scholarly journals Traditional Chinese Herbal Medicine Plays a Role in the Liver, Kidney, and Intestine to Ameliorate Hyperuricemia according to Experimental Studies

2021 ◽  
Vol 2021 ◽  
pp. 1-13
Author(s):  
Li Xu ◽  
Li Li Lu ◽  
Jian Dong Gao

In the last few decades, hyperuricemia has drawn increasing attention owing to its global prevalence. Observational surveys have manifested that there is a relation between hyperuricemia and increased risks of hypertension, chronic kidney disease, cardiovascular events, metabolic disorders, end stage renal disease, and mortality. As alternatives, Traditional Chinese medicinal herbs have demonstrated concrete effects in mitigating hyperuricemia in different experiments. Researchers have made efforts to investigate the role of herbal medicine in attenuating hyperuricemia. This review focuses on traditional Chinese herbal medicines that have been reported to ameliorate hyperuricemia in experimental studies.

2013 ◽  
Vol 2013 ◽  
pp. 1-7 ◽  
Author(s):  
Weihua Chu ◽  
Shuxin Zhou ◽  
Yan Jiang ◽  
Wei Zhu ◽  
Xiyi Zhuang ◽  
...  

Traditional Chinese herbal medicines (TCHMs) were tested for their ability of antiquorum sensing. Water extracts ofRhubarb, Fructus gardeniae, and Andrographis paniculatashow antiquorumsensing activity when usingChromobacterium violaceumCV12472 as reporter; the sub-MIC concentrations of these TCHMs were tested against AHL-dependent phenotypic expressions of PAO1. Results showed significant reduction in pyocyanin pigment, protease, elastase production, and biofilm formation in PAO1 without inhibiting the bacterial growth, revealing that the QSI by the extracts is not related to static or killing effects on the bacteria. The results indicate a potential modulation of bacterial cell-cell communication,P. aeruginosabiofilm, and virulence factors by traditional Chinese herbal medicine. This study introduces not only a new mode of action for traditional Chinese herbal medicines, but also a potential new therapeutic direction for the treatment of bacterial infections, which have QSI activity and might be important in reducing virulence and pathogenicity of pathogenic bacteria.


2020 ◽  
Vol 15 (2) ◽  
pp. 1934578X2090514 ◽  
Author(s):  
Na Zhao ◽  
Xiaoming Su ◽  
Yueyang Wang ◽  
Jianguang Chen ◽  
Wenyue Zhuang

Melanin is the chief pigment responsible for the pigmentation of human skin. Increasing evidence indicates that traditional Chinese drugs with skin-whitening effects are attracting the attention of consumers and researchers because they are perceived to be milder, safer, and healthier than synthetic alternatives. This commentary summarizes the current research on Chinese herbal medicines that inhibit melanin and their biological activities. The findings presented in this study suggest that these traditional Chinese herbal medicines might be potential candidates for novel skin-whitening agents.


2019 ◽  
Vol 20 (1) ◽  
pp. 54-64 ◽  
Author(s):  
Abedin Abdallah ◽  
Pei Zhang ◽  
Qingzhen Zhong ◽  
Zewei Sun

Background: Misuse of synthetic antibiotics in livestock leads to the transfer of antibiotic resistant pathogens into humans and deposits toxic residues in meat and milk. There is therefore an urgent need for safe and viable alternative approaches to improve the nutrition and wellbeing of farm animals. An alternative source that has been widely exploited is Traditional Chinese Herbal Medicine (TCHM). These herbs contain several but less toxic bioactive compounds which are generally regarded as biodegradable. Recently, advances in the knowledge of the importance of TCHM have led to a rapid increase in its production and hence, increasing the amount of by-products generated. Such by-products have become a serious environmental challenge because producers regard them as industrial waste and discard them directly. This review summarizes scientific findings on the bioactive compounds in TCHM and TCHM by-products, discusses functional dietary patterns and outlines challenges that may hinder full utilization of TCHM by-products in animal production. Methods: Information for this review was obtained through scientific databases and websites such as Pubmed and Google scholar from 2004 to 2017 using experimental studies on bioactive compounds in TCHM and their effects in animal production. Results: Studies have shown that TCHM by-products contain high amounts of bioactive compounds which confer several nutritional and health benefits to animals and thus could be incorporated as feed additives. Conclusion: The findings for this review indicate that TCHM by-products apart from being a good alternative for synthetic antibiotics could also minimize the current environmental challenges associated with its disposal.


2015 ◽  
Vol 88 (6) ◽  
pp. 1365-1373 ◽  
Author(s):  
Ming-Yen Lin ◽  
Yi-Wen Chiu ◽  
Jung-San Chang ◽  
Hung-Lung Lin ◽  
Charles Tzu-Chi Lee ◽  
...  

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