scholarly journals Hippocampal Subfield Volumes in Major Depressive Disorder Adolescents with a History of Suicide Attempt

2021 ◽  
Vol 2021 ◽  
pp. 1-8
Author(s):  
Qi Zhang ◽  
Su Hong ◽  
Jun Cao ◽  
Yi Zhou ◽  
Xiaoming Xu ◽  
...  
Keyword(s):  
Major Depressive Disorder ◽  
Suicide Attempt ◽  
Depressive Disorder ◽  
Suicidal Behavior ◽  
Clinical Characteristics ◽  
Suicide Attempts ◽  
Healthy Controls ◽  
Major Depressive ◽  
Suicide Attempters ◽  
Functional Studies

Suicidal behavior is a leading cause of death and often commences during adolescence/young adulthood (15~29 years old). The hippocampus, which consists of multiple functionally specialized subfields, may contribute to the pathophysiology of depression and suicidal behavior. We aimed to investigate the differences of hippocampal subfield volume between major depressive disorder (MDD) patients with and without suicide attempts and healthy controls in adolescents and young adults. A total of 40 MDD suicide attempters (MDD+SA), 27 MDD patients without suicide attempt (MDD-SA), and 37 healthy controls (HC) were recruited. High-resolution T1 MRI images were analyzed with the automated hippocampal substructure module in FreeSurfer 6.0. Volume differences among the groups were analyzed by a generalized linear model controlling for intracranial cavity volume (ICV). The relationship between hippocampal subfield volumes and clinical characteristics (HAM-D and SSI scores) was assessed using two-tailed partial correlation controlling for ICV in MDD+SA and MDD-SA. We found that MDD-SA had significantly smaller bilateral hippocampal fissure volume than HC and MDD+SA. No significant correlation was observed between hippocampal subfield volume and clinical characteristics (HAM-D and SSI scores) in MDD+SA and MDD-SA. Adolescent/young adult suicide attempters with MDD suicide attempters have larger bilateral hippocampal fissures than depressed patients without suicide attempts, independently from clinical characteristics. Within the heterogeneous syndrome of major depressive disorder that holds a risk for suicidality for subgroups, hippocampal morphology may help to explain or possibly predict such risk, yet longitudinal and functional studies are needed for understanding the biological mechanisms underlying.

scholarly journals Phosphodiesterase 8A to discriminate in blood samples depressed patients and suicide attempters from healthy controls based on A-to-I RNA editing modifications

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Nicolas Salvetat ◽  
Fabrice Chimienti ◽  
Christopher Cayzac ◽  
Benjamin Dubuc ◽  
Francisco Checa-Robles ◽  
...  
Keyword(s):  
Major Depressive Disorder ◽  
Depressive Disorder ◽  
Rna Editing ◽  
Whole Blood ◽  
Healthy Controls ◽  
Major Depressive ◽  
Suicide Attempters ◽  
Blood Samples ◽  
Depressed Patients ◽  
The Brain

AbstractMental health issues, including major depressive disorder, which can lead to suicidal behavior, are considered by the World Health Organization as a major threat to global health. Alterations in neurotransmitter signaling, e.g., serotonin and glutamate, or inflammatory response have been linked to both MDD and suicide. Phosphodiesterase 8A (PDE8A) gene expression is significantly decreased in the temporal cortex of major depressive disorder (MDD) patients. PDE8A specifically hydrolyzes adenosine 3′,5′-cyclic monophosphate (cAMP), which is a key second messenger involved in inflammation, cognition, and chronic antidepressant treatment. Moreover, alterations of RNA editing in PDE8A mRNA has been described in the brain of depressed suicide decedents. Here, we investigated PDE8A A-to-I RNA editing-related modifications in whole blood of depressed patients and suicide attempters compared to age-matched and sex-matched healthy controls. We report significant alterations of RNA editing of PDE8A in the blood of depressed patients and suicide attempters with major depression, for which the suicide attempt took place during the last month before sample collection. The reported RNA editing modifications in whole blood were similar to the changes observed in the brain of suicide decedents. Furthermore, analysis and combinations of different edited isoforms allowed us to discriminate between suicide attempters and control groups. Altogether, our results identify PDE8A as an immune response-related marker whose RNA editing modifications translate from brain to blood, suggesting that monitoring RNA editing in PDE8A in blood samples could help to evaluate depressive state and suicide risk.

scholarly journals Evaluation of Sociodemographic Characteristics and Depression Diagnosis of Adolescents who Had Suicide Attempt

2021 ◽  
Author(s):  
Ayşe Nihal Eraslan ◽  
Rezzan Aydın Görücü ◽  
Mehmet Öztürk ◽  
Arzu Yılmaz ◽  
Medine Aysin Taşar
Keyword(s):  
Risk Factors ◽  
Major Depressive Disorder ◽  
Suicide Attempt ◽  
Depressive Disorder ◽  
Attempted Suicide ◽  
Suicide Attempts ◽  
Psychiatric Evaluation ◽  
Major Depressive ◽  
Problem Solving Skills ◽  
Dsm 5

Objective: Suicide attempts of adolescents have become one of the most common reasons among the admission to emergency departments for psychiatric reasons. The aim of this study is to identify sociodemographic and clinical characteristics, the diagnosis of depressive disorder and to assess the risk factors of adolescents who attempted suiside. Method: For this study, the patients that were admitted to Ankara Research and Training Hospital Emergency Department and were referred to Child and Adolescent Psychiatry outpatient clinic due to suicide attempt between April 2018 and December 2018 were included. “Child Depression Inventory”, “Beck Depression Inventory “ and “Sociodemographic Data Form” were used for the study. It was also evaluated whether the patients were diagnosed with “Major Depressive Disorder” according to DSM-5 as a result of psychiatric examination. SPSS 24.0 was used in the analyzes. T-test, Kruskal-Wallis test, Chi-square and Fisher’s exact test were used where appropriate. Results: Out of 38 patients who attempted suicide, 92,1% (n=35) were female. It was found that 92.1% (n=35) of the cases attempted suicide by overdose drug intake. Approximately half of the cases (44.7% n=17) reported the reason for suicide as “familial stressors”. As a result of the psychiatric evaluation, 42.1% (n=16) of the cases were diagnosed with “Major Depressive Disorder” according to DSM-5. Conclusion: Comprehensive evaluation of individual and environmental factors in adolescents who attempted suicide is considered important to identify the risk factors. Moreover strengthening the professional psychosocial support systems about increasing coping skills, gaining problem-solving skills of adolescents and informing families about approach to adolescents are thought that may contribute to protective measures.

scholarly journals A Meta-Analysis of 5-Hydroxytryptamine Receptor 1B Polymorphisms With Risk of Major Depressive Disorder and Suicidal Behavior

2021 ◽  
Vol 12 ◽  
Author(s):  
Pingliang Yang ◽  
Mengchang Yang ◽  
Peng Li ◽  
Dejun Cao ◽  
Daoyin Gong ◽  
...  
Keyword(s):  
Major Depressive Disorder ◽  
Depressive Disorder ◽  
Suicidal Behavior ◽  
Suicide Attempts ◽  
Association Studies ◽  
Meta Analysis ◽  
Significant Risk ◽  
China National Knowledge Infrastructure ◽  
Major Depressive ◽  
Increased Risk

Purpose: Previous association studies have investigated whether genetic polymorphisms in HTR1B influenced individuals' susceptibility to major depressive disorder (MDD), anti-depressant response (ADR) and suicidal behavior. However, equivocal evidence was obtained. In this meta-analysis, we aimed to examine the association of HTR1B polymorphisms with risk of MDD, ADR and suicidal behavior.Materials and Methods: Studies evaluating the association between HTR1B polymorphisms and risk of MDD, ADR and suicidal behavior were searched in Pubmed, Ovid Medline, web of science and China National Knowledge Infrastructure databases. Summary odds ratios (ORs), 95 % confidence intervals (CIs) and p-values were calculated using a fixed or random effects model.Results: Meta-analysis findings revealed a significantly increased risk of MDD with rs6296 GC and GC/CC genotypes (GC vs. GG: OR = 1.26, 95% CI, 1.07–1.48; GC/CC vs. GG: OR = 1.22, 95% CI, 1.04–1.43, respectively). Moreover, rs6298 CT genotype was significantly associated with an increased risk of suicidal behavior (CT vs. CC: OR = 1.48, 95% CI, 1.16–1.88). However, both rs6296 and rs130058 were not significant risk factors for lethal suicidal behavior.Conclusion: This meta-analysis identified that rs6296 and rs6298 in HTR1B may be significantly related to the risk of MDD and lethality of suicide attempts, respectively. Further studies are required to assess the markers in larger cohorts.

Resequencing three candidate genes discovers seven potentially deleterious variants susceptibility to major depressive disorder and suicide attempts in Chinese

Gene ◽  
2017 ◽  
Vol 603 ◽  
pp. 34-41 ◽  
Author(s):  
Shitao Rao ◽  
Cherry She Ting Leung ◽  
Macro Hb Lam ◽  
Yun Kwok Wing ◽  
Mary Miu Yee Waye ◽  
...  
Keyword(s):  
Major Depressive Disorder ◽  
Depressive Disorder ◽  
Candidate Genes ◽  
Suicide Attempts ◽  
Major Depressive
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