scholarly journals Relationship of Urinary Phthalate Metabolites with Cardiometabolic Risk Factors and Oxidative Stress Markers in Children and Adolescents

2021 ◽  
Vol 2021 ◽  
pp. 1-12
Author(s):  
Majid Hashemi ◽  
Mohammad Mehdi Amin ◽  
Afsane Chavoshani ◽  
Nasim Rafiei ◽  
Karim Ebrahimpour ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Risk Factors ◽  
Children And Adolescents ◽  
Cardiometabolic Risk ◽  
Cardiometabolic Risk Factors ◽  
Oxidative Stress Markers ◽  
Phthalate Metabolites ◽  
Stress Markers ◽  
Relationship Of ◽  
And Oxidative Stress

Introduction. Studies have proved that exposure of adults to phthalates might be related to cardiometabolic risk factors and changes in markers of oxidative stress. Such studies conducted on school-age children and adolescents are limited and fail to assess the simultaneous effect of phthalates on these risk factors and oxidative stress markers. Therefore, it was attempted to identify the relationship of urinary phthalate metabolites with cardiometabolic risk factors and oxidative stress markers in children and adolescents. Methods. In this cross-sectional study, 108 children and adolescents, living in Isfahan industrial city of Iran, were examined. Urine samples taken from the participants were analyzed for mono-butyl phthalate (MBP), mono-benzyl phthalate (MBzP), mono-(2-ethylhexyl) phthalate (MEHP), mono-(2-ethyl-5-hydroxyhexyl) phthalate (MEHHP), mono-(2-ethyl-5-exohexyl) phthalate (MEOHP), and mono-methyl phthalate (MMP). Results. Results showed that, among phthalate metabolites, MBP had the highest concentration, followed by MBzP, MEOHP, MEHHP, MEHP, and MMP. Concentrations of these metabolites had a significant relationship with some of the cardiometabolic risk factors including systolic blood pressure (SBP), fasting blood sugar (FBS), and triglycerides (TG) ( p  < 0.05). Furthermore, the crude and adjusted linear regression models indicated the significant association of phthalate metabolites with superoxide dismutase (SOD), malondialdehyde (MDA), and homeostasis model assessment of insulin resistance (HOMA-IR) ( p  < 0.05). Conclusion. Although urinary phthalate concentrations could not exactly reflect the long-term exposure level in the studied age groups, the consumption of phthalate-free products during childhood and adolescent development shall be assumed helpful in maintaining a healthy lifestyle. To confirm these findings and develop effective intervention strategies, it would be necessary to perform longitudinal studies on diverse population.

Changes in oxidative stress markers and cardiometabolic risk factors among Roux-en-Y gastric bypass patients after 3- and 12-months postsurgery follow-up

2019 ◽  
Vol 15 (10) ◽  
pp. 1738-1745
Author(s):  
Sônia Lopes Pinto ◽  
Leidjaira Lopes Juvanhol ◽  
Leandro Licursi de Oliveira ◽  
Rodolfo Castilho Clemente ◽  
Josefina Bressan
Keyword(s):  
Oxidative Stress ◽  
Risk Factors ◽  
Gastric Bypass ◽  
Cardiometabolic Risk ◽  
Cardiometabolic Risk Factors ◽  
Oxidative Stress Markers ◽  
Stress Markers

Inflammatory and oxidative stress markers among children and adolescents with bipolar disorder

2017 ◽  
Vol 27 ◽  
pp. S21
Author(s):  
F. Hernandez Alvarez ◽  
G. Salazar de Pablo ◽  
R. Vicente Moreno ◽  
A. Del Rey Mejías ◽  
K. McDowell ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Bipolar Disorder ◽  
Children And Adolescents ◽  
Oxidative Stress Markers ◽  
Stress Markers ◽  
And Oxidative Stress

scholarly journals Abnormal Levels of Inflammatory and Oxidative Stress Markers in Patients with Arterial Hypertension and Diabetes Mellitus

2013 ◽  
Vol 6 (2) ◽  
pp. 89-93
Author(s):  
Maya P. Danovska ◽  
Margarita L. Alexandrova ◽  
Irena I. Gencheva
Keyword(s):  
Oxidative Stress ◽  
Diabetes Mellitus ◽  
Risk Factors ◽  
Arterial Hypertension ◽  
Oxidative Stress Markers ◽  
Stress Markers ◽  
Cardiovascular Morbidity And Mortality ◽  
Significant Difference ◽  
Traditional Risk Factors ◽  
And Oxidative Stress

Summary Individuals with hypertension and diabetes mellitus are at high risk of cerebrovascular and cardiovascular morbidity and mortality. Recent advances in the multifactorial pathophysiology of atherogenesis provide important information about the complex interrelations between traditional risk factors, inflammation and oxidative stress in mediating all stages of atherosclerosis. The objective of the study was to determine if some inflammatory and oxidative stress markers in patients with arterial hypertension and diabetes mellitus differ from those in healthy age-matched controls. Our results revealed a significant difference in blood pro/antioxidant activities in hypertensive diabetics and the controls. The investigation of inflammatory and oxidative stress markers along with traditional risk factors proves useful in complex assessment of vascular risk and primary prophylaxis of cerebrovascular and cardiovascular events.

scholarly journals APO B/APO A1 RATIO AND ITS CORRELATION WITH CARDIOMETABOLIC RISK FACTORS AND OXIDATIVE STRESS IN SUBJECTS WITH METABOLIC SYNDROME

2020 ◽  
pp. 1-3
Author(s):  
Deepthy C Sahadevan* ◽  
Archna Sing ◽  
Busi Karunanand ◽  
Himani Thakkar ◽  
Ajay Kumar Gautam
Keyword(s):  
Oxidative Stress ◽  
Risk Factors ◽  
Cardiometabolic Risk ◽  
Low Density Lipoprotein ◽  
Density Lipoprotein ◽  
Cardiometabolic Risk Factors ◽  
Oxidative Stress Marker ◽  
Low Density ◽  
Apo B ◽  
And Oxidative Stress

Objective: This study was designed to assess the apolipoprotein B (Apo-B), apolipoprotein A (Apo A) and Apo B/Apo A-I ratio in subjects with and withoutmetabolic syndrome andtoevaluate the correlationofApoB/ApoA-Iratiowithoxidative stressmarker andcardiovasculardisease risk. Methods:Atotal of 308 subjects including one hundred and fty- ve cases and one hundred and fty- three controls were recruited for this study. All the subjects were classied according to the NCEPATP III (National cholesterol education program – Adult treatment panel III) criteria for MetS. Anthropometric and clinical characteristics were recorded using clinical Proforma. Blood samples were collected for doing plasma glucose, Lipid prole analysis [Total Cholesterol (TC), Triglyceride (TG), high-density lipoprotein (HDL)], ApoA1, Apo B and oxidative stress marker - Malondialdehyde (MDA). Serum low-density lipoprotein (LDL), very-low-density lipoprotein (VLDL) and Apo B/Apo A-I ratio were calculated. Comparison of data between the two groups was done by t test. Correlation coefcient of Apo B/ Apo A1 ratio with cadiometabolic risk factors were calculated. Result: We found that cardiometabolic risk factors like abdominal obesity, systolic and diastolic blood pressure, fasting plasma glucose, TG, atherogenic lipoproteins LDL, Apo B, Apo B/Apo A-I ratio and MDA were signicantly high in subjects with MetS whereas anti-atherogenic factor Apo A1 was signicantly low. We also observed that Apo B/AI ratio was positively related to cardiometabolic risk factors and with oxidative stress marker. Conclusion:Apo B/AI ratio was related to metabolic syndrome and was found to be a reliable indicator of cardiovascular risk in MetS.

scholarly journals Subclinical Cardiovascular Risk Signs in Adults with Juvenile Idiopathic Arthritis in Sustained Remission

2020 ◽  
Author(s):  
Inmaculada Concepcion Aranda-Valera ◽  
Iván Arias de la Rosa ◽  
Rosa Roldan-Molina ◽  
Maria del Carmen Abalos-Aguilera ◽  
Carmen Torres-Granados ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Risk Factors ◽  
Juvenile Idiopathic Arthritis ◽  
Endothelial Activation ◽  
Sustained Remission ◽  
Oxidative Stress Markers ◽  
Cvd Risk Factors ◽  
Cvd Risk ◽  
Stress Markers ◽  
And Oxidative Stress

Abstract Background: Juvenile Idiopathic Arthritis (JIA) is one of the most common chronic diseases of childhood that often persists into adulthood and can result in significant long-term morbidity. As a long lasting chronic inflammatory disease, concern has been raised regarding the risk of premature development of cardiovascular disease (CVD) in JIA. This study aims to determine whether adults with JIA in clinical remission display clinical and subclinical signs of CVD risk: inflammatory mediators, adipokines, endothelial dysfunction and oxidative stress markers.Methods: This is a cross-sectional study including 25 patients diagnosed with JIA according to the International League of Associations for Rheumatology criteria (ILAR 2001) and 25 age- and sex-matched controls. Remission was determined by JADAS10<1 and according to Wallace criteria. The presence of traditional CVD risk factors was analyzed. An extensive clinical analysis including body mass index (BMI), lipid profile, homeostatic model assessment – insulin resistance (HOMA-IR) and arterial blood pressure was performed. Intima media thickness of the common carotid artery (CIMT) was measured as a marker of subclinical atherosclerosis. Several proinflammatory cytokines, molecules involved in the endothelial dysfunction, oxidative stress and adipokines were quantified on serum by ELISA and on peripheral blood mononuclear cells (PBMCs) by RT-PCR. In vitro studies were carried out in healthy PBMCs, adipocytes and endothelial cells which were treated with serum from JIA patients under sustained remission. Results: Mean duration of the disease was 13.47 ± 5.47 years. Mean age was 25.11 ± 7.21. Time in remission was 3.52 ± 3.33 years. Patients were in remission with no treatment (40%) and with treatments (60%). CVD risk factors and CIMT were similar in JIA patients and controls. However, cholesterol levels were significantly elevated in JIA patients. Levels of adipocytokines, oxidative stress and endothelial activation markers were elevated in serum and PBMCs from JIA patients. Serum of those JIA patients induced the activation of adipocytes, endothelial cells and healthy PBMCs.Conclusions: JIA adult patients in remission have subclinical signs of inflammation and CVD risk, showed by an increase in the levels of inflammatory cytokines, endothelial activation and oxidative stress markers and adipokines, molecules closely involved in the alteration of the vascular system.

Association of urinary concentrations of phthalate metabolites with cardiometabolic risk factors and obesity in children and adolescents

Chemosphere ◽  
2018 ◽  
Vol 211 ◽  
pp. 547-556 ◽  
Author(s):  
Mohammad Mehdi Amin ◽  
Karim Ebrahimpour ◽  
Saeed Parastar ◽  
Bahareh Shoshtari-Yeganeh ◽  
Majid Hashemi ◽  
...  
Keyword(s):  
Risk Factors ◽  
Children And Adolescents ◽  
Cardiometabolic Risk ◽  
Cardiometabolic Risk Factors ◽  
Phthalate Metabolites ◽  
Obesity In Children
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