scholarly journals Microwave-Assisted Regioselective Synthesis and 2D-NMR Studies of New 1,2,3-Triazole Compounds Derived from Acridone

2021 ◽  
Vol 2021 ◽  
pp. 1-10
Author(s):  
Mohammed Aarjane ◽  
Siham Slassi ◽  
Bouchra Tazi ◽  
Amina Amine
Keyword(s):  
1H Nmr ◽  
13C Nmr ◽  
Cycloaddition Reaction ◽  
Reaction Times ◽  
2D Nmr ◽  
Dipolar Cycloaddition ◽  
Microwave Assisted Synthesis ◽  
Nmr Studies ◽  
Microwave Assisted ◽  
Acridone Derivatives

A simple and mild protocol towards the synthesis of new 1,2,3-triazole compounds derived from acridone has been developed via regiospecific 1,3-dipolar cycloaddition reaction between 10-(prop-2-yn-1-yl)acridone derivatives and aromatic azides using CuI as a catalyst. The cycloaddition reaction has been performed using conventional as well as microwave-assisted methods. Microwave-assisted synthesis caused a significant reduction in the reaction times and improvement in the yields of all the synthesized compounds compared with the conventional method. The structure of the 1,4-disubstituted 1,2,3-triazoles has been elucidated by IR, HRMS, 1H-NMR, 13C-NMR, and 2D NMR (1H-13C HMBC, 1H-1H COSY, and 1H-1H NOESY) spectroscopies.

Microwave-assisted Synthesis of Unsymmetrical Tetrapyrrolic Compounds

2008 ◽  
Vol 59 (9) ◽  
Author(s):  
Radu Socoteanu ◽  
Rica Boscencu ◽  
Veronica Nacea ◽  
Anabela Sousa Oliveira ◽  
Luis Filipe Vieira Ferreira
Keyword(s):  
Microwave Irradiation ◽  
Ftir Spectroscopy ◽  
1H Nmr ◽  
13C Nmr ◽  
Microwave Assisted Synthesis ◽  
Microwave Assisted ◽  
Experimental Approaches

Unsymmetrical porphyrin, 5-(3-hydroxyphenyl)-10,15,20-tris-(4-carboxymethylphenyl)-21,23-H-porphine (TCMPOHM) and also the parent symmetrical compound 5,10,15,20-meso-tetrakis-(4-carboxymethylphenyl)-21,23H porphine (TCMP) were synthesized with superior yields using microwave irradiation. Structures were confirmed by 1H-NMR, 13C-NMR, UV-Vis and FTIR spectroscopy. Various NMR experimental approaches (including 13C-NMR, DEPT, COSY, HMBC and HMQC) were used to completely elucidate some interesting aspects concerning the structure of the new porphyrin compounds.

scholarly journals Synthesis of new optically pure isoxazolines via 1,3-dipolar cycloaddition of nitrile oxides with allyl esters derived from eugenol

2016 ◽  
Vol 12 (4) ◽  
pp. 4333-4337 ◽  
Author(s):  
Ghada Lahouar ◽  
Amira Bahy ◽  
Ridha Touati ◽  
Bechir Ben hassine
Keyword(s):  
1H Nmr ◽  
13C Nmr ◽  
Chemical Structure ◽  
2D Nmr ◽  
Dipolar Cycloaddition ◽  
Nmr Analysis ◽  
Allyl Ester ◽  
Optically Pure ◽  
Tof Ms ◽  
Allyl Esters

1,3-dipolar cycloaddition of arylnitrile oxides with allyl ester prepared from eugenol afforded new chiral isoxazolines in good yields. The chemical structure of this compounds was characterized by 1H NMR,13C NMR, 2D NMR and TOF-MS analysis. All the cycloadducts were obtained through a regiospecific and stereospecific pathway and all cases, only one isomer was isolated, as established by unambiguous NMR analysis

scholarly journals 1D AND 2D NMR STUDIES OF BENZYL O–VANILLIN

2010 ◽  
Vol 8 (3) ◽  
pp. 411-417 ◽  
Author(s):  
Mohammed Hadi Al–Douh ◽  
Shafida Abd Hamid ◽  
Hasnah Osman
Keyword(s):  
1H Nmr ◽  
13C Nmr ◽  
Benzyl Bromide ◽  
2D Nmr ◽  
Coupling Constants ◽  
Nmr Studies

The reaction of o-vanillin A with benzyl bromide B2 in acetone as the solvent and K2CO3 as a base in the presence of tetra-n-butylammonium iodide (TBAI) as catalyst formed benzyl o-vanillin, C. The complete assignments of C using PROTON, APT, DEPT-135, COSY, NOESY, HMQC and HMBC NMR in both CDCl3 and acetone-d6 are discussed, and the coupling constants J are reported in Hertz (Hz).     Keywords: 1H NMR; 13C NMR; 2D NMR; Benzyl o-Vanillin

scholarly journals Design, Microwave-Assisted Synthesis and In Silico Prediction Study of Novel Isoxazole Linked Pyranopyrimidinone Conjugates as New Targets for Searching Potential Anti-SARS-CoV-2 Agents

Molecules ◽  
2021 ◽  
Vol 26 (20) ◽  
pp. 6103
Author(s):  
Faisal K. Algethami ◽  
Maher Cherif ◽  
Salma Jlizi ◽  
Naoufel Ben Ben Hamadi ◽  
Anis Romdhane ◽  
...  
Keyword(s):  
Cycloaddition Reaction ◽  
Dipolar Cycloaddition ◽  
Microwave Assisted Synthesis ◽  
Dimroth Rearrangement ◽  
One Pot ◽  
Microwave Assisted ◽  
Three Component Reaction ◽  
Key Steps ◽  
Modes Of Interaction ◽  
Native Ligand

A series of novel naphthopyrano[2,3-d]pyrimidin-11(12H)-one containing isoxazole nucleus 4 was synthesized under microwave irradiation and classical conditions in moderate to excellent yields upon 1,3-dipolar cycloaddition reaction using various arylnitrile oxides under copper(I) catalyst. A one-pot, three-component reaction, N-propargylation and Dimroth rearrangement were used as the key steps for the preparation of the dipolarophiles3. The structures of the synthesized compounds were established by 1H NMR, 13C NMR and HRMS-ES means. The present study aims to also predict the theoretical assembly of the COVID-19 protease (SARS-CoV-2 Mpro) and to discover in advance whether this protein can be targeted by the compounds 4a–1 and thus be synthesized. The docking scores of these compounds were compared to those of the co-crystallized native ligand inhibitor (N3) which was used as a reference standard. The results showed that all the synthesized compounds (4a–l) gave interesting binding scores compared to those of N3 inhibitor. It was found that compounds 4a, 4e and 4i achieved greatly similar binding scores and modes of interaction than N3, indicating promising affinity towards SARS-CoV-2 Mpro. On the other hand, the derivatives 4k, 4h and 4j showed binding energy scores (−8.9, −8.5 and −8.4 kcal/mol, respectively) higher than the Mpro N3 inhibitor (−7.0 kcal/mol), revealing, in their turn, a strong interaction with the target protease, although their interactions were not entirely comparable to that of the reference N3.

scholarly journals An efficient, microwave-assisted, one-pot synthesis of novel 5,6,7,8-tetrahydroquinoline-3-carbonitriles

2011 ◽  
Vol 76 (6) ◽  
pp. 823-830 ◽  
Author(s):  
Dipti Dodiya ◽  
Haresh Ram ◽  
Amit Trivedi ◽  
Viresh Shah
Keyword(s):  
1H Nmr ◽  
13C Nmr ◽  
Microwave Assisted Synthesis ◽  
Spectroscopic Techniques ◽  
One Pot ◽  
Antifungal Activities ◽  
Microwave Assisted ◽  
Antibacterial And Antifungal Activities ◽  
Elemental Analyses ◽  
Antibacterial And Antifungal

An efficient, microwave-assisted synthesis of novel 2-alkoxy- 5,6,7,8-tetrahydroquinoline-3-carbonitriles, which have not hitherto been reported, via reactions of cyclohexanone and arylidene malononitriles in the corresponding alcohols in presence of sodium is described. All the newly synthesized compounds were characterized by the IR, 1H-NMR, 13C-NMR and mass spectroscopic techniques and by elemental analyses. The newly synthesized compounds were evaluated for their antibacterial and antifungal activities.

scholarly journals 1D AND 2D NMR STUDIES OF 2–(2–(BENZYLOXY)–3–METHOXYPHENYL)–1H–BENZIMIDAZOLE

2010 ◽  
Vol 7 (2) ◽  
pp. 190-196
Author(s):  
Mohammed Hadi Al–Douh ◽  
Shafida Abd Hamid ◽  
Hasnah Osman
Keyword(s):  
1H Nmr ◽  
13C Nmr ◽  
2D Nmr ◽  
Coupling Constants ◽  
Nmr Studies ◽  
Phenylene Diamine

The reaction of Benzyl o-vanillin 1 and o-phenylene diamine 2 in dichloromethane produced new benzimidazole, 3. The complete assignments of 3 were made using 1D and 2D NMR including COSY, HMQC and HMBC NMR in CDCl3 and acetone-d6. The coupling constants J are reported in Hertz, and the differences in the peak splittings using both solvents are discussed.   Keywords: 1H NMR; 13C NMR; 2D NMR; Benzimidazole

Efficient CDI/CH3SO3H -Catalyzed, Microwave-Assisted Synthesis of 2-Substituted Benzothiazoles

2018 ◽  
Vol 16 (1) ◽  
pp. 34-39
Author(s):  
Yao-Wei Li ◽  
Pei-Ming Zhang ◽  
Rui Li ◽  
Yan Bai ◽  
Yu Yu ◽  
...  
Keyword(s):  
Mass Spectrometry ◽  
Carboxylic Acids ◽  
1H Nmr ◽  
Good Yield ◽  
Microwave Assisted Synthesis ◽  
Synthetic Method ◽  
Benzothiazole Derivatives ◽  
Microwave Assisted ◽  
Highly Effective

CDI combined with CH3SO3H was found to be highly effective for the cyclization of 2-aminothiophenol derivatives with carboxylic acids under MW condition. Fourteen benzothiazole derivatives were synthesized in good yield and their structures were characterized by 1H-NMR, 13CNMR, IR and mass spectrometry. This simple, rapid synthetic method is believed to provide a useful process for the synthesis of 2-substituted benzothiazole compounds.

1H NMR and 13C NMR Studies of Oil from Pyrolysis of Indonesian Oil Sands

2016 ◽  
Vol 30 (3) ◽  
pp. 2478-2491 ◽  
Author(s):  
Wang Qing ◽  
Jia Chunxia ◽  
Ge Jianxin ◽  
Guo Wenxue
Keyword(s):  
1H Nmr ◽  
13C Nmr ◽  
Oil Sands ◽  
Nmr Studies

Microwave-assisted synthesis of zinc 5-(4-carboxyphenyl)-10,15,20-triphenylporphyrin and zinc 5-(4-carboxyphenyl)-10,15,20-triphenylchlorin

2015 ◽  
Vol 19 (04) ◽  
pp. 595-600 ◽  
Author(s):  
Rima Chouikrat ◽  
Aymeric Champion ◽  
Régis Vanderesse ◽  
Céline Frochot ◽  
Albert Moussaron
Keyword(s):  
Reaction Times ◽  
Microwave Assisted Synthesis ◽  
Spectroscopic Techniques ◽  
H Nmr ◽  
Microwave Assisted ◽  
Experimental Protocols ◽  
Time Of Reaction

The microwave-assisted synthesis of zinc 5-(4-carboxyphenyl)-10,15,20-triphenylporphyrin and zinc 5-(4-carboxyphenyl)-10,15,20-triphenylchlrorin are described and compared to classic conditions of synthesis in terms of time of reaction and yields obtained. The new experimental protocols are easy to implement required small amounts of reagents and solvents and lead to short reaction times. All compounds have been characterized by 1 H NMR, MS and spectroscopic techniques.

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