scholarly journals Comparative Analgesic Efficacies of Ropivacaine and Bupivacaine for Postoperative Rectus Sheath Block in Paediatric Abdominal Surgery: A Meta-Analysis of Randomized Controlled Trial and Retrospective Cohort Studies

2021 ◽  
Vol 2021 ◽  
pp. 1-8
Author(s):  
Lan Winnie ◽  
Yi-Hsuan Kao ◽  
Chien-Chang Liao ◽  
Takahiro Tamura ◽  
Ming-Long Chang ◽  
...  
Keyword(s):  
Postoperative Pain ◽  
Pain Relief ◽  
Abdominal Surgery ◽  
Pain Score ◽  
Randomized Clinical Trials ◽  
Meta Analysis ◽  
Postoperative Pain Relief ◽  
Male Participant ◽  
Postoperative Pain Score ◽  
Rectus Sheath Block

Background. The optimal dose and concentration of analgesic efficacy of ropivacaine (RPV) and bupivacaine (BPV) for postoperative pain relief in paediatric abdominal surgery patients is still unclear. Therefore, this meta-analysis compared the efficacy of these analgesics, their administered modes (ultrasound-guided RSB versus LAI) for postoperative pain relief, and side effects. Methods. Three databases, PubMed, Embase, and Cochrane Database of Systematic Reviews, were exhaustively searched with predefined keywords. Eight randomized clinical trials and retrospective studies were selected. Analgesic effect, postoperative pain score, level of side effect, applied dose, and concentration of drug were analysed. Results. Drug dose ranged from 0.5–2.5 mL/kg of 0.2 to 0.5% concentrations. Male participant for RSB and LAI treatment groups varied from 40–62% and 25–83%, respectively. Mean age of RSB and LAI groups ranged from 3.8–11.65 years and 4.3–11.27 years, respectively. Our meta-analysis revealed that RSB could reduce total opioid use postoperatively (WMD = −0.02, 95% CI: −0.02, −0.02), with I2 value of 15%. We found that the RPV (0.25%, 2.5 ml/kg) was optimal in suppressing the pain. Its lower concentration (0.2%) was ineffective, whereas higher one (0.375%) seems to increase risk of systemic toxicity. Similarly, BPV (0.25%, 2.5 mg/kg) efficaciously reduced the pain score, while its lower concentration was ineffective. The combined postoperative pain score in the RPV-treated group was found to be significantly reduced ( p < 0.01 ) with I2 value of 85% indicating high heterogeneity. Conclusion. Both RPV and BPV were significantly effective in reducing postoperative pain score. It appears that RSB could be a preferred choice to deliver analgesia, due to reduced opiate dose requirement and improved clinical safety without significant postoperative adverse events.

scholarly journals Postoperative Pain Relief after Major Pancreatic Resection: Systematic Review and Meta-analysis of Analgesic Modalities

HPB ◽  
2021 ◽  
Vol 23 ◽  
pp. S893
Author(s):  
N. Akter ◽  
B. Ratnayake ◽  
D.B. Joh ◽  
S.-J. Chan ◽  
E. Bonner ◽  
...  
Keyword(s):  
Systematic Review ◽  
Postoperative Pain ◽  
Pain Relief ◽  
Pancreatic Resection ◽  
Meta Analysis ◽  
Postoperative Pain Relief

scholarly journals CLINICAL STUDIES ON HYPOXEMIA AFTER UPPER ABDOMINAL SURGERY -IN RELATION TO ANESTHESIA AND POSTOPERATIVE PAIN RELIEF-

1979 ◽  
Vol 40 (5) ◽  
pp. 966-970
Author(s):  
Masao HASHIMOTO ◽  
Masaharu KATSUMI ◽  
Nobuji KONO ◽  
Sadao OKAMURA ◽  
Tadaaki HASHIMOTO ◽  
...  
Keyword(s):  
Postoperative Pain ◽  
Pain Relief ◽  
Abdominal Surgery ◽  
Clinical Studies ◽  
Postoperative Pain Relief ◽  
Upper Abdominal Surgery ◽  
Upper Abdominal

Efficacy of surgical transversus abdominis plane block for postoperative pain relief following abdominal surgery in pediatric patients

2015 ◽  
Vol 25 (6) ◽  
pp. 614-620 ◽  
Author(s):  
Saowaphak Lapmahapaisan ◽  
Niramol Tantemsapya ◽  
Naiyana Aroonpruksakul ◽  
Wiriya Maisat ◽  
Suwannee Suraseranivongse
Keyword(s):  
Postoperative Pain ◽  
Pain Relief ◽  
Abdominal Surgery ◽  
Pediatric Patients ◽  
Transversus Abdominis Plane Block ◽  
Transversus Abdominis ◽  
Postoperative Pain Relief ◽  
Transversus Abdominis Plane

scholarly journals Comparison of efficacy and safety of oxycodone versus fentanyl for intravenous patient-controlled analgesia in postoperative pain management: a systematic review and meta-analysis

2019 ◽  
Author(s):  
Peng Chen ◽  
Fuchao Chen ◽  
Jiexin Lei ◽  
zhou benhong
Keyword(s):  
Patient Satisfaction ◽  
Postoperative Pain ◽  
Pain Relief ◽  
Rating Scale ◽  
Numerical Rating Scale ◽  
Meta Analysis ◽  
Postoperative Pain Relief ◽  
Cochrane Library ◽  
Patient Controlled Analgesia ◽  
Significant Difference

Abstract Backgroud Patient-controlled analgesia(PCA) with intravenous an opioid has been suggested as a effective method of postoperative pain relief. There are several randomized controlled trials (RCTs) of comparison of oxycodone and fentanyl for IV-PCA in surgical patients. The purpose of this study was to performed a meta-analysis to compare the effect of intravenous oxycodone and fentanyl on post-operative pain in sugical patients from collected current data. Methods The RCTs of oxycodone versus fentanyl for IV-PCA were gathered from PubMed, Embase, Cochrane library, CNKI and VIP data. After data extraction and quality assessment of the included RCTs, the RevMan 5.3 software was applied for meta-analysis of numerical rating scale (NRS) scores, accumulated IV-PCA consumption of oxycodone and fentanyl, patient satisfaction, postoperative nausea and vomiting (PONV), and other adverse events (AEs). Results Results reported from eight RCTs involving 600 patients are included in the meta-analysis. The NRS score at rest and upon movement of group oxycodone was significantly lower than that of group fentanyl (WMD= -3.85, 95% CI -4.93~-2.76, P<0.00001; WMD= -4.31, 95% CI -5.79~-2.84, P<0.00001); however, the incidence of PONV and dizziness was significantly higher in group oxycodone than in group fentanyl (OR = 2.41, 95% CI 1.60~3.63, P < 0.0001; OR=3.69, 95% CI 2.17~6.26, P<0.00001). Accumulated IV-PCA consumption in group oxycodone was less than in group fentanyl overall the 48 hours postoperatively (WMD= -12.11, 95% CI -18.42~-5.80, P = 0.0002). There was no significant difference in patient satisfaction between oxycodone and fentanyl (OR=0.73, 95% CI 0.11~5.04, P= 0.75). Conclusion According to the evidence, this meta-analysis suggest that oxycodone IV-PCA is superior to fentanyl in postoperative pain relief, whereas the higher incidence of PONV and dizziness was accompanied with oxycodone. Further large-scale and well-designed studies are needed to summarize and analyse the data to draw a more convincing conclusion.

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