scholarly journals Relationships of Rheumatoid Factor with Thickness of Retina and Choroid in Subjects without Ocular Symptoms Using Swept-Source Optical Coherence Tomography

2021 ◽  
Vol 2021 ◽  
pp. 1-6
Author(s):  
Qingjian Li ◽  
Yiwen Qian ◽  
Sennan Xu ◽  
Minjie Zhang ◽  
Xu Liang ◽  
...  
Keyword(s):  
Optical Coherence Tomography ◽  
Rheumatoid Factor ◽  
Choroidal Thickness ◽  
Retinal Thickness ◽  
Statistical Significance ◽  
Optical Coherence ◽  
Cross Sectional ◽  
Swept Source ◽  
Ocular Symptoms ◽  
Significant Difference

Purpose. Researches have confirmed that the retinal and choroidal thickness in patients with autoimmune disease-associated uveitis displays significant changes. However, the relationships between rheumatoid factor (RF) and thickness of the retina and choroid in individuals without ocular manifestations remain unclear. The aim of this study is to assess the associations of RF with retinal and choroidal thickness. Methods. The individuals enrolled in the cross-sectional research received full ocular examinations. The participants were classified as the RF (+) group ( RF ≥ 15.0  IU/ml) and the RF (−) group ( RF < 15.0  IU/ml) according to the serum RF titers. The thickness of the retina and choroid was measured by swept-source optical coherence tomography (SS-OCT). Results. The study covered 65 right eyes of 65 individuals that are RF-positive and 130 right eyes of 130 age- and sex-matched individuals that are RF-negative. The RF (+) group showed decreased choroidal thickness that achieved statistical significance only in the outer inferior and outer temporal sectors, as compared to the RF (−) group. There was no statistically significant difference regarding the retinal thickness between the two groups. Pearson’s correlation analysis revealed that the RF was significantly negatively related to the choroidal thickness in all areas. However, there was no significant correlation between the RF and the retinal thickness. Conclusions. Serum RF titers are closely linked with choroidal thickness before the emergence of ocular symptoms. Research into the relationships may improve our understanding of the role of serum RF in the pathogenesis of uveitis.

scholarly journals Retinal and Choroidal Thickness in relation to C-Reactive Protein on Swept-Source Optical Coherence Tomography

2021 ◽  
Vol 2021 ◽  
pp. 1-6
Author(s):  
Dawei Fang ◽  
Qingjian Li ◽  
Ke Yan ◽  
Sennan Xu ◽  
Jing Jiang ◽  
...  
Keyword(s):  
Optical Coherence Tomography ◽  
Choroidal Thickness ◽  
Retinal Thickness ◽  
Cross Sectional Study ◽  
Optical Coherence ◽  
C Reactive Protein ◽  
Cross Sectional ◽  
Swept Source ◽  
Reactive Protein ◽  
Significant Difference

Purpose. To evaluate the relationships between C-reactive protein (CRP) and retinal and choroidal thickness by swept-source optical coherence tomography (SS-OCT). Methods. The participants included in the prospective cross-sectional study underwent a comprehensive ophthalmic examination. Based on the CRP values, the subjects were divided into the CRP (+) group ( CRP ≥ 8.2  mg/L) and the CRP (−) group ( CRP < 8.2  mg/L). The retinal and choroidal thickness was compared between the two groups. Results. This study enrolled 43 right eyes of 43 subjects from the CRP (+) group and 86 right eyes of 86 gender- and age-match subjects from the CRP (−) group. The choroidal thickness in the CRP (+) group was thinner than that in the CRP (−) group except for the outer nasal sector of the Early Treatment Diabetic Retinopathy Study (ETDRS) grid. However, the retinal thickness only in the inner temporal sector showed a significant difference. According to Pearson’s correlation analysis, the CRP was significantly negatively correlated with the choroidal thickness in all sectors and the retinal thickness only in the inner temporal and outer nasal sectors of the ETDRS grid. Conclusion. CRP levels are associated with retinal and choroidal thickness. The data related to the retinal and choroidal thickness changes may help understand the pathogenesis of specific ocular abnormalities in patients with systemic inflammation.

scholarly journals Comparison of two different optical coherence tomography angiography devices in detecting healthy versus glaucomatous eyes – an observational cross-sectional study

2020 ◽  
Vol 20 (1) ◽  
Author(s):  
A. R. Kee ◽  
V. C. H. Yip ◽  
E. L. T. Tay ◽  
C. W. Lim ◽  
J. Cheng ◽  
...  
Keyword(s):  
Optical Coherence Tomography ◽  
Diagnostic Accuracy ◽  
Optic Disc ◽  
Optical Coherence Tomography Angiography ◽  
Optical Coherence ◽  
Cross Sectional ◽  
Swept Source ◽  
Retest Reliability ◽  
Significant Difference ◽  
Test Retest Reliability

Abstract Background To understand the differences between two different optical coherence tomography angiography (OCTA) devices in detecting glaucomatous from healthy eyes by comparing their vascular parameters, diagnostic accuracy and test-retest reliability. Methods A cross-sectional observational study was performed on healthy and glaucoma subjects, on whom two sets of OCTA images of optic disc and macula were acquired using both AngioVue (Optovue, USA) and Swept Source (Topcon, Japan) OCTA devices during one visit. A novel in-house software was used to calculate the vessel densities. Diagnostic accuracy of the machines in differentiating healthy versus glaucomatous eyes was determined using area under the receiver operating characteristic curve (AUROC) and test-retest repeatability of the machines was also evaluated. Results A total of 80 healthy and 38 glaucomatous eyes were evaluated. Glaucomatous eyes had reduced mean vessel density compared to healthy controls in all segmented layers of the optic disc and macula using AngioVue (p ≤ 0.001). However, glaucomatous eyes had higher mean vessel density on optic disc scans using Swept Source, with lack of statistically significant difference between healthy and glaucomatous eyes. The AUROC showed better diagnostic accuracy of AngioVue (0.761–1.000) compared to Swept Source (0.113–0.644). The test-retest reliability indices were generally better using AngioVue than Swept Source. Conclusions AngioVue showed better diagnostic capability and test-retest reliability compared to Swept Source. Further studies need to be undertaken to evaluate if there is any significant difference between the various machines in diagnosing and monitoring glaucoma.

scholarly journals Macular Thickness and Volume Assessed by Spectral-Domain Optical Coherence Tomography in Patients With Coronavirus Disease 2019: A Case-Control Study

2020 ◽  
Author(s):  
Mojtaba Abrishami ◽  
Fariba Tohidinezhad ◽  
Zahra Emamverdian ◽  
Ramin Daneshvar ◽  
Neda Saeedian ◽  
...  
Keyword(s):  
Optical Coherence Tomography ◽  
Retinal Thickness ◽  
Spectral Domain ◽  
Case Group ◽  
Special Focus ◽  
Optical Coherence ◽  
Cross Sectional ◽  
Significant Difference ◽  
Normal Controls ◽  
Sd Oct

Abstract Purpose: To quantify the retinal thickness and volume using spectral-domain optical coherence tomography (SD-OCT) analysis in the macular region of patients with Coronavirus Disease 2019 (COVID-19).Methods: In a comparative cross-sectional, observational study, patients recovered from COVID-19 were included. All included subjects had a reverse transcription-polymerase chain reaction (RT-PCR) - confirmed diagnosis of COVID-19. Macular SD-OCT was performed at least two weeks after recovery from systemic COVID-19. Inner, outer and full retinal thicknesses and volumes were measured in COVID-19 recovered patients versus age-matched normal controls.Results: Twenty-five patients (11 male) with a mean age of 36.4 ± 11 years and 60 healthy controls (31 males) with a mean age of 39.3 ± 7.7 years were enrolled in the study. There was no statistically significant difference in the retinal thickness or volume measures between the two groups. However, the thickness in the case group was minimally more than the controls. Conclusion: Retinal thickness in COVID-19 patients may be higher than healthy subjects. Comprehensive ocular examination with special focus on posterior segment manifestations should be considered in these patients.

scholarly journals Changes in the Retinal Microvasculature Measured Using Optical Coherence Tomography Angiography According to Age

2020 ◽  
Vol 9 (3) ◽  
pp. 883 ◽  
Author(s):  
Seung Hun Park ◽  
Heeyoon Cho ◽  
Sun Jin Hwang ◽  
Beomseo Jeon ◽  
Mincheol Seong ◽  
...  
Keyword(s):  
Optical Coherence Tomography ◽  
Foveal Avascular Zone ◽  
Vascular Density ◽  
Inner Plexiform Layer ◽  
Optical Coherence ◽  
Cross Sectional ◽  
Swept Source ◽  
Age Related ◽  
Retinal Microvasculature ◽  
Significant Difference

In this cross-sectional study, we examined age-related changes in the retinal vessels of 100 healthy participants, aged from 5 to 80 years, and divided into four groups (G1, under 20 years of age; G2, from 20 to 39 years of age; G3, from 40 to 59 years of age; G4, age 60 years or older). All subjects underwent swept-source optical coherence tomography (SS-OCT) and OCT angiography (OCTA). The vascular density (VD) of the superficial (SCP) and deep capillary plexus (DCP), and choriocapillaris (CCP) were measured using OCTA. The vascular density of each capillary layer, foveal avascular zone (FAZ) area, ganglion cell-inner plexiform layer (GC-IPL) thickness, retinal thickness (RT), and choroidal thickness (CT) were compared between age groups. Most OCT variables were correlated with OCTA variables. The FAZ area; VD of the SCP, DCP, and CCP; GC-IPL thickness; RT; and CT showed significant difference (p < 0.001) between G1 + G2 and G3 + G4, except for central GC-IPL thickness (p = 0.14) and central RT (p = 0.25). Density of the retinal capillary vasculature reduced and FAZ area increased after age 40, which represents the onset of middle age.

scholarly journals Differences in Choroidal Structures Between Idiopathic and Steroid-Induced Central Serous Chorioretinopathy

2018 ◽  
Vol 3 (1) ◽  
pp. 10-15
Author(s):  
Takahiko Izumi ◽  
Hideki Koizumi ◽  
Yohei Takahashi ◽  
Ichiro Maruko ◽  
Shozo Sonoda ◽  
...  
Keyword(s):  
Optical Coherence Tomography ◽  
Layer Thickness ◽  
Central Serous Chorioretinopathy ◽  
Choroidal Thickness ◽  
Optical Coherence ◽  
Cross Sectional ◽  
Swept Source ◽  
The Mean ◽  
Binarization Method ◽  
Pathophysiologic Mechanisms

Purpose: The purpose of this article is to investigate the differences in intrachoroidal structures between eyes with idiopathic central serous chorioretinopathy (CSC) and those with steroid-induced CSC. Methods: Thirty eyes of 30 patients with idiopathic CSC and 17 eyes of 15 patients with steroid-induced CSC were studied. Cross-sectional swept-source optical coherence tomography images of eyes with idiopathic and steroid-induced CSC were retrospectively analyzed by the manual layer delineation technique and by the binarization technique. Results: The mean subfoveal choroidal thickness (SCT) was not significantly different between the eyes with idiopathic CSC (408.0 ± 106.6 µm) and those with steroid-induced (389.9 ± 105.4 µm; P = .67) CSC. Manual layer delineation showed that the mean ratio of the large choroidal vessel layer thickness to the SCT was significantly higher in eyes with idiopathic CSC (0.874 ± 0.070) than in eyes with steroid-induced CSC (0.828 ± 0.083; P = .02). The binarization method showed that the mean ratio of the luminal areas to the choroidal areas centered at the fovea was significantly higher in eyes with idiopathic CSC (0.747 ± 0.064) than in eyes with steroid-induced CSC (0.701 ± 0.046; P = .01). Conclusion: The intrachoroidal structures in steroid-induced CSC were different from those in idiopathic CSC. These findings suggest different pathophysiologic mechanisms may be involved in the pathogenesis of these 2 entities.

scholarly journals Correlation of retinal changes with choroidal changes in acute and recurrent central serous chorioretinopathy assessed by swept-source optical coherence tomography

2020 ◽  
Vol 12 ◽  
pp. 251584141989982
Author(s):  
Durgasri Jaisankar ◽  
Meenakshi Kumar ◽  
Pukhraj Rishi ◽  
Sumeer Singh ◽  
Rajiv Raman
Keyword(s):  
Optical Coherence Tomography ◽  
Layer Thickness ◽  
Central Serous Chorioretinopathy ◽  
Choroidal Thickness ◽  
Retinal Layer ◽  
Optical Coherence ◽  
Swept Source ◽  
Acute Group ◽  
Significant Difference

Purpose: To evaluate affected choroidal regions and corresponding retinal changes in acute and recurrent central serous chorioretinopathy using swept-source optical coherence tomography. Methods: The foveal and subfoveal choroidal thicknesses were measured with swept-source optical coherence tomography. The retina was divided into five zones on the swept-source optical coherence tomography image based on baseline choroidal thickness being <100, 100–199, 200–299, 300–399 and ⩾400 μm. The retinal and choroidal thicknesses in the same five regions were evaluated during follow-up. The measurements were then compared between baseline (when central serous chorioretinopathy was active) and follow-up (after complete resolution of disease). Results: At baseline, in the acute group, the mean outer retinal layer thickness was significantly higher in areas with thicker choroid and lower in areas with thinner choroid. No such change was noticed in the recurrent group. In the acute group, the overall retinal thickness from baseline to follow-up decreased from 269.84 to 251.9 µm, ganglion cell layer thickness decreased from 107.14 to 101.28 µm, retinal nerve fibre layer thickness decreased from 56.96 to 49.33 µm, and no significant difference was noted in choroidal thickness. In the recurrent group, choroidal thickness significantly increased from 254.58 to 262.55 µm and ganglion cell layer decreased from 103.43 to 94.01 µm. No significant difference was noted in overall retina and retinal nerve fibre layer. Reduction in choroidal and retinal layer thicknesses was better in eyes which underwent laser treatment than the observation group. Conclusion: Swept-source optical coherence tomography might serve as an important non-invasive tool for both evaluating the extent of pathology and to predict the recurrence rate.

scholarly journals Retinal Changes before and after Silicone Oil Removal in Eyes with Rhegmatogenous Retinal Detachment Using Swept-Source Optical Coherence Tomography

2021 ◽  
Vol 10 (22) ◽  
pp. 5436
Author(s):  
Jung Wook Lee ◽  
Heeyoon Cho ◽  
Min Ho Kang ◽  
Rimkyung Hong ◽  
Mincheol Seong ◽  
...  
Keyword(s):  
Optical Coherence Tomography ◽  
Retinal Detachment ◽  
Choroidal Thickness ◽  
Silicone Oil ◽  
Inner Plexiform Layer ◽  
Optical Coherence ◽  
Mechanical Pressure ◽  
Swept Source ◽  
Significant Difference ◽  
Fellow Eyes

This study aimed to evaluate and compare the retinal and choroidal thickness and vessel density (VD) changes between silicone oil (SO) tamponade and after SO removal using swept-source optical coherence tomography (SS-OCT) and OCT angiography (OCTA). Thirty patients who underwent pars plana vitrectomy for retinal detachment (RD) with SO tamponade were included. SS-OCT and OCTA were conducted before RD surgery, during SO tamponade, and after SO removal. A 3-dimensional volumetric wide scan protocol was used for the analysis. The segmented retina, choroidal thickness map, and peripapillary thickness were then measured. For the OCTA analysis, 4.5 × 4.5 mm scans were used. Superficial and deep capillary plexus VDs in unaffected fellow eyes and eyes after SO removal were compared. During the SO tamponade period, the thickness of the parafoveal total retina, ganglion cell-inner plexiform layer, and peripapillary retinal nerve fiber layer (ppRNFL) were significantly thinner than those of unaffected fellow eyes (p < 0.05). The parafoveal layer thickness thinning recovered up to three to six months after SO removal. Moreover, six months after SO removal, the parafoveal thickness was not significantly different compared to that of unaffected fellow eyes (p > 0.05). However, the ppRNFL thickness was significantly decreased during SO tamponade and remained unrecovered six months after SO removal. There was no significant difference in the VD on the OCTA. Thus, SO tamponade and removal for RD resulted in a change in the retinal and peripapillary thickness. This may be due to the mechanical pressure effect of SO.

scholarly journals Choroidal vascular sublayers in Chinese pre-eclampsia and healthy pregnancy

2019 ◽  
Author(s):  
Tingting Hong ◽  
Xin Meng ◽  
Xinxiao Gao ◽  
Jun Wang
Keyword(s):  
Optical Coherence Tomography ◽  
Choroidal Thickness ◽  
Normal Subjects ◽  
Cross Sectional Study ◽  
Optical Coherence ◽  
Cross Sectional ◽  
Subfoveal Choroidal Thickness ◽  
Healthy Pregnancy ◽  
Significant Difference ◽  
Sd Oct

Abstract Background: Using spectral-domain optical coherence tomography (SD-OCT) to investigate choroidal vascular sublayers in Chinese pre-eclampsia (PE) and healthy pregnancy. Methods: This was an observational, cross-sectional study, including 20 normal subjects, 23 healthy pregnancy and 37 patients with PE. Using SD-OCT, subfoveal choroidal thickness (SFCT)， 750μm nasal and temporal to the fovea, 1500μm nasal and temporal to the fovea（T1500, T750, SFCT, N750, N1500）and sublayers (choriocapillaris/Sattler layer and Haller layer) were measured. Results: There was no significant difference in mean age, spherical equivalent among the three groups (P=0.532). Additionally, no significant difference in the gestational age between the healthy pregnancy and PE group was found (P=0.783). Significant differences were seen in large choroid vessel thickness(LCVT), medium choroidal vessel thickness (MCVT) and choroidal thickness (CT) at 5 locations among three groups (P<0.05). There was significant increase in healthy pregnancy group than in normal subjects at N1500-CT, N750-CT, SFCT, T750-CT and MCVT (P<0.05), while no significant difference was observed at T1500CT and LCVT (P>0.05). Meanwhile, significant increase was detected in PE group than in healthy pregnancy group at N1500-CT, N750-CT, SFCT, T750-CT, T1500CT and LCVT (P<0.05), whereas no significant difference was observed at MCVT(P=0.709). Conclusion: Our study revealed the variation of choroidal vascular sublayers during pregnancy and PE. Key words: Pre-eclampsia, subfoveal choroidal thickness, choroidal sublayers, optical coherence tomography

scholarly journals Macular and choroidal thicknesses in a healthy Hispanic population evaluated by high-definition spectral-domain optical coherence tomography (SD-OCT)

2020 ◽  
Vol 6 (1) ◽  
Author(s):  
Diana A. Cortés ◽  
Daniela Roca ◽  
Pedro Iván Navarro ◽  
Francisco J. Rodríguez
Keyword(s):  
Optical Coherence Tomography ◽  
Choroidal Thickness ◽  
Correlation Study ◽  
Spectral Domain ◽  
Optical Coherence ◽  
Hispanic Population ◽  
High Definition ◽  
Cross Sectional ◽  
Significant Difference ◽  
Sd Oct

Abstract Purpose To report normal values of macular and choroidal thickness obtained from a healthy Hispanic population using Optovue (Optovue Inc, Freemont CA, USA) spectral domain optical coherence tomography (SD-OCT). Design Observational, cross-sectional, correlation study. Methods A total of 290 eyes (145 healthy subjects) were included; 69% of subjects were female. The median age was 39 ± 29 years (IQR), with a range between 18 and 89 years. The study sample was stratified into three age groups: Group 1, 18–40 years (50.3%), Group 2, 41–60 years (30.7%), and Group 3, older than 61 years (19%). Central macular, perifoveal (inner quadrants), and parafoveal (outer quadrants) thicknesses were estimated. In addition, central and peripheral choroidal thicknesses were estimated. Data analysis was performed to calculate the standardized mean difference according to the variance (Student’s t-test) and its differences with Epidat 4.1. Results Median macular central thickness was 250 ±30 µm (IQR) with Optovue. Median central choroidal thickness was 263 ± 48 µm (IQR). Median central choroidal thickness was greater than mean peripheral thickness. Macular evaluation showed a statistically significant difference in central, perifoveal, and parafoveal thicknesses, with lower values being recorded for the study sample compared with the manufacturer’s data. Conclusions SD-OCT has become a useful tool to obtain high-resolution images of the macula and choroid. This method allows precise assessment of the retinal and choroidal layers to diagnose and follow up posterior segment diseases. We are reporting normal cut-off values of macular and choroidal thicknesses in healthy Hispanic subjects evaluated with Optovue SD-OCT as new diagnostic normal parameters for research and clinical activities.

scholarly journals Identification of microvascular and morphological alterations in eyes with central retinal non-perfusion

PLoS ONE ◽  
2020 ◽  
Vol 15 (11) ◽  
pp. e0241753
Author(s):  
Dorottya Hajdu ◽  
Reinhard Told ◽  
Orsolya Angeli ◽  
Guenther Weigert ◽  
Andreas Pollreisz ◽  
...  
Keyword(s):  
Optical Coherence Tomography ◽  
Visual Acuity ◽  
Visual Outcome ◽  
Retinal Ischemia ◽  
Foveal Avascular Zone ◽  
Optical Coherence ◽  
Cross Sectional ◽  
Swept Source ◽  
Morphological Alterations ◽  
Significant Difference

Purpose To evaluate the characteristics and morphological alterations in central retinal ischemia caused by diabetic retinopathy (DR) or retinal vein occlusion (RVO) as seen in optical coherence tomography angiography (OCTA) and their relationship to visual acuity. Methods Swept-source optical coherence tomography (SSOCT) and OCTA (Topcon, Triton) data of patients with central involving retinal ischemia were analyzed in this cross-sectional study. The following parameters were evaluated: vessel parameters, foveal avascular zone (FAZ), intraretinal cysts (IRC), microaneurysms (MA), vascular collaterals in the superficial (SCP) and deep plexuses (DCP), hyperreflective foci (HRF), epiretinal membrane (ERM), external limiting membrane (ELM) and ellipsoid zone (EZ) disruption, as well as the disorganization of retinal inner layers (DRIL). Best-corrected visual acuity (BCVA), age, gender, disease duration and ocular history were also recorded. Results 44 eyes of 44 patients (22 with RVO, 22 with DR) were analyzed. The mean age was 60.55 ± 11.38 years and mean BCVA 0.86 ± 0.36 (Snellen, 6m). No significant difference was found between DR subgroups (non proliferative vs. proliferative). Between RVO subgroups (CRVO vs. BRVO) a significant difference was found in term of collateral vessel of the DCP (p = 0.014). A pooled DR and RVO group were created and compared. Significantly more MAs (p = 0.007) and ERM (p = 0.007) were found in the DR group. Statistically significant negative correlation was demonstrated between FAZ and BCVA (p = 0.45) when analyzing all patients with retinal ischemia. Conclusion This study has shown that the best predictor of visual outcome in center involved ischemic diseases is the size of FAZ. Besides the presence of MAs and ERM, all other OCT and OCTA parameters were present in a similar extent in DR and RVO group despite the completely different disease origins. Our results suggest that as soon as retinal ischemia in the macular region is present, it has a similar appearance and visual outcome independently of the underlying disease.

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