scholarly journals Diffuse-Type Tenosynovial Giant Cell Tumor of the Knee with Concurrent Polymicrobial Infection (Klebsiella oxytoca and Group B Streptococcus)

2021 ◽  
Vol 2021 ◽  
pp. 1-6
Author(s):  
J. Hunter Marshall ◽  
John G. Skedros ◽  
Chris F. Campana ◽  
Allan M. Seibert
Keyword(s):  
Septic Arthritis ◽  
Giant Cell ◽  
Klebsiella Oxytoca ◽  
Group B Streptococcus ◽  
Pigmented Villonodular Synovitis ◽  
Acute Onset ◽  
Left Knee ◽  
Diffuse Type ◽  
Giant Cell Tumors ◽  
Group B

Tenosynovial giant cell tumors (TGCT) are a rare class of benign proliferative tumors that are classified according to their presentation: localized-type (L-TGCT) or diffuse-type (D-TGCT). TGCT is synonymous with pigmented villonodular synovitis (PVNS). We describe the unique case of a 56-year-old obese male with type 2 diabetes who had polymicrobial septic arthritis of his left knee joint with concurrent D-TGCT in the same knee. While on a vacation, he noticed spontaneous left knee pain and swelling with an acute onset of fever. He was diagnosed with septic arthritis that was attributed to hematogenous spread from a leg laceration. The septic arthritis was treated with arthroscopic lavage and debridement, including simultaneous excision of the D-TGCT lesions, followed by intravenous ceftriaxone. Cultures of the synovial tissue that were obtained during arthroscopy grew Klebsiella oxytoca and beta-hemolytic (group B) Streptococcus agalactiae. We were not able to find another reported case of any joint with (1) a polymicrobial bacterial infection that included Klebsiella oxytoca and (2) concurrent bacterial septic arthritis and TGCT.

scholarly journals Tenosynovial Giant Cell Tumor of the thigh

10.3823/2360 ◽  
2017 ◽  
Vol 10 ◽  
Author(s):  
Hasna Salhi ◽  
Olfa Jaidane ◽  
Jamel Ben Hassouna ◽  
Tarek Ben Dhieb ◽  
Monia Hechiche ◽  
...  
Keyword(s):  
Giant Cell Tumor ◽  
Giant Cell ◽  
Pigmented Villonodular Synovitis ◽  
Left Thigh ◽  
Cell Tumor ◽  
Villonodular Synovitis ◽  
Diffuse Type ◽  
Giant Cell Tumors ◽  
Pigmented Villonodular

Tenosynovial giant cell tumors (TGCT) are a group of generally benign intra-articular and soft tissue tumors with common histological features. TGCT is also known as pigmented villonodular synovitis. There are localized and diffuse forms. Localized types include giant cell tumors of tendon sheath and localized pigmented villonodular synovitis, whereas diffuse types encompass conventional pigmented villonodular synovitis and diffuse type giant cell tumor. Localized tumors are generally indolent, whereas diffuse tumors are locally aggressive. In this article, we report the case of a diffuse-type extra-articular TGCT found in the left thigh of a 73-year-old woman who presented with a painless but gradually progressive swelling in the left thigh since eighteen months. On examination, there was a soft cystic swelling measuring 22 cm. The swelling was fixed to the underlying soft tissues. She had a Computed Tomography scan of the left thigh showing a mass of fluid density, well encapsulated between the muscles of the thigh, measuring 20x10 cm of major axes, compressing the femoral vessels without invading them. The patient had a complete marginal resection of the tumor. The immune-histopathological findings were consistent with those of a diffuse type of Giant Cell Tenosynovial Tumor. At 18 months follow-up, the patient is asymptomatic with no evidence of disease recurrence.  The extra-articular diffuse type TGCT is more aggressive than the localized type. Although these tumors are benign in the majority of cases, malignant transformation has been reported. Therefore, close follow-up is recommended after tumor excision.

scholarly journals Giant cell tumors of synovium (pigmented villonodular synovitis) involving the vertebral column

Cancer ◽  
1986 ◽  
Vol 57 (10) ◽  
pp. 2030-2036 ◽  
Author(s):  
Noel Weidner ◽  
Venkata R. Challa ◽  
Stephen M. Bonsib ◽  
Courtland H. Davis ◽  
Thomas J. Carroll
Keyword(s):  
Giant Cell ◽  
Vertebral Column ◽  
Pigmented Villonodular Synovitis ◽  
Villonodular Synovitis ◽  
Giant Cell Tumors ◽  
Pigmented Villonodular

Septic Arthritis of the Hip Caused by Group B Streptococcus in a Postpartum Patient

2012 ◽  
Vol 2 (4) ◽  
pp. e62 ◽  
Author(s):  
Anokhi D. Mehta ◽  
Kathleen S. Beebe ◽  
Daniel A. Seigerman ◽  
John D. Koerner ◽  
John S. Hwang ◽  
...  
Keyword(s):  
Septic Arthritis ◽  
Group B Streptococcus ◽  
Group B

scholarly journals Long term term follow-up of tyrosine kinase inhibitors treatments in inoperable or relapsing diffuse type tenosynovial giant cell tumors (dTGCT)

PLoS ONE ◽  
2020 ◽  
Vol 15 (5) ◽  
pp. e0233046 ◽  
Author(s):  
Mehdi Brahmi ◽  
Philippe Cassier ◽  
Armelle Dufresne ◽  
Sylvie Chabaud ◽  
Marie Karanian ◽  
...  
Keyword(s):  
Tyrosine Kinase ◽  
Giant Cell ◽  
Tyrosine Kinase Inhibitors ◽  
Kinase Inhibitors ◽  
Diffuse Type ◽  
Giant Cell Tumors

Recurrence Potential of Diffuse-Type Giant Cell Tumor in the Foot: Radiologic and Pathologic Features

2005 ◽  
Vol 26 (6) ◽  
pp. 474-478 ◽  
Author(s):  
Tominaga Shimizu ◽  
Takeshi Uehara ◽  
Tsutomu Akahane ◽  
Kenichi Isobe ◽  
Hideki Arai
Keyword(s):  
Giant Cell Tumor ◽  
Giant Cell ◽  
Tumor Resection ◽  
Cell Tumor ◽  
Cell Contact ◽  
Diffuse Type ◽  
Mri Findings ◽  
Giant Cell Tumors ◽  
Pathologic Features ◽  
Type Giant

Background: Aggressive musculoskeletal tumors in the foot, such as diffuse-type giant cell tumors or extra-abdominal desmoid tumors, are difficult to treat because the foot does not have enough soft tissue to allow wide tumor resection. We reviewed the clinical behavior of diffuse-type giant cell tumor in the foot and evaluated the recurrence potential of these tumors from radiologic and pathologic perspectives. Methods: Six patients with a mean age of 37.6 years were included in this study. Radiologic studies, including sonography, computed tomography (CT), magnetic resonance imaging (MRI), and bone and gallium citrate scintigraphy, were obtained followed by surgical treatment and histologic evaluation of the tumor. Results: Recurrence occurred in three patients. Although CT and MRI findings were similar in the recurrent and nonrecurrent tumors, marked differences were found between the two by scintigraphy; positive radiotracer uptake to the affected foot with gallium citrate scintigraphy was noted only in recurrent tumors, although positive accumulation was seen in all patients with bone scintigraphy. Histologically, the necrotic area and mitotic activity were more apparent in recurrent than in the nonrecurrent tumors, and tumor cell dyscohesion was noted in the former, (the intercellular space was increased). Conclusions: Repeated recurrence with tumor invasion into tarsal bone resulted in breakage of the tarsal arch that supports the body's weight. Amputation would be necessary for patients in whom the disease had progressed to obtain local cure and relief of pain. In the present study, we found two features of the recurrence potential of diffuse-type giant cell tumors: sparse cell to cell contact on pathologic examination and positive accumulation in the tumor on gallium citrate scintigraphy. We concluded that giant cell tumors with these two features have a strong potential for local recurrence, and thus require intensive followup.

Cutaneous Myiasis from Panama, South America: Case Report and Review

2008 ◽  
Vol 12 (3) ◽  
pp. 133-138 ◽  
Author(s):  
Patricia T. Ting ◽  
Benjamin Barankin
Keyword(s):  
Case Report ◽  
South America ◽  
Group B Streptococcus ◽  
Left Knee ◽  
South American ◽  
History Of ◽  
Clinical Variants ◽  
Group B ◽  
Streptococcus A ◽  
Increasing Trends

Background: Myiasis is a cutaneous infestation with larvae of Diptera, the two-winged arthropod order. Eggs and/or larvae are transmitted directly from the environment or via arthropod vectors. Larvae are able to burrow into the dermis of intact skin or external body orifices. Three clinical variants of myiasis are furuncular, migratory (creeping), and infestation of wounds. Methods: A 35-year-old male presented with a 1-month history of worsening furuncles on the left knee and posterior thigh following his return from Panama, South America. Clinical examination revealed tender 6 cm and 2 cm erythematous to violaceous furuncles with surrounding desquamation and central puncta draining serosanguinous fluid. Five-millimeter punch biopsies and tissue swabs were performed. Results: All larvae were of the Dermatobia hominis species. The patient was empirically treated with cephalexin and ciprofloxacin for secondary bacterial cellulitis. Tissue swabs later cultured group B streptococcus. A tetanus booster was recommended. Conclusion: This case report describes a relatively rare cutaneous infestation with D. hominis, a Central and South American endemic larva of the human botfly. Increasing trends toward immigration and global travel to tropical and subtropic areas will likely increase the frequency of encounters with such parasitic cutaneous infestations in North American outpatient dermatology clinics.

scholarly journals Bilateral septic arthritis of the knee caused by group B streptococci: a case report

2019 ◽  
Author(s):  
Seyed Ali Dehghan Manshadi ◽  
Ramazanali Alizadeh ◽  
Mohammadreza Salehi ◽  
Arash Seifi ◽  
Mojgan Seifi
Keyword(s):  
Septic Arthritis ◽  
Left Knee ◽  
Diabetic Woman ◽  
Group B Streptococci ◽  
Knee Arthritis ◽  
Timely Initiation ◽  
Etiologic Agents ◽  
Wbc Count ◽  
Group B ◽  
Empirical Antibiotics

Septic arthritis (SA) remains to be a critical diagnosis for a swollen knee at the emergency department. Here, we report a rare case of bilateral knee arthritis in a 59-year-old diabetic woman who had been immobilized 5 months prior to admission. Her right knee swelling exacerbated in 10 days leading to left knee involvement. In 5 days the clear synovial tap in the first hos- pital turned purulent in the second hospital and empirical antibiotics get started with high WBC count, dominant neutrophils, and Gram-positive cocci in smear. Knee arthrotomy was performed after 6 days in the third hospital with the same smear results but negative blood and synovial cultures of both knees. When followed in retrograde, two positive blood cultures were reported for Streptococcus agalactiae in the second hospital. Vancomycin was changed to ampicillin and symptoms were resolved in 4 weeks. Despite improvement, mobility was not retained. Uncommon etiologic agents of knee arthritis should be in mind specifically in debilitated patients. Timely initiation of proper antibiotics hinders permanent sequels, hence clinicians should be suspicious of such organisms.

First prospective observational study in diffuse-type tenosynovial giant cell tumors.

2018 ◽  
Vol 36 (15_suppl) ◽  
pp. 11560-11560 ◽  
Author(s):  
Monique Mastboom ◽  
Emanuela Palmerini ◽  
Silvia Stacchiotti ◽  
Eric Staals ◽  
Bart Schreuder ◽  
...  
Keyword(s):  
Observational Study ◽  
Giant Cell ◽  
Prospective Observational Study ◽  
Diffuse Type ◽  
Giant Cell Tumors
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