scholarly journals A Brief Review of Analytical Methods for the Estimation of Allopurinol in Pharmaceutical Formulation and Biological Matrices

2021 ◽  
Vol 2021 ◽  
pp. 1-12
Author(s):  
Hemraj Sharma ◽  
Hari Prasad Sapkota ◽  
Nim Bahadur Dangi
Keyword(s):  
Capillary Electrophoresis ◽  
Analytical Methods ◽  
Analytical Techniques ◽  
Analytical Investigation ◽  
Review Article ◽  
Hyphenated Techniques ◽  
Biological Matrices ◽  
Near Ir ◽  
Uv Visible

This review article represents the collection and discussion of various analytical methods available in the literature for the determination of allopurinol (ALLP) in pharmaceutical and biological samples consisting of HPLC, UV-visible method, near-IR spectroscopy, spectrofluorometry, capillary electrophoresis, polarography, voltammetry, and hyphenated techniques such as LC-MS, LC-MS/MS, UPLC-MS/MS, and GC-MS. The anticipated review provides details about the comparative utilization of various analytical techniques for the determination of ALLP. The present review article can be effectively explored to conduct future analytical investigation for the estimation of ALLP.

scholarly journals Overview of the Determination of Captopril Levels in Pharmaceutical Preparations and Biological Matrices

2021 ◽  
Vol 6 (4) ◽  
pp. 1-11
Author(s):  
Nanda Aflyona Darma ◽  
Roslinda Rasyid ◽  
Harrizul Rivai
Keyword(s):  
High Performance ◽  
Pharmaceutical Preparations ◽  
Analytical Techniques ◽  
Review Article ◽  
Biological Matrices ◽  
Pharmaceutical Dosage Forms ◽  
Analytical Technique ◽  
Data Collection Process ◽  
Uv Visible

Captopril is the most commonly prescribed ACE-Inhibitor class of drugs because it is easily accessible and affordable. Therefore, to ensure drug quality, captopril levels were determined. This review article aims to provide an overview of the various analytical techniques that have been carried out in selecting the groups of captopril in both pharmaceutical dosage forms and biological matrices. Some of these analytical methods include the UV-Visible spectrophotometric method, high-performance liquid chromatography (HPLC), voltammetry, and flow injection. The data collection process in this review article is to collect research journals through trusted sites in the last ten years (2011-2021) with the search keywords "Determination of Captopril," "Analysis of Captopril on Pharmaceutical Preparations," and Analysis of Captopril on Biological Matrices." From the data that has been collected, the voltammetric method is the most widely used analytical technique in determining captopril for both pharmaceutical preparations and biological matrices in the last ten years.

scholarly journals Human Poisoning from Poisonous Higher Fungi: Focus on Analytical Toxicology and Case Reports in Forensic Toxicology

2020 ◽  
Vol 13 (12) ◽  
pp. 454
Author(s):  
Estelle Flament ◽  
Jérôme Guitton ◽  
Jean-Michel Gaulier ◽  
Yvan Gaillard
Keyword(s):  
Analytical Methods ◽  
Case Reports ◽  
Forensic Toxicology ◽  
Analytical Techniques ◽  
Ibotenic Acid ◽  
Biological Matrices ◽  
Analytical Toxicology ◽  
Fatal Poisoning ◽  
Toxicological Analysis ◽  
Chemical Structures

Several families of higher fungi contain mycotoxins that cause serious or even fatal poisoning when consumed by humans. The aim of this review is to inventory, from an analytical point of view, poisoning cases linked with certain significantly toxic mycotoxins: orellanine, α- and β-amanitin, muscarine, ibotenic acid and muscimol, and gyromitrin. Clinicians are calling for the cases to be documented by toxicological analysis. This document is therefore a review of poisoning cases involving these mycotoxins reported in the literature and carries out an inventory of the analytical techniques available for their identification and quantification. It seems indeed that these poisonings are only rarely documented by toxicological analysis, due mainly to a lack of analytical methods in biological matrices. There are many reasons for this issue: the numerous varieties of mushroom involved, mycotoxins with different chemical structures, a lack of knowledge about distribution and metabolism. To sum up, we are faced with (i) obstacles to the documentation and interpretation of fatal (or non-fatal) poisoning cases and (ii) a real need for analytical methods of identifying and quantifying these mycotoxins (and their metabolites) in biological matrices.

Analytical Methods in Tracing Honey Authenticity

2017 ◽  
Vol 100 (4) ◽  
pp. 827-839 ◽  
Author(s):  
Jelena Trifković ◽  
Filip Andrić ◽  
Petar Ristivojević ◽  
Etil Guzelmeric ◽  
Erdem Yesilada
Keyword(s):  
Stable Isotopes ◽  
Natural Product ◽  
Cross Section ◽  
Analytical Methods ◽  
Scientific Community ◽  
Analytical Techniques ◽  
Consumer Health ◽  
Wide Range ◽  
Medicinal Properties

Abstract Honey is a precious natural product that is marketed with a wide range of nutritional and medicinal properties. However, it is also a product subjected to frequent adulteration through mislabeling and mixing with cheaper and lower-quality honeys and various sugar syrups. In that sense, honey authentication regarding its genuine botanical and geographical origins, as well as the detection of any adulteration, is essential in order to protect consumer health and to avoid competition that could create a destabilized market. Various analytical techniques have been developed to detect adulterations in honey, including measuring the ratios of stable isotopes (mostly 13C/12C) and the use of different spectroscopic, chromatographic, and electrochemical methods. This review aims to provide a cross-section of contemporary analytical methods used for the determination of honey authenticity in order to help the scientific community engaged in the field of honey chemistry make appropriate choices and select the best applications that should lead to improvements in the detection and elimination of fraudulent practices in honey manufacturing.

scholarly journals Analytical Methods for Determination of Salbutamol, Ambroxol and Fexofenadine

2020 ◽  
Vol 1 (1) ◽  
pp. 01-11
Author(s):  
Mahmoud Sebaiy
Keyword(s):  
Biological Samples ◽  
Analytical Methods ◽  
Degradation Products ◽  
Review Article ◽  
Pure Form

In this review article, we will introduce all reported methods that have been developed for determination of certain anti-tussive and anti-histaminic drugs such as salbutamol, ambroxol and fexofenadine in their pure form, combined form with other drugs, combined form with degradation products, and in biological samples. We also will shed the light on the most important combination of drugs that are used for treatment of asthma and related diseases.

scholarly journals Review for Analytical Methods for the Determination of Mefenamic Acid

2021 ◽  
pp. 426-437
Author(s):  
T. V. Ashira ◽  
T. Mohamed Rafeeque ◽  
Saba Maanvizhi ◽  
S. Kathirvel ◽  
P. C. Indukala ◽  
...  
Keyword(s):  
Mefenamic Acid ◽  
Analytical Methods ◽  
High Performance ◽  
Active Pharmaceutical Ingredient ◽  
Review Article ◽  
Computer Assisted ◽  
Extensive Literature ◽  
Pharmaceutical Dosage Forms ◽  
Layer Chromatography

Mefenamic acid (MFA) is a non-steroidal anti-inflammatory drug that belongs to the anthranilic acid derivative family. It is used to relieve mild to moderate pain. The present review article includes a compilation of articles on the various properties along with an extensive literature survey on the reported analytical methods of MFA. Using a comprehensive computer assisted literature review; this article discusses the analytical methodologies for quantifying MFA both in active pharmaceutical ingredient and pharmaceutical dosage forms. This is the first review article in this series with focus on the analytical profile of MFA. Although, several methods like High Performance Liquid Chromatography (HPLC), Thin Layer Chromatography (TLC), spectrophotometry, fluorimetry, turbidimetry, Atomic Absorption Spectroscopy (AAS), Mass Spectroscopy (MS) and electro analytical methods were reported in the literature, HPLC stands out first for the quantification of MFA.

scholarly journals An Overview of the Analytical Methods for the Determination of Organic Ultraviolet Filters in Cosmetic Products and Human Samples

Molecules ◽  
2021 ◽  
Vol 26 (16) ◽  
pp. 4780
Author(s):  
Izabela Narloch ◽  
Grażyna Wejnerowska
Keyword(s):  
Analytical Methods ◽  
Limit Of Detection ◽  
Biological Fluids ◽  
Analytical Techniques ◽  
Detection Accuracy ◽  
Uv Filters ◽  
Cosmetic Products ◽  
Monitoring Protocols ◽  
Accuracy And Repeatability

UV filters are a group of compounds commonly used in different cosmetic products to absorb UV radiation. They are classified into a variety of chemical groups, such as benzophenones, salicylates, benzotriazoles, cinnamates, p-aminobenzoates, triazines, camphor derivatives, etc. Different tests have shown that some of these chemicals are absorbed through the skin and metabolised or bioaccumulated. These processes can cause negative health effects, including mutagenic and cancerogenic ones. Due to the absence of official monitoring protocols, there is an increased number of analytical methods that enable the determination of those compounds in cosmetic samples to ensure user safety, as well as in biological fluids and tissues samples, to obtain more information regarding their behaviour in the human body. This review aimed to show and discuss the published studies concerning analytical methods for the determination of organic UV filters in cosmetic and biological samples. It focused on sample preparation, analytical techniques, and analytical performance (limit of detection, accuracy, and repeatability).

Evaluation of Cancer Bio-markers through Hyphenated Analytical Techniques

2021 ◽  
pp. 235-242
Author(s):  
Ch. Prudhvi Raju ◽  
G. Raveendra Babu ◽  
Sowjanya M. ◽  
Ramayyappa M.
Keyword(s):  
Blood Serum ◽  
Diagnostic Tests ◽  
Analytical Techniques ◽  
Prognostic Indicators ◽  
Selective Detection ◽  
Hyphenated Techniques ◽  
Common Cancer ◽  
Current Availability ◽  
Productive Research

Background: The accurate and efficient diagnosis at the early stages of cancers is the key feature for effective treatment and productive research for finding out news to types of cancers. It is essentially true for cancers, where there is no effective cure, but only one treatment is available. But most people have a combination of treatments, such as surgery with chemotherapy or radiation therapy or immunotherapy or targeted therapy or hormone therapy.Cancers symptoms of abnormal periods or pelvic pain, changes in bathroom habits, bloating, breast changes, chronic coughing, chronic headache, difficulty swallowing, excessing bruising. Despite the fact of having great need, the current availability of diagnostic tests is unable to diagnose different forms of cancers. Aim: The aim of the review is to explore the application of GC-MS, LC-MS and UP-LC/Q-TOF MS for the evaluation of changes in the biochemical composition of blood serum, urine and saliva. The power of high differentiation method will promote the translation of hyphenated techniques from a laboratory to clinical useful tool. Determination of biochemical information derives from hyphenated techniques from blood, serum, saliva and urine that will yield accurate and selective detection of cancer disorders. They will also provide diagnostic and prognostic indicators and will also play a significant role in the development of personalized medicine. Conclusion: Hyphenated techniques will allow differentiating blood serum, saliva and urine samples of common cancer disorders from normal control patients with sensitivity and specificity.

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