scholarly journals Update in the Management of ANCA-Associated Vasculitis: Recent Developments and Future Perspectives

2021 ◽  
Vol 2021 ◽  
pp. 1-14
Author(s):  
Karla N. Samman ◽  
Carolyn Ross ◽  
Christian Pagnoux ◽  
Jean-Paul Makhzoum
Keyword(s):  
Granulomatosis With Polyangiitis ◽  
Microscopic Polyangiitis ◽  
Future Perspectives ◽  
Significant Progress ◽  
Treatment Algorithms ◽  
The Past ◽  
Anca Associated Vasculitis ◽  
Recent Developments ◽  
Maintenance Of Remission ◽  
Made In

Significant progress has been made in the treatment of ANCA-associated vasculitides (AAV), notably in granulomatosis with polyangiitis and microscopic polyangiitis. Over the past few years, many innovative studies have changed the way we now induce and maintain remission in AAV; achieving remission while limiting treatment toxicity is the key. This article provides an in-depth, up-to-date summary of recent trials and suggests treatment algorithms for induction and maintenance of remission based on the latest guidelines. Future possible therapies in AAV will also be discussed.

Supercarboranes: Achievements and perspectives

2012 ◽  
Vol 85 (4) ◽  
pp. 661-670 ◽  
Author(s):  
Jian Zhang ◽  
Zuowei Xie
Keyword(s):  
Reducing Agents ◽  
Future Perspectives ◽  
Significant Progress ◽  
Boron Clusters ◽  
The Past ◽  
The Future ◽  
Made In ◽  
Carborane Anions

This article highlights the achievements in the chemistry of supercarboranes (carboranes with more than 12 vertices) in the past decade and the future perspectives. The chemistry of boron clusters has been dominated by 12-vertex carboranes for several decades. Only in recent years has significant progress been made in the chemistry of supercarboranes. Such a breakthrough relies on the use of CAd (carbon-atoms-adjacent) 12-vertex nido-carborane anions as starting materials. A series of 13- and 14-vertex carboranes as well as their corresponding 14- and 15-vertex metallacarboranes have been prepared and structurally characterized. Reactions of supercarboranes with reducing agents, electrophiles, and nucleophiles are studied, which reveal a more diverse and richer reaction chemistry than their icosahedral cousins.

scholarly journals ANCA-Associated Vasculitides and Hematologic Malignancies: Lessons from the Past and Future Perspectives

2019 ◽  
Vol 2019 ◽  
pp. 1-9 ◽  
Author(s):  
Marco Folci ◽  
Giacomo Ramponi ◽  
Dana Shiffer ◽  
Aurora Zumbo ◽  
Michele Agosti ◽  
...  
Keyword(s):  
Granulomatosis With Polyangiitis ◽  
Hematologic Malignancy ◽  
Hematologic Malignancies ◽  
Future Perspectives ◽  
The Past ◽  
Anca Associated Vasculitis ◽  
Uncommon Presentation ◽  
Immunotherapy Target ◽  
And Function

The purpose of this paper is to collect and summarize all evidences relating to an association between ANCA-associated vasculitides (AAVs) and hematologic malignancies, in the form of either a paraneoplastic vasculitis or leukemias and lymphomas developing on a preexisting vasculitis. Additionally, the role of cyclophosphamide in vasculitis treatment has been assessed and compared to rituximab. Paraneoplastic AAV seems to be an uncommon presentation of hemopathies. Hematologic malignancy risk in AAV is more likely to be increased by cyclophosphamide, although not yet definitely proven. Furthermore, the pathogenesis of ANCA-associated vasculitis has been reviewed with particular emphasis on the role of proteinase 3 (PR3) in fuelling granulomatosis with polyangiitis (GPA) inflammation. PR3 is a bactericidal protein expressed by neutrophilic granules and on their plasma membrane. Derangements in its expression and function have been linked to leukemias and GPA alike. PR3-derived PR1 peptide is being studied as an immunotherapy target in leukemia and multiple myeloma. This study is aimed at bringing together various evidences from the field of immunological and hematological research, at exposing contradictions, and at revealing novel insights on the association between ANCA-associated vasculitis and hematologic malignancies.

scholarly journals ANCA Status or Clinical Phenotype — What Counts More?

2021 ◽  
Vol 23 (6) ◽  
Author(s):  
Martin Windpessl ◽  
Erica L. Bettac ◽  
Philipp Gauckler ◽  
Jae Il Shin ◽  
Duvuru Geetha ◽  
...  
Keyword(s):  
Clinical Trials ◽  
Granulomatosis With Polyangiitis ◽  
Clinical Phenotype ◽  
Antineutrophil Cytoplasmic Antibody ◽  
Cardiovascular Death ◽  
Genetic Associations ◽  
Ongoing Debate ◽  
The Past ◽  
Anca Associated Vasculitis

Abstract Purpose of Review There is ongoing debate concerning the classification of antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis. That is, whether classification should be based on the serotype (proteinase 3 (PR3)- or myeloperoxidase (MPO)-ANCA) or on the clinical phenotype (granulomatosis with polyangiitis (GPA) or microscopic polyangiitis (MPA)). To add clarity, this review focused on integration of the most recent literature. Recent Findings Large clinical trials have provided evidence that a serology-based risk assessment for relapses is more predictive than distinction based on the phenotype. Research conducted in the past decade indicated that a serology-based approach more closely resembles the genetic associations, the clinical presentation (i.e., lung involvement), biomarker biology, treatment response, and is also predicting comorbidities (such as cardiovascular death). Summary Our review highlights that a serology-based approach could replace a phenotype-based approach to classify ANCA-associated vasculitides. In future, clinical trials and observational studies will presumably focus on this distinction and, as such, translate into a “personalized medicine.”

scholarly journals Speech After Long Silence—An Appraisee-Based Comprehensive Analysis With Retrospective and Future Perspectives on Current ID Policy of Transpersons in China

2021 ◽  
Vol 9 ◽  
Author(s):  
Jian Shi ◽  
Yadong Guo ◽  
María José Cavagnaro ◽  
Jifeng Cai ◽  
Zhuoying Liu
Keyword(s):  
Comprehensive Analysis ◽  
Sex Reassignment Surgery ◽  
Sex Reassignment ◽  
Future Perspectives ◽  
Significant Progress ◽  
Police Station ◽  
Local Police ◽  
Developmental Conditions ◽  
Male To Female ◽  
Made In

As the sexual minority in China, transpersons remain faced with various realistic challenges. In recent years, however, there has been a significant progress made in the protection given to the rights that transpersons deserve. Currently, the citizens who have changed their gender through sex reassignment surgery can make applications to the local police station for changing their gender registration and get issued a new ID card. This is regarded as a crucial milestone in reducing the bias against transpersons and protecting their legitimate rights in China. Highlighted by the case of an extraordinary appraisee who have received SRS to change from male to female and started a new life with a new ID, not only does this article construe the current ID policy and the detailed process of ID card change for transpersons in China, it also reveals the living and developmental conditions facing transpersons in China. Finally, the visibility of the community of transpersons is improved to eradicate the discrimination against transpersons.

scholarly journals Recent Advances in Palladium-Catalyzed Isocyanide Insertions

Molecules ◽  
2020 ◽  
Vol 25 (21) ◽  
pp. 4906
Author(s):  
Jurriën W. Collet ◽  
Thomas R. Roose ◽  
Bram Weijers ◽  
Bert U. W. Maes ◽  
Eelco Ruijter ◽  
...  
Keyword(s):  
Organic Synthesis ◽  
Building Blocks ◽  
Insertion Reactions ◽  
Chemical Reagents ◽  
The Past ◽  
Recent Advances ◽  
Recent Developments ◽  
Palladium Catalyzed ◽  
Made In ◽  
Rapid Incorporation

Isocyanides have long been known as versatile chemical reagents in organic synthesis. Their ambivalent nature also allows them to function as a CO-substitute in palladium-catalyzed cross couplings. Over the past decades, isocyanides have emerged as practical and versatile C1 building blocks, whose inherent N-substitution allows for the rapid incorporation of nitrogeneous fragments in a wide variety of products. Recent developments in palladium catalyzed isocyanide insertion reactions have significantly expanded the scope and applicability of these imidoylative cross-couplings. This review highlights the advances made in this field over the past eight years.

A Review of Recent Developments in the Mechanisms of Antifatigue Agents

1985 ◽  
Vol 58 (2) ◽  
pp. 269-283 ◽  
Author(s):  
Gerald Scott
Keyword(s):  
Structural Design ◽  
Material Design ◽  
The Past ◽  
Truck Tires ◽  
Recent Developments ◽  
Shoulder Region ◽  
Major Factors ◽  
High Level ◽  
Vulcanization Process ◽  
Made In

Abstract In spite of the remarkable advances that have been made in the engineering design of tires during the past two decades, the basic formulations used in vulcanization and protection during service have essentially remained unchanged. This is to a large extent due to two major factors: 1. The versatility of the traditional accelerated sulfur curing system which provides the necessary combination of resilience and strength with good resistance to cyclical stress. 2. The development of diarylamine antidegradants which confer a high level of thermal-oxidative and mechano-oxidative (fatigue) resistance to the rubber. Both of these developments have occurred slowly with small incremental improvements and, probably because of their success, relatively little fundamental work has been published which addresses the questions of why a polysulfide network is so resistant to fatigue and why N-sec-alkyl-N′-phenyl-p-phenylenediamines are so much more successful as antidegradants than other classes of antioxidant. It is becoming evident, however, that if tires are to withstand the increasingly demanding conditions to which they are subjected in service, much more attention must be paid to the material design as opposed to the structural design of tires. Nowhere is this more evident than in aircraft tires. Recent studies have shown that the tires of heavily laden wide-bodied aircraft reach temperatures in excess of 70°C at the relatively modest speed of 32 km/h (20 mph). Similarly, in heavy duty truck tires, temperatures over 100°C are not abnormal in the shoulder region. This leads to extensive restructurization of the fatigue resistant polysulfide network, particularly in the shoulder of the tire, to give a much weaker mono-disulfide structure. It is no coincidence then that failure normally occurs in this region. The practice of multiple retreading exacerbates the change in chemical decomposition of the rubber. It is well known to the rubber scientist that extending the vulcanization process also leads to restructurization of the rubber network from polysulfide to mono- and disulfide. This is shown typically for a HAF-black tire formulation at 140°C in Figure 1. Antidegradants have virtually no effect on anaerobic restructurization (see Figure 2), and indeed, the established antifatigue agent, IPPD (I), actually accelerates the loss of polysulfide crosslinks from the vulcanizate at 140°C. During fatiguing, on the other hand, IPPD effectively retards restructurization (see Figure 3), whereas a typical bisphenol, nonstaining antidegradant, II, has much less effect.

scholarly journals Immunopathogenesis of ANCA-Associated Vasculitis

2020 ◽  
Vol 21 (19) ◽  
pp. 7319
Author(s):  
Andreas Kronbichler ◽  
Keum Hwa Lee ◽  
Sara Denicolo ◽  
Daeun Choi ◽  
Hyojeong Lee ◽  
...  
Keyword(s):  
Granulomatosis With Polyangiitis ◽  
Microscopic Polyangiitis ◽  
Autoimmune Disorder ◽  
Eosinophilic Granulomatosis With Polyangiitis ◽  
Proteinase 3 ◽  
Disease Biomarkers ◽  
Disease Phenotypes ◽  
Anca Associated Vasculitis ◽  
Clinical Presentations ◽  
Eosinophilic Granulomatosis

Anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitis is an autoimmune disorder which affects small- and, to a lesser degree, medium-sized vessels. ANCA-associated vasculitis encompasses three disease phenotypes: granulomatosis with polyangiitis (GPA), microscopic polyangiitis (MPA), and eosinophilic granulomatosis with polyangiitis (EGPA). This classification is largely based on clinical presentations and has several limitations. Recent research provided evidence that genetic background, risk of relapse, prognosis, and co-morbidities are more closely related to the ANCA serotype, proteinase 3 (PR3)-ANCA and myeloperoxidase (MPO)-ANCA, compared to the disease phenotypes GPA or MPA. This finding has been extended to the investigation of biomarkers predicting disease activity, which again more closely relate to the ANCA serotype. Discoveries related to the immunopathogenesis translated into clinical practice as targeted therapies are on the rise. This review will summarize the current understanding of the immunopathogenesis of ANCA-associated vasculitis and the interplay between ANCA serotype and proposed disease biomarkers and illustrate how the extending knowledge of the immunopathogenesis will likely translate into development of a personalized medicine approach in the management of ANCA-associated vasculitis.

scholarly journals Pulsar wind nebulae created by fast-moving pulsars

2017 ◽  
Vol 83 (5) ◽  
Author(s):  
O. Kargaltsev ◽  
G. G. Pavlov ◽  
N. Klingler ◽  
B. Rangelov
Keyword(s):  
Hubble Space Telescope ◽  
Ambient Medium ◽  
Pulsar Wind Nebulae ◽  
The Past ◽  
Recent Developments ◽  
Pulsar Velocity ◽  
Bow Shocks ◽  
Observational Status ◽  
Pulsar Wind ◽  
Made In

We review multiwavelength properties of pulsar wind nebulae created by supersonically moving pulsars and the effects of pulsar motion on the pulsar wind nebulae morphologies and the ambient medium. Supersonic pulsar wind nebulae are characterized by bow-shaped shocks around the pulsar and/or cometary tails filled with the shocked pulsar wind. In the past several years significant advances in supersonic pulsar wind nebula studies have been made in deep observations with the Chandra and XMM-Newton X-ray observatories and the Hubble Space Telescope. In particular, these observations have revealed very diverse supersonic pulsar wind nebula morphologies in the pulsar vicinity, different spectral behaviours of long pulsar tails, the presence of puzzling outflows misaligned with the pulsar velocity and far-UV bow shocks. Here we review the current observational status focusing on recent developments and their implications.

scholarly journals Emergent processes in cognitive-emotional interactions

2010 ◽  
Vol 12 (4) ◽  
pp. 433-448 ◽  
Keyword(s):  
Basal Forebrain ◽  
Significant Progress ◽  
Brain Organization ◽  
The Past ◽  
Mind And Brain ◽  
The Mind ◽  
The Brain ◽  
Anatomical Evidence ◽  
Made In

Emotion and cognition have been viewed as largely separate entities in the brain. Within this framework, significant progress has been made in understanding specific aspects of behavior. Research in the past two decades, however, has started to paint a different picture of brain organization, one in which network interactions are key to understanding complex behaviors. From both basic and clinical perspectives, the characterization of cognitive-emotional interactions constitutes a fundamental issue in the investigation of the mind and brain. This review will highlight the interactive and integrative potential that exists in the brain to bring together the cognitive and emotional domains. First, anatomical evidence will be provided, focusing on structures such as hypothalamus, basal forebrain, amygdala, cingulate cortex, orbitofrontal cortex, and insula. Data on functional interactions will then be discussed, followed by a discussion of a dual competition framework, which describes cognitive-emotional interactions in terms of perceptual and cognitive competition mechanisms.

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