scholarly journals Identifying Mitochondrial-Related Genes NDUFA10 and NDUFV2 as Prognostic Markers for Prostate Cancer through Biclustering

2021 ◽  
Vol 2021 ◽  
pp. 1-15
Author(s):  
Haokun Zhang ◽  
Yuanhua Shao ◽  
Weijun Chen ◽  
Xin Chen
Keyword(s):  
Gene Expression ◽  
Prostate Cancer ◽  
Survival Analysis ◽  
Cancer Patients ◽  
Gene Expression Profile ◽  
Expression Profile ◽  
Prognostic Markers ◽  
The United States ◽  
The Core ◽  
Core Genes

Prostate cancer is currently associated with higher morbidity and mortality in men in the United States and Western Europe, so it is important to identify genes that regulate prostate cancer. The high-dimension gene expression profile impedes the discovery of biclusters which are of great significance to the identification of the basic cellular processes controlled by multiple genes and the identification of large-scale unknown effects hidden in the data. We applied the biclustering method MCbiclust to explore large biclusters in the TCGA cohort through a large number of iterations. Two biclusters were found with the highest silhouette coefficient value. The expression patterns of one bicluster are highly similar to those found by the gene expression profile of the known androgen-regulated genes. Further gene set enrichment revealed that mitochondrial function-related genes were negatively correlated with AR regulation-related genes. Then, we performed differential analysis, AR binding site analysis, and survival analysis on the core genes with high phenotypic contribution. Among the core genes, NDUFA10 showed a low expression value in cancer patients across different expression profiles, while NDUFV2 showed a high expression value in cancer patients. Survival analysis of NDUFA10 and NDUFV2 demonstrated that both genes were unfavorable prognostic markers.

Gene Expression Profile of Prostate Cancer Patients by Chemiluminescent Analysis

2009 ◽  
Vol 42 (1) ◽  
pp. 166-177
Author(s):  
Vivian Alonso ◽  
Adriana Freitas Neves ◽  
Karina Marangoni ◽  
Paula Cristina Batista de Faria ◽  
Elisângela Rosa Cordeiro ◽  
...  
Keyword(s):  
Gene Expression ◽  
Prostate Cancer ◽  
Cancer Patients ◽  
Gene Expression Profile ◽  
Expression Profile

scholarly journals Human Pleural Fluid and Human Serum Albumin Modulate the Behavior of a Hypervirulent and Multidrug-Resistant (MDR) Acinetobacter baumannii Representative Strain

Pathogens ◽  
2021 ◽  
Vol 10 (4) ◽  
pp. 471
Author(s):  
Camila Pimentel ◽  
Casin Le ◽  
Marisel R. Tuttobene ◽  
Tomas Subils ◽  
Jasmine Martinez ◽  
...  
Keyword(s):  
Gene Expression ◽  
Human Serum Albumin ◽  
Serum Albumin ◽  
Human Serum ◽  
Acinetobacter Baumannii ◽  
Pleural Fluid ◽  
Gene Expression Profile ◽  
Expression Profile ◽  
The United States ◽  
World Health

Acinetobacter baumannii is a nosocomial pathogen capable of causing serious infections associated with high rates of morbidity and mortality. Due to its antimicrobial drug resistance profile, A. baumannii is categorized as an urgent priority pathogen by the Centers for Disease Control and Prevention in the United States and a priority group 1 critical microorganism by the World Health Organization. Understanding how A. baumannii adapts to different host environments may provide critical insights into strategically targeting this pathogen with novel antimicrobial and biological therapeutics. Exposure to human fluids was previously shown to alter the gene expression profile of a highly drug-susceptible A. baumannii strain A118 leading to persistence and survival of this pathogen. Herein, we explore the impact of human pleural fluid (HPF) and human serum albumin (HSA) on the gene expression profile of a highly multi-drug-resistant strain of A. baumannii AB5075. Differential expression was observed for ~30 genes, whose products are involved in quorum sensing, quorum quenching, iron acquisition, fatty acid metabolism, biofilm formation, secretion systems, and type IV pilus formation. Phenotypic and further transcriptomic analysis using quantitative RT-PCR confirmed RNA-seq data and demonstrated a distinctive role of HSA as the molecule involved in A. baumannii’s response.

scholarly journals Gene Expression Profile, Androgen Independence and Prostate Cancer

2012 ◽  
Vol 03 (05) ◽  
pp. 637-644
Author(s):  
Maxwell Omabe ◽  
Joel C. Onyeanusi ◽  
Nworie Amos ◽  
Martin Ezeani ◽  
Simon Imakwu Okekpa
Keyword(s):  
Gene Expression ◽  
Prostate Cancer ◽  
Gene Expression Profile ◽  
Expression Profile ◽  
Androgen Independence

Abstract 4267: Gene expression profile of fibroblasts from different topographical origins in breast cancer patients

2012 ◽  
Author(s):  
Paulo Roberto Del Valle ◽  
Maria Lucia Hirata Katayama ◽  
Patricia Bortman Rozenchan ◽  
Cintia Milani ◽  
Eduardo Carneiro Lyra ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Gene Expression ◽  
Cancer Patients ◽  
Gene Expression Profile ◽  
Expression Profile ◽  
Breast Cancer Patients

Abstract A147: Curcumin modulates gene expression profile and delays tumor progression of prostate cancer

2010 ◽  
Author(s):  
Peter H. Killian ◽  
Emanuel Kronski ◽  
Valentina Mirisola ◽  
Ulrich Pfeffer ◽  
Andreas G. Nerlich ◽  
...  
Keyword(s):  
Gene Expression ◽  
Prostate Cancer ◽  
Tumor Progression ◽  
Gene Expression Profile ◽  
Expression Profile

Integrated gene expression profile predicts prognosis of breast cancer patients

2008 ◽  
Vol 113 (2) ◽  
pp. 231-237 ◽  
Author(s):  
Lian-Fang Li ◽  
Xiao-Jing Xu ◽  
Ying Zhao ◽  
Zhe-Bing Liu ◽  
Zhen-Zhou Shen ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Gene Expression ◽  
Cancer Patients ◽  
Gene Expression Profile ◽  
Expression Profile ◽  
Breast Cancer Patients

Gene expression profile of FVII and AR in primary prostate cancer

2016 ◽  
Vol 17 (3) ◽  
pp. 353-358 ◽  
Author(s):  
Shirin Shahbazi ◽  
Maryam Khorasani ◽  
Reza Mahdian
Keyword(s):  
Gene Expression ◽  
Prostate Cancer ◽  
Gene Expression Profile ◽  
Expression Profile ◽  
Primary Prostate Cancer
Sign in / Sign up

Export Citation Format

Share Document