scholarly journals Variations in Soft and Hard Tissues following Immediate Implant Placement versus Delayed Implant Placement following Socket Preservation in the Maxillary Esthetic Region: A Randomized Controlled Clinical Trial

2021 ◽  
Vol 2021 ◽  
pp. 1-19
Author(s):  
Muthukumar Santhanakrishnan ◽  
Nithyakalyani Ramesh ◽  
R. Kamaleeshwari ◽  
Vedavalli Subramanian
Keyword(s):  
Plate Thickness ◽  
Test Group ◽  
Clinical Information ◽  
Control Group ◽  
Controlled Clinical Trial ◽  
Bovine Bone ◽  
Individual Values ◽  
Socket Preservation ◽  
Implant Placement ◽  
Significant Difference

Introduction. Although retrospective analysis has shown immediate placement of implants (IIP) in the maxillary esthetic zone showing promising outcomes compared to delayed placement of implants following socket preservation (DIP), a direct comparison in a prospective, well-designed randomized fashion with adequate power analysis between the two implant placement protocols is still lacking. This study is aimed at radiographically evaluating the effect of IIP after extraction as compared to implant placed in preserved sockets 4 months following extraction (DIP) in terms of changes in buccal plate thickness(CBT) after 6 months of healing and evaluation of pink esthetic score (PES) for assessment of soft tissue changes and patient-related outcome measures (PROMs) using visual analogue scale (VAS). Materials and Methods. 25 implants were placed immediately following extraction in the IIP group, and 25 implants were placed four months following socket preservation with demineralized bovine bone mineral (DBBM) and advanced platelet-rich fibrin (A-PRF) in the DIP group, control group, in the maxillary esthetic region. CBCT was taken preoperatively and 6 months postoperatively to assess the dimensional changes in the buccal bone plates(CBT). PES and PROMs for pain threshold and patient satisfaction using VAS were evaluated at the time of implant placement and 6 months postoperatively. Results. Significant differences in mean reduction in buccal plate thickness (CBT) were found in the test group (IIP) 0.2 ± 0.02 compared to the control group (DIP) which showed a mean reduction in CBT of 0.4 ± 0.1 ( p < 0.001 ) at the end of 6 months. Although there was no statistically significant difference in PES between the groups, there was a significant difference between the groups when individual values of PES were compared at p < 0.001 . Conclusion. The IIP group showed lesser reduction in CBT and a better PES which is an important clinical information which could be translated clinically in situations where implant placement is planned in the maxillary esthetic region. This trial is registered with CTRI/2019/06/019723.

scholarly journals Clinical and Immunological Efficacy of Mangosteen and Propolis Extracted Complex in Patients with Gingivitis: A Multi-Centered Randomized Controlled Clinical Trial

Nutrients ◽  
2021 ◽  
Vol 13 (8) ◽  
pp. 2604
Author(s):  
Jin-Young Park ◽  
Kyung-A Ko ◽  
Ji-Yeong Lee ◽  
Jae-Woon Oh ◽  
Hyun-Chang Lim ◽  
...  
Keyword(s):  
Patient Reported Outcomes ◽  
Daily Intake ◽  
Test Group ◽  
Control Group ◽  
Controlled Clinical Trial ◽  
Control Groups ◽  
Immunological Parameters ◽  
Significant Difference ◽  
Patient Reported ◽  
And Control

Background: Mangosteen and propolis extracts (MAEC) have been potential therapeutic agents known to exhibit powerful antioxidant and anti-inflammatory properties. The aim of the current study was to evaluate the clinical and immunological efficacy of MAEC as well as safety and patient-reported outcomes (PROMs) on gingivitis and incipient periodontitis. Methods: This study was performed on 104 patients diagnosed with gingivitis or incipient periodontitis. At baseline, the participants were randomly allocated to either the test group, with daily intake of a single capsule containing 194 mg of MAEC for eight weeks, or control group, with placebo. Clinical periodontal evaluation and immunological parameters from saliva and gingival sulcular fluid were assessed at baseline, four, and eight weeks. Individual PROMs were assessed by OHIP-14 questionnaires. Results: There was a significant difference of modified gingival index at four and eight weeks between the test and control groups. In the test group, crevicular interleukin (IL)-6 was reduced, and the salivary matrix metalloproteinase (MMP)-9 was increased after eight weeks. PROMs were improved up to four weeks compared to placebo. Conclusion: Oral administration of MAEC would have a potential to reduce gingival inflammation clinically and immunologically in the patients with gingivitis and incipient periodontitis.

scholarly journals Peri-implant evaluation of osseointegrated implants subjected to orthodontic forces: results after three years of functional loading

2016 ◽  
Vol 21 (2) ◽  
pp. 73-80 ◽  
Author(s):  
Bruna de Rezende Marins ◽  
Suy Ellen Pramiu ◽  
Mauro Carlos Agner Busato ◽  
Luiz Carlos Marchi ◽  
Adriane Yaeko Togashi
Keyword(s):  
Test Group ◽  
Control Group ◽  
Orthodontic Anchorage ◽  
Clinical Evaluations ◽  
Implant Placement ◽  
Osseointegrated Implants ◽  
Probing Depth ◽  
Significant Difference ◽  
Orthodontic Forces

ABSTRACT Objective: The objective of this study was to clinically and radiographically assess the peri-implant conditions of implants used as orthodontic anchorage. Methods: Two groups were studied: 1) a test group in which osseointegrated implants were used as orthodontic anchorage, with the application of 200-cN force; and 2) a control group in which implants were not subjected to orthodontic force, but supported a screw-retained prosthesis. Clinical evaluations were performed three, six and nine months after prosthesis installation and 1- and 3-year follow-up examinations. Intraoral periapical radiographs were obtained 30 days after surgical implant placement, at the time of prosthesis installation, and one, two and three years thereafter. The results were compared by Kruskal-Wallis test. Results: There was no statistically significant difference in clinical probing depth (p = 0.1078) or mesial and distal crestal bone resorption (p = 0.1832) during the study period. After three years of follow-up, the mean probing depth was 2.21 mm for the control group and 2.39 mm for the test group. The implants of the control group showed a mean distance between the bone crest and implant shoulder of 2.39 mm, whereas the implants used as orthodontic anchorage showed a mean distance of 2.58 mm at the distal site. Conclusion: Results suggest that the use of stable intraoral orthodontic anchorage did not compromise the health of peri-implant tissues or the longevity of the implant.

scholarly journals Socket Preservation Using a (Dense) PTFE Barrier with or without Xenograft Material: A Randomized Clinical Trial

Materials ◽  
2019 ◽  
Vol 12 (18) ◽  
pp. 2902 ◽  
Author(s):  
Márcio de Carvalho Formiga ◽  
Ulisses Ribeiro Campos Dayube ◽  
Cristiane Kern Chiapetti ◽  
Daniela de Rossi Figueiredo ◽  
Jamil Awad Shibli
Keyword(s):  
Alveolar Bone ◽  
Blood Clot ◽  
Test Group ◽  
Control Group ◽  
Socket Preservation ◽  
Height Control ◽  
Ptfe Membrane ◽  
Implant Placement ◽  
Bone Width ◽  
Simple Alternative

When alveolar preservation procedures are not performed after tooth extraction, aesthetic and functional impairment could occur. Guided bone regeneration using polytetrafluoroethylene (PTFE) membranes has proven to be a simple alternative treatment that results in good maintenance of the alveolar bone for mediate/late implant placement. Therefore, this study compared the effect of alveolar preservation with the use of dense PTFE membranes, with and without xenograft material by Computerized tomography-based body composition (CTBC) analysis, after four months of the socket preservation procedure. A total of 29 teeth indicated for extraction. In the test group, the sockets were filled with bone graft biomaterial and subsequently coated with a dense PTFE membrane. In the control group, the sockets were filled with the blood clots and subsequently coated with a dense PTFE membrane. The results we found on the changes of the bone width and height after the procedures were: buccal plate: control group 0.46 mm, test group 0.91 mm; alveolar height: control group −0.41 mm, test group 0.35 mm; cervical third: control group −0.89 mm, test group −0.11 mm; middle third: control group −0.64, test group −0.50; and apical third: control group 0.09 mm, test group −0.14 mm. The use of a xenograft in conjunction with d-PTFE membranes proved to be superior to the use of the same membrane and blood clot only in regions of the crest, middle third, and alveolar height.

scholarly journals The Effects of 6-Month Vitamin D Supplementation during the Non-Surgical Treatment of Periodontitis in Vitamin-D-Deficient Patients: A Randomized Double-Blind Placebo-Controlled Study

Nutrients ◽  
2020 ◽  
Vol 12 (10) ◽  
pp. 2940
Author(s):  
Marina Perić ◽  
Dominique Maiter ◽  
Etienne Cavalier ◽  
Jérôme F. Lasserre ◽  
Selena Toma
Keyword(s):  
Vitamin D ◽  
Vitamin D3 ◽  
Test Group ◽  
Controlled Study ◽  
Control Group ◽  
Controlled Clinical Trial ◽  
Pocket Depth ◽  
Double Blind ◽  
Double Blind Placebo ◽  
Significant Difference

Background: This study assessed the effects of weekly vitamin D (VD) supplementation on clinical and biological parameters after scaling and root planning (SRP) in the treatment of periodontitis and served to validate the VD dosage regimen. Methods: It was a monocentric, randomized, double-blind, placebo-controlled clinical trial with 6 months follow-up. Healthy Caucasian periodontitis patients presenting serum 25(OH) vitamin D3 below 30 ng/mL were randomly allocated to test group (SRP + VD 25,000 international units (IU)/week) or the control group (SRP + placebo). Results: A total of 59 patients were screened, 27 were included and 26 completed 3 months (M) and 21 completed 6M control. Test (n = 13) and control groups (n = 14) had similar 25(OH) vitamin D3 levels at baseline (17.6 ± 7.4 vs. 14.4 ± 5.2, respectively). After one month, there was a significant difference between groups (32.9 ± 5.2 vs. 16.1 ± 4.7), also seen at M3 and M6 (t-test, p < 0.001). Periodontal treatment was successful in both groups, since it resulted in a reduction of all measured clinical parameters at M3 and M6 (probing pocket depth (PPD), full mouth bleeding and plaque). However, the reduction in PPD was greater in the test group. Conclusions: In this short-term pilot study, no significant differences were observed between two groups. However, supplementation with VD tended to improve the treatment of periodontitis in patients with initial 25(OH) vitamin D3 < 30 ng/mL and proved safe and efficacious. NCT03162406.

Limited Benefit of Copaifera Oil on Gingivitis Progression in Humans

2010 ◽  
Vol 11 (1) ◽  
pp. 57-64 ◽  
Author(s):  
Sérgio Luís da Silva Pereira ◽  
Cristiane Simões Barros ◽  
Thiago Daher Yunes Salgado ◽  
Vicente Paulo Pereira Filho ◽  
Flávio Nogueira Costa
Keyword(s):  
Treatment Options ◽  
Test Group ◽  
Clinical Results ◽  
Control Group ◽  
Controlled Clinical Trial ◽  
Posterior Teeth ◽  
Treatment And Prevention ◽  
Significant Difference ◽  
Oral Conditions

Abstract Aim The aim of this in vivo study was to evaluate the antiplaque and antigingivitis effect of Copaifera sp (Cp). Methods and Materials Twenty-three subjects participated in a randomized controlled clinical trial using a 21-day, partial-mouth experimental model of gingivitis. A custom tooth shield was fabricated for each subject to prevent the brushing of the four experimental posterior teeth in the lower-left quadrant. The subjects were randomly assigned to either the control group (using a placebo gel) or the test group (using the test gel containing 10% Cp). Results The clinical results showed statistically significant differences for plaque (PLI), bleeding (BI), and gingival (GI) indexes at days 0 and 21 in both groups (p<0.05). However, on day 21 there was no statistically significant difference between groups for all indexes (p>0.05). Conclusions The test gel containing 10% Cp did not prevent plaque formation and development of gingivitis. Clinical Significance Several medicinal herbs are used empirically by persons in the treatment and prevention of oral conditions. Research in this area must be encouraged to determine which herbal agents would be a useful addition to the current range of chemotherapeutic periodontal treatment options. Citation Pereira SLS, Barros CS, Salgado THY, Filho VPP, Costa FN. Limited Benefit of Copaifera Oil on Gingivitis Progression in Humans. J Contemp Dent Pract [Internet]. 2010 Jan; 11(1):057-064. Available from: http://www.thejcdp. com/journal/view/volume11-issue1-pereira.

scholarly journals Effect of Using a Plastic Stent with Apically Repositioned Flap in Peri-Implant Soft Tissue Augmentation: A Randomized Controlled Clinical Trial

2021 ◽  
Vol 2021 ◽  
pp. 1-6
Author(s):  
Ahmed Hamdy ◽  
Hala K. Abd El Gaber ◽  
Dalia M. Ghalwash ◽  
Waleed M. Abbas
Keyword(s):  
Statistical Significance ◽  
Test Group ◽  
Soft Tissue Augmentation ◽  
Control Group ◽  
Controlled Clinical Trial ◽  
Stent Group ◽  
Plastic Stent ◽  
Keratinized Tissue ◽  
Significant Difference ◽  
Keratinized Mucosa

Objectives. This study aimed to clinically assess and compare the width of peri-implant keratinized mucosa following the use of a readymade plastic stent with apically repositioned flap versus conventional apically repositioned flap with papillary sparing incisions during single-stage implant placement protocol. Materials and Methods. A total of 20 patients were enrolled in this study. In the test group, a prefabricated implant-retained stent was clipped on the healing abutment after implant surgery to reposition the keratinized tissue buccoapically. In the control group, simple interrupted sutures were applied instead of using a stent. After the surgical procedure, the width of the buccal keratinized mucosa was measured at the mesial, middle, and distal aspects of the healing abutment. The change in the width of the buccal keratinized mucosa was assessed at 3 months and 6 months. Results. No statistically significant difference was found between the stent group and control group in 6 months’ interval where p = 0.840 , where both groups showed the same mean value of 4.70 ± 0.35 and 4.70 ± 0.63, respectively. The percent of change in the width of KM was found to be higher in the stent group than in the control group with no statistical significance. Conclusion. The use of a readymade plastic stent in combined full/partial-thickness apically repositioned flap shows to be effective in increasing the width of KM compared to the conventional technique. This trial is registered with NCT03754894.

scholarly journals The effect of vitamin C on bone mineral density of menopausal women with equilibrated regime: A randomized clinical trial study, 2012-2013

2014 ◽  
Vol 8 (4) ◽  
pp. 26-30
Author(s):  
Jokar Azam ◽  
Farahi Farzaneh ◽  
Asadi Nasrin ◽  
Salehi Mosa ◽  
Foruhari Sedeghe ◽  
...  
Keyword(s):  
Clinical Trial ◽  
Vitamin C ◽  
Block Design ◽  
Test Group ◽  
Control Group ◽  
Placebo Control ◽  
Controlled Clinical Trial ◽  
Mineral Density ◽  
Menopausal Women ◽  
Significant Difference

The objective of the current study was to estimate the effect of vitamin C on BMD in menopausal women with balanced dietary. In the randomized controlled clinical trial, 150 menopausal women suffering from osteoporosis were chosen in purposive sampling method. In randomized block design, the individuals were placed in the received vitamin C (test) and placebo (control) groups. After integrating groups, the test group received 1000 mg of vitamin C in two divided doses for 6 months and the placebo control group received in the same method. There was a significant correlation between obstetric history with lumbar BMD (r= -295 and p<0.001) and femoral BMD (r= -0.226 and p=0.006). The average index changes of vertebral bone density did not indicate a statistically significant difference in the vitamin C group (0.02±0.05, P=0.001) and the placebo group (0.02±0.04, P<0.001) before and after treatment. With respect to the findings of the study about the effects of vitamin C on BMD, antioxidant is suggested to add to the current treatments.DOI: http://dx.doi.org/10.3126/ijls.v8i4.10930

scholarly journals The Influence of Local Pamidronate Application on Alveolar Dimensional Preservation after Tooth Extraction—An Animal Experimental Study

2020 ◽  
Vol 21 (10) ◽  
pp. 3616
Author(s):  
Frederic Kauffmann ◽  
Christian Höhne ◽  
Alexandre Thomas Assaf ◽  
Tobias Vollkommer ◽  
Jan Semmusch ◽  
...  
Keyword(s):  
Tooth Extraction ◽  
Test Group ◽  
Control Group ◽  
Local Inflammation ◽  
Socket Preservation ◽  
Randomized Controlled ◽  
Significant Difference ◽  
Bone Substitute Materials ◽  
Animal Experimental Study ◽  
Substitute Materials

The aim of this randomized, controlled animal exploratory trial was to investigate the influence of local application of aminobisphosphonate pamidronate during the socket preservation procedure. Mandibular premolars were extracted in five Göttingen minipigs. Two animals underwent socket preservation using BEGO OSS (n = 8 sockets) and three animals using BEGO OSS + Pamifos (15 mg) (n = 12 sockets). After jaw impression, cast models (baseline, eight weeks postoperative) were digitized using an inLab X5 scanner (Dentsply Sirona) and the generated STL data were superimposed and analyzed with GOM Inspect 2018 (GOM, Braunschweig). After 16 weeks, the lower jaws were prepared and examined using standard histological methods. In the test group (BEGO OSS + pamidronate), buccooral dimensional loss was significantly lower, both vestibulary (−0.80 ± 0.57 mm vs. −1.92 ± 0.63 mm; p = 0.00298) and lingually (−1.36 ± 0.58 mm vs. −2.56 ± 0.65 mm; p = 0.00104) compared with the control group (BEGO OSS). The test group showed a significant difference between vestibular and lingual dimensional loss (p = 0.04036). Histology showed cortical and cancellous bone in the alveolar sockets without signs of local inflammation. Adjuvant application of pamidronate during socket preservation reduces alveolar dimensional loss significantly. Further investigations with regard to dose–response relationships, volume effects, side effects, and a verification of the suitability in combination with other bone substitute materials (BSMs) are necessary.

scholarly journals Torque Analysis of Self-drilling Mini-screws placed with and without a Pilot Drill: A Canine Study

2014 ◽  
Vol 4 (2) ◽  
pp. 77-86
Author(s):  
Eric S Solomon ◽  
David G Kerns ◽  
William W Hallmon ◽  
Daniela A Zambon-Fagundes
Keyword(s):  
Success Rate ◽  
Test Group ◽  
Control Group ◽  
Success Rates ◽  
Removal Torque ◽  
Implant Placement ◽  
Significant Difference ◽  
Torque Analysis ◽  
The Mean ◽  
Canine Study

ABSTRACT Purpose The use of temporary anchorage devices (TADs), such as mini-screws, palatal implants and mini-plates, has become a popular treatment option in orthodontics. The objectives of this study were: (1) to compare the success rates of self-drilling mini-screws placed with or without use of a pilot drill, (2) to evaluate the implant placement torque (IPT) of self-drilling miniscrews and (3) to measure the removal torque of self-drilling mini-screws. Materials and methods Six American foxhounds served as subjects in this study. Three OsteoMed self-drilling mini-screws (1.6 mm diameter and 8 mm length) were planned to be placed in each side of the mandible between the roots of the teeth canine/premolar 1 (PM1), PM2/PM3 and PM3/PM4. The sites were allocated randomly in: (1) control group—mini-screws placed with pilot drill and (2) test group—mini-screws placed without pilot drill (self-drilling). The implant placement torque (IPT) and the number of turns performed by the mini-screws during placement were measured. After a healing period of 6 weeks, the mini-screws were removed, and the removal torque was measured. Results A total of 33 mini-screws were placed in six animals. After 6 weeks, the success rate for the control and test groups were 46.7 and 80% respectively (difference not statistically significant). There was no statistically significant difference in the terminal mean IPT values and the mean number of turns for failed and successful mini-screws. The difference between the mean IPT values at the 3rd turn during mini-screw placement in the successful and failed mini-screws (5.56 and 14.03 Ncm respectively) was statistically significant (p < 0.01). Conclusion There was no statistically significant difference in the success rate between self-drilling mini-screws that did or did not have osteotomies (46 vs 80% respectively). However, the IPT at the third revolution for successful mini-screws averaged 5.56 Ncm (p < 0.01). How to cite this article Zambon-Fagundes DA, Kerns DG, Hallmon WW, Solomon ES. Torque Analysis of Self-Drilling Mini-screws placed with and without a Pilot Drill: A Canine Study. J Contemp Dent 2014;4(2):77-86.

Is perioperative antibiotic necessary in straightforward implant placement procedures?

2020 ◽  
Author(s):  
Elçin Bedeloğlu ◽  
Mustafa Yalçın ◽  
Cenker Zeki Koyuncuoğlu
Keyword(s):  
Clavulanic Acid ◽  
Dental Implant ◽  
Prophylactic Antibiotic ◽  
Antibiotic Use ◽  
Implant Failure ◽  
Control Group ◽  
Implant Placement ◽  
Significant Difference ◽  
Amoxicillin Clavulanic Acid ◽  
Experimental Group

The purpose of this non-random retrospective cohort study was to evaluate the impact of prophylactic antibiotic on early outcomes including postoperative pain, swelling, bleeding and cyanosis in patients undergoing dental implant placement before prosthetic loading. Seventy-five patients (45 males, 30 females) whose dental implant placement were completed, included to the study. Patients used prophylactic antibiotics were defined as the experimental group and those who did not, were defined as the control group. The experimental group received 2 g amoxicillin + clavulanic acid 1 h preoperatively and 1 g amoxicillin + clavulanic acid twice a day for 5 days postoperatively while the control group had received no prophylactic antibiotic therapy perioperatively. Data on pain, swelling, bleeding, cyanosis, flap dehiscence, suppuration and implant failure were analyzed on postoperative days 2, 7, and 14 and week 12. No statistically significant difference was detected between the two groups with regard to pain and swelling on postoperative days 2, 7, and 14 and week 12 ( p &gt;0.05), while the severity of pain and swelling were greater on day 2 compared to day 7 and 14 and week 12 in both groups ( p =0.001 and p &lt;0.05, respectively). Similarly, no significant difference was found between the two groups with regard to postoperative bleeding and cyanosis. Although flap dehiscence was more severe on day 7 in the experimental group, no significant difference was found between the two groups with regard to the percentage of flap dehiscence assessed at other time points. Within limitations of the study, it has been demonstrated that antibiotic use has no effect on implant failure rates in dental implant surgery with a limited number of implants. We conclude that perioperative antibiotic use may not be required in straightforward implant placement procedures. Further randomized control clinical studies with higher numbers of patients and implants are needed to substantiate our findings.

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