resonance angiography (MRA) provides a noninvasive contrast-free angiographic examination; whereas magnetic resonance imaging (MRI) provides superior spatial resolution and soft-tissue contrast for lesion assessment. Ninety patients with moyamoya disease were examined by MRI and DSA to assess the distribution of lesions and their diagnostic agreement between modalities. MRI examination revealed 439 lesions. Punctate lesions were the most abundant, followed by patchy lesions. These lesions generally covered a smaller area than the abnormal-vascular corresponding brain parenchyma. Steno-occlusive changes at bilateral anterior, medial, and posterior cerebral arteries were identified by MRA and DSA. MRI showed moderate agreement in identifying lesions after steno-occlusive changes in anterior and medial cerebral arteries, and good agreement in posterior cerebral arteries; 6% to 11% of cases were misdiagnosed by MRA.

Computed Tomography and Magnetic Resonance Imaging Overlay in the Spine for Surgical Planning: A Technical Report

2021 ◽  
pp. 155633162110395
Author(s):  
Alberto A. Perez ◽  
Edward S. Yoon ◽  
Sravisht Iyer ◽  
Virginie Lafage ◽  
Harvinder Sandhu ◽  
...  
Keyword(s):  
Magnetic Resonance Imaging ◽  
Computed Tomography ◽  
Magnetic Resonance ◽  
Surgical Planning ◽  
Large Scale ◽  
Senior Author ◽  
Resonance Imaging ◽  
Single Cross Section ◽  
Fusion Images ◽  
Magnetic Resonance Imaging Mri

Background: Computed tomography (CT) and magnetic resonance imaging (MRI) studies are used separately for surgical planning of spine surgery. Advanced techniques exist for creating CT-MR fusion images, but at this time these techniques are not easily accessible for large-scale use. Technique: We propose a simple graphical technique for CT-MR image overlay, for use in the surgical planning of spinal decompression and guidance of intraoperative resection. The proposed technique involves overlaying a single cross-section from anatomically comparable MRI and CT studies on any software with basic image editing functions. Results: We demonstrate CT-MR fusion images of 8 patients of the senior author in which the technique was used. We found that it can also be referenced intraoperatively for navigation.Conclusions: Compared to other techniques, our proposed method can be easily implemented by clinicians to create simple CT-MRI fusion images that can be useful for preoperative planning and intraoperative navigation.

scholarly journals Magnetic resonance imaging in acute mastoiditis

2014 ◽  
Vol 3 (2) ◽  
pp. 204798161452341 ◽  
Author(s):  
Ivan Platzek ◽  
Hagen H Kitzler ◽  
Volker Gudziol ◽  
Michael Laniado ◽  
Gabriele Hahn
Keyword(s):  
Magnetic Resonance Imaging ◽  
Magnetic Resonance ◽  
Spin Echo ◽  
Resonance Imaging ◽  
Acute Mastoiditis ◽  
Subperiosteal Abscess ◽  
Diffusion Weighted Images ◽  
Tof Mra ◽  
Magnetic Resonance Imaging Mri

Background In cases of suspected mastoiditis, imaging is used to evaluate the extent of mastoid destruction and possible complications. The role of magnetic resonance imaging (MRI) in mastoiditis has not been systematically evaluated. Purpose To assess the diagnostic performance of MRI in patients with suspected acute mastoiditis. Material and Methods Twenty-three patients with suspected acute mastoiditis were included in this retrospective study (15 boys, 8 girls; mean age, 2 years 11 months). All patients were examined on a 1.5 T MRI system. The MRI examination included both enhanced and non-enhanced turbo spin echo (TSE), diffusion-weighted images, and venous time-of-flight magnetic resonance angiography (TOF MRA) for the evaluation of the venous sinuses. Surgical findings, as well as clinical and imaging follow-up were used as the standard of reference. The sensitivity and accuracy of MRI for mastoiditis and subperiosteal abscesses was calculated. Results Twenty (87%) of 23 patients had mastoiditis, and 12 (52%) of 23 patients had a subperiosteal abscess in addition to mastoiditis. Mastoiditis and subperiosteal abscesses were identified by MRI in all cases. Sensitivity for mastoiditis was 100%, specificity was 66%, and accuracy was 86%. Sensitivity for subperiosteal abscesses was 100% and accuracy was 100%. Conclusion Multiparametric MRI has high accuracy for mastoiditis and subperiosteal abscesses.

scholarly journals Advances in magnetic resonance imaging contrast agents for glioblastoma-targeting theranostics

2021 ◽  
Author(s):  
Zijun Wu ◽  
Lixiong Dai ◽  
Ke Tang ◽  
Yiqi Ma ◽  
Bin Song ◽  
...  
Keyword(s):  
Magnetic Resonance Imaging ◽  
Magnetic Resonance ◽  
Contrast Agents ◽  
Mri Contrast Agents ◽  
Research Progress ◽  
Resonance Imaging ◽  
Contrast Imaging ◽  
Improve Patient Survival ◽  
Management Procedures ◽  
Magnetic Resonance Imaging Mri

Abstract Glioblastoma (GBM) is the most aggressive malignant brain tumour, with a median survival of 3 months without treatment and 15 months with treatment. Early GBM diagnosis can significantly improve patient survival due to early treatment and management procedures. Magnetic resonance imaging (MRI) using contrast agents is the preferred method for the preoperative detection of GBM tumours. However, commercially available clinical contrast agents do not accurately distinguish between GBM, surrounding normal tissue, and other cancer types due to their limited ability to cross the blood-brain barrier (BBB), their low relaxivity, and their potential toxicity. New GBM-specific contrast agents are urgently needed to overcome the limitations of current contrast agents. Recent advances in nanotechnology have produced alternative GBM-targeting contrast agents. The surfaces of nanoparticles (NPs) can be modified with multimodal contrast imaging agents and ligands that can specifically enhance the accumulation of NPs at GBM sites. Using advanced imaging technology, multimodal NP-based contrast agents have been used to obtain accurate GBM diagnoses in addition to an increased amount of clinical diagnostic information. NPs can also serve as drug delivery systems for GBM treatments. This review focuses on the research progress for GBM-targeting MRI contrast agents as well as MRI-guided GBM therapy.

Assessment of extracranial-intracranial bypass in Moyamoya disease using 3T time-of-flight MR angiography: Comparison with CT angiography

VASA ◽  
2014 ◽  
Vol 43 (4) ◽  
pp. 278-283 ◽  
Author(s):  
Qian Chen ◽  
Rongfeng Qi ◽  
Xiaoqing Cheng ◽  
Changsheng Zhou ◽  
Song Luo ◽  
...  
Keyword(s):  
Image Quality ◽  
Moyamoya Disease ◽  
Mr Angiography ◽  
Time Of Flight ◽  
Consecutive Series ◽  
Tof Mra ◽  
Bypass Patency ◽  
Significant Difference ◽  
Contrast Technique ◽  
Vessel Integrity

Background: To evaluate the value of time-of-flight MR angiography (TOF MRA) for the assessment of extracranial-intracranial (EC-IC) bypass in Moyamoya disease in comparison with computed tomography angiography (CTA). Patients and methods: A consecutive series of 23 patients with Moyamoya disease were analyzed retrospectively. Twenty three patients underwent 25 procedures of extracranial-intracranial bypass. Cranial CTA was performed within one week after the surgery to assess bypass patency. Then TOF MRA was scanned within 24 h after CTA on a 3T MRI system. Using 5-point scales (0 = poor to 4 = excellent), two radiologists rated the image quality and vessel integrity of bypass for three segments (extracranial, trepanation, intracranial). Results: Image quality was high in both CTA and TOF MRA (mean quality score 3.84 ± 0.37 and 3.8 ± 0.41), without statistical difference (p = 0.66). Mean scores of TOF MRA with respect to bypass visualization were higher than CTA in the intracranial segment (p = 0.026). No significant difference of bypass visualization regarding the extracranial and trepanation segments was found between TOF MRA and CTA (p = 0.66 and p = 0.34, respectively). For the trepanation segment, TOF MRA showed pseudo lesions in 2 of all 25 cases. Conclusions: 3T TOF MRA, a non-contrast technique not exposing the patients to radiation, proved to be at least equal to CTA for the assessment of EC-IC bypass, and even superior to CTA with respect to the intracranial segment. In addition, readers should be aware of a potential overestimation showing focal pseudo lesions of the bypass at the trepanation segment in TOF MRA.

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