scholarly journals Q Fever Endocarditis in Northeast Iran

2021 ◽  
Vol 2021 ◽  
pp. 1-3
Author(s):  
Ali Akbar Heydari ◽  
Ehsan Mostafavi ◽  
Masoumeh Heidari ◽  
Mina Latifian ◽  
Saber Esmaeili
Keyword(s):  
Weight Loss ◽  
Q Fever ◽  
Igg Antibodies ◽  
Duke Criteria ◽  
Chronic Q Fever ◽  
Indirect Immunofluorescent Assay ◽  
Male Farmer ◽  
Indirect Immunofluorescent ◽  
Northeast Iran ◽  
Phase I And Ii

This report presents a case of chronic Q fever endocarditis. A 60-year-old male farmer and rancher was admitted to the hospital with symptoms of weight loss, fever, severe sweating, weakness, and anorexia. PCR was negative for C. burnetii in the blood sample, but phase I and II IgG antibodies against C. burnetii were positive (1 : 16384 and 1 : 2048, respectively) by the indirect immunofluorescent assay (IFA). According to the adjusted Duke criteria, Q fever endocarditis was confirmed, and the patient was successfully treated with doxycycline and hydroxychloroquine.

scholarly journals Q Fever Endocarditis in Iran

2019 ◽  
Vol 9 (1) ◽  
Author(s):  
Pardis Moradnejad ◽  
Saber Esmaeili ◽  
Majid Maleki ◽  
Anita Sadeghpour ◽  
Monireh Kamali ◽  
...  
Keyword(s):  
Q Fever ◽  
Molecular Evidence ◽  
Tissue Samples ◽  
Duke Criteria ◽  
Chronic Q Fever ◽  
High Prevalence ◽  
The Mean ◽  
Polymerase Chain ◽  
Criteria For Diagnosis ◽  
Culture Negative

Abstract Patients with the underlying valvular heart disease are at the high risk of developing sub-acute or chronic endocarditis secondary to Coxiella burnetii. Q fever endocarditis is the most common manifestation along with persistent the infection. There is some serologic and molecular evidence of C. burnetii infection in humans and livestock in Iran. As it is possible to observe chronic Q fever in Iran, it seems necessary to study the prevalence of Q fever endocarditis in this country. In the present study, Infective Endocarditis (IE) patients (possible or definite based on Duke Criteria) hospitalized in Rajaie Cardiovascular Medical and Research Center were enrolled from August 2016 to September 2018. Culture-negative endocarditis patients were evaluated by Raoult criteria for diagnosis Q fever endocarditis. The serological results for brucellosis were negative for all subjects. All blood and tissue samples including valve samples were tested for C. burnetii infection using serology and Polymerase Chain Reaction (PCR). In this study, 126 patients who were admitted to the hospital were enrolled; of which 52 subjects were culture-negative IE. Among the participants, 16 patients (30.77%) were diagnosed with Q fever IE and underwent medical treatment. The mean age of patients was 46.6 years ranging from 23 to 69 years and 75% of them were male. Considering the high prevalence of Q fever IE, evaluation of the patients with culture-negative IE for C. burnetii infections was highly recommended.

The immune response in a cat-related outbreak of Q fever as measured by the indirect immunofluorescence test and the enzyme-linked immunosorbent assay

1990 ◽  
Vol 36 (4) ◽  
pp. 292-296 ◽  
Author(s):  
J. Embil ◽  
J. C. Williams ◽  
T. J. Marrie
Keyword(s):  
Immune Response ◽  
Phase I ◽  
Phase Ii ◽  
Q Fever ◽  
Elisa Test ◽  
Enzyme Linked Immunosorbent Assay ◽  
Whole Cells ◽  
Chronic Q Fever ◽  
Acute Q Fever ◽  
Indirect Immunofluorescent

The isotypic immune response of 16 individuals who developed Q fever pneumonia following exposure to an infected parturient cat was studied. The enzyme-linked immunosorbent (ELISA) test was used to detect IgM, IgA, and IgG antibodies to phase I and phase II Coxiella burnetii whole-cell antigens and to the phase I lipopolysaccharide. The indirect immunofluorescent antibody (IFA) test was also used to detect antibodies to phase I and phase II whole cells. None of the 16 subjects developed antibodies to the phase I lipopoly saccharide. The ELISA was more sensitive than the IFA test. IgM antibodies to phase II antigen were detectable by ELISA in 80% of the subjects at the time of onset of symptoms and were still present in 7 of the 8 tested at 32 weeks following the onset of symptoms. In all instances (ELISA: IgG, IgM; IFA: IgG, IgM) phase II antibodies developed earlier and reached higher levels than did phase I antibodies. The absence of antibodies to phase I lipopolysaccharide in acute Q fever combined with our unpublished findings of antibodies to phase I lipopoly saccharide in chronic Q fever suggests that this test may be used to distinguish acute from chronic Q fever. Key words: Q fever, immune response, ELISA.

scholarly journals Chronic Q fever: An ongoing challenge in diagnosis and management

2014 ◽  
Vol 25 (1) ◽  
pp. 35-37 ◽  
Author(s):  
Ira Das ◽  
Nicola Guest ◽  
Richard Steeds ◽  
Peter Hewins
Keyword(s):  
Q Fever ◽  
Phase 1 ◽  
Laboratory Diagnosis ◽  
Serological Response ◽  
Diagnosis And Management ◽  
Duke Criteria ◽  
Chronic Q Fever ◽  
History Of ◽  
Level 1 ◽  
High Level

Chronic Q fever is a potentially fatal disease. The current difficulty in the diagnosis of this condition is discussed in the present article. A 51-year-old woman with a history of aortic valve replacement presented with complaints of feeling generally unwell, pyrexia and occasional unproductive cough over a period of several weeks. Phase 1 immunoglobulin G titre toCoxiella burnetiiwas initially detected at a low level (1:320, detected using immunofluorescence) and was not considered to be significant according to the modified Duke criteria. Later in the course of her illness, the patient’s antibody titre rose to a high level (1:1280). The issues regarding current laboratory diagnosis and management of Q fever are discussed. Chronic Q fever can be associated with an inadequate serological response. Close follow-up of cases is essential. The recommended serological criteria for the diagnosis of Q fever endocarditis needs to be revisited.

scholarly journals Treatment of Chronic Q Fever: Clinical Efficacy and Toxicity of Antibiotic Regimens

2017 ◽  
Vol 66 (5) ◽  
pp. 719-726 ◽  
Author(s):  
Sonja E van Roeden ◽  
Chantal P Bleeker-Rovers ◽  
Marieke J A de Regt ◽  
Linda M Kampschreur ◽  
Andy I M Hoepelman ◽  
...  
Keyword(s):  
Clinical Efficacy ◽  
Q Fever ◽  
Chronic Q Fever

scholarly journals Chronic Q fever prosthetic valve endocarditis — an important cause of prosthetic valve dysfunction in Australia

2015 ◽  
Vol 202 (4) ◽  
pp. 212-213 ◽  
Author(s):  
Mohammad Paymard ◽  
Lisa Nicotra ◽  
Andrew Dettrick ◽  
Brendan Bell ◽  
Alex Chaudhuri ◽  
...  
Keyword(s):  
Prosthetic Valve ◽  
Q Fever ◽  
Prosthetic Valve Endocarditis ◽  
Valve Dysfunction ◽  
Prosthetic Valve Dysfunction ◽  
Chronic Q Fever

scholarly journals Questing one Brazilian query: reporting 16 cases of Q fever from Minas Gerais, Brazil

2006 ◽  
Vol 48 (1) ◽  
pp. 5-9 ◽  
Author(s):  
Paulo Sérgio Gonçalves da Costa ◽  
Marco Emilio Brigatte ◽  
Dirceu Bartolomeu Greco
Keyword(s):  
Phase I ◽  
Phase Ii ◽  
Fever Of Unknown Origin ◽  
Q Fever ◽  
Acute Infection ◽  
Case Series ◽  
Febrile Illness ◽  
Unknown Origin ◽  
Clinical Form ◽  
Chronic Q Fever

Q fever has been considered non-existing in Brazil where reports of clinical cases still cannot be found. This case-series of 16 patients is a result of a systematic search for such illness by means of clinical and serologic criteria. Serologic testing was performed by the indirect microimmunofluorescence technique using phase I/II C. burnetii antigens. Influenza-like syndrome was the most frequent clinical form (eight cases - 50%), followed by pneumonia, FUO (fever of unknown origin), mono-like syndrome (two cases - 12.5% each), lymphadenitis (one case - 6.3%) and spondylodiscitis associated with osteomyelitis (one case - 6.3%). The ages varied from four to 67 years old with a median of 43.5. All but one patient had positive serologic tests for phase II IgG whether or not associated with IgM positivity compatible with acute infection. One patient had both phase I and phase II IgG antibodies compatible with chronic Q fever. Seroconvertion was detected in 10 patients. Despite the known limitations of serologic diagnosis, the cases here reported should encourage Brazilian doctors to include Q fever as an indigenous cause of febrile illness.

Legionella and Public Water Supplies

1988 ◽  
Vol 20 (11-12) ◽  
pp. 5-10 ◽  
Author(s):  
J. S. Colbourne ◽  
P. J. Dennis ◽  
R. M. Trew ◽  
C. Berry ◽  
G. Vesey
Keyword(s):  
Surface Water ◽  
Heat Shock ◽  
Distribution Systems ◽  
Potable Water ◽  
Water Sources ◽  
Water Supplies ◽  
Indirect Immunofluorescent Assay ◽  
Water Mains ◽  
Legionnaires Disease ◽  
Indirect Immunofluorescent

A survey for legionella in public water supplies in England failed to detect culturable L.pneumophila in all but samples from taps in buildings; however, the organism was detected in underground and surface water sources and distribution systems using an indirect immunofluorescent assay (IFA) to L.pneumophila serogroup 1. Culturability was related to water temperatures above 20°C. In water mains L.pneumophila was associated with biofilms or sediment. Non-culturable L.pneumophila detected in potable waters by IFA were recovered by heat shock experiments demonstrating their viability. Although the strain found in potable water is rarely asociated with disease, monoclonal expression, a virulence marker, was altered by heat shock. These findings have implications for the prevention of legionellosis and may explain the sporadic nature of legionnaires disease in the community.

scholarly journals Genetic Variation in Pattern Recognition Receptors and Adaptor Proteins Associated With Development of Chronic Q Fever

2015 ◽  
Vol 212 (5) ◽  
pp. 818-829 ◽  
Author(s):  
Teske Schoffelen ◽  
Anne Ammerdorffer ◽  
Julia C. J. P. Hagenaars ◽  
Chantal P. Bleeker-Rovers ◽  
Marjolijn C. Wegdam-Blans ◽  
...  
Keyword(s):  
Pattern Recognition ◽  
Genetic Variation ◽  
Q Fever ◽  
Adaptor Proteins ◽  
Pattern Recognition Receptors ◽  
Chronic Q Fever
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